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汪芳裕

领域:生物产业 学校:南京大学职称:

消化道早期癌内镜诊治;炎症性肠病的发病机制及肠道微生态相关研究;消化道肿瘤疾病分子标志物的探索...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

工作经历

项目课题经历

承担国家自然科学基金4项、总后勤部和南京军区卫生部医药卫生科研基金多项;参与“十一五”国家科技支撑计划重大项目等,基金总金额240万元.中草药来源的MiR-5368对溃疡性结肠炎的治疗作用与机制研究国家自然科学基金(81873559)2019

2.microRNA-17-92簇调控分化的骨髓间充质干细胞对实验性结肠炎黏膜修复的影响及其机制研究,国家自然科学基金(81570506)2016

3.COX-2调控的TLR4/NF-κB信号通路在溃疡性结肠炎相关异型增生及癌变中的作用机制研究,国家自然科学基金(81270453)2013

4.溃疡性结肠炎黏膜损伤与修复基因DNA甲基化的意义探讨,国家自然科学基金(81070289)2010

论文、成果、著作等

表论著120余篇1.L. Ye, X.L. Sun, H.M. Wu, J. Wang, X. Ding, H. Shi, L.S. Lu, J. Wei, L. Li, F.Y. Wang.A simple system for differentiation of functional intestinal stem cell-like cells from bone marrow mesenchymal stem cells.Molecular Therapy-Nucleic Acids.Available online (IF=6.392)

2.Hui-Min Wu, Juan Wei, Kai Wang , Ying Qi, Fang-Yu Wang.Mucus protectors: Promising therapeutic strategies for inflammatory bowel disease.Medical Hypotheses.2018(120),55-59 (IF=1.066)

3.Lei Ye, Wei Chen, Bi-qin Chen, Xing Lan, Shao-dong Wang, Xiao-chen Wu, Wei Huang, Fang-yu Wang. Levels of Faecal Calprotectin and Magnetic Resonance Enterocolonography Correlate with Severity of Small Bowel Crohn’s Disease: A Retrospective Cohort Study. Scientific Reports. 2017 May 16;7(1):1970 (IF=5.2)

4.Lei Ye, Yu-Ping Zhang, Na Yu, Ya-Xu Jia, Shu-Jun Wan, Fang-Yu Wang. Serum platelet factor 4 is a reliable activity parameter in adult patients with inflammatory bowel disease: a pilot study. Medicine (Baltimore). 2017;96(11):e6323. (IF=2.1)

5.Lei Ye, Bi-qin Chen, Shao-dong Wang, Chen Wei, Xiao-chen Wu, Zhao Yang, Fang yu Wang. Fecal calprotectin is a strong predictive marker of relapse in Chinese patients with Crohn's disease: a two-year prospective study.《Scandinavian Journal of Gastroenterology》2017:1-7(IF=2.5)

6.Chen B, Yang Z, Lu H, Wei C, Wang F, Liu C. Eosinophilic Gastroenteritis Presenting as Upper Gastrointestinal Hematoma and Ulcers After Endoscopic Biopsy: A Case Report and Literature Review. MEDICINE. 2017;96(37):e8075 .(IF:1.803)

7.Yu-PingZhang,ChangLiu,LeiYe,NaYu,Yuan-NingYe,Wen-RongSun,LinWu,Fang-YuWang. Early Prediction of Persistent Organ Failure by Serum Angiopoietin-2 in Patients with Acute Pancreatitis. Dig Dis Sci. 2016,61(12):3584-3591 (IF=2.5)

8.Wang Z,Lu H,Wu L,Yuan B, Liu J, Shi H, Wang F.Long-term outcomes of endoscopic multiband mucosectomy for early esophageal squamous cell neoplasia: a retrospective, single-center study.Gastrointestinal Endoscopy. 2016,84(6):893-899 (IF=6.217)

9.Chang Liu,Jie Dai,Heng Lu,Hui Shi,Youke Lu,Fangyu Wang. EGCG suppresses NF-kB activation induced by gastroesophageal reflux contents in human esophageal epithelial cells. Int J Clin Exp Pathol. 2016,9(5):5421-5428(IF=1.581)

10.Lei Ye, Hui Shi, Min Wu, et al. Primarily isolated hepatic involvement of amyloidosis: a case report and overview. Medicine (Baltimore).2016;95(52):e5645. (IF=2.1)

