2002/9–2005/7，中国科学院，上海药物研究所，博士。

1999/9–2002/7，南开大学，元素有机化学研究所，硕士。

2014/11–至今，华中科技大学，同济医学院药学院，教授，博士生导师。 2010/9–2014/10，华中科技大学，同济医学院药学院，副教授，博士生导师。 2009/5–2010/9，华中科技大学，同济医学院药学院，副教授，硕士生导师。 2007/12–2009/5，美国夏威夷太平洋大学，博士后。 2006/02–2007/12，美国明尼苏达大学，博士后。 2005/07–2006/02，石家庄制药集团药物研究院暨中奇公司，中药新药研发项目组长

天然药物化学与创新药物的研究与开发。主要是从传统中草药、药用植物、微生物等天然药物资源中寻找结构新颖、具有显著生物活性的天然产物，并以此为先导化合物，通过化学结构改造、结构优化等方法从中发现高效低毒的新药候选化合物，开发出具有自主知识产权的创新药物。

(1) Zong Jin(*), Guangmin Yao(*). Amaryllidaceae and Sceletium alkaloids. Natural Product Reports 2019, DOI: 10.1039/c8np00055g. (IF: 11.876)

(2) Haofeng Zhou, Yindengzhi Guoruoluo, Yali Tuo, Junfei Zhou, Hanqi Zhang, Wei Wang, Ming Xiang, Haji Akber Aisa, Guangmin Yao(*). Cassiabudanols A and B, immunostimulative diterpenoids with a cassiabudane carbon skeleton featuring a 3-oxa-tetracyclo[6.6.1.02,6.010,14]pentadecane scaffold from the cassia buds. Organic Letters 2019, 21 (2), 549−553. (IF: 6.555)

(3) Na Sun, Guijuan Zheng, Meijun He, Yuanyuan Feng, Junjun Liu, Meicheng Wang, Hanqi Zhang, Junfei Zhou, Guangmin Yao(*). Grayanane diterpenoids from the leaves of Rhododendron auriculatum and their analgesic activities. Journal of Natural Products 2019, 82 (7), 1849−1860. (IF: 4.257)

(4) Na Sun, Yuanyuan Feng, Qihua Zhang, Junjun Liu, Haofeng Zhou, Hanqi Zhang, Guijuan Zheng, Junfei Zhou, Guangmin Yao(*). Analgesic diterpenoids with diverse carbon skeletons from the leaves of Rhododendron auriculatum. Phytochemistry 2019, 168, 112113. (IF: 2.905)

(5) Na Sun, Yue Qiu, Yan Zhu, Junjun Liu, Hanqi Zhang, Qihua Zhang, Mengke Zhang, Guijuan Zheng, Chun Zhang, Guangmin Yao(*). Rhodomicranosides A−I, analgesic diterpene glucosides with diverse carbon skeletons from Rhododendron micranthum. Phytochemistry 2019, 158, 1−12. (IF: 2.905)

(6) Ting Dang, Guijuan Zheng, Qihua Zhang, Pengfei Jin, Hanqi Zhang, Lingjie Su, Dongmei Qin(*), Guangmin Yao(*). Sesquiterpenoids with diverse carbon skeletons from the roots of Cichorium glandulosum and their anti-inflammatory activities. Fitoterapia 2019, 136, 104170. (IF: 2.431)

(7) Junfei Zhou, Junjun Liu, Ting Dang, Haofeng Zhou, Hanqi Zhang, and Guangmin Yao(*). Mollebenzylanols A and B, highly modified and functionalized diterpenoids with a 9-benzyl-8,10-dioxatricyclo[5.2.1.01,5]decane core from Rhododendron molle. Organic Letters 2018, 20 (7), 2063−2066. (IF: 6.555)

(8) Na Sun, Yan Zhu, Haofeng Zhou, Junfei Zhou, Hanqi Zhang, Mengke Zhang, Hong Zeng, and Guangmin Yao(*). Grayanane diterpenoid glucosides from the leaves of Rhododendron micranthum and their bioactivities evaluation. Journal of Natural Products 2018, 81 (12), 2673−2681. (IF: 4.257)

