2007 “药品生产质量管理规范” 课程, 美国斯隆-凯特林癌症研究中心

2000 2004 理学博士, 法国巴黎第十一大学分子与材料化学学院

1999 2000 理学硕士, 法国巴黎第十一大学分子与材料化学学院

1997 1999 硕士研究生, 华中师范大学化学系

1993 1997 理学学士, 华中师范大学化学系

2014 今 副院长，华中科技大学同济药学院 2012 今 教授，博士生导师，华中科技大学同济药学院 2007 2011 研究科学家, 美国安进制药, 药物化学部 2004 2007 博士后，美国哥伦比亚大学，斯隆-凯特林癌症研究中心 2000 2004 研究助理, 法国巴黎第十一大学分子与材料化学学院

2017 Asian Core Program/Advanced Research Network Lectureship Award (from Taiwan)

2017 Asian Core Program/Advanced Research Network Lectureship Award (from Singapore)

2017 2020 国家自然科学基金面上项目No. 21672077 (直接经费：66 万)

2015 2016 华中科技大学自主创新研究基金:创新交叉重点项目(15万)

2016 2019 武汉市创新人才开发资金 (20 万)

2015 华中科技大学 “三育人奖”

2015 2017 湖北省杰出青年基金 No. 2015CFA035 (20 万)

2015 2018 国家自然科学基金面上项目No. 21472054 (85 万)

2014 华中科技大学科技创新活动优秀指导教师

2014 2015 华中科技大学自主创新研究基金: 国际科技合作专项No.2014ZZGH015 (10万)

2014 2015 上海有机化学研究所生命有机化学国家重点实验室开放基金 (5 万)

2013 湖北省特聘专家

2013 2016 国家自然科学基金面上项目No. 21272082 (80 万)

2012 2015 高等学校博士学科点专项科研基金（新教师类）No. 20120142120092 (4 万)

2012 2015 华中科技大学人才引进基金 (200 万)


2011 美国安进制药“第一届绿色药物化学奖”

2006 美国威廉和爱丽丝·古德温公益癌症研究基金会基金 (13 万美元)

2000 2004 法国外交与欧洲事务部“艾菲尔-优秀人才”国际学生奖学金

专业学会: 美国化学学会、美中生物医药协会、美中医药开发协会、中国化学会

学术兼职： 《Frontiers in Chemical Biology》Review Editor；荆楚理工学院客座教授

《The Pharmaceutical Index-Worldwide 2014 NCEs》编委会委员

48. Xu, Y.; Zhang, Q.; Xiao, Y.; Wu, P.; Chen, W.; Song, Z.; Xiao, X.; Meng, L.; Zeng, J.; Wan, Q.* “Practical Synthesis of Latent Disarmed S-2-(2-Propylthio)benzyl Glycosides for Interrupted Pummerer Reaction Mediated Glycosylation” Tetrahedron Lett. 2017, 58, 2381.

47. Zeng, J.*; Sun, G.; Yao, W.; Zhu, Y.; Wang, R.; Cai, L.; Liu, K.; Zhang, Q.; Liu, X.; Wan, Q.* “3-Aminodeoxypyranoses in Glycosylation: Diversity-Oriented Synthesis and Assembly in Oligosaccharides” Angew. Chem. Int. Ed. 2017, 56, 5227. (IF: 11.709)

• Front Cover Article: Angew. Chem. Int. Ed. 2017, 56, 5133.

•《有机化学》“亮点介绍”

• Highlighted by Wiley Advanced Science News (ASNChina)：2017 April 05

• Highlighted by Chemistryviews: A Practical Glycodiversification Method, 2017 April 14

• Highlighted by Wiley Advanced Science News (Chemviews)：2017 April 18

46. Zeng, J.; Xu, Y.; Wang, H.; Meng, L.;Wan, Q.*“Recent Progress on the Synthesis of 2-Deoxy Glycosides”Sci. China Chem.2017, 60, DOI:10.1007/s11426-016-9010-9. (IF. 2.429). Invited contribution

45. Xiao, X.; Zhao, Y.; Shu, P.; Zhao, X.; Liu, Y.; Sun, J.; Zhang, Q.; Zeng, J.; Wan, Q.* “Remote Activation of Disarmed Thioglycosides in Latent-Active Glycosylation via Interrupted Pummerer Reaction” J. Am. Chem. Soc. 2016, 138, 13402. (IF: 13.038)

• Highlighted by X-MOL: http://www.x-mol.com/news/5072

• Highlighted by Synpacts, 2017 February.

44.方静，朱阳斌，陈薇，刘艳，孙久常，曾静，万谦*“四乙酰基-d-吡喃岩藻糖的合成”中国科技论文在线, 2016,http://www.paper.edu.cn/releasepaper/content/201605-876.;中国科技论文在线精品论文, 2016, 9 (19): 2030.;Highlights of Sciencepaper Online, 2016, 9 (19): 2030.

