教育背景
1982年毕业于华中农业大学
工作经历
1982年至1987年在中国农业科学院原子能利用研究所任研究实习员;1987年至2005年供职于中国科学院武汉植物研究所,2001年至2005年任副所长、首席研究员和博士生导师;2006年至今任武汉大学药学院教授,2007年至2016年任副院长,2008年至2018年任中药与天然药物研究所所长。2001年至2017年,分别到新西兰皇家科学院(2001)、马来西亚国家医学研究所(2002)、法国国家健康与医学研究院(2003)、巴基斯坦卡拉奇大学H.E.J化学研究所(2005)、日本富山大学(2008)、英国剑桥大学(2009)、美国奥本大学(2009)、俄罗斯喀山大学(2010)和智利康塞普西翁大学(2017)作访问学者或合作交流。
项目课题经历
主持完成了国家重大专项、国家科技支撑计划、国家公益性行业专项、国家863计划等共30多个科研项目
论文、成果、著作等
1. Yuxin Chen, Ziping Zhou, Qigui Mo, Gao Zhou,Youwei Wang*. Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats. BioMed Research International 2018(22):1-14 DOI:10.1155/2018/1682743
2. Bingxin Ma, Xiaoshan Meng, Jing Tong, Lanlan Ge, Gao Zhou, Youwei Wang*. Protective effects of Coptis chinensis inflorescence extract and linarin against carbon tetrachloride-induced damage in HepG2 cells through the MAPK/Keap1-Nrf2 pathway. Food & Function 2018, 9: 2353-2361
3. Lanlan Ge, Ling Chen, Qigui Mo, Gao Zhou, Xiaoshan Meng, Youwei Wang*. Total phenylethanoid glycosides and magnoloside Ia from Magnolia officinalis var. biloba fruits inhibit ultraviolet B-induced phototoxicity and inflammation through MAPK/NF-κB signaling pathways. Rsc Advances 2018, 8(8): 4362-4371
4. Jing Tong, Qigui Mo, Bingxin Ma, Lanlan Ge, Gao Zhou and Youwei Wang*. The protective effects of Cichorium glandulosum seed and cynarin against cyclophosphamide and its metabolite acrolein-induced hepatotoxicity in vivo and in vitro. Food & Function 2017, 8: 209-219
5. Lanlan Ge, Wenhui Zhang, Gao Zhou, Bingxin Ma, Qigui Mo, Yuxin Chen, Youwei Wang*. Nine phenylethanoid glycosides from Magnolia officinalis var. biloba fruits and their protective effects against free radical-induced oxidative damage. Scientific Reports 2017, 7: 45342. pp1-12
6. Bingxin Ma, Jing Wang, Jing Tong, Gao Zhou, Yuxin Chen, Jingsheng He, Youwei Wang*. Protective effects of Chaenomeles thibetica extract against carbon tetrachloride-induced damage via the MAPK/Nrf2 pathway. Food & Function 2016, 7(3):1492-1500
7. Bingxin Ma, Jing Tong, Gao Zhou, Qigui Mo, Jingsheng He, Youwei Wang*. Coptis chinensis inflorescence ameliorates hyperglycaemia in 3T3-L1 preadipocyte and streptozotocin-induced diabetic mice. Journal of Functional Food 2016, 21:455-462
8. Jing Tong, Bingxin Ma, Lanlan Ge, Qigui Mo, Gao Zhou, Jingsheng He, Youwei Wang*. Dicaffeoylquinic acid-enriched fraction of Cichorium glandulosum seeds attenuates experimental type 1 diabetes via multi-pathway protection. Journal of Agricultural Food Chemistry 2015, 63(50): 10791-10802
9. Yuxin Chen, Jing Tong, Lanlan Ge, Bingxin Ma, Youwei Wang*. Ethyl acetate fraction of Terminalia bellirica fruit inhibits rat hepaticstellate cell proliferation and induces apoptosis. Industrial Crops and Products 2015, 76: 364-373
10. Bingxin Ma, Xiaoquan Ban, Bo Huang, Jingsheng He, Jun Tian, Hong Zeng, Yuxin Chen, Youwei Wang*. Interference and Mechanism of Dill Seed Essential Oil and Contribution of Carvone and Limonene in Preventing Sclerotinia Rot of Rapeseed. PLoS ONE 2015, 10(7), e0131733:1-15
11. Jing Tong, Xincheng Yao, Hong Zeng, Gao Zhou, Yuxin Chen, Bingxin Ma, Youwei Wang*. Hepatoprotective activity of flavonoids from Cichorium glandulosum seeds in vitro and in vivo carbon tetrachloride-induced hepatotoxicity. Journal of Ethnopharmacology 2015, 174: 355-363
12. Jun Tian, Xiaobin Zeng, Aijun Lv, Aihua Zhu, Xue Peng, Youwei Wang*. Perillaldehyde, a Potential Preservative Agent in Foods: Assessment of Antifungal Activity against Microbial Spoilage of Cherry Tomatoes. LWT - Food Science and Technology 2015, 60(1): 63-70
