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周梦良

领域:生物产业 学校:南京大学职称:副主任医师

脑出血/脑外伤...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

1998年考入南京大学医学院7年制,2004年直接转博,2007年博士毕业2008年-2010年在美国华盛顿大学(Washington University in St. Louis)神经外科学习(导师Gregory Zipfel教授),

工作经历

2011年晋升副主任医师,2018年聘为南京大学博士研究生导师

项目课题经历

姓名
周梦良
研究方向:
脑出血/脑外伤


联系方式
njzyzx@126.com, 15850698800


学术兼职:

现任或曾任:中国医师协会神经外科医师分会青年委员、中国医师协会神经外科医师分会英语教育与对外交流专家委员会委员、全军灾难医学会青年委员、江苏省神经科学学会青年工作委员会副主任委员、江苏省医学会神经外科分会青年委员、江苏省中西医结合学会神经外科分会青年委员。


个人简介




1979年7月出生,浙江海宁人。1998年考入南京大学医学院7年制,2004年直接转博,2007年博士毕业(导师史继新教授,获江苏省优秀博士学位论文),2008年-2010年在美国华盛顿大学(Washington University in St. Louis)神经外科学习(导师Gregory Zipfel教授), 2011年晋升副主任医师,2018年聘为南京大学博士研究生导师。迄今共发表SCI论文70篇,其中以第一(共同第一)及通讯(共同通讯)作者在PNAS、Stroke及JCBFM等杂志发表论文17篇。临床专业方向为神经急重症,研究方向为脑出血与脑外伤。现为神经外科实验室主任。为《神经外科手术彩色图解》(2013年出版)主编助理、《Al-Mefty脑膜瘤》(2016年出版)副主译。主持国家自然科学基金3项(完成1项,在研2项)、全军课题1项,入选江苏省“333人才工程”、“六大人才高峰”及江苏省卫计委青年医学人才。




代表性论文[近5年通讯作者和第一作者]

Han BH*, Zhou ML*(共同第一作者), Johnson AW, Singh I, Liao F, Vellimana AK, Nelson JW, Milner E, Cirrito JR, Basak J, Yoo M, Dietrich HH, Holtzman DM, Zipfel GJ. The contribution of reactive oxygen species to cerebral amyloid angiopathy, cerebrovascular dysfunction, and microhemorrhage in aged Tg2576 mice. Proc Natl Acad Sci USA. 2015;112(8):E881-90.

Zhou C, Xie G, Wang C, Zhang Z, Chen Q, Zhang L, Wu L, Wei Y, Ding H, Hang C, Zhou M#(共同通讯作者),Shi J#. Decreased progranulin levels in patients and rats with subarachnoid hemorrhage: a potential role in inhibiting inflammation by suppressing neutrophil recruitment. J Neuroinflammation.2015;12(1):200.

Wang CX, Lin YX, Xie GB, Shi JX, Zhou ML. Wang CX, Lin YX, Xie GB, Shi JX, Zhou ML(通讯作者). Constriction and dysfunction of pial arterioles after regional hemorrhage in the subarachnoid space. Brain Res. 2015;1601:85-91.

Wang CX, Xie GB, Zhou CH, Zhang XS, Li T, Xu JG, Li N, Ding K, Hang CH, Shi JX#, Zhou ML#(共同通讯作者). Baincalein alleviates early brain injury after experimental subarachnoid hemorrhage in rats: Possible involvement of TLR4/NF-κB-mediated inflammatory pathway. Brain Res. 2015;1594:245-55.

Milner E* , Zhou ML*(共同第一作者), Johnson AW, Vellimana AK, Greenberg JK, Holtzman DM, Han BH, Zipfel GJ. Cerebral amyloid angiopathy increases susceptibility to infarction after focal cerebral ischemia in Tg2576 mice. Stroke.2014;45(10):3064-9.

Zhang XS, Zhang X#, Wu Q, Li W, Zhang QR, Wang CX, Zhou XM, Li H, Shi JX, Zhou ML#(共同通讯作者). Astaxanthin alleviates early brain injury following subarachnoid hemorrhage in rats: possible involvement of Akt/bad signaling. Mar Drugs.2014;12(8):4291-310.

Zhang XS, Zhang X#, Wu Q, Li W, Wang CX, Xie GB, Zhou XM, Shi JX, Zhou ML#(共同通讯作者). Astaxanthin offers neuroprotection and reduces neuroinflammation in experimental subarachnoid hemorrhage. J Surg Res.2014;192(1):206-13.

Zhou XM, Zhou ML#(共同通讯作者), Zhang XS, Zhuang Z, Li T, Shi JX, Zhang X#. Resveratrol prevents neuronal apoptosis in an early brain injury model.J Surg Res. 2014;189(1):159-65.

Zhou XM, Zhang X#, Zhang XS, Zhuang Z, Li W, Sun Q, Li T, Wang CX, Zhu L, Shi JX, Zhou ML#(共同通讯作者). SIRT1 inhibition by sirtinol aggravates brain edema after experimental subarachnoid hemorrhage.J Neurosci Res.2014;92(6):714-22.

Zhuang Z, Sun XJ, Zhang X, Liu HD, You WC, Ma CY, Zhu L,Zhou ML#(共同通讯作者), Shi JX#. Nuclear factor-κB/Bcl-XL pathway is involved in the protective effect of hydrogen-rich saline on the brain following experimental subarachnoid hemorrhage in rabbits. J Neurosci Res. 2013;91(12):1599-608.

