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刘天罡

领域:生物产业 学校:武汉大学职称:教授

合成生物学 代谢工程 新型液体燃料 微生物药物发现与高产...

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教育背景

2002年- 2008年 上海交通大学生命科学技术学院,博士

2006年- 2007年 美国布朗大学化学系,博士生联合培养

1998年- 2002年 山东大学生命科学学院,本科

工作经历

2015年-至今 武汉大学药学院,教授三级、博导 2012年-至今 合成微生物技术湖北省工程实验室,主任 武汉生物技术研究院,副总工程师 2010年-2015年 武汉大学药学院,教授四级、博导 2008年- 2010年 美国斯坦福大学化学系,博士后

项目课题经历

1. 共建海正药业-武汉大学联合研究院技术开发项目(2018/06-2022/6,主持)

2. 湖北省自然科学基金杰青项目(2017CFA054,2017/8-2020/8,主持)

3. 国家自然科学基金面上项目(31670090,2017/01-2020/12,主持)

4. 2014年万人计划青年拔尖人才(2016/01-2018/12,主持)

5. 国家自然科学基金优秀青年基金(31222002,2013/01-2015/12,主持)

6. 科技部973计划课题(2012CB721001,2012/01-2016/08,主持)

7. 国家自然科学基金面上项目(31170096,2012/01-2015/12,主持)

8. 科技部973计划子课题(2011CBA00806,2011/01-2015/08,主持)

9. 国家自然科学基金主任基金(31040086, 2011/01-2013/12,主持)

论文、成果、著作等

1. Ma T#, Shi B, Ye Z, Li X, Liu M, Chen Y, Xia J, Jens N, Deng ZX, Liu T*. 2019. Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene. Metabolic Engineering, 52: 134-142.

2. Bian G#, Rinkel J#, Wang Z, Lauterbach L, Hou A, Yuan Y, Deng Z, Liu T*, Dickschat JS*. 2018. A Clade II-D Fungal Chimeric Diterpene Synthase from Colletotrichum gloeosporioides Making Dolasta-1(15), 8-diene. Angew Chem Int Ed Engl, 57:15887-15890.

3. Mary A#, Zhang Y#, Whitney H, Wang G, Baidoo E, Liu T*, Tang Y*. 2018. Comparative Studies of Glycolytic Pathways and Channeling Under in Vitro and in Vivo Modes. AIChE Journal. doi 10.1002 / aic.16367.

4. Liu R#, Deng Z, Liu T*. 2018. Streptomyces species: Ideal chassis for natural product discovery and over production. Metabolic Engineering, 50: 74–84.

5. Ding J#, Liang H, Fu S, Liu R, Deng Z, Liu T*. 2018. Modification of E-Poly-L-Lysine In Vivo to Reduce Self-Toxicity and Enhance Antibiotic Overproduction. AIChE Journal, 64(12):4187-4192.

6. Bian G#, Hou A, Yuan Y, Hu B, Cheng S, Ye Z, Di Y, Deng Z, Liu T*. 2018. Metabolic engineering-based rapid characterization of a sesquiterpene cyclase and the skeletons of fusariumdiene and fusagramineol from Fusarium graminearum. Organic Letters, 20(6): 1626-1629.

7. Bian G#, Deng Z, Liu T*. 2017. Strategies for terpenoid overproduction and new terpenoid discovery. Current Opinion in Biotechnology, 48:234–241.

8. Bian G#, Han Y, Hou A, Yuan Y, Liu X, Deng Z, Liu T*. 2017. Releasing the potential power of terpene synthases by a robust precursor supply platform. Metabolic Engineering, 42:1-8.

9. Tan G#, Deng K, Liu X, Tao H, Chang Y, Chen J, Chen K, Sheng Z, Deng Z, Liu T*. 2017. Heterologous Biosynthesis of Spinosad: An Omics-Guided Large Polyketide Synthase Gene Cluster Reconstitution in Streptomyces. ACS Synthetic Biology, 6(6):995-1005

10. Liu Z#, Zhang Y#, Jia X, Hu M, Deng Z, Xu Y*, Liu T*. 2017. In Vitro Reconstitution and Optimization of the Entire Pathway to Convert Glucose into Fatty Acid. ACS Synthetic Biology, 6(4):701-709

11. Tan G#, Liu T*. 2017. Rational synthetic pathway refactoring of natural products biosynthesis in actinobacteria. Metabolic Engineering, 39: 228-236.

12. Liu Q#, Wu K, Lu L, Cheng Y, Zhang Y, Deng Z, Liu T*. 2015. Engineering an iterative polyketide pathway in Escherichia coli results in single-form alkene and alkane overproduction. Metabolic Engineering. 28, 82-90.

13. Tao H#, Guo D, Zhang Y, Deng Z, Liu T*. 2015. Metabolic engineering of microbes for branched-chain biodiesel production with low-temperature property. Biotechnology for Biofuels. 8:92.

14. Liu R#, Zhu F, Lu L, Fu A, Lu J, Deng Z, Liu T*. 2014. Metabolic engineering of fatty acyl-ACP reductase-dependent pathway to improve fatty alcohol production in Escherichia coli. Metabolic Engineering, 22, 10-21.

15. Guo D#, Zhu J, Deng Z, Liu T*. 2014. Metabolic Engineering of Escherichia coli for Production of Fatty Acid Short-Chain Esters through Combination of the Fatty Acid and 2-Keto Acid Pathways. Metabolic Engineering, 22, 69-75

16. Yu X#, Liu T#*, Zhu F, Khosla C*. 2011.In vitro reconstitution and steady-state analysis of the fatty acid synthase from Escherichia coli. Proc Natl Acad Sci U S A. 108(46):18643-8.

17. Liu T#*, Khosla C*. 2010. A Balancing Act for Taxol Precursor Pathways in E. coli. Science. 330:44-45

18. Liu T#, Vora H, Khosla C*. 2010. Quantitative analysis and engineering of fatty acid biosynthesis in E. coli. Metabolic Engineering. 12:378-86

专利、著作版权等

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