2000年毕业于四川大学化学系有机化学专业，获理学博士学位

2000年至2001年香港大学(The University of Hong Kong, with Prof. Chi-Ming Che)化学系研究助理。2001年至2003年加拿大渥太华大学(University of Ottawa, with Prof. Howard Alper)化学系博士后。2003年至2007年美国伊利诺伊大学香槟分校(University of Illinois at Urbana-Champaign, with Prof. John A. Katzenellenbogen)化学系博士后研究员。2007年至今任武汉大学药学院教授、博士生导师。

主持国家自然科学基金重大研究计划培育项目及面上项目、教育部新世纪优秀人才支持计划项目、教育部科学技术研究重大项目、教育部博士点博导类基金等项目10余项。1) 主持国家自然科学基金面上项目(No. 81573279), 2016.01.01-2019.12.31。

2) 主持国家自然科学基金面上项目(No. 81373255), 2014.01-2017.12。

3) 主持湖北省医学领军人才培养工程项目, 2014/01--2016/12。

4) 主持武汉市创新人才开发资金资助计划项目, 2014.01-2015.12。

5) 主持中央高校基本科研业务费专项资金拔尖创新人才资助项目(No.2042014kf0204), 2014.1 -2015.12, 已结题。

6) 主持教育部科学技术研究重大项目(No. 313040), 2013.1-2015.12。

7) 主持国家自然科学基金面上项目(No. 81172935), 2012.1-2015.12, 已结题。

8) 主持国家自然科学基金重大研究计划培育项目(No. 91017005), 2011.1-2013.12, 已结题。

9) 主持武汉市高新技术产业科技创新团队计划项目(2013070204020048), 2013.1-2014.12，已结题。

10) 主持教育部新世纪优秀人才支持计划项目(No. NCET-10-0625), 2010.1-2012.12, 已结题。

11) 主持国家自然科学基金面上项目(No. 20872116), 2009.1-2011.12, 已结题。

12) 主持高等学校博士点基金 (No. 20100141110021), 2011-2013, 已结题。

13) 国家科技部重大新药创制专项“武汉综合性新药研究开发技术大平台”(No. 2009ZX09301-014-1, 参加者), 已结题。

14) 主持教育部留学回国人员科研启动基金(No.教外司留[2009]1001), 已结题。

已发表SCI论文60余篇，多篇论文发表在Nature Chemical Biology, Molecular Systems Biology, Chemistry Biology, J. Med. Chem., J. Org. Chem., Bioconjugate Chem., ChemMedChem, Adv. Synth. Catal., Bioorg. Med. Chem. Lett.等国际著名期刊上。其中以第一作者或通讯作者身份在药物化学顶尖期刊J. Med. Chem.上发表论文8篇1) Full Antagonism of the Estrogen Receptor without a Prototypical Ligand Side Chain. Sathish Srinivasan, Jerome C. Nwachukwu, Nelson E. Bruno, Venkatasubramanian Dharmarajan, Devrishi Goswami, Irida Kastrati, Scott Novick, Jason Nowak, Valerie Cavett, Hai-Bing Zhou, Nittaya Boonmuen, Yuechao Zhao, Jian Min,Jonna Frasor, Be, nita S. Katzenellenbogen, Patrick R. Griffin, John A. Katzenellenbogen, Kendall W. Nettles*. Nature Chemical Biology 2016, AOP, doi:10.1038/nchembio.2236. (IF: 12.709)

2) Gossypol with Hydrophobic Linear Esters Exhibits Enhanced Anti-Tumor Activity as an Inhibitor of Antiapoptotic Proteins. Yuzhi Lu, Shuangchan Wu, Yuan Yue, Si He, Jun Li, Jun Tang, Wei Wang,* and Hai-Bing Zhou*. ACS Med. Chem. Lett., 2016, Article ASAP. (IF: 3.355)