11.Shi Hui, Wang Fangyu.Protective effects of bilobalide against ethanol-induced gastric ulcer in vivo/vitro. Biomedicine & Pharmacotherapy .2017,85,592–600 (IF=3.457)

12.Wang Z, Yang X, Wu L, Shi H, Lu Y, Yuan B, Wang Y, Wang F. Blue rubber bleb nevus syndrome: treatment of lesions in the small intestine with repeated injection of lauromacrogol. Gastrointest Endosc. 2015,81(5):1274-1275.(IF=6.217)

13.Wu XW, Wu L, Ji HZ, Wang FY. Relationship between cytomegalovirus infection and steroid-resistance in inflammatory bowel disease: a meta-analysis. Dig Dis Sci. 2015,60(11):3203-3208(IF=2.5)

14.Wu XW, Yang MF, Li N, Wang FY. Unfavorable outcome of antiviral therapy in cytomegalovirus-positive ulcerative colitis may be due to inappropriate study inclusion in meta-analysis. World J Gastroenterol. 2015,21(5):1689-1690(IF=2.787)

15.Wu XW, Ji HZ, Yang MF, Wu L, Wang FY. Helicobacter pylori infection and inflammatory bowel disease in Asians: A meta-analysis. World J Gastroenterol. 2015, 21(15):4750-4756(IF=2.787)

16.Bosi Yuan,Shuping Zhou,Youke Lu,Jiong Liu,Xinxin Jin,Haijun Wan,andFangyu Wang. Changes in the Expression and Distribution of Claudins, Increased Epithelial Apoptosis, and a Mannan-Binding Lectin-Associated Immune Response Lead to Barrier Dysfunction in Dextran Sodium Sulfate-Induced Rat Colitis. Gut Liver. 2015,23;9(6):734-740(IF=2)

17.Chang Liu, Jiong Liu, Fangyu Wang.Intrahepatic splenosis mimicking liver cancer: report of a case and review of literature,Int J Clin Exp Pathol.2015,8(1):1031-1035(IF=1.581)

18.Zhenkai Wang,Hui Shi,Shaodong Wang,Jiong Liu,Weiming Zhu,Miaofang Yang, Chang Liu,Heng Lu,Fangyu Wang. Confusing untypical intestinal Behcet’s disease: Skip ulcers with severe lower gastrointestinal hemorrhage. World Journal of Gastrointestinal Endoscopy. 2014,6(1):27-31(IF=2.5)

19.袁柏思,金鑫鑫,路又可,刘炯,王震凯,吴琳,汪芳裕,检测6种血清学抗体在120例炎症性肠病中的I临床应用价值,中华消化杂志,2015,35(4): 270-272

20.王震凯,魏娟,吴琳,袁柏思,路又可,刘炯,金鑫鑫,杨妙芳,刘畅,汪芳裕,自体骨髓干细胞对肝硬化患者外周血淋巴细胞和免疫球蛋白的影响,中华细胞与干细胞杂志,2015,5(1):13-18

21.王震凯,魏娟,吴琳,袁柏思,路又可,刘炯,金鑫鑫,杨妙芳,刘畅,汪芳裕,预测重症溃疡性结肠炎患者需手术治疗的临床指标,中华消化杂志,2014,34增刊

22.魏娟,施慧,陆恒,汪芳裕,T-SPOT.TB与PPD在消化系统结核感染鉴别诊断中的价值,胃肠病学和肝病学杂志,2014,23(3):289-291

23.汪芳裕,肝硬化自体骨髓干细胞回输前后外周血免疫功能的变化,中华消化杂志, 2014,34(3):189-190

24.王震凯,魏娟,吴琳,袁柏思,路又可,刘炯,金鑫鑫,杨妙芳,刘畅,汪芳裕,自体骨髓干细胞移植治疗肝硬化难治性腹水的临床观察,中华细胞与干细胞杂志,2014,4(4):6-10

25.汪芳裕,张新华,周淑萍,袁柏思,林梅,王少东,路又可,刘炯,李晓华,周晓军,溃疡性结肠炎相关腺瘤和结直肠癌回顾性临床病例分析,胃肠病学杂志,2013,18(4):233-236

26.王文辉,汪芳裕,魏娟,沈芸竹,刘畅,舒小闯,CpG甲基转移酶诱导紧密连接蛋白7和8基因表达下调对人结肠癌HT-29细胞增殖和凋亡的影响,中华肿瘤杂志,2013,35(6): 405-411



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