● 1988.9―1992.7 江西农业大学 攻读植物遗传育种专业学士学位

● 1997.9―2001.3 华中农业大学 攻读生物化学与分子生物学专业硕士学位

● 2001.3―2004.3 上海交通大学 攻读生物化学与分子生物学专业博士学位

● 1992.7―1998.9 江西农业大学 生物技术研究开发中心，研究实习员 ● 1998.9―2002.10 江西农业大学 生物技术研究开发中心，助理研究员 ● 2002.10―2006.11 江西农业大学 生物工程系，副教授 ● 2006.11―2009.11 江西农业大学 生物工程与技术学院，教授 ● 2005.1―2010.5 剑桥大学 生物化学系，Royal Society China Fellow、Senior Research Associate ● 2010.5―现在 武汉大学 药学院，教授、湖北省“楚天学者特聘教授计划”入选者

● 科技部国家重点研发计划项目（2020-2024）

● 国家自然科学基金重点国际（地区）合作研究项目（2020-2024）

● 国家自然科学基金面上项目（2013-2016，2015-2018，2018-2022）

● 微生物代谢国家重点实验室（上海交通大学）开放课题（2015-2017，2018-2020）

● 国家重点基础研究发展计划(973)子课题（2012-2016）

● 国家高技术研究发展计划(863计划)子课题（2012-2015）

● 武汉大学医学部协同创新项目（2013-2015）

● 教育部海外名师项目（2012-2017）

● 教育部高等学校博士点专项科研基金(博导类)（2012-2014）

● 湖北省研究与开发计划项目（2012-2014）

● 国家“重大新药创制”科技重大专项子课题（2011-2013）

● 武汉大学自主科研项目（2011-2013）

在国内外学术期刊，如Nature Chemical Biology、Proceedings of the National Academy of Sciences of the United States of America、Angewandte Chemie International Edition等发表研究论文五十余篇● Rory Little, Fernanda C. R. Paiva, Robert Jenkins, Hui Hong, Yuhui Sun, Yuliya Demydchuk, Markiyan Samborskyy, Manuela Tosin, Finian J. Leeper, Marcio V. B. Dias and Peter F. Leadlay* (2019) Unexpected enzyme-catalysed [4+2] cycloaddition and rearrangement in polyether antibiotic biosynthesis. Nature Catalysis 2:1045-1054.

● Weixin Tao*, Li Chen, Chunhua Zhao, Jing Wu, Dazhong Yan, Zixin Deng and Yuhui Sun* (2019) In vitro packaging mediated one-step targeted cloning of natural product pathway. ACS Synthetic Biology 8:1991-1997.

● Jingjing Zhou, Chengbin Qiu, Ni Pi, Sicong Li, Xiyao Cheng, Lei Zhang, Yao Chen, Yongqi Huang*, Yuhui Sun* and Zhengding Su* (2018) A protein biosynthesis machinery strategy for identifying P53PTC-rescuing compounds as synergic anti-tumor drugs. ChemistrySelect 3: 11048-11053.

● Weixin Tao, Anna Yang, Zixin Deng and Yuhui Sun* (2018) CRISPR/Cas9-based editing of streptomyces for discovery, characterization, and production of natural products. Frontiers in Microbiology 9:1660.

● Sicong Li#, Jun Zhang#, Yuanzhen Liu, Guo Sun, Zixin Deng and Yuhui Sun* (2018) Direct evidence and enzymatic evidence for oxidative cyclization in hygromycin B biosynthesis. ACS Chemical Biology 13:2203-2210.

● Yuan Li#, Wan Zhang#, Hui Zhang, Wenya Tian, Lian Wu, Shuwen Wang, Mengmeng Zheng, Jinru Zhang, Chenghai Sun, Zixin Deng, Yuhui Sun, Xudong Qu* and Jiahai Zhou* (2018) Structural basis of a broadly selective acyltransferase from the polyketide synthase of splenocin. Angewandte Chemie International Edition 57:5823-5827.

● Sicong Li#, Junhong Guo#, Anna Reva, Fanglu Huang, Binbin Xiong, Yuanzhen Liu, Zixin Deng, Peter F. Leadlay* and Yuhui Sun* (2018) Methyltransferases of gentamicin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America 115:1340-1345.

● Yuanzhen Liu, Xu Chen, Zhengyuan Li, Wei Xu, Weixin Tao, Jie Wu, Jian Yang, Zixin Deng and Yuhui Sun* (2017) Functional analysis of cytochrome P450s involved in streptovaricin biosynthesis and generation of anti-MRSA analogues. ACS Chemical Biology 12:2589-2597.

● Priscila dos Santos Bury, Fanglu Huang, Sicong Li, Yuhui Sun, Peter F. Leadlay and Marcio Vinicius Bertacine Dias* (2017) Structural basis of the selectivity of GenN, an aminoglycoside N-methyltransferase involved in gentamicin biosynthesis. ACS Chemical Biology 12:2779-2787.

