教育背景
1983年毕业于上海第二军医大学军医系;1997获日本京都大学医学院博士学位
工作经历
1999-2009年在美国加州大学伯克利分校营养与毒理系从事科研工作;2010年至今,南京大学医学院教授。
项目课题经历
National Natural Science Foundation of China – 81072292 (2011-2013)
National Natural Science Foundation of China – 81273068 (2013-2016)
National Natural Science Foundation of China – 81773417 (2018-2021)
Li Ka Shing/ UC-Berkeley Research Award – Prof. Elizabeth C. Theil and Chinese Woman Scientist Collaborator Prof. Chen Huijun 2011/01-12
论文、成果、著作等
ChenM, ZhengJ, LiuG, XuE, WangJ, FuquaBK, VulpeCD, AndersonGJ, Chen H*.Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux.Redox Biology.2018; 17: 432-439.
Zheng J, Jiang R, Chen M, Maimaitiming Z, Wang J, Anderson GJ, Vulpe CD, Dunaief JL, Chen H*.Multi-copper ferroxidase deficient mice have increased brain iron concentrations and learning and memory deficits. Journal of Nutrition.2018; 148: 643-649.
Zheng J, Chen M, Liu G, Xu E, Chen H.*Ablation of Hephaestinand Ceruloplasmin Results in Iron Accumulation in Adipocytes and Type 2 Diabetes.FEBS Lett.2018; Jan 21. 12978.
Jiang B, Liu G, Zheng J, Chen M, Maimaitiming Z, Chen M, Liu S, Jiang R, Fuqua BK, Dunaief JL, Vulpe CD, Anderson GJ, Wang H*, Chen H*. Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney.Sci Rep.2016; Dec 19;6:39470.
Jiang R, Hua C, Wan Y, Jiang B, Hu H, Zheng J, Fuqua BK, Dunaief JL, Anderson GJ, David S, Vulpe CD, and Chen H*. Hephaestin and Ceruloplasmin Play Distinct but Interrelated Roles in Iron Homeostasis in Mouse Brain.Journal of Nutrition. 2015; 145: 1003-1009.
Chen H*, Attieh ZK, Huang G, Regine Van Der Hee and Chris Vulpe. Decreased hephaestin expression and activity leads to decreased iron efflux fromdifferentiated Caco2 cells. Journal of Cellular Biochemistry. 2009;107: 803-808.
Chen H, Attieh ZK, Syed BA, Kuo YM, Stevens V, Fuqua BK, Andersen HS, Naylor CE, Evans RW, Gambling L, Danzeisen R, Bacouri-Haidar M, Usta J, Vulpe CD and McArdle HJ. Identification of zyklopen, a new member of thevertebrate multicopper ferroxidase family, and characterization in rodents andhuman cells.Journal of Nutrition. 2010;140: 1728-1735.
Chen H, Attieh ZK, Gao H, Huang G, Su T, Ke W and Vulpe CD. Age-related changes in iron homeostasis in mouse ferroxidase mutants. Biometals.2009; 22: 827-834.
Chen H, Huang G, Su T, Gao H, Attieh ZK, McKie AT, Anderson GJ, Vulpe CD. Decreased hephaestin level and activity in copper deficient mice causesystemic iron deficiency. Journal of Nutrition. 2006; 136: 1236-1241.
Chen H, Attieh ZK, Su T, Syed BA, Gao H, Alaeddine RM, Fox TC, Usta J, Naylor CE, Evans RW, McKie AT, Anderson GJ, Vulpe CD. Hephaestin is aferroxidase which maintains partial activity in the sex linked anemia mice.Blood. 2004;103: 3933-3939.
Kuo YM, Su T, Chen H, Attieh ZK, Syed BA, McKie AT, Anderson GJ, Gitschier J, Vulpe CD. Mislocalization of hephaestin, a multi-copper ferroxidaseinvolved in basolateral intestinal iron transport, in the sex-linked anaemia mouse. Gut. 2004; 53: 201-206.
Chen H, Su T, Attieh ZK, Fox TC, McKie AT, Anderson GJ, Vulpe CD. Systemic regulation of Hephaestin and Ireg1 revealed in studies of genetic andnutritional iron deficiency.Blood. 2003;102:1893-1899.
专利、著作版权等
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