教育背景
1978.09 西安第四军医大学本科1985.09 西安第四军医大学硕士研究生
工作经历
1983.07 第四军医大学唐都医院医师1988.07 南京军区南京总医院骨科主治医师
1995.01 南京军区南京总医院骨科副主任、副主任医师
1999.12 南京军区南京总医院骨科主任医师
2000.06 南京军区南京总医院骨科主任
项目课题经历
1、肠道菌群在人工关节无菌性松动发病过程中的作用及其机制研究 国家自然基金面上项目 2018.01-2021.12 55万
2、磨损微粒诱导的成骨细胞自噬在关节假体周围无菌性松动发病中的作用及机制研究 国家自然基金面上项目 2016.01-2019.12 57万
3、成骨细胞自噬在磨损颗粒致骨溶解过程中作用及其机制研究 江苏省自然基金 2016-2019 10万
4、江苏省骨科临床中心 江苏省科技厅资助项目 2012-2015 150万
5、内质网应激抑制剂4-Phenylbutyrate(4-PBA)减轻磨损微粒诱导骨溶解的机制研究 南京市课题
2014-2016 5万
6、抗假体松动骨水泥的研制及其抑制关节置换后骨溶解中的作用 江苏省自然基金 2012-2015 10万
论文、成果、著作等
1、Expression of XBP1s in Fibroblasts is Critical for TiAl 6 V 4 Particle-Induced RANKL Expression and Osteolysis J Orthop Res 2017,35(4):752-959 IF 2.692
2、Probiotics protect mice from cocrMo particles-induced osteolysis International Journal of Nanomedicine 2017,12:5387-5397 IF 4.300
3、TiAl 6 V 4 particles promote osteoclast formation via autophagy-mediated downregulation of interferon-beta in osteocytes Acta Biomaterialia 2017,48(15):489-498 IF 6.319
4、Estrogen-like neuroprotection of isopsoralen against spinal cord injury through estrogen receptor ERα Metab Brain Dis 2017,32(1):259-265 IF 2.297
5、Effect of ZBD-2 on chronic pain, depressive-like behaviors, and recovery of motor function following spinal cord injury in mice Behavioural Brain Research 2017,322:92-99 IF 3.00200
6、The mechanism of human β-defensin 3 in MRSA-inducedinfection of implant drug-resistant bacteria biofilmin the mouse tibial bone marrow. EXPERIMENTAL AND THERAPEUTIC MEDICINE 2017,13:1347-1352 IF:1.269
7、Dioscin enhances osteoblastic cell differentiation and proliferation by inhibiting cell autophagy via the ASPP2/NF κβ pathway. 2017,16(4):4922-4926 MOLECULAR MEDICINE REPORTS IF:1.69
8、SIRT1 protects osteoblasts against particle-induced inflammatory responses and apoptosis in aseptic prosthesis loosening Acta Biomaterialia 2017,49:541-554 IF 6.319
9、An overview of hydrogel-based intra-articular drug delivery for the treatment of osteoarthritis Colloids and Surfaces B: Biointerfaces 2017,154:33-39 IF 3.887
10、BDKRB2 þ9/?9bp polymorphisms influence BDKRB2 expression levels and NO production in knee osteoarthritis Experimental Biology and Medicine 2017,242(4):422-428 IF 2.688
11、Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative stress The America journal of translation research The America journal of translation research 2016,8(10):4472-4477 IF3.146
12、Harmful Effects of Leukocyte-Rich Platelet-Rich Plasma on Rabbit Tendon Stem Cells In Vitro The American Journal of Sports Medicine 2016,44(8):1941-1951 IF 4.517
13、The BDKRB2 +9/-9 Polymorphisms Influence Pro-Inflammatory Cytokine Levels in Knee Osteoarthritis by Altering TLR-2 Expression: Clinical and in Vitro Studies Cellular Physiology and Biochemistry 2016,38(3):1245-1256 IF 4.652
14、A novel translocator protein 18 kDa ligand, ZBD-2, exerts neuroprotective effects
against acute spinal cord injury Clinical and Experimental Pharmacology and Physiology 2016,43(10):930-938 IF 2.004
15、Histone Deacetylase Inhibitor Trichostatin a Promotes the Apoptosis of Osteosarcoma Cells through p53Signaling Pathway Activation International journal of biolojical sciences 2016,12(11):1298-1308 IF: 3.982
16、Autophagy mediated CoCrMo particle-induced peri-implant osteolysis by promoting osteoblast apoptosis Autophagy 2015,11(12):2358–2369 IF 11.753
17、The fibroblast expression of RANKL in CoCrMO-Particle-induced osteolysis is mediated by ER stress and XBP1s Acta biomaterialia 2015,24:352-360 IF 6.025
18、Osteoprotective effect of combination therapy of low-dose oestradiol with G15, a specific antagonist of GPR30/GPER in ovariectomy-induced osteoporotic rats Bioscience Reports 2015,35(4):94-100 IF 2.637
19、Associations of poiymorphisma in the bone morphogenetic protein-2 gene with risk and prognosis of osteosarcoma in a Chinese population Tumor Bio 2015,36(3):2059-2064 IF 3.611l
20、Tumor-Suppressing Effects of miR-141 in Human Osteosarcoma Cell Biochemistry and Biophysics 2014,69:319-325 IF2.38
21、Particle-induced osteolysis mediated by endoplasmic reticulum stress in prosthesis loosening BIOMATERIALS 2013,34(11):2611-2623 IF 8.312
专利、著作版权等
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