1983年毕业于重庆第三军医大学军医系，获学士学位；1988年毕业于北京解放军军医进修学院（解放军总医院），获硕士学位；2002年毕业于上海第二军医大学，获博士学位

1976年10月参加工作1983-1985年在第三军医大学附属西南医院呼吸科工作，1988-1989年在北京解放军总医院呼吸科工作。1990年起在南京军区南京总医院呼吸科工作至

主持参加国家自然科学基金面上项目2项，军区重点课题1项和一般项目3项，江苏省基金3项，其它课题6项1.2015.01－2018.12，肺内皮细胞SLPR1受体在流感病毒所致ARDS中的作用，国家自然科学基金面上项目，75万元，项目批准号：81470206 ，第一负责人

2.2013－2015，PU.1/Dectin-1在气道上皮细胞应对烟曲霉感染的作用和机制研究，国家自然科学基金面上项目，70万元，项目批准号：81270064 ，第一负责人

3.2010-2012；MK2信号通路在急性肺损伤中的调控作用，南京军区医药卫生重点课题。30万元，09Z028；第一负责人

4.2010-2011，MK2信号通路在急性肺损伤中的调控作用，江苏省自然科学基金。8万元，BK2009318，第一负责人

5.2008-2010，靶向NF-kBp65亚基穿膜拮抗肽治疗急性肺损伤的实验研究,南京总医院重点课题。10万元(Z2008014)，第一负责人

6.2007-2010，RNA干扰TSLPRr基因靶向修饰未成熟树突状细胞诱导哮喘免疫耐受的研究，全军医药卫生科研课题，5万元，第一负责人

7.2011-2013，E-钙粘蛋白：烟曲霉孢子侵袭肺泡上皮细胞的重要受体？国家自然基金青年基金，20万元，项目批准号：81000003，第二负责人

8.2011－2013，TTP和HuR在急性肺损伤重要炎症因子表达中的作用，江苏省自然基金，8万元，BK2011657，第二负责人

1.Prevalence and risk of viral infection in patients with acute exacerbation of chronic obstructive pulmonary disease:a meta-analysi.sMol Biol Rep (2014) 41:4743–4751(通讯作者)

2.Vitamin D Deficiency Causes Defective Resistance to Aspergillus fumigatus in Mice via Aggravated and Sustained Inflammation.PLOS ONE; 2014;6( 9):1-12（通讯作者）

3.Tristetraprolin is involved in the glucocorticoid-mediated interleukin 8 repression. International Immunopharmacology 22 (2014) 480–485（通讯作者）

4.Efficacy of combination therapy of triazole and echinocandin in treatment of invasive aspergillosis: a systematic review of animal and human studies. Journal of Thoracic Disease. 2014;6(2):99-108.（通讯作者）

5.Efficacy of the Combination of Voriconazole and Caspofungin in Experimental Pulmonary Aspergillosis by Different Aspergillus Species. Mycopathologia. 2014,177:11-18（通讯作者）

6.Chemotherapy plus Vandetanib or Chemotherapy Alone in Advanced Non-small Cell Lung Cancer: A Meta-analysis of Four Randomised Controlled Trials Clinical Oncology (2012) e1-e9（通讯作者）

7.Overexpression of periostin predicts poor prognosis in non-small cell lung cancer. ONCOLOGY LETTERS. 2013, 6: 1595-1603.（通讯作者）

8.Dectin-2 is predominately macrophage restricted and exhibits conspicuous expression during Aspergillus fumigatus invasion in human lung. Cellular Immunology. 2013, 284(1-2):60–67（通讯作者）

9.Activation of NF-κB and respiratory burst following Aspergillus fumigatus stimulation of macrophages. Immunobiology. Available online 4 July 2013.In Press, Corrected Proof — Note to users（通讯作者）

10.Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor-induced interleukin-6 expression via human antigen R. Chin Med J. 2013,126 (22):1-5（通讯作者）

11.Effect of noninvasive, positive pressure ventilation on patients with severe, stable chronic obstructive pulmonary disease: a meta-analysis. Chin Med J (Engl). 2013, 126(1):140-146. （通讯作者）

12.Diagnosis of airway-invasive pulmonary aspergillosis by tree-in-bud sign in an immunocompetent patient:Case report and literature review；Journal de Mycologie Médicale (2013) 23, 64—69（通讯作者）

13.Dectin-1 is inducible and plays a crucial role in Aspergillus-induced innate immune responses in human bronchial epithelial cells. European journal of clinical microbiology & infectious diseases .2012,31(10):2755-64（通讯作者）

14.Chemotherapy plus multitargeted antiangiogenic tyrosine kinase inhibitors or chemotherapy alone in advanced NSCLC: a meta-analysis of randomized controlled trials. Eur J Clin Pharmacol.. 2013 10.1007/s00228-012-1333-3.（通讯作者）

15.MK2 post-transcriptionally regulates TNF-α-induced expression of ICAM-1 and IL-8 via tristetraprolin in human pulmonary microvascular endothelial cells. AJP Lung. 2012,302,793-799

16.HuR post-transcriptionally regulates TNF-induced IL-6 expression in human pulmonary microvascular endothelial cells mainly via tristetraprolin. Respiratory Physiology Neurobiology. 2012:154– 161

17.E-cadherin mediates adhesion and endocytosis of Aspergillus fumigatus blastospores in human epithelial cells. Chinese Medical Journal. 2012 ;125(4):617-621（通讯作者）

18.Inhibition of pre-B cell colony-enhancing factor attenuates inflammation and apoptosis induced by pandemic H1N1 2009 in lung endothelium. Respiratory Physiology & Neurobiology. 2011,178:235-241.（通讯作者）

19.Induction of immune tolerance in asthmatic mice by vaccination with DNA encoding an allergen- cytotoxic T lymphocyte-associated antigen 4 combination. Clin Vaccine Immunol ，May 2011；807－814（通讯作者）

20.A soluble thymic stromal lymphopoietin (TSLP) antagonist,TSLPR-immunoglobulin, reduces the severity of allergic disease by regulating pulmonary dendritic cell；Clinical and Experimental Immunology ；2011（通讯作者）

21.Evaluation of PCR on Bronchoalveolar Lavage Fluid for Diagnosis of Invasive Aspergillosis: A Bivariate Metaanalysis and Systematic Review.Plos One, December 2011;6(12):e28467 （通讯作者）

22.Antithrombin-Ⅲ without concomitant heparin improves endotoxin induced acute lung injury rats by inhibiting the activiation of mitogen-activated protein kinase；J Chin Med; 2009, 122(20):2466-2471（通讯作者）

23.Expression of periostin in the serum of NSCLC and its function on proliferation and migration of human lung adenocarcinoma cell line (A549) in vitro. Mol Biol Rep; 2009, 18（通讯作者）

24.High mobility group box 1 as a mediator of endotoxin administration after hemorrhagic shock-primed lung injury. Brazilian Journal of Medical and Biological Research (2009) 42: 804-811（通讯作者）

25.Comparison of three different PCR-based methods to predict the penicillin nonsusceptible Streptococcus pneumoniae isolates from China. Letters in Applied Microbiclogy 2008,48:105-111（通讯作者）

26.Effects of different levels of end-expiratory positive pressure on lung recruitment and protection in patients with acute respiratory distress syndrome；Chin Med J 2008;121(22):2218-2223（通讯作者）

27.2009，《感染性疾病-基于临床病例的诊治析评》，人民卫生出版社，副主编