1991年同济医科大学药学院药学本科毕业，2002年获药学硕士学位，2012年获药理学博士学位。

1.猪苓多糖与rIL-2结合物长循环脂质体及抗瘤活性研究. 省科技攻关计划. 2003.7—2004.12，第一负责人。

2.复方猪苓多糖与rIL-2长循环脂质体及抗瘤活性研究. 湖北省科技攻关计划. 2005.1—2006.12，第一负责人。

3.新型补铁剂当归多糖铁精细结构的鉴定及方法学研究. 湖北省自然基金项目. 2007.9—2009.8，第一负责人。

4.当归多糖铁协同补血的血细胞调控分子生物学机理研究.省自然科学基金. 2007.1—2008.12，第二负责人。

5.当归多糖铁协同补血的血细胞调控分子生物学机理研究.省中医药中西医结合科研课题. 2007.1—2008.12，第二负责人。

6.新型补铁剂当归多糖铁的研制.湖北省科技攻关计划. 2005.1—2006.12，第二负责人。

7.注射级香菇多糖的提取工艺研究.横向课题. 2007.9-2008.9，第二负责人。

8.当归多糖铁口服液的研制与开发.市科技攻关计划. 2008.1-2009.12，第二负责人。

9.湖北道地植物多糖及其铁复合物开放铁释放通道调节铁代谢的作用研究.省自然基金重点项目. 2008.10-2011.9，第二负责人。

10.当归多糖特异性肝靶向的分子机理研究. 国家自然科学基金，2011.1-2013.12，第二负责人。

11.当归多糖作为肝靶向给药系统载体的可行性研究. 华中科技大学自然重点项目. 2010.10-2012.09，第二负责人。

12.香菇多糖药用研究. 横向课题, 2011.6-2013.6，第二负责人。

13.当归多糖抑制hepcidin表达的分子机制研究. 国家自然科学基金，2010.1-2010.12，第二负责人。

14.当归多糖作为铁调素抑制剂参与机体铁代谢的分子机制研究. 国家自然科学基金，2013.1-2016.12，第二负责人。

15.香菇多糖非免疫途径抗肿瘤作用的分子机制研究. 武汉市科技攻关, 2013.1-2014.12, 第二负责人。

16.香菇多糖抗肿瘤构效关系及诱导肿瘤细胞凋亡的分子机制研究. 国家自然科学基金, 2014.1-2017.12, 第一负责人。

17.药用植物多糖的绿色提取工艺、结构鉴定及新剂型的关键技术研发. 湖北省科技支撑计划项目2014BKB088, 2014.1-2015.12，第二负责人。

18.当归多糖靶向性调节肝细胞胰岛素敏感参与机体糖脂代谢的分子机制研究. 华中科技大学自主创新项目, 2014.12-2016.12,第一负责人。

19.当归多糖调节机体糖脂代谢紊乱的分子机制研究，武汉市科技计划，2016060101010059，2016/08-2018/08，15万，第二负责人

20.中药复方多糖提取工艺、降糖降脂功效及新剂型的关键技术研究，湖北省技术创新专项重大项目，2016ACA147，2017/01-2018/12，50万，第二负责人

21.生血宁片通过调节EPO表达改善肾性贫血的作用及分子机制研究.横向课题.2018.03-2019.09，第二负责人。

22.中药复方多糖提取工艺及降糖降脂功效研究. 横向课题. 2018.06-2020.06，第二负责人。

23. 天然多糖体内检测方法的建立和药代动力学机制研究. 省自然基金重点项目. 500万.第一负责人。

24. Dectin-1介导的香菇多糖体内吸收代谢机制研究.中国医疗手牵手工程. 100万. 2020.1-2013.12，第二负责人。

1. Angelica sinensis polysaccharide nanoparticles as a targeted drug delivery system for enhanced therapy of liver cancer. Carbohydrate Polymers, 2019,219:143-154

2. Oral administration of Angelica sinensis polysaccharide protects against pancreatic islets failure in type 2 diabetic mice: Pancreatic β-cell apoptosis inhibition. Journal of Functional Foods 54 (2019): 361-370

3. Correction of anemia in chronic kidney disease with Angelica sinensis polysaccharide via restoring EPO production and improving iron availability. Front Pharmacol. 2018; 9: 803.

4. A sensitive and rapid radiolabelling method for the in vivo pharmacokinetic study of lentinan. Food Funct., 2018, 9, 3114-3125

5. Dendrobium officinale polysaccharide attenuates type 2 diabetes mellitus via the regulation of PI3K/Akt-mediated glycogen synthesis and glucose metabolism. Journal of Functional Foods. January 2018, Pages 261-271

6. Pharmacokinetics, biodistribution and receptor mediated endocytosis of a natural Angelica sinensis polysaccharide. Artificial Cells, Nanomedicine, and Biotechnology. 2017 1:1-10.

7. Investigation of the transport and absorption of Angelica sinensis polysaccharide through gastrointestinal tract both in vitro and in vivo. Drug Delivery. 2017 Nov;24(1):1360-1371.