● Wei Xu#, Guifa Zhai#, Yuanzhen Liu, Yuan Li, Yanrong Shi, Kui Hong, Hui Hong, Peter F. Leadlay, Zixin Deng and Yuhui Sun* (2017) An iterative module in the azalomycin F polyketide synthase contains a switchable enoylreductase domain. Angewandte Chemie International Edition 56:5503-5506.

● Marie E. Yurkovich, Robert Jenkins, Yuhui Sun, Manuela Tosin* and Peter F. Leadlay* (2017) The polyketide backbone of thiolactomycin is assembled by an unusual iterative polyketide synthase. Chemical Communications 53:2182-2185.

● Judith Havemann, Marie E. Yurkovich, Robert Jenkins, Sophia Harringer, Weixin Tao, Shishi Wen, Yuhui Sun, Peter F. Leadlay and Manuela Tosin* (2017) Chemical probing of thiotetronate bio-assembly. Chemical Communications 53:1912-1915.

● Hui Hong, Yuhui Sun, Yongjun Zhou, Emily Stephens, Markiyan Samborskyy and Peter F. Leadlay* (2016) Evidence for an iterative module in chain elongation on the azalomycin polyketide synthase. Beilstein Journal of Organic Chemistry 12:2164-2172.

● Jianzhao Qi, Dan Wan, Hongmin Ma, Yuanzhen Liu, Rong Gong, Xudong Qu, Yuhui Sun, Zixin Deng and Wenqing Chen* (2016) Deciphering carbamoylpolyoxamic acid biosynthesis reveals unusual acetylation cycle associated with tandem reduction and sequential hydroxylation. Cell Chemical Biology 23:935-944.

● Yujie Geng, Zixin Deng and Yuhui Sun* (2016) An insight into the protospacer adjacent motif of Streptococcus pyogenes Cas9 with artificially stimulated RNA-guided-Cas9 DNA cleavage flexibility. RSC Advances 6:33514-33522.

● Weixin Tao#, Marie E. Yurkovich#, Shishi Wen#, Karen E. Lebe, Markiyan Samborskyy, Yuanzhen Liu, Anna Yang, Yunkun Liu, Yingchen Ju, Zixin Deng, Manuela Tosin, Yuhui Sun* and Peter F. Leadlay* (2016) A genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis. Chemical Science 7:376-385.

● Yunkun Liu#, Weixin Tao#, Shishi Wen, Zhengyuan Li, Anna Yang, Zixin Deng and Yuhui Sun* (2015) In vitro CRISPR/Cas9 system for efficient targeted DNA editing. mBio 6:e 01714-15.

● Hu Zeng, Shishi Wen, Wei Xu, Zhaoren He, Guifa Zhai, Yunkun Liu, Zixin Deng and Yuhui Sun* (2015) Highly efficient editing of the actinorhodin polyketide chain length factor gene in Streptomyces coelicolor M145 using CRISPR/Cas9-CodA(sm) combined system. Applied Microbiology and Biotechnology 99:10575-10585.

● Chuan Huang#, Fanglu Huang#, Eileen Moison, Junhong Guo, Xinyun Jian, Xiaobo Duan, Zixin Deng, Peter F. Leadlay* and Yuhui Sun* (2015) Delineating the biosynthesis of gentamicin X2, the common precursor of the gentamicin C antibiotic complex. Chemistry & Biology 22:251-261.

● Junhong Guo#, Fanglu Huang#, Chuan Huang, Xiaobo Duan, Xinyun Jian, Finian Leeper, Zixin Deng, Peter F. Leadlay* and Yuhui Sun* (2014) Specificity and promiscuity at the branch point in gentamicin biosynthesis. Chemistry & Biology 21:608-618.

● Yuhui Sun* (2014) A carbonate architect emerges. Nature Chemical Biology 10:486-487. (Invited Comments)

● Yanling Ma, Wei Xu, Jun Zhang, Sihong Zhang, Kui Hong, Zixin Deng and Yuhui Sun* (2014) Nitrilase superfamily aryl acylamidase from the halotolerant mangrove Streptomyces sp. 211726. Applied Microbiology and Biotechnology 98:8583-8590.

● Weixin Tao#, Manghong Zhu#, Zixin Deng and Yuhui Sun* (2013) Biosynthesis of tetronate antibiotics: A growing family of natural products with broad biological activities. Science China Chemistry 56:1364-1371. (Invited Review)

● Chompoonik Kanchanabanca#, Weixin Tao#, Hui Hong, Yajing Liu, Frank Hahn, Markiyan Samborskyy, Zixin Deng, Yuhui Sun* and Peter F. Leadlay* (2013) Unusual acetylation-elimination in the formation of tetronate antibiotics. Angewandte Chemie International Edition 52:5785-5788.