13. Jun Tian, Xiaobin Zeng, Zhaozhong Feng, Xiangmin Miao, Xue Peng, Youwei Wang*. Zanthoxylum molle Rehd. Essential Oil as a Potential Natural Preservative in Management of Aspergillus flavus. Industrial Crops and Products 2014, 60: 151-159
14. Bo Huang, Yuxin Chen, Bingxin Ma, Gao Zhou, Jing Tong, Jingsheng He, Youwei Wang*. Protective effect of Cichorium glandulosum seeds from ultraviolet B-induced damage in rat liver mitochondria. Food & Function 2014, 5: 869-875
15. Yuxin Chen, Hong Zeng, Jun Tian, Xiaoquan Ban, Bingxin Ma, Youwei Wang*. Dill (Anethum graveolens L.) seed essential oil induces Candida albicans apoptosis in a metacaspase-dependent manner. Fungal Biology 2014, 118(4): 394-401
16. Ying Diao, Chaozhu Yang, Mi Yan, Xingfei Zheng, Surong Jin, Youwei Wang*, Zhongli Hu*. De Novo Transcriptome and Small RNA Analyses of Two Amorphophallus Species. PLoS ONE 2014, 9(4), e95428. doi:10.1371/journal.pone.0095428
17. Jing Tong, Shilpa Buch, Honghong Yao, Chengxiang Wu, Hsin-I Tong, Youwei Wang*, Yuanan Lu*. Monocytes-Derived Macrophages Mediated Stable Expression of Human Brain-Derived Neurotrophic Factor, a Novel Therapeutic Strategy for NeuroAIDS. PLoS ONE 2014, 9(2), e82030. doi:10.1371/journal.pone.0082030
18. Jun Tian,Yuxin Chen, Bingxin Ma, Jingsheng He, Jing Tong, Youwei Wang*. Drosera peltata Smith var. lunata (Buch.-Ham.) C. B. Clarke as a feasible source of plumbagin: phytochemical analysis and antifungal activity assay. World Journal of Microbiology and Biotechnology 2014, 30:737-745
19. Jingsheng He, Jianwei Fan, shengbo Li, Bo Huang, Xiaoquan Ban, Youwei Wang*. Genetic variability of cultivated Chaenomeles speciosa (Sweet) Nakai based on AFLP analysis. Biochemical Systematics and Ecology 2014, 57: 445-450
20. Bingxin Ma, Ling Zhu, Xiaoyan Zang, Yuxin Chen, Dong Li, Youwei Wang*. Coptis chinensis inflorescence and its main alkaloids protect against ultraviolet-B-induced oxidative damage. Journal of Functional Foods 2013, 5(4): 1665-1672
21. Yuxin Chen, Hong Zeng, Jun Tian, Xiaoquan Ban, Bingxin Ma, Youwei Wang*. Antifungal mechanism of essential oil from Anethum graveolens seeds against Candida albicans. Journal of Medical Microbiology 2013, 62:1175-1183
22. Song Liu, Dong Li, Bo Huang, Yuxin Chen, Xiaocong Lu, Youwei Wang*. Inhibition of pancreatic lipase, α-glucosidase, α-amylase, and hypolipidemic effects of the total flavonoids from Nelumbo nucifera leaves. Journal of Ethnopharmacology 2013, 149: 263-269
23. Gao Zhou, Yuxin Chen, Song Liu, Xingcheng Yao, Youwei Wang*. In vitro and in vivo hepatoprotective and antioxidant activity of ethanolic extract from Meconopsis integrifolia (Maxim.) Franch. Journal of Ethnopharmacology 2013, 148: 664-670
24. Xincheng Yao, Ling Zhu, Yuxin Chen, Jun Tian, Youwei Wang*. In vivo and in vitro antioxidant activity and α-glucosidase, α-amylase inhibitory effects of flavonoids from Cichorium glandulosum seeds. Food Chemistry 2013, 139: 59-66
25. Bo Huang, Lin Zhu, Song Liu, Dong Li, Yuxin Chen, Bingxin Ma, Youwei Wang*. In vitro and in vivo evaluation of inhibition activity of lotus (Nelumbo nucifera Gaertn.) leaves against ultraviolet B-induced phototoxicity. Journal of Photochemistry and Photobiology B: Biology 2013, 121: 1-5
26. Ling Zhu, Bo Huang, Xiaoquan Ban, Jingsheng He, Yuxin Chen, Li Han, Youwei Wang*. Coptis chinensis inflorescence extract protection against ultraviolet-B-induced phototoxicity, and HPLC–MS analysis of its chemical composition. Food and Chemical Toxicology 2012, 50(7): 2584-2588
