京总医院呼吸内科主任、肺癌综合诊治中心主任，留美医学博士后。南京大学、南方医科大学、南京医科大学、东南大学、第二军医大学博士和硕士研究生导师，南京军区南京总医院博士后联系导师

主持和承担国家自然科学基金、国家新药基金、江苏省重点科研基金等多项研究课题 nc-TL7R/DNMT1/Jmjd3通路在线粒体损伤相关分子模式介导的创伤性急性肺损伤的机制研究。国家自然基金面上项目，81570078，2016-2019，第一负责人

GGPS1调控肺巨噬细胞NLRP3炎性体启动ARDS炎症瀑布的作用机制，国家自然基金面上项目，81770082,2018-2021，第一负责人

循环线粒体DNA在战场复合伤早期伤情评估、预警和救治分拣中的应用，军事医学项目-重点培育项目，编号YYZD2014003，2014.10-2016.9，第一负责人

肺癌规范化诊疗研究，江苏省重点病专项课题，编号

发表研究论著200余篇1、2018， Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma.J Cell Mol Med

2、2018，The location, histological type and stage of lung cancer are associated with bleeding during endobronchial biopsy. Cancer management and research

3、2018，Evaluation of pulmonary reexpansion in a porcine model of bronchial foreign body.Pediatric Pulmonology

4、2018，RNA sequencing enables systematic identification of platelet transcriptomic alterations in NSCLC patients.Biomedicine & Pharmacotherapy

5、2018， Topotecan alleviates ventilator-induced lung injury via NF-κB pathway inhibition.Cytokine

6、2018， TEAD4 exerts pro-metastatic effects and is negatively regulated by miR6839-3p in lung adenocarcinoma progression. J Cell Mol Med.

7、2017，PRC1 contributes to tumorigenesis of lung adenocarcinoma in association with the Wnt/β-catenin signaling pathway.Mol Cancer.

8、2017， Long non-coding RNA 00312 regulated by HOXA5 inhibits tumour proliferation and promotes apoptosis in Non-small cell lung cancer. J. Cell. Mol.

9、2017,The biology, function and clinical implications of exosomes in lung cancer.Cancer Lett.

10、2017， Patterns and functional implications of platelets upon tumor "education".Int J Biochem Cell Biol

11、2016，Downregulation of the long noncoding RNA GAS5-AS1 contributes to tumor metastasis in non-small cell lung cancer.Sci Rep

12、2016， Circulating long noncoding RNA GAS5 is a novel biomarker for the diagnosis of nonsmall cell lung cancer.Medicine (Baltimore)

13、2016， Efficacy and safety of recombinant human tumor necrosis factor application for the treatment of malignant pleural effusion caused by lung cancer.Thorac Cancer

14、2015，Association Between the MUC5B Promoter Polymorphism rs35705950 and Idiopathic Pulmonary Fibrosis .Medicine

15、2015， PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer.Cancer Lett

16、2015， Recombinant HMGB1 A box protein inhibits Th17 responses in mice with neutrophilic asthma by suppressing dendritic cell-mediated Th17 polarization.Int Immunopharmacol

17、2014， Prognostic value of secreted phosphoprotein-1 in pleural effusion associated with non-small cell lung cancer.BMC Cancer

18、2014, Metadherin regulates proliferation and metastasis via actin cytoskeletal remodelling in non-small cell lung cancer.British Journal of Cancer

19、2014， Conventional hypoglycaemic agents and the risk of lung cancer in patients with diabetes: a meta-analysis. PLoS One

20、2014， The effect of P2X7 receptor 1513 polymorphism on susceptibility to tuberculosis: A meta-analysis.Infect Genet Evol

21、2014，Identification of novel driver mutations of the discoidin domain receptor 2 (DDR2) gene in squamous cell lung cancer of Chinese patients.BMC Cancer

22、2014，The role of serum carcinoembryonic antigen in predicting responses to chemotherapy and survival in patients with non-small cell lung cancer. J Cancer Res Ther.

23、2014，Is high-frequency oscillatory ventilation more effective and safer than conventional protective ventilation in adult acute respiratory distress syndrome patients? A meta-analysis of randomized controlled trials.Crit Care

24、2014， Diagnostic value of mutation-specific antibodies for immunohistochemical detection of epidermal growth factor receptor mutations in non-small cell lung cancer: a meta-analysis.PLoS One

25、2013， Pretreatment neutrophil to lymphocyte ratio is associated with response to therapy and prognosis of advanced non-small cell lung cancer patients treated with first-line platinum-based chemotherapy.Cancer Immunol Immunother

26、2013, Chemotherapy plus Vandetanib or chemotherapy alone in advanced non-small cell lung cancer: a meta-analysis of four randomised controlled trials.Clin Oncol (R Coll Radiol)

27、2013，Long non-coding RNAs: a new frontier in the study of human diseases.Cancer Lett

28、2013，SPOCK1 is a novel transforming growth factor-β target gene that regulates lung cancer cell epithelial-mesenchymal transition.Biochem Biophys Res Commun

29、2013，Discoidin domain receptor 1 is associated with poor prognosis of non-small cell lung cancer and promotes cell invasion via epithelial-to-mesenchymal transition. Med Oncol

30、2013,Skin rash could predict the response to EGFR tyrosine kinase inhibitor and the prognosis for patients with non-small cell lung cancer: a systematic review and meta-analysis.PLoS One