2006年职于南京大学医学院免疫学教研室，从事细胞分子免疫学的实验教学及研究工作

主持国家自然科学基金等科研项目10项，参与国家自然科学基金重大研究计划、科技部“重大新药创制”科技重大专项、江苏省科学技术厅高技术研究（医药）重大项目等科研项目17项江苏省六大人才高峰高层次人才项目，sTREM-1介导小胶质细胞M1极化在促进狼疮脑病进展中的分子机制研究，2019/01-2021/12，4万元，进行中，主持。

中央高校基本科研业务费—原创与交叉研究培养基金，021414380342，髓系抑制性细胞在3D打印精准构建小口径血管术后再狭窄中的作用研究，2018/01-2018/12，40万元，进行中，主持。

国家自然科学基金青年项目，81402940，FC-99通过miRlet-7调控巨噬细胞IL-6缓解RA的作用机制研究，2015/01-2017/ 12，23万元，已结题，主持。

江苏省自然科学基金青年项目，BK20140615，FC-99通过miR let-7调控巨噬细胞产生IL-6的分子机制及其在抗类风湿性关节炎中的作用，2014/07-2017/06，20万元，已结题，主持。

江苏省教育厅——江苏研究生培养创新工程，CXZZ11_0036，新型靶向金属碳硼烷分子探针的抗肿瘤作用及机理初探，2011/04-2013/04，1.5万，已结题，主持。

发表国内外论文 50 篇1. Shi G, Li D, Li X, Ren J, Xu J, Ding L, Dou H*, Hou Y*. mTOR inhibitor INK128 attenuates systemic lupus erythematosus by regulating inflammation induced CD11b+Gr1+cells. Biochim Biophys Acta Mol Basis Dis. 2018 Oct 4. pii: S0925-4439(18)30384-3. doi: 10.1016/j.bbadis.2018.10.007. [Epub ahead of print]

2. Zhang D, Xu J, Ren J, Ding L, Shi G, Li Dan, Dou H*, Hou Y*. MDSCs Induce Podocyte Injury through Increasing Reactive Oxygen Species in Lupus Nephritis. Front Immunol. 2018 Jun 25;9:1443. doi: 10.3389/fimmu.2018.01443. eCollection 2018.

3. Shi G, Li D, Ren J, Li X, Wang T*, Dou H*, Hou Y*. mTOR inhibitor INK128 attenuates dextran sodium sulfate-induced colitis by promotion of MDSCs on Treg cell expansion. J Cell Physiol. 2018 Aug 21. doi: 10.1002/jcp.27032. [Epub ahead of print]

4. Li X, Zhang X, Pan Y, Shi G, Ren J, Fan H, Dou H*, Hou Y*. mTOR regulates NLRP3 inflammasome activation via reactive oxygen species in murine lupus. Acta Biochim Biophys Sin (Shanghai). 2018 Sep 1;50(9):888-896.

5. Zhao Y, Zhu H, Wang H, Ding L, Xu L, Chen D, Shen S, Hou Y*, Dou H*. FC-99 ameliorates sepsis-induced liver dysfunction by modulating monocyte/macrophage differentiation via Let-7a related monocytes apoptosis. Oncotarget. 2018 Jan 10;9(19):14959-14976.

6. Song Y#,Dou H#(co-first author), Li X, Zhao X, Li Y, Liu D, Ji J, Liu F, Ding L, Ni Y*, Hou Y*. Exosomal miR-146a Contributes to the Enhanced Therapeutic Efficacy of Interleukin-1β-Primed Mesenchymal Stem Cells Against Sepsis. Stem Cells. 2017 May;35(5):1208-1221.

7. Yue H, Zhao Y, Wang H, Ma F, Liu F, Shen S, Hou Y*, Dou H*. Anti-fibrosis effect for Hirsutella sinensis mycelium based on inhibition of mTOR p70S6K phosphorylation. Innate Immun. 2017 Oct;23(7):615-624.

8. Li X, Liu F, Zhang X, Shi G, Ren J, Ji J, Ding L, Fan H, Dou H*, Hou Y*. Notch-Hes-1 axis controls TLR7-mediated autophagic death of macrophage via induction of P62 in mice with lupus. Cell Death Dis. 2016, 7(8):e2341.

9.Yang L, Dou H*(co-corresponding author), Song Y, Hou Y*. Benzenediamine analog FC-99 inhibits TLR2 and TLR4 signaling in peritoneal macrophage in vitro. Life Sci, 2016 Jan 1;144:129-37.

10. Song Y, Liu X, Yue H, Ji J, Dou H*, Hou Y*. Anti-inflammatory effects of benzenediamine derivate FC-98 on sepsis injury in mice via suppression of JNK, NF-κB and IRF3 signaling pathways. Mol Immunol. 2015 Oct;67(2 Pt B):183-92.

11. Ji J, Fan H, Li F, Li X, Dong G, Gong W, Song Y, Liu F, Hua C, Tan R, Dou H*, Hou Y*. A benzenediamine derivative fc-99 attenuates lupus-like syndrome in MRL/lpr mice related to suppression of pDC activation. Immunol Lett. 2015 Dec;168(2):355-65. doi: 10.1016/j.imlet.2015.10.017. Epub 2015 Nov 3.

12. Dou H, Song Y, Liu X,Yang L,Jiang N, Chen D, Li E, Tan R, Hou Y*. A Novel Benzenediamine Derivate Rescued Mice from Experimental Sepsis by Attenuating Pro-inflammatory Mediators via IRAK4. Am J Respir Cell Mol Biol. 2014 Aug;51(2):191-200.

13. Yang Y, Dou H*(co-corresponding author), Li X,Song Y,Gong W, Tan R, Hou Y*. FC-98 Regulates TLR9-Mediated of CXCL-10 Expression in Dendritic Cells via MAPK and STAT1 Signaling Pathway. Biomed Res Int. , 2014;2014:926130.

14. Ji J, Dou H*(co-corresponding author), Li X, Song Y, Li X, Li E, Tan R, Hou Y*. Novel benzenediamine derivative FC99 ameliorates zymosan-induced arthritis by inhibiting RORγt expression and Th17 cell differentiation. Acta Biochim Biophys Sin (Shanghai). 2014 Oct;46(10):829-36.

15 Dou H, Zhong W, Yang L, Wang T, Yan H*, Hou Y*. Synthesis, cytotoxic activities and cell cycle arrest profiles of half-sandwich N-sulfonamide based dithio-o-carborane metal complexes. Bioorg Med Chem., 2012; 20(15):4693-700.

16. Dou H, Song Y, Liu X, Gong W, Li E*, Tan R*, Hou Y*. Chaetoglobosin Fex from the Marine-Derived Endophytic Fungus Inhibits Induction of Inflammatory Mediators via Toll-Like Receptor 4 Signaling in Macrophages. Biol Pharm Bull., 2011;34(12):1864-73.

申请发明专利 5项