2005-2009：上海交通大学，博士2013-2014：美国加州大学洛杉矶分校(UCLA)，博士后(CSC Scholarship)

2011-至今：武汉大学药学院，副教授 2009-2011：上海交通大学邓子新团队，研究组长(博士后)

，主持国家自然科学基金面上项目3项，973子课题1项，企业横向合作及其他项目等多项

1. Xu G , Kong L, Xu L, Gao Y, Jiang M, Cai Y-S, Hong K, Hu Y, Liu P, Deng Z, Price NP, Chen W*. (2018) Coordinated biosynthesis of the purine nucleoside antibiotics aristeromycin and coformycin in Actinomycetes. Appl Environ Microbiol. 84(22). DOI: 10.1128/AEM.01860-18 (*通讯作者)

2. Liu Y, Gong R, Liu X, Zhang P, Zhang Q, Cai Y-S, Deng Z, Winkler M, Wu J*, Chen W*. (2018) Discovery and characterization of the tubercidin biosynthetic pathway from Streptomyces tubercidicus NBRC 13090. Microb Cell Fact. 17:131. (*共通讯作者)

3. Gong R, Qi J, Wu P, Cai Y-S, Ma H, Liu Y, Duan H, Wang M, Deng Z, Price N, Chen W*. (2018) An ATP-dependent ligase with substrate flexibility involved in assembly of the peptidyl nucleoside antibiotic polyoxin. Appl Environ Microbiol. 84(13). (*通讯作者)

4. Gao Y#, Xu G#, Wu P#, Liu J, Deng Z, Chen W*. (2017) Biosynthesis of 2’-chloropentostatin and 2’-amino-2’-deoxyadenosine highlights a single gene cluster responsible for two individual pathways in Actinomadura sp. ATCC 39365. Appl Environ Microbiol. 83(10). (*通讯作者)

5. Wu P#, Wan D #, Xu G #, Wang G, Ma H, Wang T, Gao Y, Qi J, Chen X, Zhu J, Li Y-Q, Deng Z, Chen W*. (2017) An unusual protector-protégé strategy for the biosynthesis of purine nucleoside antibiotics. Cell Chem Biol. 24(2):171-181 (*通讯作者)

6. He N#, Wu P#, Lei Y, Xu B, Zhu X, Xu G, Gao Y, Qi J, Deng Z, Tang G, Chen W*, Xiao Y*. (2017) Construction of the octosyl acid backbone catalyzed by a radical S-adenosylmethionine enzyme and a phosphatase in the biosynthesis of high-carbon sugar nucleoside antibiotics.Chem Sci. 8:444-451. (*共通讯作者)

7. Zhao H, Wang L, Wan D, Qi J, Gong R, Deng Z, Chen W*. (2016) Characterization of the aurantimycin biosynthetic gene cluster and enhancing its production by manipulating two pathway-specific activators in Streptomyces aurantiacus JA 4570. Microb Cell Fact. 15:160. (*通讯作者)

8. Qi J, Wan D, Ma H, Liu Y, Gong R, Qu X, Sun Y, Deng Z, Chen W*. (2016) Deciphering carbamoylpolyoxamic acid biosynthesis reveals unusual acetylation cycle associated with tandem reduction and sequential hydroxylation. Cell Chem Biol. 23(8):935-944. (*通讯作者) (Featured as Issue Highlights in Cell Chem Biol)

9. Chen W#, Li Y#, Li J, Wu L, Li Y, Wang R, Deng Z, Zhou J. (2016) An unusual UMP C-5 methylase in nucleoside antibiotic polyoxin biosynthesis. Protein Cell. 7(9):673-683. (#共第一作者)

10.Chen W, Qi J, Wu P, Wan D, Liu J, Deng Z. (2016) Natural and engineered biosynthesis of nucleoside antibiotics in Actinomycetes. J Ind Microbiol Biotechnol. 43(2-3):401-17.

11.Qi J, Liu J, Wan D, Wang Y, Cai Y, Feng X, Wu P, Li S, Qiu G, Yang S, Chen W*, Deng Z. (2015) Metabolic engineering of an industrial polyoxin producer for the targeted overproduction of designer nucleoside antibiotics. Biotechnol Bioeng. 112(9):1865-1871. (*通讯作者) (Featured as Spotlight in Biotechol Bioeng)

12. Chen W, Dai D, Wang C, Huang T, Zhai L, Deng Z. (2013) Genetic dissection of the polyoxin building block-carbamoylpolyoxamic acid biosynthesis revealing the "pathway redundancy" in metabolic networks. Microb Cell Fact. 12:121. (Most accessed paper, Top 2)

13. Xu D, Liu G, Cheng L, Lu X, Chen W*, Deng Z*. (2013) Identification of Mur34 as the novel negative regulator responsible for the biosynthesis of muraymycin in Streptomyces sp. NRRL 30471. PLoS One. 8(10):e76068 (*共通讯作者)

14. Zhai L, Lin S, Qu D, Hong X, Bai L, Chen W*, Deng Z*. (2012) Engineering of an industrial polyoxin producer for the rational production of hybrid peptidyl nucleoside antibiotics. Metab Eng. 14(4):388-93. (*共通讯作者)

