主持“精准医学研究”国家重点研发计划1项、国家杰出青年科学基金1项、国家自然科学基金重点课题1项、国家973课题1项，总科研经费3000万元基于恶性肿瘤免疫微环境，代谢及耐药相关分子靶标鉴定及干预研究。科技部精准医学重点专项，2016YFC0905900，1200万元。 项目负责人。2016.7-2021.6

循环非编码RNA调控肿瘤浸润免疫细胞NF-κB/STAT3网络在肝癌复发与转移中机制及诊断价值研究. 国家自然科学基金重点项目，81430062， 320万元。项目负责人。2015.1-2018.12

慢性炎症与肝癌.国家自然科学基金杰出青年基金，81225017，280万元。项目负责人。2013.1-2016.12

肾包膜下细胞移植技术对癌基因致瘤性的重新评价，国家自然科学基金面上项目，30672367，27万元。项目负责人。2007.1-2009.12。

慢病毒载体介导的T细胞受体基因治疗EBV相关肿瘤。国家自然科学基金面上项目,30772003，32万元。项目负责人。2008.1-2010.12。

性激素及IL-1/IL-1R 通路在原发性肝癌发生中的作用, 国家自然科学基金面上项目，81072029，35万元。项目负责人。2011.1-2013.12。

巨噬细胞、T淋巴细胞及其分泌的IL-22等炎症因子对肝脏非可控性炎症恶性转化的调控，国家自然科学基金重大研究计划（培育项目），91029721，50万元。项目负责人。2011.1-2013.12。

炎症诱导肿瘤的分子调控网络研究,国家基础研究计划（973）， 2012CB910800,课题负责人，240万元。2012.1-2016.12

教育部新世纪优秀人才基金资助。NCET-09-0160，50万元。2010.1-2012.12。

江苏省医学重点人才项目。RC2007057。100万元。2007.1-2011.12.

江苏省人民医院创新团队A类，首席科学家，300万元。2011.1-2013.12。

慢病毒载体介导的针对端粒酶的RNA干扰技术联合TK基因治疗肝癌及其它实体肿瘤。国家卫生部重点科研基金项目，wkj-2006-2-1，20万元。2005.1-2007.12

发表SCI文章60余篇Xia AL, Wang XC, Lu YJ, Lu XJ, Sun B. Chimeric-antigen receptor T (CAR-T) cell therapy for solid tumors: challenges and opportunities. Oncotarget. 2017 Jul 18;8(52):90521-90531. doi: 10.18632/oncotarget.19361. eCollection 2017 Oct 27. Review. (Corresponding author), (IF: 5.165)

Xu X, Yin Y, Tang J, Xie Y, Han Z, Zhang X, Liu Q, Qin X, Huang X, Sun B. Long non-coding RNA Myd88 promotes growth and metastasis in hepatocellular carcinoma via regulating Myd88 expression through H3K27 modification. Cell Death Dis.2017 Oct 12;8(10):e3124. doi: 10.1038/cddis.2017.519. (Corresponding author), (IF: 5.965)

Lu XJ, Li XH, Yuan ZX, Sun HY, Wang XC, Qi X, Zhang X, Sun B. Assessment of liver fibrosis with the gamma-glutamyl transpeptidase to platelet ratio: a multicentre validation in patients with HBV infection. Gut. 2017 Nov 3. pii: gutjnl-2017-315299. doi: 10.1136/gutjnl-2017-315299. [Epub ahead of print] No abstract available. (Corresponding author), (IF: 16.658)

Chen K, Ye H, Lu XJ, Sun B, Liu Q. Towards In Silico Prediction of the Immune-Checkpoint Blockade Response. Trends Pharmacol Sci. 2017 Dec;38(12):1041-1051. doi: 10.1016/j.tips.2017.10.002. Epub 2017 Oct 28. Review. (Corresponding author), (IF: 12.797)