3) Identification and Structure–Activity Relationships of Diarylhydrazides as Novel Potent and Selective Human Enterovirus Inhibitors. Xin Han, Ningyuan Sun, Haoming Wu, Deyin Guo, Po Tien, Chune Dong, Shuwen Wu*, and Hai-Bing Zhou*. J. Med. Chem. 2016, 59 (5), 2139-2150. (IF: 5.589) (Highlighted by BioCentury Innovations (Formerly SciBX, Science-Business eXchange) on March 3, 2016)

4) Predictive Features of Ligand-Specific Signaling through the Estrogen Receptor. Jerome C. Nwachukwu, Sathish Srinivasan, Yangfan Zheng, Song Wang, Jian Min, Chune Dong, Zongquan Liao, Jason Nowak, Nicholas J. Wright, René Houtman, Kathryn E. Carlson, Jatinder S. Josan, Olivier Elemento, John A. Katzenellenbogen*, Hai-Bing Zhou*, Kendall W. Nettles*. Molecular Systems Biology 2016, 12, 864. (IF: 10.581)

5) Application of chiral squaramides:from asymmetric organocatalysis to biologically active compounds. Xin Han, Hai-Bing Zhou, Chune Dong*. Chemical Record 2016, 16 (2), 897-906. (IF: 3.459)

6) Synthesis and structure–activity relationships of novel hybrid ferrocenyl compounds based on a bicyclic core skeleton for breast cancer therapy. Changhao Li, Chu Tang, Zhiye Hu, Chenxi Zhao, Chenlu Li, Silong Zhang, Chune Dong, Hai-Bing Zhou*, Jian Huang*, Bioorg. Med. Chem. 2016, 24 (13), 3062-3074. (IF: 2.923)

7) Sarah Preston, Junjie Luo, Yuezhou Zhang, Abdul Jabbar, Simon Crawford, Jonathan Baell, Andreas Hofmann, Min Hu, Hai-Bing Zhou* and Robin B. Gasser*. Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus. Parasites & Vectors 2016, 9, 346. (IF: 3.234)

8) Novel Bioactive Hybrid Compounds Dual Targeting Estrogen Receptor and Histone Deacetylase for Treatment of Breast Cancer. Chu Tang, Changhao Li, Silong Zhang, Zhiye Hu, Jun Wu, Chune Dong*, Jian Huang*, and Hai-Bing Zhou*. J. Med. Chem. 2015, 58 (11), 4550-4572. (IF: 5.447)

9) Tunable Bifunctional Phosphine Squaramide Promoted Morita-Baylis-Hillman Reaction of N-alkyl Isatins with Acrylates. Ze Dong, Chao Yan, Yongzhi Gao, Chune Dong, Guofu Qiu*, Hai-Bing Zhou*. Adv. Synth. Catal. 2015, 357 (9), 2132–2142. (IF: 5.663).

10) Synthesis of N-benzyl-N-phenylthiophene-2-carboxamide Analogues as a Novel Class of Enterovirus 71 Inhibitors. Jiawei Pan, Xin Han, Ningyuan Sun, Haoming Wu, Dandan Lin, Po Tien, Hai-Bing Zhou* and Shuwen Wu*. RSC Advances 2015, 5 (31), 55100-55108. (IF: 3.840)

11) Recyclable BINOL-Quinine-Squaramide as Highly Efficient Organocatalyst for α-Amination of 1, 3-Dicarbonyl Compounds and α-Cyanoacetates. Yongzhi Gao, Bin Liu, Wei Wang, Hai-Bing Zhou and Chune Dong*. RSC Advances 2015, 5 (31), 24392-24396. (IF: 3.840)

12) Halolactones are Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors. X. Han, H. Wu, C. Dong, P. Tien, W. Xie, S. W. Wu*, H.-B. Zhou*. RSC Advances 2015, 5 (13), 10005-10013. (IF: 3.840)

