教育背景
工作经历
项目课题经历
国家自然科学基金面上项目(81870695,2019-2022):激发巨噬细胞的抗复发性HSK新型DNA疫苗研制及免疫机制研究;项目负责人。
江苏省自然科学基金(BK20141346,2014-2017): 新型靶向DC的DNA纳米疫苗治疗复发性HSK的实验研究;项目负责人。
南京市科技发展计划(201402001,2014-2017):眼表滴种靶向DC的纳米pRSC-NLDC145•gD-IL-21 DNA疫苗治疗复发性HSK的研究;项目负责人。
江苏省卫计委医学科研课题(Z2018034,2019-2020):新型DNA疫苗防治复发性HSK及其机制研究;项目负责人。
南京市医学科技发展课题(YKK16107,2017-2019):DNA疫苗pRSC-gD•gC-IL-21的研制及眼表滴种治疗复发性HSK的研究;项目负责人。
中央高校基本科研业务费专项资金资助课题(021414380367):激发巨噬细胞的抗复发性HSK新型DNA疫苗研制及免疫机制研究;项目负责人。
美国NIH R01课题(1R01EY022695-01A1,2012-2018):The Role of Plasmacytoid Dendritic Cells in Corneal Immunity;为共同研究者(co-investigator
论文、成果、著作等
Kai Hu*, Jinlong Li, Xianwen Yuan. MicroRNA-411 plays a protective role in Diabetic Retinopathy through Targeted Regulating Robo4. European Review for Medical and Pharmacological Sciences. 2019 (Accepted).
Jinlong Li*, Kai Hu(共同第一), Yongchen Zhang, Zhaoli Zhang, Hao Li. Highly sensitive detection of Smoothened based on the drug binding and rolling cycle amplification. Analytical and Bioanalytical Chemistry. 2019 Jun 18(Online).
Tejsu Malla, Jing Jiang, Kai Hu*. Clinical outcome of combined conjunctival autograft transplantation and amniotic membrane transplantation in pterygium surgery. International Journal of Ophthalmology. 2018, 11(03) :395-400.
Ru Tang, Yujia Zhai, Lili Dong, Tejsu Malla, Kai Hu*. Immunization with dendritic cell-based DNA vaccine pRSC-NLDC145.gD-IL21 protects mice against herpes simplex virus keratitis. Immunotherapy. 2018, 10(03) :189-200.
Lili Dong, Ru Tang, Yujia Zhai, Tejsu Malla, Kai Hu*. DNA vaccine expressing herpes simplex virus 1 glycoprotein C and D protects mice against herpes simplex keratitis. International Journal of Ophthalmology. 2017, 10(11):1633-1639.
Kai Hu*, Tejsu Malla, Yujia Zhai, Lili Dong, Ru Tang. Topical Administration Is A Promising Inoculating Route versus Intramuscular Inoculation for The Nanoparticle-Carried DNA Vaccine to Prevent Corneal Infections. Ophthalmic Research. 2016, 55(2):99-110.
Kai Hu, Deshea L. Harris, Takefumi Yamaguchi, Ulrich von Andrian, Pedram Hamrah*. A Dual Role for Corneal Dendritic Cells in Herpes Simplex Keratitis: Local Suppression of Corneal Damage and Promotion of Systemic Viral Dissemination. Plos one. 2015; 10(9): e0137123.
Kai Hu, Jun Dou*, Fangliu Yu, et al. An ocular mucosal administration of nanoparticles containing DNA vaccine pRSC-gD-IL-21 confers protection against mucosal challenge with herpes simplex virus type 1 in mice. Vaccine. 2011; 29(7):1455-62.
Kai Hu, Xiangfeng He, Fangliu Yu, Xianwen Yuan, Weihua Hu, Chunsheng Liu, Fengshu Zhao, Jun Dou*. Immunization with DNA Vaccine Expressing Herpes Simplex Virus Type 1 gD and IL-21 Protects against Mouse Herpes Keratitis. Immunological Investigations. 2011; 40(3):265-78.
专利、著作版权等
已获授权国家发明专利2项(201510362141.2;201510362541.3
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