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邢峥

领域:生物产业 学校:南京大学职称:教授

分子病毒和病毒免疫学 新现病毒性病原和控制...

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教育背景

1983-1986 中国医学科学院、中国预防医学科学院 病毒研究所 研究生
1978-1983 安徽医科大学 公共卫生学院 本科

工作经历

2009- 南京大学 教授、博士生导师;院长助理(2014- ) 2005-2009 加州大学戴维斯分校 助理研究员、项目科学家 1999-2004 美国宾夕法尼亚大学、加州大学伯克利分校 博士后 1990-1992 美国The Scripps Research Institute访问学者 1987-1990 中国预防医学科学院病毒所 助理研究员

项目课题经历

国家自然科学基金面上项目(PI):蜱传布尼亚病毒SFTSV非结构蛋白NSs和脂质小滴相互作用及其机制和功能的研究(2016.1 – 2019.12)

科技部国家重点研发计划项目“重要新发突发病原体宿主适应与损伤机制研究”课题四(PI):新发突发病毒导致脑炎等病症的机制研究(2016.7 - 2019.6)

论文、成果、著作等

1. Chunyang Wang, Xinhui Yuan, Lianfu Ji, Yu Jin, Carol J. Cardona, Zheng Xing*. 2017.Enterovirus 71 Suppresses Interferon Responses by Blocking JAK/STAT Signalingthrough Inducing Karyopherin-α1 Degradation.

Journal of Biological Chemistry292(24):10262-10274. doi: 10.1074/jbc.M116.745729




2. Xue Li, Bingqian Qu, GanlinHe, Carol Cardona, Yongchun Sun, &Zheng Xing*.

2017. Critical Role of HAX-1 in Promoting Avian Influenza Virus Replication in Lung Epithelial Cells. Mediators of InflammationIn press



3. FuJG, ShiC, XuC, LinQ, ZhangJ, YiQH, ZhangJ, BaoCJ, HuoX, ZhuYF, AiJ, &Zheng Xing*. 2017. Outbreaks of Acute Gastroenteritis Associated with a Re-emerging GII.P16-GII.2 Norovirus in the Spring of 2017 in Jiangsu, China.
PLoS OneIn press




4. Li Z, Hu J, Cui L, Hong Y, Liu J, Li P, Guo X, Liu W, Wang X, Qi X, Wu B, Feng Z, Shen A, Liu X, Zhao H, Tan W, Zhou J, XingZ, Bao C.2017. Increased Prevalence of Severe Fever with Thrombocytopenia Syndrome in Eastern China Clustered with Multiple Genotypes and Reasserted Virusduring 2010-2015.
ScientificReports7(1):6503. doi: 10.1038/s41598-017-06853-1.




5. Sun Q, Qi X, Zhang Y, Wu X, Liang M, Li C, Li D, Cardona CJ, Xing Z*. 2016. Synaptogyrin-2 Promotes Replication of a Novel Tick-borne Bunyavirus through Interacting with Viral Nonstructural Protein NSs.

Journal ofBiologicalChemistry291(31):16138-49. doi: 10.1074/jbc.M116.715599

6. Li Z, Bao C, Hu J, Liu W, Wang X, Zhang L, Ji Z, Feng Z, Li L, Shen A, Liu X, Zhao H, Tan W, Zhou J, Qi X, Zhu Y, Tang F, CardonaCJ, XingZ*.2016.
Ecology of the Tick-Borne Phlebovirus Causing Severe Fever with Thrombocytopenia Syndrome in an Endemic Area of China.PLoS Neglected Tropical Diseases10(4):e0004574. doi: 10.1371/journal.pntd.0004574.

7. Wang C, Ji L, Yuan X, Jin Y, CardonaCJ, XingZ*.2016. Differential Regulation of TLR Signaling on the Induction of Antiviral Interferons in Human Intestinal Epithelial Cells Infected with Enterovirus 71.
PLoS One11(3):e0152177. doi: 10.1371/journal.pone.0152177.

8.Wang CY, Zhou R, Zhang Z, Jin Y*, Cardona CJ, and Xing Z*. 2015.
Intrinsic Apoptosis and Proinflammatory Cytokines Regulated in Human Astrocytes Infected with Enterovirus 71.
Journal of General Virology09 July, 2015 doi: 10.1099/jgv.0.000235

9. Zhao C, Gao LY, Wang CY, Liu B, Jin Y*, and Xing Z*.2015. Structural Characterization andAntiviral activity of A Novel Heteropolysaccharide Isolated from Grifola frondosaagainst Enterovirus 71.
Carbohydrate PolymersDOI: 10.1016/j.carbpol.2015.12.005

10.Wang CY, Gao L, Jin Y, Cardona CJ, Xing Z*. 2015. Regulation of host responses and viral replication by the mitogen-activated protein kinases in intestinal epithelial cells infected with Enterovirus 71.
Virus Research197:75-84. doi: 10.1016/j.virusres.2014.12.016.