Wang XC, Zhang XY, Zhang X, Yuan ZX, Li XH, Wang JC, Sun B, Lu XJ. Pitfalls in the non-invasive assessment of liver fibrosis with eLIFT-FMVCTE algorithm. J Hepatol. 2017 Oct 6. pii: S0168-8278(17)32338-3. doi: 10.1016/j.jhep.2017.08.038. [Epub ahead of print] (Corresponding author), (IF: 12.486)

Yan S, Han B, Gao S, Wang X, Wang Z, Wang F, Zhang J, Xu D, Sun B. Exosome-encapsulated microRNAs as circulating biomarkers for colorectal cancer. Oncotarget. 2017 Jun 16;8(36):60149-60158. doi: 10.18632/oncotarget.18557. (Corresponding author), (IF: 5.168)

Wang X, Lu XJ, Sun B. The pros and cons of dying tumour cells in adaptive immune responses. Nat Rev Immunol. 2017 Sep;17(9):591. doi: 10.1038/nri.2017.87. Epub 2017 Jul 31. (Corresponding author), (IF: 39.932)

Li G, Mu X, Huang X, Qian X, Qin J, Tan Z, Zhang W, Xu X, Tan S, Zhu Z, Li W, Wang X, Wang X, Sun B. Liver transplantation using the otherwise-discarded partial liver resection graft with hepatic benign tumor: Analysis of a preliminary experience on 15 consecutive cases. Medicine (Baltimore). 2017 Jul;96(29):e7295. doi: 10.1097/MD.0000000000007295. (Corresponding author), (IF: 1.803)

Sun X, Zhangyuan G, Shi L, Wang Y, Sun B, Ding Q. Prognostic and clinicopathological significance of cyclin B expression in patients with breast cancer: A meta-analysis. Medicine (Baltimore). 2017 May;96(19):e6860. doi: 10.1097/MD.0000000000006860. Review. (Corresponding author), (IF: 1.803)

Zhu H, Liu Q, Tang J, Xie Y, Xu X, Huang R, Zhang Y, Jin K, Sun B. Alpha1-ACT Functions as a Tumour Suppressor in Hepatocellular Carcinoma by Inhibiting the PI3K/AKT/mTOR Signalling Pathway via Activation of PTEN. Cell Physiol Biochem. 2017;41(6):2289-2306. doi: 10.1159/000475648. Epub 2017 Apr 26. Corresponding author), (IF: 5.104)

Tang J, Xie Y, Xu X, Yin Y, Jiang R, Deng L, Tan Z, Gangarapu V,Tang J,Sun B. Bidirectional transcription of Linc00441 and RB1 via H3K27 modification- dependent way promotes hepatocellular carcinoma.Cell Death Dis. 2017 Mar 16;8(3):e2675. doi: 10.1038/cddis.2017.81. (Corresponding author), (IF: 5.77)

Jiang R, Tang J, Chen Y, Deng L, Ji J, Xie Y, Jia W, Chu W, Sun B. The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion. Nature Communications, 2017; Doi: 10.1038/ncomms15129. (Corresponding author), (IF: 11.329)

Deng L,Tang J, Yang H, Cheng C, Lu S, Jiang R,Sun B. MTA1 modulated by miR-30e contributes to epithelial-to-mesenchymal transition in hepatocellular carcinoma through an ErbB2-dependent pathway.Oncogene. 2017 Jul 13;36(28):3976-3985. doi: 10.1038/onc.2016.491. Epub 2017 Mar 13. Corresponding author)(IF: 8.559)

Tan Z, Liu Q, Jiang R, Lv L, Shoto SS, Maillet I, Quesniaux V, Tang J, Zhang W,Sun B, Ryffel B. Interleukin-33 drives hepatic fibrosis through activation of hepatic stellate cells. Cell Mol Immunol. 2017 Feb 13. (Corresponding author) (IF: 5.897)

Zhang W, Wang X, Huang R, Jin K, Zhangyuan G, Yu W, Yin Y, Wang H, Xu Z, Sun B. Prognostic value of marital status on stage at diagnosis in hepatocellular carcinoma. Sci Rep. 2017 Jan 31;7:41695. (Corresponding author) (IF: 5.228)

