1996.9 – 2002.6 华中农业大学生物技术基地班，本硕连读
2003.9 – 2007.6 中科院微生物研究所，博士

2007.7 – 2009.6 上海交通大学生命科学技术学院生物工程系，讲师 2007.3 – 2009.6 上海有机化学研究所，合作研究 2009.7 – 2010.6 华中农业大学生命科学技术学院，讲师 2012.8 – 2013.8 美国Washington University in Saint Louis, 访问学者 2010.7 至今 武汉大学药学院，副教授、教授、博导 2018.1 – 2018.12 英国牛津大学，高级访问学者

2010年度武汉市青年科技晨光计划，6万
2010年度教育部新教师基金，3万

2011年国家自然科学基金青年项目，25万

2011年973子课题，26万

2014年973子课题，28.8万
2015年国家自然科学基金面上项目，78万

2017年武汉大学自主科研-拔尖创新人才，15万

2018年国家自然科学基金中英合作交流项目，10万

2018年国家自然科学基金面上项目，65万

1. Ding W., Ji W., Wu Y., Wu R., Liu W., Ma X., Zhang W., Xu P., Deng Z., Tang B., Yu Y.*, Zhang Q*. Biosynthesis of the nosiheptide indole side ring centers on a cryptic carrier protein NosJ. Nature Communications, 2017, 8(1):437. DOI: 10.1038/s41467-017-00439-1

2. Yu Y., Zhang Q., Deng Z., Parallel pathways in the biosynthesis of aminoglycoside antibiotics. F1000Res. 2017, doi: 10.12688/ f1000research.11104.1

3. Su Li, Zhang R, Kyeremeh K, Deng Z, Deng H* and Yu Y*. Dissection of the neocarazostatin A C4 alkyl side chain biosynthesis by in vitro reconstitution. Organic & Biomolecular Chemistry, 2017, 15(18): 3843-3848

4. Ding W, Li Y, Zhao J, Ji X, Mo T, Qianzhu H, Tu T, Deng Z, Yu Y, Chen F, Zhang Q*. The Catalytic Mechanism of the Class C Radical S-Adenosylmethionine Methyltransferase NosN. Angew Chem Int Ed Engl., 2017, 56(14):3857-3861

5. Ding W, Wu Y, Ji X, Qianzhu H, Chen F, Deng Z, Yu Y, Zhang Q*. Nucleoside-linked shunt products in the reaction catalyzed by the class C radical S-adenosylmethionine methyltransferase NosN. Chem Commun (Camb)., 2017, 53(37):5235-5238

6. Su Li, Lv Meinan, Kyeremeh Kwaku, Deng Zixin, Deng Hai and Yu Yi *. A ThDP-dependent enzymatic carboligation reaction involved in Neocarazostatin A tricyclic carbazole formation. Organic & Biomolecular Chemistry, 2016, 14(37): 8679-8684

7. Lv M, Ji X, Zhao J, Li Y, Zhang C, Su L, Ding W, Deng Z, Yu Yi* and Zhang Q*. Characterization of a C3 Deoxygenation Pathway Reveals a Key Branch Point in Aminoglycoside Biosynthesis. J AM CHEM SOC, 2016, 138(20):6427-35

8. Huang S., Elsayed S., Lv M., Tabudravu J., Rateb M., Gyampoh R., Kyeremyh K., Ebel R., Jaspars M., Deng Z., Yu Yi* and Deng H.* Biosynthesis of neocarazostatin A reveals the sequential carbazole prenylation and hydroxylation in the tailoring steps. Chemistry & Biology, 2015, 22(12):1633-42

9. Lv Meinan, Zhao Junfeng, Deng Zixin and Yu Yi*. Characterization of the biosynthetic gene cluster for benzoxazole antibiotics A33853 reveals unusual assembly logic. Chemistry & Biology, 2015, 22(10):1313-1324.

10. Huang S, Tabudravu J, Elsayed SS, Travert J, Peace D, Tong MH, Kyeremeh K, Kelly SM, Trembleau L, Ebel R, Jaspars M, Yu Yi* and Deng H*. Discovery of a Single Monooxygenase that Catalyzes Carbamate Formation and Ring Contraction in the Biosynthesis of the Legonmycins. Angew Chem Int Ed Engl. 2015, 54(43):12697-12701

11. Huang S, Tong MH, Qin Z, Deng Z, Deng H, Yu Y.*. Identification and characterization of the biosynthetic gene cluster of thiolutin, a tumor angiogenesis inhibitor, in Saccharothrix algeriensis NRRL B-24137. Anticancer Agents Med Chem, 2015, 15(3):277-84.