13) Triaryl-substituted Schiff Bases are High-Affinity Subtype-Selective Ligands for the Estrogen Receptor. Zong-Quan Liao, Chune Dong, Kathryn E. Carlson, Sathish Srinivasan, Jerome C. Nwachukwu, Robert W. Chesnut, Abhishek Sharma, Kendall W. Nettles, John A. Katzenellenbogen,* and Hai-Bing Zhou*. J. Med. Chem. 2014, 57 (8), 3532-3545. (IF: 5.447)

14) C3-Symmetric Cinchonine-Squaramide-Catalyzed Asymmetric Chlorolactonization of Styrene-Type Carboxylic Acids with 1,3-Dichloro-5,5-dimethylhydantoin: An Efficient Method to Chiral Isochroman-1-ones. Xin Han, Chune Dong, and Hai-Bing Zhou*. Adv. Synth. Catal. 2014, 356 (6), 1275–1280. (IF: 5.663).

15) Synthesis and SARs of Indole-based α-Amino Acids as Potent HIV-1 Non-Nucleoside Reversed Transcriptase Inhibitors. Xin Han, Haoming Wu, Wei Wang, Chune Dong, Po Tien, Shuwen Wu*, Hai-Bing Zhou*. Org. Biomol. Chem., 2014, 12 (41), 8308 - 8317. (IF: 3.562)

16) One-pot to fused pyrazoles by a double cyclization of o-alkynylaldehydes with ketones and hydrazine under metal-free condition, Jinxia Qiao, Bin Liu, Zongquan Liao, Ying Li, Lei Ma, Chune Dong, and Hai-Bing Zhou*. Tetrahedron 2014, 70 (24), 3782-3787. (IF: 2.641)

17) Thiophene-Core Estrogen Receptor Ligands Having Superagonist Activity. Jian Min, Pengcheng Wang, Sathish Srinivasan, Jerome C. Nwachukwu, Pu Guo, Minjian Huang, Kathryn E. Carlson, John A. Katzenellenbogen*, Kendall W. Nettles, Hai-Bing Zhou*. J. Med. Chem., 2013, 56 (8), 3346–3366. (IF: 5.480)

18) Enantioselective inhibition of reverse transcriptase (RT) of HIV-1 by non-racemic indole-based trifluoropropanoates developed by asymmetric catalysis using recyclable organocatalysts. Xin Han, Wenjie Ouyang, Bin Liu, Wei Wang*, Po Tien, Shuwen Wu*, Hai-Bing Zhou*. Org. Biomol. Chem., 2013, 11 (48), 8463-8475. (IF: 3.487)

19) Highly enantioselective Michael addition of 1, 3-dicarbonyl compounds to nitroalkenes catalyzed by designer chiral BINOL-Quinine-Squaramide: Efficient access to optical active nitroalkanes and their isoxazole derivatives. Bin Liu, Xin Han, Ze Dong, Hao Lv, Hai-Bing Zhou, Chune Dong*. Tetrahedron Asymmetry 2013, 24 (20), 1276-1280. (IF: 2.165)

20) Design, Synthesis and Biological Evaluation of Novel Estrogen-derived Steroidal Metal Complexes. Xinlong Zhang, Ziqing Zuo, Juan Tang, Kai Wang, Caihua Wang, Weiyan Chen, Changhao Li, Wen Xu, Xiaolin Xiong, Kangxiang Yuntai, Jian Huang, Xiaoli Lan, Hai-Bing Zhou*. Bioorg. Med. Chem. Lett. 2013, 23 (13), 3793-3797. (IF: 2.331)

21) Modification of peptides and proteins via HMDO-mediated ligation in ionic liquids. Jianli Duan, Yao Sun, Hao Chen, Guofu Qiu, Haibing Zhou, Ting Tang, Zixin Deng, Xuechuan Hong*. J. Org. Chem. 2013, 78(14), 7013–7022. (IF: 4.638)