Huang R, Wang X, Zhang W, Zhangyuan G, Jin K, Yu W, Xie Y, Xu X, Wang H, Sun B. Down-Regulation of LncRNA DGCR5 Correlates with Poor Prognosis in Hepatocellular Carcinoma. Cell Physiol Biochem. 2016 ; 40(3-4):707-715. (Corresponding author) (IF: 4.652)

Yan S, Wang Z, Wang Z, Duan Q, Wang X, Li J, Sun B. Glutathione S-transferase M1 null genotype related to poor prognosis of colorectal cancer. Tumour Biol. 2016 Aug;37(8):10229-34. (Corresponding author) (IF: 2.926)

Wang X, Zhang W, Tang J, Li J, Xu D, Xie Y, Huang R, Jiang R, Deng L, Zhang X, Chai Y, Qin X, Sun B*. LINC01225 promotes occurrence and metastasis of hepatocellular carcinoma in an epidermal growth factor receptor-dependent pathway. Cell Death and Disease.2016;7: doi:10.1038/cddis.2016.26 (Corresponding author), (IF:5.77)

Zhuo H, Tang J, Lin Z, Jiang R, Zhang X, Ji J, Wang P, Sun B*.The aberrant expression of MEG3 regulated by UHRF1 predicts the prognosis of hepatocellular carcinoma.Mol Carcinog. 2016;55(2):209-19. (Corresponding author), (IF: 4.8)

Font-Burgada J, Sun B*, Karin M. Obesity and Cancer: The Oil that Feeds the Flame.Cell Metab. 2016;23(1):48-62.(Corresponding author), (IF:17.57)

Ji J, Tang J, Deng L, Xie Y, Jiang R, Li G, Sun B*.LINC00152 promotes proliferation in hepatocellular carcinoma by targeting EpCAM via the mTOR signaling pathway.Oncotarget. 2015;6(40):42813-24. (Corresponding author), (IF:6.627)

Deng L, Yang H, Tang J, Lin Z, Yin A, Gao Y, Wang X, Jiang R, Sun B*. Inhibition of MTA1 by ERα contributes to protection hepatocellular carcinoma from tumor proliferation and metastasis.J Exp Clin Cancer Res. 2015 Oct 26;34:128 (Corresponding author), (IF:4.9)

Wang X, Yan S, Xu D, Li J, Xie Y, Hou J, Jiang R, Zhang C, Sun B*. Aggravated Liver Injury but Attenuated Inflammation in PTPRO-Deficient Mice Following LPS/D-GaIN Induced Fulminant Hepatitis.Cell Physiol Biochem. 2015;37(1):214-24. (Corresponding author), (IF:2.875)

Zhang W, Wang X, Jiang R, Hou J, Mu X, Li G, Sun B*.Effect of Tumor Size on Cancer-Specific Survival in Small Hepatocellular Carcinoma. Mayo Clinic Proceedings. 2015 Sep;90(9):1187-95. (Corresponding author), (IF:6.262)

Hou J, Deng L, Zhuo H, Lin Z, Chen Y, Jiang R, Chen D, Zhang X, Huang X, Sun B*.PTPROt maintains T cell immunity in the microenvironment of hepatocellular carcinoma.J Mol Cell Biol. 2015;7(4):338-50. (Corresponding author), (IF:6.771)

Wen Y, Han J, Chen J, Dong J, Xia Y, Liu J, Jiang Y, Dai J, Lu J, Jin G, Han J, Wei Q, Shen H, Sun B*, Hu Z. Plasma miRNAs as early biomarkers for detecting hepatocellular carcinoma.Int J Cancer. 2015;137(7):1679-90.(Corresponding author), (IF:5.52)

Wan X, Cheng C, Lin Z, Jiang R, Zhao W, Yan X, Tang J, Yao K, Sun B*, Chen Y. The attenuated hepatocellular carcinoma-specific Listeria vaccine Lmdd-MPFG prevents tumor occurrence through immune regulation of dendritic cells.Oncotarget. 2015;6(11):8822-38. (Corresponding author), (IF:6.627)

