现任解放军南京总医院检验科副主任

主持国家自然科学基金项目四项、作为技术骨干参加国家“973计划”子项目1项国家自然科学基金：“血浆分泌型miRNA作为非小细胞肺癌分子标志物及参与肿瘤 微环境调节的机制研究”（81672102），2017.1-2020.12， 57万，负责人




国家自然科学基金：“miR-651和miR-708作为肾细胞癌分子标志物的价值及其作用机制研究” (81472021),2015.1-2018.12, 80万，负责人




国家自然科学基金：“血清miRNA作为恶性星形细胞肿瘤无创伤性分子标记物的筛选研究”（81171661）,2012.1-2015.12，58万，负责人




国家重点基础研究发展计划“973”计划子项目：“内源性循环 miRNA 的生物学功能及临床应用研究”(2014CB542301)2014.1-2017.12,208万，技术骨干

发表论文160多篇Comparison of four commercial exosome isolation kits for circulating exosomal microRNA profiling. Anal Bioanal Chem.2018;410(16):3805-3814.(通讯作者)




PU.1/microRNA-142-3p targets ATG5/ATG16L1 to inactivate autophagy and sensitize hepatocellular carcinoma cells to sorafenib. Cell Death Dis. 2018;9(3):312. (通讯作者)




miR-25 is upregulated before the occurrence of esophageal squamous cell carcinoma.Am J Transl Res.2017;9(10):4458-4469. (通讯作者)




Distinct expression profile of HCMV encoded miRNAs in plasma from oral lichen planus patients. J Transl Med. 2017;15(133):1-12. (通讯作者)




Establishment of reference interval for alkaline phosphatase in healthy children of various ethnicities, aged 0-12 years. Lab Med. 2017;48(2):166-171. (通讯作者)




miR-28-5pacts as a tumor suppressor in renal cell carcinoma for multiple antitumor effects by targeting RAP1B. Oncotarget.2016;7(45):73888-73902. (通讯作者)




Systematic characterization of seminal plasma piRNAs as molecular biomarkers for male infertility. Sci Rep.2016;6:24229.(通讯作者)




Elevation of circulating miR-210-3p in high-altitude hypoxic environment. Front Physiol. 2016;7,Article 84,1-9.(通讯作者)




Increased serum microRNAs are closely associated with the presence of microvascular complications in type 2 diabetes mellitus. Sci Rep.2016;6:20032. (共通讯作者)




A panel of four decreased serum microRNAs as a novel biomarker for early Parkinson’s disease. Biomarkers.2016;21(2):129-137.(通讯作者)




A five-miRNA panel identified from a multicentric case–control study serves as a novel diagnostic tool for ethnically diverse non-small-cell lung cancer patients. Ebiomedicine. 2015;(10): 1377–1385.(共通讯作者)




Influence of a high-altitude hypoxic environment on human plasma microRNA profiles. Sci Rep. 2015;5:15156.(通讯作者)




Differentially expressedmicroRNAsin kidney biopsies from various subtypes of nephrotic children.Exp Mol Pathol. 2015;99(3):590-595.(通讯作者)




A panel of five serum miRNAs as a potential diagnostic tool for early-stage renal cell carcinoma.Sci Rep. 2015;5:7610.(通讯作者)




Investigation of microRNA expression in human serum during the aging process. J Gerontol A Biol Sci Med Sci.2015;70(1):102-109. (通讯作者)




Diagnostic and prognostic implications of a serum miRNA panel in oesophageal squamous cell carcinoma. PLoS One.2014;9(3):e92292.(通讯作者)




Identification of serum microRNAs for cardiovascular risk stratification in dyslipidemia subjects.Int J Cardiol. 2014; 172(1):232-234. (共通讯作者)

Increased serum and urinary microRNAs in children with idiopathic nephrotic syndrome. Clin Chem. 2013;59(4):658-666. (通讯作者)




Identification of seven serum microRNAs from a genome-wide serum microRNA expression profile as potential noninvasive biomarkers for malignant astrocytomas.Int J Cancer.2013;132(1): 116-127. (通讯作者)

获得授权的国家发明专利3项