教育背景
2001~2006年于武汉大学生命科学学院生物化学及分子生物学专业硕博连读2006年毕业获博士学位。
工作经历
2006~2016年,武汉大学药学院,讲师;
2015~2016年,亚利桑那州立大学,访问学者;
2016年~,武汉大学药学院,副教授。
项目课题经历
主持课题情况:
1.2008年,武汉大学专业学位研究生课程教学案例课题,已结题。
2.2009年11月~2011年10月,中央高校基本科研业务费专项资金青年教师资助项目,3082034,HIV蛋白酶抑制剂药物经非血脂算途径引发动脉硬化的机理研究,5万元,已结题。
3.2016年1月~2018年12月,青年科学基金项目: 81502311,新型雌激素调节剂抑制乳腺癌转移的机制研究,18万元,已结题。
1.国家自然科学基金面上项目,21375101,基于雌激素受体及芳香化酶靶向识别分析新方法及其在抗乳腺癌药物分析中应用,2014/01-2017/12,80万元,已结题。
2.国家自然科学基金面上项目,31170328,苦参碱逆转ABCG2介导白血病细胞多药耐药的机制研究,2012/01-2015/12,68万元,已结题。
3.国家自然科学基金面上项目,31070317,半枝莲中逆转卵巢癌对顺铂耐药的黄酮类成分及其作用机制研究,2011/01-2013/12,30万元,已结题。
4.国家自然科学基金青年科学基金项目,20905059,基于植物病毒的肿瘤靶向纳米双光子荧光探针研究,2010/01-2012/12,19万元,已结题。
5.国家自然科学基金青年科学基金项目,30900122,苦参碱与VASP互作抑制胃癌细胞迁移的机制研究,2010/01-2012/12,23万元,已结题。
论文、成果、著作等
1. Jin Xiang, Xiang Liu, Jing Ren, Kun Chen, Hong-lu Wang, Yu-yang Miao & Miao-miao Qi. How does estrogen work on autophagy? Autophagy. 2019, 15, 197-211. (IF11.1, corresponding author)
2. Jin Xiang, Eugene Chun, Chang Liu, Liang Jing, Zina Al-Sahouri, Lan Zhu, Wei Liu. Successful strategies to determine high-resolution structures of GPCRs. Trends in Pharmacological Sciences. 2016, 37:1055-1069. (IF12.797)
3. Jin Xiang, Ying Wang, Ke Su, Min Liu, Peng-Chao Hu, Tian Ma, Jia-Xi Li, Lei Wei, Zhongliang Zheng, Fang Yang, Ritonavir binds to and downregulates estrogen receptors: Molecular mechanism of promoting early atherosclerosis. Experimental Cell Research. 2014, 327: 318-330.
4. Shucai Liang, Yanbin Liu, Jin Xiang, Meng Qin, Hui Yu, Guoping Yan. Fabrication of a new fluorescent polymeric nanoparticle containing naphthalimide and investigation on its interaction with bovine serum albumin. Colloids and Surfaces B: Biointerfaces. 2014, 116: 20-210.
5. Jing-wei Zhang, Ke Su, Wen-tao Shi, Ying Wang, Peng-chao Hu, Yang Wang, Lei Wei, Jin Xiang, Fang Yang, Matrine inhibits the adhesion and migration of BCG823 gastric cancer cells by affecting the structure and function of the vasodilator-stimulated phosphoprotein (VASP). Acta Pharmacologica Sinica. 2013, 34: 1084-1092. (co-corresponding author)
6. Tao Jia, Jin Xiang, Jing Wang, Peng Guo, and Junping Yu. Interactions of newly designed dicationic carbazole derivatives with double-stranded DNA: syntheses, binding studies and AFM imaging. Organic & Biomolecular Chemistry. 2013, 11: 5512-5520.
7. Fanghua Mei, Jin Xiang, Song Han, Yuan He, Yajing Lu, Jian Xu, Deyin Guo, Gengfu Xiao, Po Tien, Guihong Sun, Expression, purification, and secondary structure characterization of recombinant KCTD1. Biochemistry-moscow. 2012, 77: 941-945. (co-first author)
8. Shucai Liang, Hui Yu, Jin Xiang, Wang Yang, Xiaohui Chen, Yanbin Liu, Chen Gao, Guoping Yan. New naphthalimide modified polyethylenimine nanoparticles as fluorescent. Spectrochim Acta A. 2012, 97: 359-365.
9. Tao Huang, Jian Xu, Jin Xiang, Yajing Lu, Rui Chen, Liqin Huang, Gengfu Xiao, Guihong Sun, PrPC interacts with potassium channel tetramerization domain containing 1 (KCTD1) protein through the PrP51-136 region containing octapeptide repeats. Biochemical and Biophysical Research Communications. 2012, 417: 182-186.
10. Jin Xiang, Guihong Sun, Yongxin Mu, Hui Liu, Ying Liu, Fang Yang, Jian Xu, Hong Ding, Ritonavir stimulates foam cell formation by activating PKC. Chemico-Biological Interactions. 2011, 194: 127-133.
11. Ying Liu, Jin Xiang, Min Liu, Shi Wang, Robert J. Lee, and Hong Ding. Protective effects of glycyrrhizic acid by rectal treatment on a TNBS-induced rat colitis model. Journal of Pharmacy and Pharmacology. 2011, 63: 439-446.
12. Min Liu, Jin Xiang, Juan Zhou, and Hong Ding, A disposable amperometric sensor for rapid detection of serotonin in the blood and brain of the depressed mice based on Nafion membrane-coated colloidal gold screen-printed electrode. Journal of Electroanalytical Chemistry. 2010, 640, 1-7.
13. Jin Xiang, Changping Yu, Fang Yang, Ling Yang, Hong Ding, Conformation-activity studies on the interaction of berberine with acetylcholinesterase: Physical chemistry approach. Progress in Natural Science. 2009, 19: 1721-1725.
14. Jin Xiang, Jun-Bao Fan, Nan Chen, Jie Chen, and Yi Liang, Interaction of cellulase with sodium dodecyl sulfate at critical micelle concentration level. Colloids and Surfaces B-Biointerfaces. 2006, 49, 175-180.
专利、著作版权等
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