Zhang W, Hou J, Wang X, Jiang R, Yin Y, Ji J, Deng L, Huang X, Wang K, Sun B*.PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis.Oncotarget. 2015;6(11):9420-33.(Corresponding author), (IF:6.627)

Zhang W, Jiang R, Hou J, Sun B*.Clinicopathological features and prognostic factors of young patients with surgically treated liver cancer.Medicine (Baltimore). 2015;94(12):e684. (Corresponding author), (IF:5.723)

Tang J, Zhuo H, Zhang X, Jiang R, Ji J, Deng L, Qian X, Zhang F, Sun B*. A novel biomarker, Linc00974 interacting with KRT19 promotes proliferation and metastasis in hepatocellular carcinoma. Cell Death & Disease, 2014; 5:e1549.(Corresponding author), (IF:5.177)

Jiang R, Chen D, Hou J, Tan Z, Wang Y, Huang X, Wang X, Sun B*. Survival and Inflammation Promotion Effect of PTPRO in Fulminant Hepatitis Is Associated with NF-kappaB Activation. Journal of Immunology. 2014, 193(10):5161-70 (Corresponding author), (IF:5.362)

Hou J, Xia Y, Jiang R, Chen D, Xu J, Deng L, Huang X, Wang X, Sun B*. PTPRO plays a dual role in hepatic ischemia reperfusion injury through feedback activation of NF-κB.J Hepatol. 2014;60(2):306-312. (corrresponding author) (IF:11.336) .

Sun B*, Karin M*. The therapeutic value of targeting inflammation in gastrointestinal cancers.Trends Pharmacol Sci. 2014; 35(7):349-57. (Corresponding author), (IF: 11.84)

Lin Z, Wan X, Jiang R, Deng L, Gao Y, Tang J, Yang Y, Zhao W, Yan X, Yao K, Sun B*, Chen Y*.Epstein-Barr virus-encoded latent membrane protein 2A promotes the epithelial-mesenchymal transition in nasopharyngeal carcinoma via metastatic tumor antigen 1 and mechanistic target of rapamycin signaling induction.J Virol. 2014; 88(20):11872-85. (Co-corrresponding author) (IF:4.648).

Xu D, Wang X, Yan S, Yin Y, Hou J, Wang X, Sun B. Interaction of PTPRO and TLR4 signaling in hepatocellular carcinoma.Tumour Biol. 2014;35(10):10267-73. (corrresponding author) (IF:2.84).

Yang Y, Hou J, Lin Z, Zhuo H, Chen D, Zhang X, Chen Y,Sun B*. Attenuated Listeria monocytogenes as a cancer vaccine vector for the delivery of CD24, a biomarker for hepatic cancer stem cells. Cell Mol Immunol, 2014; 11: 184-196. (corrresponding author) (IF:4.185) .

Yan S, Xu D, Sun B*. Combination of Radiofrequency Ablation with Transarterial Chemoembolization for Hepatocellular Carcinoma: A Meta-Analysis. Dig Dis Sci, 2013. (IF:2.55)

Tan, ZM and Sun B*. Effects of antiviral therapy on preventing liver tumorigenesis and hepatocellular carcinoma recurrence. World J Gastroenterol, 2013. 19(47): 8895-901. (IF:2.433)

Tan Z, Qian X, Jiang R, Liu Q, Wang Y, Chen C, Wang X, Ryffel B,Sun B*. IL-17A plays critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation. J Immunology, 2013; 191(4):1835-44. (corrresponding author) (IF:5.362)

Sun B*, Mu X, Wang X. Successful adult-to-adult liver transplantation of an otherwise discarded partial liver allograft with a cavernous hemangioma: new strategy for expanding liver donor pool. Transplantation International, 2013;26(9):e79-80 (corrresponding author) (IF:3.12).

Mu X, Lin S, Yang J, Chen C, Chen Y, Herzig MC, Washburn K, Halff GA, Walter CA, Sun B*, Sun LZ. TGF-β Signaling Is Often Attenuated during Hepatotumorigenesis, but Is Retained for the Malignancy of Hepatocellular Carcinoma Cells. PLoS One,2013; 8(5):e63436. (co-corrresponding author) (IF:3.534).