You WC, Wang CX, Pan YX, Zhang X, Zhou XM, Zhang XS, Shi JX, Zhou ML(通讯作者).Activation of nuclear factor-κB in the brain after experimental subarachnoid hemorrhage and its potential role in delayed brain injury. PLoS One.2013;8(3):e60290.







承担科研项目[项目负责人]

1、国家自然科学基金面上项目,81771292、低氧预处理对蛛网膜下腔出血后神经和血管的保护作用及其机制的实验研究、2018/01-2021/12、54万、在研、主持。

2、国家自然科学基金面上项目,81571162、蛛网膜下腔出血后脑微循环障碍发生过程中Nrf2与NF-κB通路间crosstalk及其在治疗中的作用、2016/01-2019/12、57万、在研、主持。

3、国家自然科学基金青年项目,81000503、蛛网膜下腔出血后脑微循环功能障碍以及NADPH氧化酶来源的氧自由基在其中作用的实验研究、2011/01-2013/12、20万、已结题、主持。

4、全军医学科技青年培育项目(成长项目),15-QNP024,野战条件下颅脑战创伤快速救治与流程相关问题的研究、2016/01-2018/12、15万、在研、主持。

5、江苏省卫计委”科教强卫”青年医学人才、QNRC2016897、蛛网膜下腔出血后脑微循环障碍新机制:淀粉样蛋白β所致平滑肌细胞功能障碍、2016/1-2020/12 25万。

6、江苏省第五期“333”工程第三层次培养对象,2017/1-2020/12


论文、成果、著作等

发表SCI论文70篇Han BH*, Zhou ML*(共同第一作者), Johnson AW, Singh I, Liao F, Vellimana AK, Nelson JW, Milner E, Cirrito JR, Basak J, Yoo M, Dietrich HH, Holtzman DM, Zipfel GJ. The contribution of reactive oxygen species to cerebral amyloid angiopathy, cerebrovascular dysfunction, and microhemorrhage in aged Tg2576 mice. Proc Natl Acad Sci USA. 2015;112(8):E881-90.

Zhou C, Xie G, Wang C, Zhang Z, Chen Q, Zhang L, Wu L, Wei Y, Ding H, Hang C, Zhou M#(共同通讯作者),Shi J#. Decreased progranulin levels in patients and rats with subarachnoid hemorrhage: a potential role in inhibiting inflammation by suppressing neutrophil recruitment. J Neuroinflammation.2015;12(1):200.

Wang CX, Lin YX, Xie GB, Shi JX, Zhou ML. Wang CX, Lin YX, Xie GB, Shi JX, Zhou ML(通讯作者). Constriction and dysfunction of pial arterioles after regional hemorrhage in the subarachnoid space. Brain Res. 2015;1601:85-91.

Wang CX, Xie GB, Zhou CH, Zhang XS, Li T, Xu JG, Li N, Ding K, Hang CH, Shi JX#, Zhou ML#(共同通讯作者). Baincalein alleviates early brain injury after experimental subarachnoid hemorrhage in rats: Possible involvement of TLR4/NF-κB-mediated inflammatory pathway. Brain Res. 2015;1594:245-55.

Milner E* , Zhou ML*(共同第一作者), Johnson AW, Vellimana AK, Greenberg JK, Holtzman DM, Han BH, Zipfel GJ. Cerebral amyloid angiopathy increases susceptibility to infarction after focal cerebral ischemia in Tg2576 mice. Stroke.2014;45(10):3064-9.

Zhang XS, Zhang X#, Wu Q, Li W, Zhang QR, Wang CX, Zhou XM, Li H, Shi JX, Zhou ML#(共同通讯作者). Astaxanthin alleviates early brain injury following subarachnoid hemorrhage in rats: possible involvement of Akt/bad signaling. Mar Drugs.2014;12(8):4291-310.

Zhang XS, Zhang X#, Wu Q, Li W, Wang CX, Xie GB, Zhou XM, Shi JX, Zhou ML#(共同通讯作者). Astaxanthin offers neuroprotection and reduces neuroinflammation in experimental subarachnoid hemorrhage. J Surg Res.2014;192(1):206-13.

Zhou XM, Zhou ML#(共同通讯作者), Zhang XS, Zhuang Z, Li T, Shi JX, Zhang X#. Resveratrol prevents neuronal apoptosis in an early brain injury model.J Surg Res. 2014;189(1):159-65.

Zhou XM, Zhang X#, Zhang XS, Zhuang Z, Li W, Sun Q, Li T, Wang CX, Zhu L, Shi JX, Zhou ML#(共同通讯作者). SIRT1 inhibition by sirtinol aggravates brain edema after experimental subarachnoid hemorrhage.J Neurosci Res.2014;92(6):714-22.

Zhuang Z, Sun XJ, Zhang X, Liu HD, You WC, Ma CY, Zhu L,Zhou ML#(共同通讯作者), Shi JX#. Nuclear factor-κB/Bcl-XL pathway is involved in the protective effect of hydrogen-rich saline on the brain following experimental subarachnoid hemorrhage in rabbits. J Neurosci Res. 2013;91(12):1599-608.

You WC, Wang CX, Pan YX, Zhang X, Zhou XM, Zhang XS, Shi JX, Zhou ML(通讯作者).Activation of nuclear factor-κB in the brain after experimental subarachnoid hemorrhage and its potential role in delayed brain injury. PLoS One.2013;8(3):e60290.




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