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李冬梅

领域:生物产业 学校:南京大学职称:副教授

环境污染与雄性生殖健康;泌尿生殖系肿瘤发生的机制研究...

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教育背景

1997年6月获南京医科大学临床医学学士学位;2007年6月获南京大学理学博士学位;2013年-2014年

工作经历

现任南京大学医学院副教授,博士生导师

项目课题经历

1.miR-7a表达上调在邻苯二甲酸二丁酯(DBP)干扰青春期前睾丸支持细胞增殖中的机制研究 国家自然科学基金(21377052)

2. miR-7a表达上调在邻苯二甲酸二丁酯(DBP)干扰青春期前睾丸支持细胞增殖中的机制研究 2017年度学校重点引智项目

3. 水体典型环境内分泌干扰物联合作用雄性生殖功能影响的机制研究国家自然科学基金(30800115)

4. 微囊藻毒素低剂量长时期暴露对雄性大鼠生殖系统的影响及其机制研究国家自然科学基金(30970530)

5. miR-7的表达下调在前列腺癌发生中的机制研究江苏省自然科学基金(BK20131281)

6. 雌激素受体β亚型(ER-β)基因多态性与前列腺癌易感的相关性研究江苏省自然科学基金(BK2010367)

7. ER-β基因启动子区甲基化水平与前列腺癌易感的相关性研究江苏省第八批“六大人才高峰”高层次人才培养对象项目(卫生行业2011-WS070)

8. 水体典型环境内分泌干扰物联合作用雄性生殖功能影响的机制研究 教育部新青年教师基金(200802841006)

9. 肿瘤抑制基因雌激素受体β亚型(ER-β)的表达变化在前列腺癌细胞信号网络中的作用分析 吴阶平基金会(320.6752.1219)

10. miR-7的表达下调在前列腺癌发生中的机制研究 生命分析化学国家重点实验室开放研究基金

11. 应用星形金纳米探针对肺干细胞分化机制的研究生物电子学国家重点实验室开放研究基金(G5)

12. 拮抗血小板活化因子对过敏级联反应的影响扬子江药业集团江苏紫龙药业有限公司

13. miR-7a表达上调在邻苯二甲酸二丁酯(DBP)干扰青春期前睾丸支持细胞增殖中的机制研究 中央高校基本科研业务费立项项目(020620130656)

14. GPR30介导外源性雌激素干扰精原细胞微环境促精原干细胞异常增殖的作用机制研究中央高校基本科研业务费

15. GPR30介导雌激素和外源性雌激素影响大鼠血睾屏障的比较研究中央高校基本科研业务费专项资金(新世纪优秀人才培养计划)(1095021440)

16. 水体中典型环境内分泌干扰物联合作用雄性生殖功能影响的机制研究 中央高校基本科研业务费苗圃项目(1117021401)

17. 雌激素受体β亚型(ER-β)基因多态性与前列腺癌易感的相关性研究 中央高校基本科研业务费自由探索项目(1118021402)

18. GPR30 介导外源性雌激素干扰精原细胞微环境促精原干细胞异常增殖的作用机制研究南京大学医学院青年发展基金项目

论文、成果、著作等

Ning Liu, Weidong Gan, Feng Qu, Zhen Wang, Wenyuan Zhuang, Sezim Agizamhan, Linfeng Xu, Juanjuan Yin,Hongqian Guo, and Dongmei Li(通讯作者). Does the Fuhrman or World Health Organization/International Society of Urological Pathology Grading System Apply to the Xp11.2 Translocation Renal Cell Carcinoma?A 10-Year Single-Center Study. Am J Pathol. 2018 Apr;188(4):929-936.

Ling Zhang, Xiannan Meng, Zou Xiang, Dongmei Li(通讯作者), Xiaodong Han*. Roles of mmu_piR_003399 in microcystin-leucine arginine (MC-LR)-induced reproductive toxicity in the spermatogonial cells and testis. Toxicological Sciences, 161(1), 2018, 159–170

Xiaoqin Yin, Tan Ma, Ruitong Han, Jie Ding, Huan Zhang*, Han Xiaodong*, Li DongMei(通讯作者), MiR-301b-3p/3584-5p enhances low-dose mono-n-butyl phthalate (MBP)–induced proliferation by targeting Rasd1 in Sertoli cells. Toxicol In Vitro. 2018; 47: 79-88.

Chen Yabing, Wang Jing, Pan Chun, Li Dongmei(通讯作者), Han Xiaodong. Microcystin-leucine arginine causes blood-testis barrier disruption and degradation of occludin mediated by matrix metalloproteinase-8. Cellular and molecular life sciences, Cell. Mol. Life Sci. (2018) 75:1117–1132

Tan Ma, Xiaoqin Yin, Ruitong Han, Jie Ding, Huan Zhang, Xiaodong Han and Dongmei Li(通讯作者).Effects of In Utero Exposure to Di-n-Butyl Phthalate on Testicular Development in Rat. Int. J. Environ. Res. Public Health. 2017, 14, 1284; doi:10.3390/ijerph14101284.

Lei Xiong, Xiancheng Chen, Ning Liu, Zhen Wang, Baolei Miao, Weidong Gan*, Dongmei Li(通讯作者), Hongqian Guo. PRCC-TFE3 dual-fusion FISH assay: A new method for identifying PRCC-TFE3 renal cell carcinoma in paraffin-embedded tissue. PLoS ONE 12(9): e0185337.