Jiang R, Zhang C, Xia Y, Qian X, Wang X, Sun B*.Serum interleukin-22 level is a negative prognostic indicator in patients with HBV-related hepatocellular carcinoma.Hepatology, 2014;9(3):1208.(corresponding author) (IF:12.003).

Chen C, Hou J, Lin Z, Yao M, Jiang R, Wang Y, Gao Y, Shao Q, Deng L, Chen Y, Sun B. A bystander cell-based GM-CSF secreting vaccine synergizes with a low dose of cyclophosphamide and induces therapeutic immune responses against murine hepatocellular carcinoma. Cell Mol Immunol, 2013; 10(4):349-59 (corrresponding author) (IF:4.185).

Li GQ, Zhang F, Lu H, Lu L, Li XC, Wang XH, Sun B*.Drainage by urostomy bag after blockage of abdominal drain in patients with cirrhosis undergoing hepatectomy.Hepatobiliary Pancreat Dis Int. 2013;12(1):99-102. (corrresponding author) (IF:1.06).

Qin JJ, Xia YX, Lv L, Wang ZJ, Zhang F, Wang XH, Sun B*.Successful disintegration, dissolution and drainage of intracholedochal hematoma by percutaneous transhepatic intervention.World J Gastroenterol. 2012;18(47):7122-6. (corrresponding author) (IF:2.228).

Lv L, Wang P, Zhou X, Sun B*. Association between the p53 codon 72 Arg/Pro polymorphism and hepatocellular carcinoma risk. Tumour Biol.2013; 34(3):1451-9. (corrresponding author) (IF:2.84).

Jiang R, Wang H, Deng L, Hou J, Shi R, Yao M, Gao Y, Yao A, Wang X, Yu L, Sun B. IL-22 is related to development of human colon cancer by activation of STAT3.BMC Cancer. 2013;13:59. (corrresponding author) (IF:3.33).

Tan Z, Jiang R, Wang X, Wang Y, Lu L, Liu Q, Zheng SG, Sun B*, Ryffel B*. RORγt+IL-17+ neutrophils play a critical role in hepatic ischemia-reperfusion injury.J Mol Cell Biol. 2013;5(2):143-6. (Co-corresponding author) (IF:8.432).

Hou J, Xu J, Jiang R, Wang Y, Chen C, Deng L, Huang X, Wang X, Sun B*. Estrogen sensitive PTPRO expression represses hepatocellular carcinoma progression by control of STAT3. Hepatology.2013;57:678-688. (corresponding author) (IF:12.003).

Sun B*, Karin M*. Obesity, Inflammation and Liver Cancer. Journal of Hepatology. 2012；56(3): 704-713 (Co-corresponding author) (IF:11.336).

Jiang R, Tan Z, Deng L, Xia Y, Gao Y, Wang X,Sun B*. IL-22 Promotes Human Hepatocellular Carcinoma By Activation of STAT3. Hepatology. 2011;54(3):900. (corresponding author) (IF:12.003).

Jiang R, Deng L, Zhao L, Li X, Zhang F, Xia Y, Gao Y, Wang X, Sun B*. miR-22 Promotes HBV-Related Hepatocellular Carcinoma Development in Males. Clinical Cancer Research. 2011;17(17):5593-603. (corresponding author) (IF:8.193).

Chen Y, Yang D, Li S, Gao Y, Jiang R, Deng L, Frankel FR, Sun B*. Development of a Listeria monocytogenes based vaccine against hepatocellular carcinoma. Oncogene. 2012;31(17):2140-52. (corresponding author) (IF: 8.559).

Yang D, Shao Q, Sun H, Mu X, Gao Y, Jiang R, Hou J, Yao K, Chen Y, Sun B*. Evaluation of Epstein-Barr virus latent membrane protein 2 specific T-cell receptors driven by T-cell specific promoters using lentiviral vector.Clin Dev Immunol. 2011;2011:716926. (corresponding author) (IF:3.064).

