1、PCOS雄激素代谢相关基因的遗传（htSNPs）与表遗传（DNA甲基化）调控机制研究；

2、p66shc调控PCOS卵巢纤维化病理的机理研究

3、发育期高雄激素介导卵巢细胞间去乙酰化酶差异表达在PCOS发病中的机制研究

4、胰岛素信号系统相关基因多态性与PCOS表型的关系探索

获奖

2015年获评“本科生教学优秀”；

2016年获评“学生最喜爱的老师”；

2017年获评“本科生教学优秀”；

2016年获评“研究生招生先进个人”。

Wang R,Wang L,Luo Y,Wang D,Du R,Du J,Wang Y.Maggotproteinamelioratesdextransulphatesodium-inducedulcerativecolitisinmice.Biosci Rep.2018 Nov 28;38(6). pii: BSR20181799.

Wang D,Wang W,Liang Q,He X,Xia Y,Shen S,Wang H,Gao Q,Wang Y.DHEA-inducedovarianhyperfibrosisismediatedby TGF-βsignalingpathway.JOvarianRes.2018 Jan 10;11(1):6. doi: 10.1186/s13048-017-0375-7.

Chen XF, Wang L, Wu YZ, Song SY, Min HY, Yang Y, He X, Liang Q, Yi L, Wang Y, Gao Q.Effectofpuerarininpromotingfattyacidoxidationbyincreasingmitochondrialoxidativecapacityandbiogenesisinskeletalmuscleindiabeticrats.Nutr Diabetes.2018 Jan 12;8(1):1. doi: 10.1038/s41387-017-0009-6.

Linghui Kong, Qien Wang, Jiewen Jin, Zou Xiang, Taoyu Chen, Shanmei Shen, Hongwei Wang, Qian Gao, YongWangInsulin resistance enhances the mitogen-activated protein kinase signaling pathway in ovarian granulosa cells. PLoS One.2017 Nov 10;12(11):e0188029.

Deng Z,Liu X,Jin J,Xu H,Gao Q,Wang Y,Zhao J. HistoneDeacetylaseInhibitorTrichostatinaPromotestheApoptosisofOsteosarcomaCellsthroughp53SignalingPathwayActivation.Int J Biol Sci.2016;12(11):1298-1308.

YANJIE XIA, WENQING WANG , LEI WANG , SHANMEI SHEN , YUNXIA CAO , LONG YI, QIAN GAO and YONG WANG, hOGG1 gene polymorphisms and susceptibility to polycystic ovary syndrome, BIOMEDICAL REPORTS 4: 421-426, 2016

Xiao Huang, Jiewen Jin, Shanmei Shen, Yanjie Xia, Pei Xu, Xiang Zou, Hongwei Wang, Long Yi, Yong Wang & Qian Gao(2015): Modulation of expression of 17-Hydroxylase/17,20 lyase (CYP17) and P450 aromatase (CYP19) by inhibition of MEK1 in a human ovarian granulosa-like tumor cell line, Gynecological Endocrinology,2016;32(3):201-5.

Yanjie Xia, Shanmei Shen , Xinlin Zhang, Zhantao Deng, Zou Xiang, Hongwei Wang, Long Yi, Qian Gao andYong Wang, Epigenetic pattern changes in prenatal female Sprague-Dawley rats following exposure to androgen, Reproduction, Fertility and Development2015 Mar 31. doi: 10.1071/RD14292.

Qu J, Che Y, Xu P, Xia Y, Wu X andWang Y.The higher response of vascular endothelial growth factor and angiotensin-II to human chorionic gonadotropin in women with polycystic ovary syndrome. Int J Fertil Steril 2015 8:373-8

Chen J, Shen S, Tan Y, Xia D, Xia Y, Cao Y, Wang W, Wu X, Wang H, Yi L, Gao Q and Wang Y.The correlation of aromatase activity and obesity in women with or without polycystic ovary syndrome. J Ovarian Res 2015 Mar 22;8:11. doi: 10.1186/s13048-015-0139-1.

Wang C, Gao C, Meng K, Qiao H and Wang Y.Human adipocytes stimulate invasion of breast cancer MCF-7 cells by secreting IGFBP-2. PLoS One 2015 Mar 6;10(3):e0119348.

Zhang X, Zhang C, Shen S, Xia Yj, Yi L andWang Y. Dehydroepiandrosterone induces ovarian and uterine hyperfibrosis in female rats. Hum Reprod 2013 28:3074-85