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项光亚

领域:生物产业 学校:华中科技大学职称:教授

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教育背景

1990年毕业于华东师范大学化学系,1995年毕业于武汉大学获硕士学位;2000年毕业于同济医科大学获博士学位。

工作经历

先后在德国蒂宾根大学和美国俄亥俄州立大学分别进行为期一年进修访问。现主要从事靶向药物传递系统和药物合成研究。

项目课题经历

论文、成果、著作等

◆Yannan Yang#, Yao Lu#, Prasanna Lakshmi Abbaraju, Jun Zhang, Min Zhang,Guangya Xiang,* and Chengzhong Yu*,Multi-shelled Dendritic Mesoporous Organosilica Hollow Spheres: Roles of Composition and Architecture in Cancer Immunotherapy,Angew. Chem. Int. Ed.,2017,56:8446-8450

◆Pengxuan Zhao,Shuangping Wu,Yao Cheng,Jia You,Yan Chen,Minsi Li, Chuanchuan He,Xiaojuan Zhang,TanYang,Yao Lu,Robert J. Lee,Xingxing He, Guangya Xiang, MiR-375 delivered by lipid-coated doxorubicin-calcium carbonate nanoparticles overcomes chemoresistance in hepatocellular carcinoma,Nanomedicine: Nanotechnology, Biology, and Medicine,2017,In press.

◆Muhammad Sarfraz#, Attia Afzal1#, Shahid Masood Raza, Sajid Bashir, Asadullah Madni, Muhammad Waseem Khan, Xiang Ma*, Guangya Xiang*,Liposomal co-delivered oleanolic acid attenuates doxorubicin induced multi-organ toxicity in hepatocellular carcinoma,Oncotarget,2017,8(29):47136-47153

◆Wei Li, Mengzhu Zheng, Shuangping Wu, Suyu Gao, Mei Yang, Zhimei Li, Qiuxia Min1, Weiguang Sun,Lixia Chen*, Guangya Xiang* and Hua Li*,Benserazide, a dopadecarboxylase inhibitor,suppresses tumor growth by targeting hexokinase, Journal of Experimental & Clinic Cancer Research, 2017,36:58

◆Zhongping Hu, Shasha Zhang, Weicheng Zhou, Xiang Ma*, Guangya Xiang*,Synthesis and antibacterial activity of 3-benzylamide derivatives as FtsZ Inhibitors,Bioorganic & Medicinal Chemistry Letters,2017,27:1854-1858

◆Tan Yang#,Ling Xu#,Bin Li,Weijie Li,Xiang Ma,Lingling Fan,Robert J Lee,Chuanrui Xu*, Guangya Xiang*,Antitumor activity of a folate receptor-targeted immunoglobulin G-doxorubicin conjugate, Internatioal Journal of Nanomedicine,2017,12:2505-2515

◆ Yongkang Gai#, Lingyi Sun#, Wenqi Hui, Qin Ouyang, Carolyn J. Anderson, Guangya Xiang*, Xiang Ma*, and Dexing Zeng*,New Bifunctional Chelator p‑SCN-PhPr-NE3TA for Copper-64: Synthesis, Peptidomimetic Conjugation, Radiolabeling, and Evaluation for PET Imaging,Inorganic Chemistry,2016,55(14):6892-6901(IF=4.82)

◆ Yao Lu, Yuhua Wang, Lei Miao, Matthew Haynes, Guangya Xiang*, Leaf Huang*, Exploiting in situ antigen generation and immune modulation to enhance chemotherapy response in advanced melanoma: A combination nanomedicine approach,Cancer Letters,2016,379(1):32–38(IF=5.992)

◆Yongkang Gai, Guangya Xiang, Xiang Ma, Wenqi Hui, Qin Ouyang, Lingyi Sun, Jiule Ding, Jing Sheng, and Dexing Zeng*, Universal Molecular Scaffold for Facile Construction of Multivalent and Multimodal Imaging Probes,Bioconjugate Chemistry,2016,27:515-520(IF=4.513)