(9) Junfei Zhou, Tingting Liu, Hanqi Zhang, Guijuan Zheng, Yue Qiu, Mengyi Deng, Chun Zhang, and Guangmin Yao(*). Anti-inflammatory grayanane diterpenoids from the leaves of Rhododendron molle. Journal of Natural Products 2018, 81 (1), 151−161. (IF: 4.257)

(10) Yang Teng(#), Hanqi Zhang(#), Junfei Zhou, Guanqun Zhan, Guangmin Yao(*). Hebecarposides A−K, antiproliferative lanostane-type triterpene glycosides from the leaves of Lyonia ovalifolia var. hebecarpa. Phytochemistry 2018, 151, 32−41. (IF: 2.905)

(11) Yindengzhi Guoruoluo, Haofeng Zhou, Wei Wang, Junfei Zhou, Haji Akber Aisa(*), Guangmin Yao(*). Chemical constituents from the immature buds of Cinnamomum cassia (Lauraceae). Biochemical Systematics and Ecology 2018, 78, 102−105. (IF: 1.127)

(12) Junfei Zhou, Na Sun, Hanqi Zhang, Guijuan Zheng, Junjun Liu, and Guangmin Yao(*). Rhodomollacetals A−C, PTP1B inhibitory diterpenoids with a 2,3:5,6-di-seco-grayanane skeleton from the leaves of Rhododendron molle. Organic Letters 2017, 19 (19), 5352−5355. (IF: 6.555)

(13) Junfei Zhou, Guanqun Zhan, Hanqi Zhang, Qihua Zhang, Ying Li, Yongbo Xue, and Guangmin Yao(*). Rhodomollanol A, a highly oxygenated diterpenoid with a 5/7/5/5 tetracyclic carbon skeleton from the leaves of Rhododendron molle. Organic Letters 2017, 19 (14), 3935−3938. (IF: 6.555)

(14) Lei Zhou, Yali Tuo, Yi Hao, Xiaoman Guo, Wei Tang, Yongbo Xue, Junfen Zeng, Yu Zhou, Ming Xiang, Jianping Zuo, Guangmin Yao(*), Yonghui Zhang(*). Cinnamomols A and B, immunostimulative diterpenoids with a new carbon skeleton from the leaves of Cinnamomum cassia. Organic Letters 2017, 19 (11), 3029−3032. (IF: 6.555)

(15) Yindengzhi Guoruoluo, Haofeng Zhou, Junfei Zhou, Haiqing Zhang, Haji Akber Aisa(*), and Guangmin Yao(*). Isolation and characterization of sesquiterpenoids from cassia buds and their antimicrobial activities. Journal of Agricultural and Food Chemistry 2017, 65 (28), 5614−5619. (IF: 3.571)

(16) Guanqun Zhan, Junjun Liu, Junfei Zhou, Bin Sun, Haji Akber Aisa, Guangmin Yao(*). Amaryllidaceae alkaloids with new framework types from Zephyranthes candida as potent acetylcholinesterase inhibitors. European Journal of Medicinal Chemistry 2017, 127, 771−780. (IF: 4.833)

(17) Guanqun Zhan, Junfei Zhou, Junjun Liu, Jinfeng Huang, Hanqi Zhang, Rong Liu, Guangmin Yao(*). Acetylcholinesterase Inhibitory Alkaloids from the Whole Plants of Zephyranthes carinata. Journal of Natural Products 2017, 80 (9), 2462−2472. (IF: 4.257)

(18) 滕杨(#), 张涵淇(#), 周俊飞, 李永吉(*), 姚广民(*). 毛果南烛叶中的三萜皂苷化合物及其抗肿瘤活性. 有机化学 2017, 36 (9), 2416−2422. (IF: 1.318)

(19) 朱焰, 周俊飞, 张颖, 庞现红(*), 姚广民(*). 泰山产天目琼花枝叶化学成分研究. 中草药 2017, 48 (11), 2177−2181.