8. Acidic Polysaccharide from Angelica sinensis Reverses Anemia of Chronic Disease Involving the Suppression of Inflammatory Hepcidin and NF-κB Activation, Oxidative Medicine and Cellular Longevit, Volume 2017,13 pages

9. Protective effects of Angelica sinensis polysaccharide against hyperglycemia and liver injury in multiple low-dose streptozotocininduced type 2 diabetic BALB/c mice. Food & Function. 2016, 7, 4889-4897

10. Filicinic acid based meroterpenoids with anti-Epstein–Barr virus activities from Hypericum japonicum, Org. Lett. 2016, 18:2272−2275

11. (±)-Japonones A and B, two pairs of new enantiomers with anti-KSHV activities from Hypericum japonicum, Sci. Rep. 2016, 6, 27588. DOI: 10.1038/srep27588

12. (±)-Japonicols A–D, acylphloroglucinol-based meroterpenoid enantiomers with anti-KSHV activities from Hypericum japonicum, J. Nat. Prod. 2016, 79, 1322−1328

13. A new megastigmane sesquiterpenoid from Zanthoxylum schinifolium Sieb. et Zucc., Molecules 2016, 21, 383. DOI:10.3390/molecules21030383.

14. Two new bioactive α-pyrones from Hypericum japonicum, Molecules 2016, 21, 515. DOI:10.3390/molecules21040515

15. Chronic administration of Angelica sinensis polysaccharide effectively improves fatty liver and glucose homeostasis in high-fat diet-fed mice, Sci. Rep. 2016,6:26229

16. Polysaccharide from Lentinus edodes combined with oxaliplatin possesses the synergy and attenuation effect in hepatocellular carcinoma, cancer letters. 2016,377:117-125

17. Structural characterization and in vitro antitumor activity of an acidic polysaccharide from Angelica sinensis (Oliv.) Diels. Carbohydrate Polymers. 2016

18. The effects of polysaccharides from the root of Angelica sinensis on tumor growth and iron metabolism in H22-bearing mice. Food & Function. 2016,7:1033-1039

19. Angelica sinensis polysaccharide attenuates concanavalin A-induced liver injury in mice. International Immunopharmacology. 2016,31:140-148

20. Induction of apoptosis in S180 tumour bearing mice by polysaccharide from Lentinus edodes via mitochondria apoptotic pathway. Journal of functional foods. 2015 ,15:151-159.

21. Angelica sinensis polysaccharide regulates glucose and lipid metabolism disorder in prediabetic and streptozotocin-induced diabetic mice through the elevation of glycogen levels and reduction of inflammatory factors. Food & Function. 2015,6:902-909

22. The action of JAK, SMAD and ERK signal pathways on hepcidin suppression by polysaccharides from Angelica sinensis in rats with iron deficiency anemia. Food & Function,2014,5:1381-1388.

23. Structural differences and conformational characterization of five bioactive polysaccharides from Lentinus Edodes. Food Research International, 2014,62:223-232.

24. Alkali-Soluble Polysaccharide, Isolated from Lentinus edodes, Induces Apoptosis and G2/M Cell Cycle Arrest in H22 Cells Through Microtubule Depolymerization. Phytotherapy Research,2014,12:1837-1845

25. Structure and inducing tumor cell apoptosis activity of polysaccharide isolated from Lentinus edodes. Journal of agricultural and food chemistry, 2013,61(41):9849-9858.

26. Polysaccharide Isolated from Angelica sinensis Inhibits Hepcidin Expression in Rats with Iron Deficiency Anemia. Journal Of Medical Food, 2012,15 (10):923–929.

27. Study to establish the role of JAK2 and SMAD1/5/8 pathways in the inhibition of hepcidin by polysaccharides from Angelica sinensis. Journal of Ethnopharmacology, 2012, 144(10):433-440

28. Inhibitory effect of polysaccharides isolated from Angelica sinensis on hepcidin expression. Journal of Ethnopharmacology, 2011, 134(3):944-948

29. A comparison study between different molecular weight polysaccharides derived from Lentinus edodes and their antioxidant activities in vivo, 2011,49(12):1298-1305

30. Structure，Chain comformation and antitumor activity of a novel polysaccharide from Lentinus edodes. Fitoterapia, 2010, 81(8):1163-1170

31. Molecular Weight and Proposed Structure of the Angelica sinensis Polysaccharide-iron Complex. Chinese Journal of Chemistry,2008,26(6):1-7

32. Effect of Angelica sinensis Polysaccharide-iron Complex on Iron Deficiency Anemia Rats. Chinese Journal of Integrative Medicine，2007,13(4):297-300

33. Preparation and Identification of Angelica sinensis Polysaccharide-iron Complex. Chemical Research in Chinese Universities,2005,21(6): 668-672

34. 地红霉素肠溶微丸胶囊的生物等效性，中国医院药学杂志, 2007, (6)

35. 氟康唑口服液人体相对生物利用度和生物等效性，中国医院药学杂志，2007,(4)

36. 正交试验优化当归多糖铁的合成条件研究，中成药，2007,(4)

37. 泮托拉唑钠肠溶微丸胶囊人体相对生物利用度和生物等效性研究，中国医院药学杂志，2006,(10)

38. 右旋布洛芬混悬剂人体相对生物利用度，医药导报，2006,,(11)

39. 醇析水提法提取金银花多糖，中国医院药学杂志，2006,(1)

40. 双氯芬酸锌的结构鉴定，中国医院药学杂志，2005,(11)

41. 正交试验法优选双氯芬酸锌缓释片处方，中草药，2006,(3)

42. 放射免疫分析法测定重组人白细胞介素-2含量，中国中药杂志，2006,(9)