15. Doroghazi J, Ju K, Brown D, Labeda D, Deng Z, Metcalf W, Chen W*, Price N*. (2011) Genome sequences of three tunicamycin-producing Streptomyces strains; S. chartreusis NRRL 12338, S. chartreusis NRRL 3882, and S. lysosuperificus ATCC 31396. J Bacteriol. 193(24):7021-2. (*共通讯作者)

16. Cheng L, Chen W*, Zhai L, Xu D, Huang T, Lin S, Zhou X, Deng Z*. (2011) Identification of the gene cluster involved in muraymycin biosynthesis from Streptomyces sp. NRRL 30471. Mol Biosyst. 7(3):920-927. (*共通讯作者)

17. Chen W#, Qu D#, Zhai L, Tao M, Wang Y, Lin S, Price NP, Deng Z. (2010) Characterization of the tunicamycin gene cluster unveiling unique steps involved in its biosynthesis. Protein Cell. 1(12):1093-1105. (#共第一作者)

18. Chen W, Huang T, He X, Meng Q, You D, Bai L, Li J, Wu M, Li R, Xie Z, Zhou H, Zhou X, Tan H, Deng Z. (2009) Characterization of the polyoxin biosynthetic gene cluster from Streptomyces cacaoi and engineered production of polyoxin H. J Biol Chem. 284(16): 10627-10638.




其他SCI论文

20. Zhang B, Tian W, Wang S, Yan X, Jia X, Pierens GK, Chen W, Ma H, Deng Z, Qu X. (2017)Activation of Natural Products Biosynthetic Pathways via a Protein Modification Level Regulation. ACS Chem Biol. 12(7):1732-1736.

21. Price NP, Furukawa T, Cheng F, Qi J, Chen W, Crich D. (2014) Biosynthesis of 4-aminoheptose 2-epimers, core structural components of the septacidins and spicamycins. J Antibiot (Tokyo). 67(5):405-14.

22. Xu T, Yu D, Xu P, Xu W, Chen W, Chen C, Li X. (2014) Real-time enzyme-digesting identification of double-strand DNA in a resonance-cantilever embedded micro-chamber. Lab Chip. 14(6):1206-14.

23. Huang T, Wang Y, Yin J, Du Y, Tao M, Xu J, Chen W, Lin S, Deng Z. (2011) Identification and characterization of the pyridomycin biosynthetic gene cluster of Streptomyces pyridomyceticus NRRL B-2517. J Biol Chem. 286(23):20648-57.

24. Zhao C, Huang T, Chen W, Deng Z. (2010) Enhancement of the diversity of polyoxins by a thymine-7-hydroxylase homolog outside the polyoxin biosynthesis gene cluster. Appl Environ Microbiol. 76(21):7343-7347.

25. Sun L, Chen W, Deng Z, Zhong J. (2009) Microbiological assay for quantitative determination of polyoxin B. Process Biochemistry. 44, 361-364.

26. Li R, Xie Z, Tian Y, Yang H, Chen W, You D, Deng Z, Tan H. (2009) polR, a pathway-specific transcriptional regulatory gene, positively controls polyoxin biosynthesis in Streptomyces cacaoi var. asoensis. Microbiol-SGM. 155, 1819-1831.

27. Li R, Liu G, Xie Z, He X, Chen W, Deng Z, Tan H. (2009) PolY, a transcriptional regulator with ATPase activity, directly activates transcription of polR in polyoxin biosynthesis inStreptomyces cacaoi. Mol Microbiol. 75(2): 349-364.




中文期刊论文

28. 陈文青*, 邓子新. (2016) 微生物药物学课程教学的改革与实践. 微生物学通报, 43(10): 2294−2297.

29. 王婷婷, 邓子新, 陈文青*. (2016) 抗生素生物合成基因簇克隆策略的研究进展. 生物加工过程, 14(2):70-74.

30. 吴蕴, 宋晨阳, 陈文青*. (2016) 微生物药物产量理性化提高的策略及其研究进展. 微生物学报, 56(3):454-460.

31. 汪桂, 吴蕴, 袁子雨, 邓子新, 苏二正*, 陈文青*. (2016) 春雷霉素的研究现状及展望, 生物加工过程, 14(4):70-75. (*共通讯作者)

32. 王季季, 邓子新, 陈文青*. (2016) 多氧霉素及其生物合成的研究进展, 微生物学通报, 43(1):205-210.

33. 陈文青, 邓子新. (2009) 核苷类抗生素代谢工程研究现状与展望, 中国抗生素杂志. 34(3): 129-141.

1. 陈文青，邓子新，翟李鹏，程放；多氧霉素与尼可霉素杂合抗生素及其制备方法，专利号: ZL201210049728.4

2. 陈文青，邓子新，秦娜娜，周佳海；一种Polyoxin K高产菌株的构建方法，申请号: 201210533704.6

3. 陈文青，邓子新，程放，汪长春；多氧霉素B组分高产菌株及其构建方法，申请号: 201310502123.0

4. 陈文青，祁建钊，邓子新，刘进；肽基核苷类杂合抗生素Nikkoxin E和Nikkoxin F及其制备方法，专利号：ZL201510033114.0

5. 陈文青，巫攀，邓子新，万丹，徐顾丹；喷司他丁和阿糖腺苷生物合成基因簇及其应用，申请号：­­201611181302.9

6. 陈文青，高耀杰，邓子新，徐顾丹，巫攀；2’-氯代喷司他丁和2’-氨基-2’-脱氧腺苷生物合成基因簇及其应用，申请号：­­201710054193.2