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王婷婷

领域:生物产业 学校:南京大学职称:教授

细胞与分子免疫 肿瘤与生物治疗...

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教育背景

工作经历

2018年-至今 南京大学医学院 教授 2014年-2016年 美国MD Anderson Cancer Center 博士后 2012年- 2017年 南京大学医学院 副教授 2009年- 2011年 南京大学医学院 讲师 2008年-2009年 美国University of Pittsburgh联合培养博士生

项目课题经历

国家自然科学基金面上项目,81772542,CBM信号复合体调控ILC3功能参与结肠肿瘤发生的分子机制;2018.1-2021.12,60万元,进行中,主持

国家自然科学基金面上项目,81572354,Dectin-3/CARD9通路介导的免疫应答参与炎症相关结肠肿瘤发生发展的机制;2016.1-2019.12,60万元,进行中,主持

江苏省六大人才高峰高层次人才项目,CBM 信号复合体调控肠道ILC3功能影响肠癌发生的机制;2018.1-2020.12,4万元,进行中,主持

江苏省自然科学基金面上项目,BK20161400,肠道真菌参与炎症相关结肠肿瘤发生发展的机制;2016.7-2019.6,10万元,进行中,主持

国家重点研发计划,2017YFA0104300, 间充质和神经干细胞的体内动态示踪技术与临床转化研究,2938万2017.7-2021.12,进行中,参与

国家自然科学基金青年项目, 81101552,miR-30d调控K-ras影响肺腺癌微环境中Treg细胞分化的机制研究,2012/01-2014/12,22万元,已结题,主持;

教育部高等学校博士学科点专项科研基金, 20100091120002, 恶性胸腔积液微环境中miR-24对Th17细胞的分化调控机制研究;2011/01-2013/12, 3.6万元,已结题,主持;

8. 江苏省自然科学基金面上项目,BK2011571,miR-30d调控Treg细胞参与肺腺癌免疫逃逸的机制研究,2012/01-2014/12,8万元,已结题,主持

论文、成果、著作等

Wang T*, Fan C, Yao A, Xu X, Zheng G, You Y, Jiang C, Zhao X, Hou Y, Hung M, Lin X*. Signaling via the adaptor CARD9 protects against colon cancer by restricting mycobiota-mediated expansion of myeloid-derived suppressor cells Immunity2018,49,1-11.




Ren J, Ding L, Zhang D, Shi G,Xu Q, Shen S, Wang Y,Wang T*, Hou Y*.Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19. Theranostics. 2018 Jun 24;8(14):3932-3948.




Xu H,Wang T (co-first author), Yang C, Li X, Liu G, Yang Z, Singh P, Krishnan S*, Ding D*. Supramolecular nanofibers of curcumin for highly amplified radiosensitization of colorectal cancers to ionizing radiation.Advanced Functional Material. 2018. Jan, online.




Shi G, Li D, Ren J, Li X,Wang T*, Dou H*, Hou Y*. mTOR inhibitor INK128 attenuates dextran sodium sulfate-induced colitis by promotion of MDSCs on Treg cell expansion.J Cell Physiol. 2018 Aug 21.




Shi T,Ma Y,Yu L,Jiang J,Shen S,Hou Y,Wang T*. Cancer Immunotherapy: A Focus on the Regulation of Immune Checkpoints. Int J Mol Sci.2018 May 7;19(5).




Ren J, Hou Y, Wang T*. Roles of estrogens on myeloid-derived suppressor cells in cancer and autoimmune diseases. Cellular & Molecular Immunology2017,14:1-3.




Xu Y, Wang Y, Yao A, Xu Z, Dou H, Shen S, Hou Y, Wang T*. Low Frequency Magnetic Fields Induce Autophagy-associated Cell Death in Lung Cancer through miR-486-mediated Inhibition of Akt/mTOR Signaling Pathway.Sci Rep.2017 Sep 18;7(1):11776.




Xu Z,Ji J, Xu J, Li D, Shi G, Liu F, Ding L, Ren J, Dou H, Wang T*, Hou Y*. MiR-30a increases MDSC differentiation and immunosuppressive function by targeting SOCS3 in mice with B-cell lymphoma.FEBS J. 2017 Jun 12.




Ren J, Ding L, Xu Q, Shi G, Li X , Li X, Ji J, Zhang D, Wang Y, Wang T*, Hou Y*. LF-MF inhibits iron metabolism and suppresses lung cancer through activation of P53-miR-34a-E2F1/E2F3 pathway. Sci Rep.2017 Apr 7;7(1):749.




Wang T, Xu X, Xu Q, Ren J, Shen S, Fan C, Hou Y. miR-19a promotes colitis-associated colorectal cancer by regulating tumor necrosis factor alpha-induced protein 3 (TNFAIP3)-NF-κB feedback loops. Oncogene.2017 Jun 8;36(23):3240-3251.




Wang T,Pan D,Zhou Z,You Y,Jiang C,Zhao X,Lin X*. Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut. PLoS Pathog.2016 Jun 9;12(6):e1005662.




Tang R, Xu Y, Ma F, Ren J, Shen S, Du Y, Hou Y*,Wang T*. Extremely low frequency magnetic fields regulate differentiation of regulatory T cells: Potential role for ROS-mediated inhibition on AKT.Bioelectromagnetics.2016 Feb; 37(2): 89-98.




Tang R,Shen S,Zhao X,Nie Y,Xu Y,Ren J,Lv M,Hou Y*,Wang T*. Mesenchymal stem cells-regulated Treg cells suppress colitis-associated colorectal cancer. Stem Cell Res Ther.2015 Apr 13;6:71.


Ren J, Nie Y, Lv M, Shen S, Tang R, Xu Y, Hou Y, Zhao S*, Wang T*. Estrogen up-regulates MICA/B expression in human non-small cell lung cancer through regulation of ADAM17. Cellular & Molecular Immunology. 2015 Nov;12(6):768-76.

Lv M,Xu Y,Tang R,Ren J,Shen S,Chen Y,Liu B,Hou Y*,Wang T*. miR141-CXCL1-CXCR2 signaling-induced Treg recruitment regulates metastases and survival of non-small cell lung cancer. Mol Cancer Ther.2014 Dec;13(12):3152-62.




Tang X, Tang R, Xu Y, Wang Q, Hou Y, Shen S*,Wang T*. MicroRNA networks in regulatory T cells. J Physiol Biochem. 2014 70(3) :869–875.




Zhu Y, Li J, Bai Y, Wang X, Duan N, Jiang H, Wang T*, Wang W*. Hydroxychloroquine decreases the upregulated frequencies of Tregs in patients with oral lichen planus. Clin Oral Investig.2014 Nov;18(8):1903-11.

专利、著作版权等

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