22) Identification and Structure-Activity Relationships of a Novel Series of Estrogen Receptor Ligands Based on 7-Thiabicyclo[2.2.1]hept-2-ene-7-oxide. Pengcheng Wang, Jian Min, Jerome C. Nwachukwu, Valerie Cavett, Kathryn E. Carlson, Pu Guo, Manghong Zhu, Yangfan Zheng, Chune Dong, John A. Katzenellenbogen*, Kendall W. Nettles, Hai-Bing Zhou*. J. Med. Chem. 2012, 55 (5), 2324-2341. (IF: 5.614)

23) An Expedient Approach to Highly Enantioenriched Cyclic Nitrones Mediated by Robust and Recoverable C3-Symmetric Cinchonine-Squaramide Catalysts. Xin Han, Xiangfei Wu, Chang Min, Hai-Bing Zhou, Chune Dong*. RSC Advances 2012, 2 (19), 7501-7505.

24) Synthesis, biological evaluation and structure activity relationships of new estrogen receptor ligands based on a bridged oxabicyclic core embellished with arylsulfonamides. Manghong Zhu, Chen Zhang, Jerome C. Nwachukwu, Sathish Srinivasan, Valerie Cavett, Yangfan Zheng, Kathryn E. Carlson, Chune Dong, John A. Katzenellenbogen*, Kendall W. Nettles, Hai-Bing Zhou*. Org. Biomol. Chem., 2012, 10 (43), 8692-8700. (IF: 3.568)

25) Discovery of novel SERMs with a ferrocenyl entity based on the oxabicyclo[2.2.1]heptene scaffold and evaluation of their antiproliferative effects in breast cancer cells. Yangfan Zheng, Caihua Wang, Changhao Li, Jinxia Qiao, Feng Zhang, Minjian Huang, Wenming Ren, Chune Dong, Jian Huang*, Hai-Bing Zhou*. Org. Biomol. Chem., 2012, 10 (48), 9689-9699. (IF: 3.568)

26) Development of Selective Estrogen Receptor Modulator (SERM)-Like Activity Through an Indirect Mechanism of Estrogen Receptor Antagonism: Defining the Binding Mode of 7-Oxabicyclo[2.2.1]hept-5-ene Scaffold Core Ligands. Yangfan Zheng, Manghong Zhu, Sathish Srinivasan, Jerome C. Nwachukwu, Valerie Cavett, Jian Min, Kathryn E. Carlson, Pengcheng Wang, Chune Dong, John A. Katzenellenbogen*, Kendall W. Nettles, Hai-Bing Zhou*. ChemMedChem 2012, 7 (6), 1094-1100. (IF: 2.835)

27) Enhanced efficiency of recyclable C3-symmetric cinchonine-squaramides in the asymmetric Friedel–Crafts reaction of indoles with alkyl trifluoropyruvate. Xin Han, Bin Liu, Hai-Bing Zhou, Chune Dong*. Tetrahedron Asymmetry 2012, 23 (18-19), 1332-1337. (IF: 2.115)

28) Chiral Squaramide as Multiple H-Bonds Donor Organocatalyst for Asymmetric Michael addition of 1, 3-Dicarbonyl Compounds to Nitroolefins. Ze Dong, Guofu Qiu, Hai-Bing Zhou, Chune Dong*. Tetrahedron Asymmetry 2012, 23 (22-23), 1550-1556. (IF: 2.115)

29) A simple and straightforward approach toward selective C=C bond reduction by hydrazine. Hao Chen, Jianmin Wang, Xuechuan Hong, Hai-Bing Zhou, Chune Dong*. Can. J. Chem. 2012, 90 (9), 758-761. (IF: 0.964).

30) C3-Symmetric Cinchonine-Squaramide as New Highly Efficient, and Recyclable Organocatalyst for Enantioselective Michael Addition. Chang Min, Xin Han, Zongquan Liao, Xiangfei Wu, Hai-Bing Zhou, Chune Dong*. Adv. Synth. Catal. 2011, 353 (14-15), 2715–2720. (IF: 6.048).