12. Liu G, Zhang M, Mo T, He L, Zhang W, Yu Y*, Zhang Q*, Ding W*. Metabolic flux analysis of the halophilic archaeon Haladaptatus paucihalophilus. Biochem Biophys Res Commun., 2015, 467(4):1058-62

13. Long Ma, Axel Bartholome, Ming Him Tong, Zhiwei Qin, Yi Yu, Thomas Shepherd, Kwaku Kyeremeh, Hai Deng* and David O'Hagan*. Identification of a fluorometabolite from Streptomyces sp. MA37: (2R3S4S)-5-fluoro-2,3,4-tri-hydroxypentanoic acid. Chemical Science, 2015, 6(2):1414-1419

14. Hao C.L., Huang S., Deng Z.X., Zhao C.M., Yu Y.* Mining of the pyrrolamide antibiotics analogs in Streptomyces netropsis reveals the amidohydrolase-dependent "iterative strategy" underlying the pyrrole polymerization. PLOS ONE, 2014, 9(6):e99077.

15. Qin Zhiwei, Wang Xiaoling, Rateb Mostafa, Ass'ad Lina, Jaspars Marcel, Deng Zixin, Yu Yi, Deng Hai*. Disruption of a Methyltransferase Gene in Actinomycin G Gene Cluster in Streptomyces iakyrus Increases the Production of Phenazinomycin. FEMS Microbiology Letters, 2014, 352(1): 62-8

16. Sheng Huang, Long Ma, Ming Him Tong, Yi Yu*, David O'Hagan and Hai Deng* Fluoroacetate biosynthesis from the marine-derived bacterium Streptomyces xinghaiensis NRRL B-24674. Org Biomol Chem, 2014, 12(27): 4828-4831

17. Varman, A.M. #, Yu, Y. #, You L., Tang, Y.J. Photoautotrophic production of D-lactate in an engineered cyanobacterium. Microbial Cell Factories, 2013, 12: 117 (#Contributed equally)

18. Qin, Z., Huang, S., Yu, Y.*, Deng, H*. Dithiolopyrrolone natural products: isolation, synthesis and biosynthesis. Marine Drugs, 2013, 11(10):3970-97

19. Yu, Y., You, L., Liu, D.Y., Hollinshead, W., Tang, Y.J., Zhang, F.Z. Development of Synechocystis sp. PCC 6803 as a Phototrophic Cell Factory. Marine Drugs, 2013, 11(8):2894-916

20. Wang, X., Tabudravu, J., Rateb, M.E., Annand, K.J., Qin, Z., Jaspars, M., Deng, Z., Yu, Y.*, Deng, H*. Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus. Molecular Biosystems, 2013, 9(6):1286-9

21. Wu XM, Yu Y., Han LB, Li CL, Wang HY, Zhong NQ, Yao Y, Xia GX*.The tobacco BLADE-ON-PETIOLE2 gene mediates differentiation of the corolla abscission zone by controlling longitudinal cell expansion. Plant Physiology, 2012, 159(2):835-50

22. Zhang, Q.; Yu, Y.*, Thioether Crosslinkages Created by a Radical SAM Enzyme. ChemBioChem, 2012, 13(8), 1097-1099

23. Huang, S.; Zhao, Y.D.; Qin, Z.W.; Wang, X.L.; Onega, M.; Chen, L.; He, J.; Yu, Y.*; Deng, H.*, Identification and heterologous expression of the biosynthetic gene cluster for holomycin produced by Streptomyces clavuligerus. Process Biochemistry, 2011, 46, 811-16

24. Zhang, Q.; Li, Y.X.; Chen, D.D.; Yu, Y.; Duan, L.; Shen, B.; Liu, W. Radical-mediated enzymatic carbon chain fragmentation-recombination. Nature Chemical Biology, 2011, 7, 154-60

25. Yu, Y.; Guo, H.; Zhang, Q.; Duan, L.; Ding, Y.; Liao, R.J.; Lei, C.; Shen, B.; Liu, W. NosA Catalyzing Carboxyl-Terminal Amide Formation in Nosiheptide Maturation via an Enamine Dealkylation on the Serine-Extended Precursor Peptide. J AM CHEM SOC, 2010, 132(46), 16324-26.