Zhen Wang, Ning Liu, Weidong Gan, Xiaogong Li, Gutian Zhang, Dongmei Li(通讯作者)and Hongqian Guo. Postoperative recurrence of adult renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion. Journal of International Medical Research. 2017, 45(4): 1287–1296.

Zhang Ling, Zhang Hui, Zhang Huan, Benson Mikael, Han Xiaodong, Li Dongmei(通讯作者). Roles of piRNAs in microcystin-leucine-arginine (MC-LR) induced reproductive toxicity in testis on male offspring. Food Chem Toxicol. 2017 Apr 13;105:177-185.

Hui Zhang, LihuiWang, SongShen, Chenchen Wang, Zou Xiang, Xiaodong Han*, Dongmei Li (通讯作者).Toxic effects of microcystin-LR on the development of prostate in mice.Toxicology.2017 Apr 1;380:50-61.

Yabing Chen, Yuan Zhou, Jing Wang, Lihui Wang, Xiang Zou, Dongmei Li (通讯作者), and Xiaodong Han*. Microcystin-Leucine Arginine Causes Cytotoxic Effects in Sertoli Cells Resulting in Reproductive Dysfunction in Male Mice. Sci Rep. 2016 Dec 15;6:39238.

Xiancheng Chen, Lei Xiong, Baolei Miao, Ning Liu, Zhen Wang, Weidong Gan*, Dongmei Li (通讯作者), Hongqian Guo.The value of ASPL-TFE3 dual-color single-fusion FISH assay in diagnosing alveolar soft part sarcoma. Int J Clin Exp Pathol 2016;9(10):10581-10586

Ning Liu, Zhen Wang, Weidong Gan*, Lei Xiong, Baolei Miao, Xiancheng Chen, Hongqian Guo, Dongmei Li (通讯作者). Renal Cell Carcinoma Associated with Xp11.2 Translocation/TFE3 Gene Fusions: Clinical Features, Treatments and Prognosis. PLoS One. 2016 Nov 28;11(11):e0166897. doi: 10.1371/journal.pone.0166897.

Xiannan Meng , Ling Zhang, Xiang Chen, Zou Xiang, Dongmei Li (通讯作者),and Xiaodong Han*. miR-541 Contributes to Microcystin-LR-Induced Reproductive Toxicity through Regulating the Expression of p15 in Mice. Toxins 2016, 8, 260; doi:10.3390/toxins8090260.

Ruoyu Wang, Xiaoqin Yin, Hui Zhang, JiweiWang, Lin Chen, Jingwen Chen, Xiaodong Han, Zou Xiang, and Dongmei Li (通讯作者). Effects of a Moderately Lower Temperature on the Proliferation and Degranulation of Rat Mast Cells. Journal of Immunology Research, 2016, Article ID 8439594.

Lihui Wang , Pan Zhang , Xiannan Meng, Xiaoqian Lin, Ye Liu, Weidong Gan*, Xiaodong Han*, Dongmei Li(通讯作者). Correlation between the germline methylation status in ERβ promoter and the risk in prostate cancer: a prospective study. Familial Cancer 2016,15:309–315.

Yuan Zhou, Hui Wang, Cong Wang, Xuefeng Qiu, Mikael Benson, Xiaoqin Yin, Zou Xiang, Dongmei Li(通讯作者), Xiaodong Han*. Roles of miRNAs in microcystin-LR-induced Sertoli cell toxicity. Toxicology and Applied Pharmacology 287 (2015) 1–8.

Weidong Gan, Ming Zhou, Zou Xiang, Xiaodong Han and Dongmei Li(通讯作者). Combined Effects of Nonylphenol and Bisphenol A on the Human Prostate Epithelial Cell Line RWPE-1. Int. J. Environ. Res. Public Health 2015, 12, 4141-4155; doi:10.3390/ijerph120404141

Yuan Zhou, Zou Xiang, Dongmei Li(通讯作者), Xiaodong Han*. Regulation of Microcystin-LR-Induced Toxicity in Mouse Spermatogonia by miR-96. Environmental Science and Technology. 2014, 48:6383-6390.

Yang Hu, Ruoyu Wang, Zou Xiang, Weiping Qian, Xiaodong Han*, Dongmei Li(通讯作者). Antagonistic Effects of a Mixture of Low-Dose Nonylphenol and Di-N-Butyl Phthalate (Monobutyl Phthalate) on the Sertoli Cells and Serum Reproductive Hormones in Prepubertal Male Rats In Vitro and In Vivo. Plos One. 2014, 9(3):1-9.

Yang Hu, Ruoyu Wang, Zou Xiang, Weiping Qian, Xiaodong Han*, Dongmei Li(通讯作者). Mixture effects of nonylphenol and di-n-butyl phthalate (monobutyl phthalate) on the tight junctions between Sertoli cells in male rats in vitro and in vivo. Exp Toxicol Pathol. 2014, 66(9-10): 445-54.

甘卫东,周明,胡杨,李冬梅(通讯作者). 低剂量壬基酚促进DU-145细胞增殖及雌激素膜受体GPR30表达的研究. 中华男科学杂志,2014, 20(5): 405-409.

专利、著作版权等

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