27. Jun Tian, Xiaoquan Ban, Hong Zeng, Jingsheng He, Yuxin Chen, Youwei Wang*. The mechanism of antifungal action of essential oil from dill (Anethum graveolens L.) on Aspergillus flavus. PLoS ONE 2012, 7(1): e30147. doi:10.1371/journal.pone.0030147
28. Jingsheng He, Bo Huang, Xiaoquan Ban, Jun Tian, Ling Zhu, Youwei Wang*. In vitro and in vivo antioxidant activity of the ethanolic extract from Meconopsis quintuplinervia. Journal of Ethnopharmacology 2012, 141(1): 104-110
29. Jun Tian, Bo Huang, Xiuli Luo, Hong Zeng, Xiaoquan Ban, Jingsheng He, Youwei Wang*. The control of Aspergillus flavus with Cinnamomum jensenianum Hand.-Mazz essential oil and its potential use as a food preservative. Food Chemistry 2012, 130: 520-527
30. Jun Tian, Xiaoquan Ban, Hong Zeng, Bo Huang, Jingsheng He, Youwei Wang*. In vitro and in vivo activity of essential oil from dill (Anethum graveolens L.) against fungal spoilage of cherry tomatoes. Food Control 2011, 22 : 1992-1999
31. Hong Zeng, Jun Tian, Yuechen Zheng, Xiaoquan Ban, Jingsi Zeng, Yehong Mao, Youwei Wang*. In vitro and in vivo activities of essential oil from the seed of Anethum graveolens L. against Candida spp. Evidence-Based Complementary and Alternative Medicine 2011(5):659704. DOI:10.1155/2011/ 659704
32. Xiaoquan Ban, Bo Huang, Jingsheng He, Yuxin Chen, Hong Zeng, Li Han, Youwei Wang*. In vitro and in vivo antioxidant properties of extracts from Coptis chinensis inflorescence. Plant Foods for Human Nutrition 2011, 66: 175-180
33. Yue Chen, Bo Huang, Jingsheng He, Li Han, Yichao Zhan, Youwei Wang*. In vitro and in vivo antioxidant effects of the ethanolic extract of Swertia chirayita. Journal of Ethnopharmacology 2011, 136: 309-315
34. Jun Tian, Xiaoquan Ban, Hong Zeng, Jingsheng He, Bo Huang, Youwei Wang*. Chemical composition and antifungal activity of essential oil from Cicuta virosa L. var.latisecta Celak. International Journal of Food Microbiology 2011, 145(2-3) : 464-470
35. Bo Huang, Jingsheng He, Xiaoquan Ban, Hong Zeng, Xincheng Yao and Youwei Wang*. Antioxidant activity of bovine and porcine meat treated with extracts from edible lotus (Nelumbo nucifera) rhizome knot and leaf. Meat Science 2011, 87(1): 46-53
36. Bo Huang, Haibin Ke, Jingsheng He, Xiaoquan Ban, Hong Zeng, Youwei Wang*. Extracts of Halenia elliptica exhibit antioxidant properties in vitro and in vivo. Food and Chemical Toxicology 2011, 49: 185–190
37. Bo Huang, Xiaoquan Ban, Jingsheng He, Hong Zeng, Peng Zhang, Youwei Wang*. Hepatoprotective and antioxidant effects of the methanolic extract from Halenia elliptica. Journal of Ethnopharmacology 2010, 131(2):276-281
38. Bo Huang, Xiaoquan Ban, Jingsheng He, Jing Tong, Jun Tian, Youwei Wang*. Comparative analysis of essential oil components and antioxidant activity of extracts of Nelumbo nucifera from various areas of China. Journal of Agricultural Food Chemistry 2010, 58:441-448
39. Bo Huang, Xiaoquan Ban, Jingsheng He, Jing Tong, Jun Tian, Youwei Wang*. Hepatoprotective and antioxidant activity of ethanolic extracts of edible lotus (Nelumbo nucifera Gaertn.) leaves. Food Chemistry 2010, 120: 873-878
40. Jingsheng He, Ling Chen, Ying Si, Bo Huang, Xiaoquan Ban, Youwei Wang*. Population structure and genetic diversity distribution in wild and cultivated populations of the traditional Chinese medicinal plant Magnolia officinalis subsp.biloba (Magnoliaceae). Genetica 2009, 135: 233-243
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