Gao Y, Yao A, Zhang W, Lu S, Yu Y, Deng L, Yin A, Xia Y, Sun B*, Wang X. Human mesenchymal stem cells over-expressing pigment epithelium derived factor inhibits hepatocellular carcinoma in nude mice. Oncogene, 2010; 29(19):2784-2794. (Co-corresponding author) (IF:8.559).

Shi J, Deng L, Gao Y, Zhao L, Wang X, Sun B*. Hydrodynamics based transfect -ion of plasmid encoding RANK-Fc protects against hepatic ischemia/ reperfusion injury in mice. Liver Transplantation, 2010; 16: 611-620. (corresponding author) (IF: 4.1).

Jiang R, Xia Y, Li J, Deng L, Zhao L, Shi J, Wang X, Sun B*. High expression levels of IKKa and IKKb are necessary for the malignant properties of liver cancer. Int J Cancer, 2010; 126：1263-1274. (corresponding author) (6.198).

Zhang W, Qian X, Xia Y, Wang K, Zheng Z, Wang Y, Chao Q, Wang X, Sun B*. Abdominal compartment syndrome associated with capillary leak Syndrome in a case of liver transplantation. Transplantation Proceedings, 2009; 41(9):3927-30. (corresponding author) (IF: 1.055).

Deng L, Xi L, Yin A, Gao Y, You W, Wang X, Sun B*. Hepatitis B Virus Inhibition in Mice by Lentiviral Vector Mediated Small Interference RNA. BMC Gastroenterol,2009; 9:73. (corresponding author) (IF:2.136).

Sun B, Karin M. NF-B signaling, liver disease and hepatoprotective agents. Oncogene, 2008;27(48):6228-6244. (IF: 8.559).

Sun B*, Gao Y, Deng L, Li G, Cheng F, Wang X. The Level of Oncogene H-Ras Correlates with Tumorigenicity and Malignancy. Cell Cycle,2008; 7(7):934-939 (Co-corresponding author) (IF:5.243).

Chen Y, Sun H, Liu G, Wang B, Wang F, Sun B*, Yao K.EBV LMP2A-specific T cell immune responses elicited by dendritic cells loaded with LMP2A protein.Cell Mol Immunol. 2009 Aug;6(4):269-76. (Co-corrresponding author) (IF:4.185).

Sun B*, Zhao C, Li G, Cheng F, Wang X. Late onset of GVHD after liver Transplantation. Transplant Immunology, 2006; 16(3-4).250-253 (Co-corresponding author) (IF; 2.2).

Sun B*, Chen M, Liu S, Hawks CL, Hornsby PJ, Wang XH. Tumorigenic study on hepatocytes coexpressing SV40 with Ras. Molecular Carcinogenesis,2006；45(3): 213-219. (Co-corresponding author) (IF; 4.77).

Sun B, Chen M, Liu S, Hawks CL, Hornsby PJ. The minimal set of genetic alterations required for conversion of primary human fibroblasts to cancer cells in the subrenal capsule assay. Neoplasia. 2005 ;7(6):585-93. (IF; 5.47)

Sun B, Chen M, Liu S, Hawks CL, Hornsby PJ. Immortal ALT+ human cells do not require telomerase reverse transcriptase for malignant transformation. Cancer Research., 2005;65(15):6512-5. (IF; 9.284)

Sun B, Huang Q, Hawks CL, Hornsby PJ. Progressive loss of malignant behaviorin telomerase-negative tumorigenic adrenocortical cells in an immunodeficient mouse model: Restoration of tumorigenicity by hTERT. Cancer Research,2004;64(17):6144-6151. (IF; 9.284)

Yin Y#, Xu X#, Tang J#, Zhang W, Zhangyuan G, Deng L, Lu S, Zhuo H, Sun B.CD97PromotesTumor Aggressiveness through the Traditional GProtein-CoupledReceptor-mediated signaling in Hepatocellular Carcinoma.Hepatology. 2018Apr 27. doi: 10.1002/hep.30068.（IF:13.246）

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