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翟学佳

领域:生物产业 学校:华中科技大学职称:教授

体内外药物分析及药物代谢;神经精神临床药理。...

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教育背景

工作经历

项目课题经历

1. 基于糖皮质激素代谢组学的金丝桃素抗抑郁作用机制的研究. 国家自然科学基金, 2015. 01-2017. 12, 第一负责人。

2. 金丝桃素对大鼠的抗抑郁作用及其机制研究. 华中科技大学自主创新研究基金, 2014. 01-2015. 12, 第一负责人。

3. 利用PBPK模型整合生理、代谢酶与转运体等多种因素系统研究辣椒素-药物相互作用. 国家自然科学基金, 2015.01-2018.12, 第二负责人。

4. 基于糖皮质激素代谢组学研究客观化诠释柴胡疏肝散“疏肝解郁”的作用机制. 国家自然科学基金, 2017.01-2020.12, 第二负责人。

论文、成果、著作等

1. LC-MS/MS based studies on the anti-depressant effect of hypericin in the chronic unpredictable mild stress rat model, J Ethnopharmacol, 2015, 1(169):363-369.

2. A simple LC-MS/MS method for the determination of cortisol, cortisone and tetrahydro-metabolites in human urine: assay development, validation and application in depression patients, J Pharm Biomed Anal, 2015, 25(107):450-455.

3. A simple LC-MS/MS method for quantitative analysis of underivatized neurotransmitters in rats urine: assay development, validation and application in the CUMS rat model, Biomed Chromatogr, 2015, 29(11): 1737- 1743.

4. Food-drug interactions: Effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats, Food Chem Toxicol, 2013, 53: 168-173.

5. Capsaicin pretreatment increased the bioavailability of cyclosporin in rats: Involvement of P-glycoprotein and CYP 3A inhibition, Food Chem Toxicol, 2013, 62: 323-328.

6. Food-drug interactions: effect of capsaicin on the pharmacokinetics of galantamine in rats, Xenobiotica, 2012, 42(11): 1151-1155.

7. Development and validation of a simple LC method for the determination of phenacetin, coumarin, tolbutamide, chlorzoxazone, testosterone and their metabolites as markers of cytochromes 1A2, 2A6, 2C11, 2E1 and 3A2 in rat microsomal medium, Pharmazie, 2013, 68(1): 19-26.

专利、著作版权等

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