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李尔广

领域:生物产业 学校:南京大学职称:教授

1)感染与免疫 2)分子药理学...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

北京中医药大学中药专业学士,美国密西西比大学药学院生药学博士

工作经历

2008 年回南京大学医学院工作

项目课题经历

主持中国自然科学基金课题2项,参与NIH和国家自然科学基金项目多项

论文、成果、著作等

Ren K, Zhang W, Chen X, Ma Y, Dai Y, Fan Y, Hou YY, RX Tan*, and Erguang Li*. An Epigenetic Compound Library Screen Identifies BET Inhibitors That Promote HSV-1 and -2 Replication by Bridging P-TEFb to Viral Gene Promoters through BRD4. PLoS Pathogens 12(10): e1005950, 2016.

Ren K, Lv Y, Zhuo Y, Chen C. Shi H, Guo L, Yang G, Hou Y, Tan RX*, Erguang Li*. Suppression of IRG-1 improves immune lung injury after RSV infection by reducing ROS production. J Virol, 90, 7313-7322, 2016.

Hui Jiang, Hengfei Shi, Man Sun, Yafeng Wang, Qingzhou Meng, Panpan Guo, Yanlan Cao, Jiong Chen, Xiang Gao, Erguang Li*, and Jianghuai Liu*. PFKFB3-Driven Macrophage Glycolytic Metabolism Is a Crucial Component of Innate Antiviral Defense. J Immunol, 197:2880-90, 2016.

Hengfei Shi, Ke Ren, Baojie Lv, Wei Zhang, Ying Zhao, Ren Xiang Tan*, and Erguang Li*. Baicalin from Scutellaria baicalensis blocks respiratory syncytial virus (RSV) infection and reduces inflammatory cell infiltration and lung injury in mice. Scientific Reports, 6, 35851, 2016.

Zhang W, Chen C, Shi H, Yang M, Liu Y, Ji P, Chen H, Tan RX, Erguang Li*, Curcumin is a biologically active copper chelator with antitumor activity. Phytomed, 23, 1-8, 2016.

Guo X, Liu T, Shi H, Hou Y, Tan RX and Erguang Li*. NLRC5 induction regulates MHC II expression during RSV infection of airway epithelial cells. J Virol. 89. 7636-45, 2015.

Chen CM, Zhang W, Shi H, Zhuo Y, Yang G, Zhang A, Hou Y, RX Tan, Erguang Li*. A novel benzenediamine derivative FC98 reduces insulin resistance in high fat diet-induced obese mice by suppression of metaflammation. Eur J Pharmacol. 761, 298-308, 2015.

Qiao H, X Chen, L Xu, J Wang, G Zhao, Y Hou, HM Ge, RX Tan*, and Erguang Li*. Antitumor effect of naturally occurring oligomeric resveratrol derivatives. FASEB J. 27, 4561-4571 (2013)

Chen X, Wang C, Xu L, Chen X, Wang W, Yang G, Tan RX, Y Jin* and Erguang Li*. A Laboratory Evaluation of Medicinal Herbs Used in China for the Treatment of Hand, Foot, and Mouth Disease, Evidence-Based Complementary and Alternative Medicine, ID504563 (doi: 10.1155/2013/504563) (2013)

Wang J, Chen X, Wang W, Zhang Y, Yang Z, Jin Y, Ge H.M, Erguang Li*, *Yang G. Glycyrrhizic acid as the antiviral component of Glycyrrhiza uralensis Fisch. against coxsackievirus A16 and enterovirus 71 of hand foot and mouth disease, J. Ethnopharmacology, 147, 114-121 (2013).

Guo XC, Li XY, Xu XY, Sun T, Yang G, Wu ZW, Erguang Li*. Identification of OASL d, a splice variant of human OASL, with antiviral activity. International Journal Biochemistry Cell Biology 44:1133-1138 (2012).

Chen X, Wang Z, Yang Z, Wang J, Tan RX and Erguang Li*. Houttuynia cordata blocks HSV-2 infection through inhibition of NF-kB activation. Antiviral Research 92:341-345 (2011).

Zhu, H.R., Z.Y. Wang, X.L. Zhu, X.X. Wu, Erguang Li*, and Y. Xu*. Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha expression in experimental stroke. Neuropharmacology. 59:70-76 (2010).

Lad, S.P., G. Yang, D.A. Scott, T.-H. Chao, J.d.S. Correia, J.C. de la Torre, and Erguang Li*. Identification of MAVS splicing variants that interfere with RIGI/MAVS pathway signaling. Molecular Immunology. 45:2277-2287 (2008).

Lad, S.P., J. Li, J. da Silva Correia, Q. Pan, S. Gadwal, R.J. Ulevitch, and Erguang Li*. Cleavage of p65/RelA of the NF-κB pathway by Chlamydia. Proc Natl Acad Sci USA. 104:2933-2938 (2007).

Lad, S.P., G. Yang, D.A. Scott, G. Wang, P. Nair, J. Mathison, V.S. Reddy, and Erguang Li*. Chlamydial CT441 Is a PDZ Domain-Containing Tail-Specific Protease That Interferes with the NF-κB Pathway of Immune Response. Journal of Bacteriology. 189:6619-6625 (2007).

Li, J., S. Lad, G. Yang, Y. Luo, M. Iacobelli-Martinez, F.J. Primus, R.A. Reisfeld, and Erguang Li*. Adenovirus Fiber Shaft Contains a Trimerization Element That Supports Peptide Fusion for Targeted Gene Delivery. Journal of Virology. 80:12324-12331 (2006).

Lad SP, Fukuda EY, Li J, de la Maza LM and Erguang Li*. Up-regulation of the JAK/STAT1 signal pathway during Chlamydia trachomatis infection. Journal of Immunology. 174: 7186-93 (2005).

Fukuda EY, Lad SP, Mikolon DP, Iacobelli-Martinez M and Erguang Li*. Upregulation of Prostaglandin Biosynthesis Attributes to IL-8 Production During Chlamydia Trachomatis Infection of Cervical Epithelial Cells. Infection and Immunity. 73:4017-24 (2005).

专利、著作版权等

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