◆ Lu, Yao; Miao, Lei; Wang, Yuhua; Xu, Zhenghong; Zhao, Yi; Shen, Youqing; Xiang, Guangya*; Huang, Leaf*,Curcumin Micelles Remodel Tumor Microenvironment and Enhance Vaccine Activity in an Advanced Melanoma Model,Molecular Therapy,2016,24(2):364-374(IF=6.938)

◆ Yang, Tan; Zhao, Pengxuan; Rong, Zhao; Li, Bin; Xue, Huiying; You, Jia; He, Chuanchuan; Li, Weijie; He, Xingxing; Lee, Robert J; Ma, Xiang*; Guangya Xiang*,Anti-tumor Efficiency of Lipid-coated Cisplatin Nanoparticles Co-loaded with MicroRNA-375,Theranostics,2016,6(1):142-154(IF=8.854)

◆ Gai, YK;Hu, ZP ; Rong, Z;Ma, X*;Xiang, GY*,A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant Arm,Molecules,2015,20(10):19393-19405(IF=2.416)

◆ Zhang, Wendian; Peng, Fangqi; Zhou, Taotao; Huang, Yifei; Zhang, Li; Ye, Peng; Lu, Miao; Yang, Guang; Gai, Yongkang; Yang, Tan; Ma, Xiang*; Xiang, Guangya*,Targeted delivery of chemically modified anti-miR-221 to hepatocellular carcinoma with negatively charged liposomes,International Journal of Nanomedicine, 2015,10:4825-4836. (IF=4.195)

◆ Yifei Huang,* Tan Yang,*Wendian Zhang,Yao Lu,Peng Ye,Guang Yang,Bin Li,Shibo Qi,Yong Liu,Xingxing He,Robert J Lee,Chuanrui Xu*,Guangya Xiang*,A novel hydrolysis-resistant lipophilic folate derivative enables stable delivery of targeted liposomes in vivo,International Journal of Nanomedicine ,2014:9 4581–4595(IF=4.195)

◆ Guang Yang, Tan Yang, Wendian Zhang, Miao Lu Xiang Ma,*, and Guangya Xiang*,In Vitro and in Vivo Antitumor Effects of Folate-Targeted Ursolic Acid Stealth Liposome,J. Agric. Food Chem. 2014,62:2207-2215(IF=3.107)

◆ Peng Ye,Wendian Zhang,Tan Yang,Yao Lu,Miao Lu,Yongkang Gai,Xiang Ma*,Guangya Xiang*,Folate receptor-targeted liposomes enhanced the antitumor potency of imatinib through the combination of active targeting and molecular targeting, International Journal of Nanomedicine,2014,9:2167-2178(IF=4.195)

◆ Bin Zhao, Xianmei Shang*, Ling Xu, Wendian Zhang, Guangya Xiang*,Novel mixed ligand di-n-butyltin(IV) complexes derived from acylpyrazolones and fluorinated benzoic acids: Synthesis, characterization, cytotoxicity and the induction of apoptosis in Hela cancer cells,European Journal of Medicinal Chemistry,2014,76:87-97(IF=3.432)

◆ Zhi-Gang Cheng,Xu-Yong Dai, Li-Wei Li, Qiong Wan, Xiang Ma,* and Guang-Ya Xiang*,Synthesis and Characterization of Impurities of Barnidipine Hydrochloride, an Antihypertensive Drug Substance,Molecules,2014,19:1344-1352(IF=2.095)

◆ Miao Lu, Wendian Zhang, Yongkang Gai, Tan Yang, Peng Ye, Guang Yang, Xiang Ma* and Guangya Xiang,Folate–PEG functionalized silica CdTe quantum dots as fluorescent probes for cancer cell imaging, New Journal of Chemistry, 2014,38:4519-4526(IF=3.159)

◆ Tan Yang, Bin Li, Shibo Qi, Yong Liu, Yongkang Gai, Peng Ye, Guang Yang, Wendian Zhang, Peng Zhang, Xingxing He, Weijie Li, Zhiping Zhang, Guangya Xiang*, Chuanrui Xu*, Co-delivery of Doxorubicin and Bmi1 siRNA by Folate Receptor Targeted Liposomes Exhibits Enhanced Anti-Tumor Effects in vitro and in vivo, Theranostics, 2014,4(11):1096-1111(IF=7.827)