(20) Guanqun Zhan, Junfei Zhou, Tingting Liu, Guijuan Zheng, Haji Akber Aisa, Guangmin Yao(*). Flavans with potential anti-inflammatory activities from Zephyranthes candida. Bioorganic & Medicinal Chemistry Letters 2016, 26 (24), 5967−5970. (IF: 2.448)

(21) Guanqun Zhan, Junfei Zhou, Rong Liu, Tingting Liu, Guoli Guo, Jianping Wang, Ming Xiang, Yongbo Xue, Zengwei Luo, Yonghui Zhang, Guangmin Yao(*). Galanthamine, plicamine, and secoplicamine alkaloids from Zephyranthes candida and their anti-acetylcholinesterase and anti-inflammatory activities. Journal of Natural Products 2016, 79 (4), 760−766. (IF: 4.257)

(22) Guanqun Zhan (#), Xiaolan Qu (#), Junjun Liu, Qingyi Tong, Junfei Zhou, Bing Sun, Guangmin Yao(*). Zephycandidine A, the first naturally occurring imidazo[1,2-f]phenanthridine alkaloid from Zephyranthes candida, exhibits significant anti-tumor and anti-acetylcholinesterase activities. Scientific Reports 2016, 6, 33990. (IF: 4.011)

(23) Qi Ye (#), Jue Jiang (#), Guanqun Zhan(#), Wanyao Yan, Liang Huang, Yufeng Hu, Hexiu Su, Qingyi Tong, Ming Yue, Hua Li, Guangmin Yao(*), Yonghui Zhang(*), Hudan Liu(*). Small molecule activation of NOTCH signaling inhibits acute myeloid leukemia. Scientific Reports 2016, 6, 26510. (IF: 4.011)

(24) Yongji Lai, Hong Zeng, Meijun He, Huiqin Qian, Zhaodi Wu, Zengwei Luo, Yongbo Xue, Guangmin Yao(*), Yonghui Zhang(*). 6,8-Di-C-methyl-flavonoids with neuroprotective activities from Rhododendron fortune. Fitoterapia 2016, 112, 237−243. (IF: 2.431)

(25) Yongji Lai, Tingting Liu, Rongjian Sa, Xialan Wei, Yongbo Xue, Zhaodi Wu, Zengwei Luo, Ming Xiang, Yonghui Zhang(*), Guangmin Yao(*). Neolignans with a rare 2-oxaspiro[4.5]deca-6,9-dien-8-one motif from the stem bark of Cinnamomum subavenium. Journal of Natural Products 2015, 78 (7), 1740−1744. (IF: 4.257)

(26) Mengke Zhang, Yangyang Xie, Guanqun Zhan, Liang Lei, Penghua Shu, Yongli Chen, Yongbo Xue, Zengwei Luo, Qian Wan, Guangmin Yao(*), Yonghui Zhang(*). Grayanane and leucothane diterpenoids from the leaves of Rhododendron micranthum. Phytochemistry 2015, 117, 107−115. (IF: 2.905)

(27) Qi Ye (#), Guangmin Yao(#), Mengke Zhang, Guoli Guo, Yufeng Hu, Jue Jiang, Ling Cheng, Hua Li, Guoliang Qing, Yonghui Zhang(*), Hudan Liu(*). A novel ent-kaurane diterpenoid executes anti-tumor function in colorectal cancer cells by inhibiting Wnt/b-catenin signaling. Carcinogenesis 2015, 36 (3), 318−326. (IF: 4.004)

(28) Guoli Guo(#), Guangmin Yao(#),Guanqun Zhan, Qi Ye, Jue Jiang, Yufeng Hu, Guoliang Qing, Yonghui Zhang(*), Hudan Liu(*). N-methylhemeanthidine chloride, a novel Amaryllidaceae alkaloid, inhibits pancreatic cancer cell proliferation via down-regulating AKT activation. Toxicology and Applied Pharmacology 2014, 280 (3), 475−483. (IF: 3.585)

(29) Junfen Zeng, Yongbo Xue, Penghua Shu, Huiqin Qian, Rongjian Sa, Ming Xiang, Xiao-Nian Li, Zengwei Luo, Guangmin Yao(*), Yonghui Zhang(*). Diterpenoids with immunosuppressive activities from Cinnamomum cassia. Journal of Natural Products 2014, 77 (8), 1948−1954. (IF: 4.257)