31) Metal-free Direct Amidation of Peptidyl Thiol Esters with α-Amino Esters. Hao Chen, Maomao He, Yaya Wang, Linhui Zhai, Yongbo Cui, Yangyan Li, Yan Li, Haibing Zhou*, Xuechuan Hong* and Zixin Deng. Green. Chem. 2011, 13, 2723-2726. (IF: 6.320)

32) A Novel C3-Symmetric Prolinol-Squaramide Catalyst for the Asymmetric Reduction of Ketones by Borane. Xiang-Fei Wu, Chang Min, Hai-Bing Zhou, Chune Dong*. Tetrahedron Asymmetry 2011, 22 (16-17), 1640–1643. (IF: 2.652)

33) Highly diastereoselective synthesis of quaternary α-trifluoromethyl α-amino acids from chiral imines of trifluoropyruvate, Qiao-Qiao Min, Chun-Yang He, Haibing Zhou and Xingang Zhang, Chem. Comm. 2010, 46, 8029-8031. (IF: 5.787)

34) Imaging progesterone receptor in breast tumors: Synthesis and receptor binding affinity of fluoroalkyl-substituted analogs of Tanaproget. Hai-Bing Zhou, Jae Hak Lee, Christopher G. Mayne, Kathryn E. Carlson, John A. Katzenellenbogen*, J. Med. Chem. 2010, 53 (8), 3349–3360. (IF: 5.207)

35) Development of [F-18]Fluorine-Substituted Tanaproget as a Progesterone Receptor Imaging Agent for Positron Emission Tomography. Jae Hak Lee, Hai-Bing Zhou, Carmen S. Dence, Kathryn E. Carlson, Michael J. Welch, John A. Katzenellenbogen*, Bioconjugate Chem. 2010, 21 (6), 1096-1104. (IF: 5.002)

36) Analogs of methyl-piperidinopyrazole (MPP): Antiestrogens with estrogen receptorselective activity. Hai-Bing Zhou, Kathryn E. Carlson, Fabio Stossi, Benita S. Katzenellenbogen, John A. Katzenellenbogen*. Bioorg. Med. Chem. Lett. 2009, 19 (1), 108-110. (IF: 2.650)

37) Bromination from the Macroscopic Level to the Tracer Radiochemical Level: 76Br Radiolabeling of Aromatic Compounds via Electrophilic Substitution. Dong Zhou, Haibing Zhou, Carl C. Jenks, Jason S. Lewis, John A. Katzenellenbogen, and Michael J. Welch*. Bioconjugate Chem. 2009, 20 (4) 808-816. (IF: 4.350)

38) Fluorine-18 labeling and biodistribution studies on peroxisome proliferator-activated receptor-γ ligands: potential positron emission tomography imaging agents. Byung Chul Lee, Carmen S. Dence, Haibing Zhou, Ephraim E. Parent, Michael J. Welch, John A. Katzenellenbogen*. Nucl. Med. Biol. 2009, 36 (2) 147-153. (IF: 2.456)

39) NFkB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses. K. W. Nettles*, J. B. Bruning, G. Gil, J. Nowak, S. K. Sharma, J. B. Hahm, K. Kulp, R. B. Hochberg, H. B. Zhou, J. A. Katzenellenbogen, B. S. Katzenellenbogen, Y. Kim, A. Joachmiak, G. G. Greene, Nature Chemical Biology 2008, 4 (4), 241-247. (IF: 14.612)

40) Elemental Isomerism: A Boron-Nitrogen Surrogate for a Carbon-Carbon Double Bond Increases the Chemical Diversity of Estrogen Receptor Ligands. Hai-Bing Zhou, Kendall W. Nettles, John B. Bruning, Younchang Kim, Andrzej Joachimiak, Sanjay Sharma, Kathryn E. Carlson, Fabio Stossi, Benita S. Katzenellenbogen, Geoffrey L. Greene and John A. Katzenellenbogen*, Chemistry & Biology 2007, 14 (6), 659-669. (IF: 5.718)