◆ Chang Yang, Lun Ma, Jason Maley, Ramaswami Sammynaiken,Renfei Feng, Guangya Xiang∗, and Wei Chen∗,Photoluminescence and X-Ray Excited Luminescence from Glutathione-Stabilized Gold Nanoparticles,Journal of Biomedical Nanotechnology,2013,9:1827–1836(IF=7.578)

◆ Changqin Xiao, Minqiong Tang, Jian Li, Chen-ru Yin, Guangya Xiang∗, Li Xu∗,Determination of sildenafil, vardenafil and aildenafil in human plasma by dispersive liquid–liquid microextraction-back extraction based on ionic liquid and high performance liquid chromatography-ultraviolet detection,Journal of Chromatography B,2013,931:111-116(IF=2.694)

◆ Chang Yang,Lun Ma,Xiaoju Zou,Guangya Xiang∗,Wei Chen∗,Surface plasmon-enhanced Ag/CuS nanocomposites for cancer treatment,Cancer Nano, 2013,4:81-89

◆ Xianmei Shang*, Nan Ding, Guangya Xiang*,Novel di-n-butyltin(IV) derivatives: Synthesis, high levels of cytotoxicity in tumor cells and the induction of apoptosis in KB cancer cells,European Journal of Medicinal Chemistry,2012,48:305-312(IF=3.432)

◆ Yao Lu, Nan Ding, Chang Yang, Lei Huang, Jian Liu, and Guangya Xiang∗,Preparation and in vitro evaluation of a folate-linked liposomal curcumin formulation,Journal of Liposome Research, 2012,22(2):110-119(IF=1.533)

◆ Ye, L; Huang, YF; Li; Xiang, GY; Xu, L∗,Nonaqueous capillary electrophoresis of imatinib mesylate and related substances,JOURNAL OF SEPARATION SCIENCE 2012,35(16):2108-2113(IF=2.594)

◆ Jian Li, Yifei Huang, Lei Huang, Lei Ye, Zhou Zhou, Guangya Xiang∗, Li Xu∗, Determination of imatinib mesylate and compounds by field amplified sample stacking with large volume sample injection capillary electrophoresis, Journal of Pharmaceutical and Biomedical Analysis, 2012,70:26-31(IF=2.829)

◆ Chang Yang, Wei Chen, Brian Quang Bui, and Guangya Xiang∗,Recent Progress on the Liposomes Loaded with Quantum Dots, Rev. Nanosci. Nanotechnol, 2012, 1(4):1-14

◆ Nan Ding,Yao Lu, Robert J Lee, Chang Yang, Lei Huang, Jian Liu, Guangya Xiang∗,Folate receptor targeted fluorescentparamagnetic bimodal liposomes for tumor imaging,International Journal of Nanomedicine,2011,6:2513-2520(IF=4.195)

◆ Xiaolan Qu,Chang Yang,Jing Zhang,Nan Ding,Yao Lu,Lei Huang,Guangya Xiang∗,In-vitro evaluation of a folate-bovine serum albumin doxorubicin conjugate,Journal of Drug Targeting, 2010 ,18(5): 351-61. (IF=2.723)

◆ Chang Yang, Nan Ding, Yibing Xu, Xiaolan Qu, Jing Zhang1, Chaoyang Zhao, Liang Hong, Yao Lu, Guangya Xiang*, Folate receptor–targeted quantum dot liposomes as fluorescence probes, Journal of Drug Targeting, 2009, 17(7): 502-511(IF=2.723)

◆ Guangya Xiang*,Jun Wu,Yanhui Lu, Zhilan Liu,Robert J Lee,Synthesis and evaluation of a novel ligand for folate-mediated targeting liposomes,International Journal of Pharmaceuticals,2008,356:29-36 (IF=3.785)

◆ Qi Zhang, Guang Ya Xiang*, Youjiu Zhang, et al. Increase of Doxorubicin Sensitivity for Folate Receptor Positive Cells when given as the Prodrug N-(phenylacetyl) doxorubicin in Combination with Folate-conjugated PGA,Journal of Pharmaceutical Sciences,2006, 2006, 95(10):2266-75. (IF=3.007)

专利、著作版权等

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