教育背景
工作经历
2005 - 现在, 教授。 南京大学医学院公共健康医学中心
2008 – 现在,教授,副主任,南京大学生命分析化学国家重点实验室
2006 - 现在,兼职研究员。英国南汉普顿大学社会和统计研究院
2007 – 现在,兼职副教授,纽约大学医学院,美国
2000-2005, 研究员, Leon levy 牙科研究中心,宾夕法尼亚大学牙医学院
1997-2000,助理教授,生物医学研究中心,洛克菲勒大学,美国
项目课题经历
1. 人类免疫缺陷病毒生物学和免疫应答机制研究 – 基础研究重大专项(973)
2. 杀微生物剂在预防艾滋病性传播的应用基础研究 - 十一五重大传染病专项
3. 抗HIV及病原微生物阻断药物的研究与开发 - 科技部国际合作
4. 新型杀微生物剂的临床前和临床研究 - 十二五重大传染病专项
5. 优化诱导广谱中和抗体的HIV基序疫苗 - 十二五重大传染病专项
6. Developing public health strategies to effectively tackle the spread of HIV/AIDS among the economic migrants of China - 英国文化协会/海外发展署(DEFID/BC)
7. Design of an Innate Immune Component as a HIV-1 Entry Inhibitor - Merieux Research Grant
8. Scientific, regulatory and public health aspects of microbicide research and development - 美国国际发展总署(USAID)
论文、成果、著作等
1. Min Qiu, Qin Wang, Ying Chu, Zhongping Yuan, Hongyong Song, Zhiwei Chen, and Zhiwei Wu*. (2012) Lignosulfonic Acid Exhibits Broadly Anti-HIV-1 Activity – Potential as a Microbicide Candidate for the Prevention of HIV-1 Sexual Transmission. PLoS ONE 7(4): e35906. doi:10.1371/journal.pone.0035906.
2. Zhongping Yuan, Xilin Wu, Chao Liu, Genxing Xu, and Zhiwei Wu*. Asymmetric siRNA: New strategy to improve specificity and reduce off-target gene expression. Human Gene Therapy. 2012; 23:521-532. doi: 10.1089hum.2011.145.
3. Yuanxi Kang,Zhiwei Wu,Terrence C K Lau,Xiaofan Lu,Li Liu,Allen K L Cheung,Zhiwu Tan,Jenny Ng,Jianguo Liang,Haibo Wang,Saikam Li,Bojian Zheng,Ben Li,Li Chen,Zhiwei Chen. CCR5 antagonist TD-0680 uses a novel mechanism for enhanced potency against HIV-1 entry, cell-mediated infection, and a resistant variant. Journal of Biological Chemistry. 2012; 287(20):16499-509. DOI:10.1074/jbc.M112.354084.
4. Qiu, M., Chen, Y., Song, S., Song, H., Chu, Y., Yuan, Z., Cheng, L., Zheng, D., Chen, Z., Wu, Z*. Poly (4-styrenesulfonic acid-co-maleic acid) is an entry inhibitor against both HIV-1 and HSV infections - potential as a dual functional microbicide, Antiviral Research (2012), 96 (2):138-147 doi:
5. Pinter, A.; Wu, A. Z.; Neubert, T.; Burkhart, M. D.; Honnen, W. J. Conformational heterogeneity in V1/V2 domain affects the immunological properties of this region. Retrovirology. 2012 SEP 13;9 2 2.
6. Min Qiu, Yu Chen, Lin Cheng, Yin Chu, Hong-Yong Song and Zhiwei Wu*. Pyrrolidine Dithiocarbamate Inhibits Herpes Simplex Virus 1 and 2 Replication, and Its Activity May Be Mediated through Dysregulation of the Ubiquitin-Proteasome System. Journal of Virology. August 2013 vol. 87 no. 15 8675-8686.
7. D. Nutbeam, S. Padmadas, O. Maslovskaya, Z.W. Wu. A health promotion logic model to review progress in HIV prevention in China. Health Promotion International . June 9, 2013。
8. Min Qiu, Yin Chu, Si-Wei Song, Jie Gao, Na Yang, Xiao-Hui Wang, Zhi-Wei Wu*. Zinc ionophorespyrithione inhibits herpes simplex virus type 1 and 2 replication through interfering proteasome function and NF-κB activation. Antiviral Research (2013), 100 (1): 44–53.
9. Ying Chu, Jiahuang Li, Xiling Wu, Zichun Hua, and Zhiwei Wu*. Identification of human immunodeficiency virus type 1 (HIV-1) gp120-binding sites on scavenger receptor cysteine rich 1 (SRCR1) domain of gp340. J. Biomedical Sci. 2013, 20:44.
10. Song Hongyong,Chu Ying,Zhang Hongwei, Wang Xiaohui, Zhang Tong, Qiu Min, Wu Hao, Wu Zhiwei*. Epitope specificity of cross-clade neutralizing sera from Chinese HIV-1 positive individuals. Scandinavian Journal of Immunology 2013, 78, 357–370.
11. Nan Zheng, Yanping Guo, Sabu Padmadas, Baoxi Wang, Zhiwei Wu*. The increase of STI infections calls for simultaneous preventative intervention for more effectively containing HIV epidemics in China. British Journal of Obstetrics and Gynaecology (In press).
12. Siwei Song, Min Qiu, Ying Chu, Deyan Chen, Xiaohui Wang, Airong Su, Zhiwei Wu*. Berberine inhibits herpes simplex virus replication through modulating NF-κB and JNK pathways. Antimicrobial Agents and Chemotherapy (In press).
13. Xiaowen Lv , Min Qiu, Deyan Chen, Nan Zheng, Yu Jin, Zhiwei Wu*. Apigenin and its analog, lutelin, inhibit enterovirus 71 replicaiton with distinct antiviral mechanisms. Antiviral Research (In revision).
专利、著作版权等
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