教育背景
工作经历
2009-至今,南京大学医学院
2004-2009,美国国家卫生研究院(NIH)
1999-2004,德国Justus-Liebig大学(GIESSEN)
1995-1999,南京大学生命科学院
项目课题经历
家自然科学基金(批准号:31871201 ):肿瘤相关巨噬细胞为周围肿瘤细胞提供铁源及其调控机制的研究(2019.01-2022.12)
国家自然科学基金(批准号:31571218):与系统性红斑狼疮疾病关联基因TMEM187在线粒体铁代谢中的功能研究(2016.01.01-2019.12.31)
国家重点基础研究项目(“973”计划,课题编号: 2015CB856300):靶向线粒体代谢的分子探测与过程调控,技术骨干(2015.01.01-2019.12.31)
国家自然科学基金(批准号: 31371060):弗里德赖希氏共济失调病人神经元丢失的病理机制研究
国家自然科学基金(批准号:81370387):铁调控枢纽Hepcidin-Fpn1 在动脉粥样硬化进程中的作用及其机制研究
国家自然科学基金(批准号: 31071085):弗里德赖希氏共济失调神经系统病变机制的研究
医药生物技术国家重点实验室研究基金(批准号:ZZYJ-SN-201006):弗里德赖希共济失调(FRDA)组织特异性的新型FXN亚型蛋白的调控和功能研究
回国人员启动基金(教外司留〔2010〕1561号):弗里德赖希氏共济失调神经系统病变机制的研究
中央高校重点项目培育计划(项目编号:1094021412):线粒体铁的运输与调控
国家自然科学基金(批准号: 39900030):离子束注入对狐米草诱变的生物学效应及其机制的研究
论文、成果、著作等
Li H, Liu Y, Shang L, Cai J, Wu J, Zhang W, Pu X, Dong W, Qiao T, Li K*. Iron regulatory protein 2 modulates the switch from aerobic glycolysis to oxidative phosphorylation in mouse embryonic fibroblasts. Proc Natl Acad Sci USA. 2019 May 14;116(20):9871-9876
Truman-Rosentsvit M, Berenbaum D, Spektor L, Cohen LA, Belizowsky-Moshe S, Lifshitz L, Ma J, Li W, Kesselman E, Abutbul-Ionita I, Danino D, Gutierrez L, Li H, Li K, Lou H, Regoni M, Poli M, Glaser F, Rouault TA, Meyron-Holtz EG*. Ferritin is secreted via 2 distinct nonclassical vesicular pathways. Blood. 2018 Jan 18;131(3):342-352.
Wang Q, Ji J, Hao S, Zhang M, Li K, Qiao T*. Iron together with lipid downregulates protein levels of ceruloplasmin in macrophages associated with rapid foam-cell formation. J Atheroscler Thromb2016 Oct 1; 23(10): 1201–1211
Zhang D, Yan H, Li H, Hao S, Zhuang Z, Liu M, Sun Q, Yang Y, Zhou M, Li K*, Hang C*. TGFβ-activated Kinase 1 (TAK1) Inhibition by 5Z-7-Oxozeaenol Attenuates Early Brain Injury after Experimental Subarachnoid Hemorrhage. J Biol Chem2015, 290(32):19900-9.
Wu J, Zhang M, Hao S, Jia M, Ji M, Qiu L, Sun X, Yang J,Li K*. Mitochondria-targeted peptide reverses mitochondrial dysfunction and cognitive deficits in sepsis-associated encephalopathy. Molecular Neurobiology. 2015, 52(1):783-791.
Yan H, Zhang D, Hao S,Li K*,Hang C*. Role of mitochondrial calcium uniporter in early brain injury after experimental subarachnoid hemorrhage. Molecular Neurobiology. 2015, 52(3):1637-47.
Li K, Besse EK, Ha D, Kovtunovych G, Rouault TA*. Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia. Hum Mol Genet. 2008 17 (15): 2265 -73.
Li K, Tong WH, Hughes RM, Rouault TA*. Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly.J Biol Chem. 2006 281(18):12344-51.
Zeller T, Mraheil MA, Moskvin OV, Li K, Gomelsky M, Klug G*. Regulation of hydrogen peroxide-dependent gene expression in Rhodobacter sphaeroides: regulatory functions of OxyR.J Bacteriol. 2007, 189(10):3784-92. IF: 3.993
Zeller T, Li K, Klug G*. 2006 Expression of the trxC gene of Rhodobacter capsulatus: response to cellular redox status is mediated by the transcriptional regulator OxyR.J Bacteriol.188(21): 7689-95.
Zeller T, Moskvin OV, Li K, Klug G*, Gomelsky M*. 2005 Transcriptome and physiological responses to hydrogen peroxide of the facultatively phototrophic bacterium Rhodobactersphaeroides.J Bacteriol. 187(21):7232-42.
Li K, Hein S, Zou W, Klug G*. 2004 The glutathione-glutaredoxin system in Rhodobactercapsulatus: part of a complex regulatory network controlling defense against oxidative stress.J Bacteriol. 186(20):6800-8.
Li K, Pasternak C, Härtig E, Haberzettl K, Maxwell A, Klug G*. 2004 Thioredoxin can influence gene expression by affecting gyrase activity.Nucleic Acids Res.32(15):4563-75.
专利、著作版权等
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