● Marie E. Yurkovich, Petros A. Tyrakis, Hui Hong, Yuhui Sun, Markiyan Samborskyy, Kohei Kamiya and Peter F. Leadlay* (2012) A late-stage intermediate in salinomycin biosynthesis is revealed by specific mutation in the biosynthetic gene cluster. ChemBioChem 13:66-71.

● Jeroen S. Dickschat, Olivia Vergnolle, Hui Hong, Stephen Garner, Susanna R. Bidgood, Hannah C. Dooley, Zixin Deng, Peter F. Leadlay* and Yuhui Sun* (2011) An additional dehydratase-like activity is required for lankacidin antibiotic biosynthesis. ChemBioChem 12:2408-2412.

注：本论文被 “Nature Chemical Biology, 2011,7(12):856”作为“研究亮点（Research Highlights）”推荐。

● Yunlong He, Yuhui Sun, Tiangang Liu, Xiufen Zhou, Linquan Bai* and Zixin Deng (2010) Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplification. Applied and Environmental Microbiology 76:3283-3292.

● Yuhui Sun*, Frank Hahn, Yuliya Demydchuk, James Chettle, Manuela Tosin, Hiroyuki Osada and Peter F. Leadlay* (2010) In vitro reconstruction of tetronate RK-682 biosynthesis. Nature Chemical Biology 6:99-101.

注：本论文被英国Faculty of 1000收录（http://f1000.com/）并获专家正面点评。

● Yuhui Sun, Xinyi He, Jingdan Liang, Xiufen Zhou and Zixin Deng* (2009) Analysis of functions in plasmid pHZ1358 influencing its genetic and structural stability in Streptomyces lividans 1326. Applied Microbiology and Biotechnology 82:303-310.

● David H. Kwan#, Yuhui Sun#, Frank Schulz, Hui Hong, Bojana Popovic, Joalice C.C. Sim-Stark, Stephen F. Haydock and Peter F. Leadlay* (2008) Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases. Chemistry & Biology 15:1231-1240.

● Yuliya Demydchuk#, Yuhui Sun#, Hui Hong, James Staunton, Jonathan B. Spencer and Peter F. Leadlay* (2008) Analysis of the tetronomycin gene cluster: insights into the biosynthesis of a polyether tetronate antibiotic. ChemBioChem 9:1136-1145.

● Yuhui Sun, Hui Hong, Fraser Gillies, Jonathan B. Spencer and Peter F. Leadlay* (2008) Glyceryl-S-acyl carrier protein as an intermediate in the biosynthesis of tetronate antibiotics. ChemBioChem 9:150-156.

● Barbara M. Harvey, Tatiana Mironenko, Yuhui Sun, Hui Hong, Zixin Deng, Peter F. Leadlay, Kira J. Weissman and Stephen F. Haydock* (2007) Insights into polyether biosynthesis from analysis of the nigericin biosynthetic gene cluster in Streptomyces sp. DSM4137. Chemistry & Biology 14:703-714.

● Yuhui Sun, Hui Hong, Markiyan Samborskyy, Tatiana Mironenko, Peter F. Leadlay and Stephen F. Haydock* (2006) Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin. Microbiology 152:3507-3515.

● Tiangang Liu, Delin You, Chiara Valenzano, Yuhui Sun, Jialiang Li, Qing Yu, Xiufen Zhou, David E. Cane and Zixin Deng* (2006) Identification of NanE as the thioesterase for polyether chain release in nanchangmycin biosynthesis. Chemistry & Biology 13:945-955.

● Yuhui Sun, Xiufen Zhou, Hui Dong, Guoquan Tu, Min Wang, Bofei Wang and Zixin Deng* (2003) A complete gene cluster from Streptomyces nanchangensis NS3226 encoding biosynthesis of the polyether ionophore nanchangmycin. Chemistry & Biology 10:431-441.

● Yuhui Sun, Xiufen Zhou, Guoquan Tu and Zixin Deng* (2003) Identification of a gene cluster encoding meilingmycin biosynthesis among multiple polyketide synthase contigs isolated from Streptomyces nanchangensis NS3226. Archives of Microbiology 180:101-107.

● Yuhui Sun, Xiufen Zhou, Jun Liu, Kai Bao, Guiming Zhang, Guoquan Tu, Tobias Kieser and Zixin Deng* (2002) ‘Streptomyces nanchangensis’, a producer of the insecticidal polyether antibiotic nanchangmycin and the antiparasitic macrolide meilingmycin, contains multiple polyketide gene clusters. Microbiology 148:361-371.

● Xiuhua Pang, Xiufen Zhou, Yuhui Sun and Zixin Deng* (2002) Physical map of the linear chromosome of Streptomyces hygroscopicus 10-22 deduced by analysis of overlapping large chromosomal deletions. Journal of Bacteriology 184:1958-1965.

● Xiuhua Pang, Yuhui Sun, Liu Jun, Xiufen Zhou and Zixin Deng* (2002) A linear plasmid temperature-sensitive for replication in Streptomyces hygroscopicus 10-22. FEMS Microbiology Letters 208:25-28.