11.Q Sun, C Jin, LL Zhu, MF Liang, C Li, CJ Cardona, D Li, Z Xing*. 2015.
Host Responses and Regulation by NFkB signaling in Human Liver Epithelial
Cells Infected with Severe Fever with Thrombocytopenia Syndrome Virus.
Scientific Reports2015 Jul 2;5:11816. doi: 10.1038/srep11816.

12.Shen X, Sun W, Shi Y, Xing Z*, Su X*. 2015.Altered viral replication and cell responses by inserting microRNA recognition element into PB1 in pandemic influenza A virus (H1N1) 2009.
Mediators of Inflammation2015:976575. doi: 10.1155/2015/976575.

13.Hagag I.T., Mansour S.M.G, Zhang Z.R., Ali A.H., Ismaiel E.M., Salama A.A.,
Cardona C.J., Collins J., and Xing Z*. 2015.Pathogenicity of Highly Pathogenic Avian Influenza Virus H5N1 in Naturally Infected Poultry in Egypt. PLoS One10(5):e0120061. doi: 10.1371/journal.pone.0120061

14.Wu XD, Qi, X., Liang MF, Li C, Cardona, C.J. Li D and Xing Z*. 2014. Roles of Viroplasm-like Structure Formed by NSs in Infection with Severe FeverwithThrombocytopenia Syndrome (SFTS) Virus. FASEB Journal28(6):2504-16.

15.Wu XD, Qi X, Qu B, Zhang Z, Liang M, Li C, Cardona CJ, Li D, Xing Z*.2014. Evasion of antiviral immunity through sequestering TBK1/IKKe/IRF3 into viral inclusion bodies.Journal of Virology88(6):3067-3076.

16.Xing Z* and Murtaugh M. 2014. Novel bunyavirus in domestic and captive farmed animals, Minnesota, USA [letter]. Emerging Infectious Diseases20(2):337-8.

17.Qu BQ, Qi X, Wu XD, Liang MF, Li C, Cardona CJ, Wu B, Wegner M, Li D,
Xing Z*. 2012. Suppression of Interferon and NFkB responses in macrophages infected with severe fever with thrombocytopenia syndrome (SFTS) virus.
Journal of Virology86(16):8388-401.

18.Xing Z*, Schefers, J, Schwabenlander, M, Jiao, Y, Liang, MF, Li C, Goyal S, Cardona CJ, Li D, Collins J and Murtaugh MP. 2013. SFTSV-like Bunyavirus in farm and wild life animals in the United States. Emerging Infectious Diseases19(9):1487-9.

19.Chi CZ, Sun QY, Zhang ZR, Li X, Li X, Jin Y, andXing Z. * 2013. Host Immune Response to Enterovirus 71 in Human Intestinal Epithelial Cells.
Virus Researchdoi:pii: S0168-1702(13)00149-4.

20.Qi X, Cui L, Jiao Y, Pan Y, Li X, Zu R, Huo X, Wu B, Tang F, Song Y, Zhou M Wang H, Cardona CJ,Xing Z. 2013. Antigenic and genetic characterization of a European avian-like H1N1 swine influenza virus from a boy in China in 2011.
Archives of Virology158(1):39-53. doi: 10.1007/s00705-012-1423-7.

21.Gao W, Sun W, Qu B, Cardona CJ, Powell K, Wegner M, Shi Y, Xing Z*. 2012. Distinct Regulation of Host Responses by ERK and JNK MAP Kinases in Swine Macrophages Infected with Pandemic (H1N1). 2009. Influenza Virus.
PLoS One2012;7(1):e30328.

22.Qu BQ, Li X, Gao W, Sun WQ, Jin Y, Cardona CJ, Xing Z*. 2011.
Human intestinal epithelial cells are susceptible to influenza virus subtype H9N2.
Virus Research163(1):151-9.

23.Xing, Z*. R. Harper, J.D. Anunciacion, Z.Q. Yang, W.Gao, B.Qu, and C.J. Cardona. 2011.Host Immune and Apoptotic Responses to Low Pathogenic Avian Influenza Virus H9N2 in Human Tracheobronchial Epithelial Cells.
American Journal of Respiratory Cells & Molecular Biology,44(1):24-33

24. Xing, Z*, C.J. Cardona, J.D. Anunciacion, S. Adams, N. Dao. 2010.Roles of the ERK MAP Kinase in the Regulation of Proinflammatory and Apoptotic Responses in Chicken Macrophages Infected with H9N2 Avian Influenza Virus.Journal of General Virology,91(Pt2):343-51

25.Xing Z*and Cardona CJ. 2009. Preexisting immunity in human populationsto novel influenza A (H1N1) virus. Emerging Infectious Diseases15(11):1847-9

专利、著作版权等

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