41) Bicyclo[2.2.2]octanes: Close Structural Mimics of the Nuclear Receptor-binding Motif of Steroid Receptor Coactivators. Hai-Bing Zhou, Margaret L. Collins, Jillian R. Gunther, John S. Comninos and John A. Katzenellenbogen*, Bioorg. Med. Chem. Lett. 2007, 17 (15), 4118-4122. (IF: 2.604)

42) Structure-Guided Optimization of Estrogen Receptor Binding Affinity and Antagonist Potency of Pyrazolopyrimidines with Basic Side Chain. Hai-Bing Zhou, Shubin Sheng, Dennis R. Compton, Younchang Kim, Andrzej Joachimiak, Sanjay Sharma, Kathryn E. Carlson, B. S. Katzenellenbogen, Kendall W. Nettles, Geoffrey L. Greene and John A. Katzenellenbogen*, J. Med. Chem. 2007, 50 (2), 399-403. (IF: 4.895)

43) Synthesis and Evaluation of Estrogen Receptor Ligands with Bridged Oxabicyclic Cores Containing a Diarylethylene Motif: Estrogen Antagonists of Unusual Structure. Hai-Bing Zhou, John S. Comninos, Fabio Stossi, Benita S. Katzenellenbogen, and John A. Katzenellenbogen*, J. Med. Chem. 2005, 48 (23), 7261-7274.

) 周海兵，陈浩，王健民，董春娥，一种水合肼微波还原碳碳双键的方法。申请日期，2010-10-25。授权日期，2013-04-03，中国专利号，ZL 201010518663.4。

2) 洪学传，邓子新，周海兵，陈浩等，一种酰胺类化合物的合成方法。申请日期，2011.1.13。授权日期，2013-04-24，中国专利号，ZL 201110006690.8。

3) 吴叔文，周海兵，田波，董春娥，欧阳文杰，韩欣，一种吲哚类化合物及其作为HIV-1逆转录酶抑制剂的应用。申请日期，2013.3.11。授权日期，2015-04-7，中国专利号，201310076738.1。

4) 董春娥，刘斌，乔金霞，周海兵，一种制备吡唑异吲哚类化合物的方法。申请日期，2013.6.9. 授权日期，2015-05-6，中国专利号，201310228096.2.

5) 周海兵，吴叔文，田波，舒红兵，韩欣，吴浩明，一种苯并内酯类化合物及其在制备抗艾滋病药物中的应用。申请日期，2014.5.23。申请号：201410220019.7。授权日期，2016.2.15。中国专利号：ZL201410220019.7。

6) 周海兵，吴叔文，田波，董春娥，欧阳文杰，韩欣，一种吲哚-α-氨基酸类化合物及其在制备抗艾滋病药物中的应用。申请日期，2014.5.22。申请号：201410218599.6。授权日期，2016.1.27。中国专利号：ZL 201410218599.6。

7) 周海兵，黄健，唐初，李长浩，董春娥，张思龙，一种氧桥双环-[2.2.1]-庚烯类化合物及其用途。申请日期，2014.9.25。申请号：201410493223.6。授权日期，2016-04-6，中国专利号，201410493223.6。

8) 王巍，吴叔文，何思，黄靖，周海兵，舒红兵，田波，作为甲型流感病毒抑制剂的甲酰胺和异腈类化合物及其制备与应用。申请日期，2014.04.14。授权日期，2014-07-16，中国专利号，ZL201410147716.4。

9) 周海兵，吴叔文，韩欣，田波，舒红兵，吴浩明，一种酰肼类化合物及其在制备抗手足口病药物中的应用。申请日期，2015.4.24。申请号：201510196726.1。授权日期，2016-07-20，中国专利号，ZL201510196726.1。