任南京大学医学院附属鼓楼医院消化内科行政副主任

1）国家自然基金面上项目：项目批准号：81570550，TWEAK负调控活化肝星状细胞衰老在肝纤维化中的作用及机制。2016年1月至2019年12月

2）南京市医学科技发展重点项目资助：ZKX14017，肝硬化患者HVPG对普萘洛尔应答与CYP2D6、β2-AR基因多态性的相关性研究，2015/01-2017/12

3）江苏省人社厅六大高峰人才（D）：项目编号：2015-WSN-081，TWEAK负调控活化肝星状细胞衰老在肝纤维化中的作用及机制,2015-2018

、Zhuge YZ, Wang Y, Zhang F, etal.Clinical characteristics and treatment of pyrrolizidine alkaloid-relatedhepatic vein occlusive disease. Liver Int. 2018; 00:1-8.

2、Zhang F, Xu H, Chen M，et al. Dose-dependent effect of propranolol on the hemodynamic response in cirrhotic patients with gastroesophageal varices. Eur J Gastroenterol Hepatol.2018.

3、Wang A, Zhang F, Xu H,et al. TWEAK/Fn14 promotes pro-inflammatory cytokine secretion in hepatic stellate cells via NF-κB/STAT3 pathways. Mol Immunol.2017; 87:67-75.

4、Xu M, Zhang F, Wang A, et al. Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Promotes Hepatic Stellate Cells Migration via Canonical NF-κB/MMP9 Pathway. PLoS One.2016 ;11(12)

5、Zhang F, Zhang M, Wang A,et al. TWEAK increases SIRT1 expression and promotes p53 deacetylation affecting human hepatic stellate cell senescence. Cell Biol Int.2017; 41(2):147-154.

6、Bian K, Zhang F, Wang T, et al. S-Adenosylmethionine suppresses the expression of Smad3/4 in activated human hepatic stellate cells via Rac1 promoter methylation. Mol Med Rep.2016;13(5):3867-73.

7、Zhang F, Duan X, Zhang M, et al. Influence of CYP2D6 and β2-adrenergic receptor gene polymorphisms on the hemodynamic response to propranolol in Chinese Han patients with cirrhosis. J Gastroenterol Hepatol.2016;31(4):829-34

8、Wang C, Zhang F, Cao Y,et al. Etoposide Induces Apoptosis in Activated Human Hepatic Stellate Cells via ER Stress. Sci Rep.2016 Sep 29; 6:34330.