26. Wang, J.; Yu, Y.; Tang, K.; Liu, W.; He, X.; Huang, X.; Deng, Z. Thiopeptide antibiotic cyclothiazomycin: Identification and Analysis of its biosynthetic gene cluster in Streptomyces hygroscopicus 10-22. (2010) Appl Environ Microb, 76(7), 2335-44.

27. Ding, Y.; Yu, Y.; Pan, H.; Guo, H.; Li, Y.; Liu, W. Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099. (2010) Molecular Biosystems, 6(7), 1180-85.

28. Yu, Y.; Duan, L.; Zhang, Q.; Liao, R. J.; Ding, Y.; Pan, H. X.; Wendt-Pienkowski, E.; Tang, G. L.; Shen, B.; Liu, W., Nosiheptide Biosynthesis Featuring a Unique Indole Side Ring Formation on the Characteristic Thiopeptide Framework. (2009) ACS Chem Biol, 4(10), 855-64.

29. Liao, R. J.; Duan, L.; Lei, C.; Pan, H. X.; Ding, Y.; Zhang, Q.; Chen, D. J.; Shen, B.; Yu, Y.*; Liu, W.* Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications. (2009) Chemisty & Biology, 16 (2), 141-47.

30. Liu, W.; Yu, Y. Combinatorial Biosynthesis of Pharmaceutical Natural Products. Biocatalysis for the Pharmaceutical Industry: Discovery, Development, and Manufacturing (Chapter 11) Wiley Press, ISBN: 978-0-470-82314-9, Oct. 2008, 229-246

31. Yu, Y.; Wang, H.Y.; Liu, L.N.; Chen, Z.L.; Xia, G.X. Functional identification of cytokinesis-related genes from tobacco BY-2 cells. (2007) Plant Cell Rep, 26(7), 889-94

32. Chen, Z.L.#; Yu, Y.#; Liu, L.N.; Xia, G.X. Isolation, characterization and functional analysis of a cdc48 homologue from tobacco BY-2 cells. (2007) Progress in Nature Science 17, 156-62. (#Contributed equally)

33. Yu, Y.; Bai, L. Q.; Minagawa, K.; Jian, X. H.; Li, L.; Li, J. L.; Chen, S. Y.; Cao, E. H.; Mahmud, T.; Floss, H. G.; Zhou, X. F.; Deng, Z. X., Gene cluster responsible for validamycin biosynthesis in Streptomyces hygroscopicus subsp jinggangensis 5008. (2005) Appl Environ Microb, 71 (9), 5066-76.

34. Wang, H.Y. #; Yu, Y. #, Chen, Z.L.; Xia, G.X. Functional characterization of Gossypium hirsutum profilin 1 gene (GhPFN1) in tobacco suspension cells. Characterization of in vivo functions of a cotton profilin gene. (2005) Planta 222, 594-603. (#Contributed equally)

35. 王岩；虞沂；赵群飞；孔毅；刘文，天然产物的生物合成和组合生物合成研究进展。国外医药（抗生素分册）2008，29（6），275-282

36. 张华；赵群飞；虞沂；陆大年；刘文，特异性克隆编码多肽合成酶还原结构域基因的PCR方法。中国抗生素杂志 2009，34（3），189-192

37. 吕美男；虞沂*，2-脱氧链霉胺类抗生素的生物合成研究进展。中国科技论文在线, 2014

38. 张玉；虞沂*，吡咯酰胺类化合物合成途径中醛基转移酶Pya26的功能研究。武汉大学学报（理学版），2016，62（1）：078-084

39. 黄胜；虞沂*，二硫吡咯酮类抗生素的生物合成研究与代谢工程应用。微生物学报（微生物药物创新专刊），2016，3

诺丝七肽的生物合成基因簇 (专利号：ZL 2009 1 0053427.7 授权公告日：2011年6月22日)

刘文；虞沂；段炼；雷春；丁莹；廖日晶