(30) Mengke Zhang, Yan Zhu, Guanqun Zhan, Penghua Shu, Rongjian Sa, Liang Lei, Ming Xiang, Yongbo Xue, Zengwei Luo, Qian Wan, Guangmin Yao(*), Yonghui Zhang(*). Micrantone A, a new diterpenoid with an unprecedented carbon skeleton from Rhododendron micranthum. Organic Letters 2013, 15 (12), 3094−3097. (IF: 6.555)

(31) Heng Zheng, Qiong Chen, Mengke Zhang, Yongji Lai, Liang Lei, Penghua Shu, Yongbo Xue, Zengwei Luo, Jinwen Zhang, Yan Li, Guangmin Yao(*), Yonghui Zhang(*). Cytotoxic ent-kaurane diterpenoids from Salvia cavaleriei. Journal of Natural Products 2013, 76 (12), 2253−2262. (IF: 4.257)

(32) Penghua Shu, Xialan Wei, Yongbo Xue, Weijie Li, Jinwen Zhang, Ming Xiang, Mengke Zhang, Zengwei Luo, Yan Li, Guangmin Yao(*), Yonghui Zhang(*). Wilsonols A–L, megastigmane sesquiterpenoids from the leaves of Cinnamomum wilsonii. Journal of Natural Products 2013, 76 (7), 1303−1312. (IF: 4.257)

(33) Yongji Lai(#), Yongbo Xue(#), Mengke Zhang, Jinwen Zhang, Wei Tang, Junjun Liu, Liang Lei, Juming Yan, Zengwei Luo, Jianping Zuo, Yan Li, Guangmin Yao(*), Yonghui Zhang(*). Scapiformolactones A–I: germacrane sesquiterpenoids with an unusual Δ3-15,6-lactone moiety from the whole plants of Salvia scapiformis. Phytochemistry 2013, 96, 378−388. (IF: 2.905)

(34) Xincai Hao(#), Jinwen Zhang(#), Guangxin Xia, Yongbo Xue, Zengwei Luo, Yanyan Si, Guangmin Yao(*), Yonghui Zhang(*). A new triterpenoid from Teucrium viscidum. Molecules 2013, 18 (1), 1262−1269. (IF: 3.06)

(35) Yongji Lai(#), Shuiping Ding(#), Huiqin Qian, Jinwen Zhang, Yongbo Xue, Zengwei Luo, Guangmin Yao(*), Yonghui Zhang(*). A new lignan glucoside from the whole plants of Salvia scapiformis. Molecules 2013, 18 (9), 11377−11383. (IF: 3.06)

(36) Xincai Hao(#), Jinwen Zhang(#), Guanqun Zhan, Yongbo Xue, Zengwei Luo, Guangmin Yao(*), Yonghui Zhang(*). Chemical constituents from Teucrium viscidum. Biochemical Systematics and Ecology 2013, 51, 78−82. (IF: 1.127)

(37) 魏夏兰，舒朋华，刘婷婷，向明，张锦文，薛永波，罗增伟，姚广民(*)，张勇慧(*).川桂皮中具有免疫调节活性的甾体和苯丙素类化学成分，有机化学，2013, 33 (6), 1273−1278. (IF: 1.318)

(38) 曾红，钱慧琴，梁兆昌，杨亚军，褚洪标，张勇慧，姚广民(*). 云锦杜鹃化学成分研究，中草药，2013, 44 (22), 3123−3126.

(39) Zengwei Luo(#), Fuqian Wang(#), Jinwen Zhang, Xingyao Li, Mengke Zhang, Xincai Hao, Yongbo Xue, Yan Li, F. David Horgen, Guangmin Yao(*), Yonghui Zhang(*). Cytotoxic alkaloids from the whole plants of Zephyranthes candida. Journal of Natural Products 2012, 75 (12), 2113−2120. (IF: 4.257)

(40) Jieru Guo, Jinwen Zhang, Penghua Shu, Lingmei Kong, Hao, Xincai; Xue, Yongbo; Zengwei Luo, Gao Li, Yan Li, Guangmin Yao(*), Yonghui Zhang(*). Two new diterpenoids from the buds of Wikstroemia chamaedaphne. Molecules 2012, 17 (6), 6424−6433. (IF: 3.06)