医学硕士 南京医科大学神经内科

哲学博士 （PhD） 美国密西西比大学医学中心，医学微生物和免疫学

博士后 美国约翰斯霍普金斯大学医学院肿瘤中心，肿瘤分子生物学

1998-2003 美国约翰斯霍普金斯大学医学院 Instructor 2003-2010 美国美国约翰斯霍普金斯大学医学院 Assistant Professor 2011- 南京大学医学院教授

2015-2018 国家自然科学基金 （81470940）PPARγ乙酰化调控Klotho缓解慢性肾脏病矿物质与骨异常的作用及机理研究 主持人

2013-2016 国家自然科学基金 （81271301） 蛋白质乙酰化调控减轻脑缺血炎症和脑损伤的作用机理研究主持人

2012- 江苏省双创人才重点实验室 感染和炎症的信号传导和基因调控 主持人

2012-2016 国家重点基础研究发展计划973项目 （2012CB517605）环境表观遗传学在肾小球损伤中的机制研究 子课题负责人：崔恒宓教授

2011-2013 国家自然科学基金 （81070940） 一氧化碳激活 NrF2-HO1 通路在脑缺血损伤保护中的机理研究主持人

1. Youngtae Jeong, Ronghui Du, Xiaolei Zhu, Shasha Yin, Jian Wang, Hengmi Cui, Wangsen Cao*, and Charles J. Lowenstein. Histone deacetylase isoforms regulate innate immune responses by deacetylating mitogen-activated protein kinase phosphatase-1. Journal of Leukocyte Biology. 95(2014);651-659.

2. Yuan Liu， Qinlei Jiang，Shaoheng Wu, Wangsen Cao，Chenggong Yu, Hengmi Cui. Correlation of MiT-483 with Colorectal Cancer. Chinese Journal of Gastroenterology. 2014(3).

3. Rong Hui Du , Si Yuan Qin, Lu Sen Shi, Zi Qian Zhou, Xi Yu Zhu,Juan Liu, Ren Xiang Tan, Wangsen Cao * . Fumigaclavine C activates PPARg pathway and attenuates atherogenesis in ApoE-deficient mice . Atherosclerosis 234 (2014) 120-128.

4. Bing Wang, Sofiyan Saleem, Rung-chi Li, Yun Tai Kim, Siyuan Huang, Yun Xu, Sylvain Dore, and Wangsen Cao. Histone Deacetylase Inhibition Activates Transcription Factor Nrf2 and Protects Against Cerebral Ischemic Damage Free Radical Biology & Medicine 2012. 52 (2012) 928–936

5. Bing Wang, Wangsen Cao, Shyam Biswal, Sylvain Dore. Carbon onoxide–Activated Nrf2 Pathway Leads to Protection Against Permanent Focal Cerebral Ischemia Stroke 2011, 42:2605-2610.

6. Cao W , Bao C, Padalko E, Lowenstein CJ. Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling. Journal of Experimental Medicine. 2008 June 9;205(6):1491-503.

7. Matsushita K, Morrell C, Cambien B, Yang SX, Yamakuchi M, Bao C, Hara M, Quick RA, Cao W, O’Rourke B, Lowenstein JM, Pevsner J, Wagner DD, and Lowenstein CJ. Nitric Oxide Regulation of Exocytosis by S-Nitrosylation of N-ethylmaleimide Sensitive Factor. Cell 2003 October 17, 2003; 115 (2):139-150.

8. Wangsen Cao, Mary Lynn Baniecki, William J. McGrath, Clare Bao, Clayton B. Deming, Jeffrey J. Rade, Charles J. Lowenstein, and Walter F. Mangel Nitric oxide inhibits the adenovirus proteinase in vitro and viral infectivity in vivo. FASEB Journal., 2003 Dec;17(15):2345-6.

9. Cao W, Bao C, and Lowenstein CJ. Inducible nitric oxide synthase expression inhibition by adenovirus E1A. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7773-8

10. Cao W, Mattagajasingh SN, Xu H, Kim K, Fierlbeck W, Deng J, Lowenstein CJ, Ballermann BJ. TIMAP, a novel CAAX box protein regulated by TGF-beta1 and expressed in endothelial cells. Am J Physiol Cell Physiol. 2002 Jul;283(1):C327-37

11. Wangsen Cao, Neeraj Adya, Martin Britos-Bray, P. P Paul Liu, Alan D. Friedman. 1998. The core binding factor(CBF)alpha interaction domain and the smooth muscle myosin heavy chain (SMMHC) segment of CBFb-SMMHC are both required to slow cell proliferation. J. Biol. Chem. 273(47).31534-31540.

12. Cao WS, Britos-Bray M, Claxton DF, Kelley CA, Speck NA, Liu PP, and Friedman AD. 1997. CBFβ-SMMHC, expressed in M4eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells. Oncogene 15:1513-1527