43.舒朋华，孙久常，方静，曾静，万谦*“11(S)-药喇叭酸甲酯的制备”中国科技论文在线, 2016,http://www.paper.edu.cn/releasepaper/content/201605-599.;中国科技论文在线精品论文, 2016, 9 (13): 1288.;Highlights of Sciencepaper Online, 2016, 9 (13):1288.

• Highlighted as月热门优秀论文

• Highlighted as周热门新增论文

42.O’Cearbhaill, R. E.; Ragupathi, G.; Zhu, J.;Wan, Q.; Yang, G.; Spassova, M. K.; Iasonos, A.; Kravetz, S.; Mironov, S.; Livingston, P. O.; Ouerfelli, O.; Spriggs, D. R.; Danishefsky, S. J.; Sabbatini, P. J. “A phase I study of unimolecular pentavalent (GLOBO-H-GM2-STN-TF-TN) immunization of patients with epithelial ovarian, fallopian tube, or peritoneal cancer in first remission”Cancers2016,8, 46: doi:10.3390/cancers8040046.

41. Shu, P.; Yao, W.; Xiao, X.; Shun, J.; Zhao, X.; Zhao, Y.; Xu, Y.;Yao, G.; Zeng, J.;Wan, Q.*“Glycosylation via Remote Activation of Anomeric Leaving Groups: Development of 2-(2-Propylsulfinyl)benzyl Glycosides as Novel Glycosyl Donors”Org. Chem. Front.2016,3,177. (IF: 4.693)

• the1stEmerging Investigators Themed Collection

• Hot article in December 2015 (Org. Chem. Front.)

• Abstracted byCheminform47(24), 2016 May.

40. Li, S.; Jin, S.; Song, C.; Chen, C.; Zhang, Y.; Xiang, Y.; Xu, Y.; Feng, Y.;Wan, Q.*; Jiang, H*. “The Metabolic Change of serum lysophosphatidylcholines involved in the lipid lowering effect of triterpenes from Alismatis rhizoma on high-fat diet induced hyperlipidemia mice”J. Ethnopharmacology2016,177, 10.(IF: 3.055).

39. Shu, P.; Xiao, X.; Zhao, Y.; Tao, J.; Wang, H.; Lu, Z.; Yao, G.; Zeng, J.; Wan, Q.* “Interrupted Pummerer Reaction in Latent-Active Glycosylation: A Novel Type of Glycosyl Donors with Recyclable and Regenerative Leaving Group” Angew. Chem. Int. Ed. 2015, 54, 14432. (IF: 11.709).

• Highlighted by X-MOL: http://www.x-mol.com/news/1422

• 7th ACGG 2015 Best Poster Award, Miyagi, Japan,

• Abstracted by Cheminform 47(15), 2016 March.

• Highlighted by Synpacts, 2017 February.

• 第三届阿达玛斯学术论文奖“探索优秀奖”

38. Zhang, M.; Xie, Y.; Zhan, G.; Lei, L.; Shu, P.; Chen, Y.; Xue, Y.; Luo, Z.;Wan, Q.; Yao, G.;*Zhang, Y.*“Grayanane and Leucothane Diterpenoids from Rhododendron Micranthum and Their Immunomodulatory Activities”Phytochemistry2015,117, 107.(IF: 2.779)

37. Ma, J.; Zeng, J.;Wan, Q.*“Postligation-Desulfurization: A General Approach for Chemical Protein Synthesis”Topics in Current Chemistry2015,363, 57. (IF: 4.014)

36. Shu, P.; Zeng, J.; Tao, J.; Zhao, Y.; Yao, G.;Wan, Q.*“Selective S-deacetylation Inspired by Native Chemical Ligation:Practical Syntheses of Glycosyl Thiols and Drug Mercapto-analogues”Green Chem.2015,17, 2545. (IF: 8.506)

•第二届阿达玛斯学术论文奖“探索优秀奖”

35. Wang, H.; Tao, J.; Cai, X.; Chen, W.; Zhao, Y.; Xu, Y.; Yao, W.; Zeng, J.;Wan, Q.*“Stereoselective Synthesis of α-linked 2-Deoxy Glycosides Enabled by Visible Light Mediated Reductive Deiodination”Chem. Eur. J.2014,20, 17319.(IF: 5.771)

• Highlighted by Photocatalysis:Wiley-VCH Hot Topics

•第二届阿达玛斯学术论文奖 “探索鼓励奖”

34. Copeland, K. W.; Boezio, A. A.; Cheung, E.; Lee, J.; Olivieri, P.; Schenkel, L. B.;Wan, Q.; Wang, W.; Wells, M. C.; Youngblood, B.; Gavva, N. R.; Lehto, S. G.; Geuns-Meyer, S.Bioorg. Med. Chem. Lett.2014, 3464.(IF: 2.486)

33.张孟科, 朱焰, 詹冠群, 薛永波, 罗增伟,万谦, 姚广民*, 张勇慧, “照山白花水溶性成分研究”,中国科技论文在线, 2014,http://www.paper.edu.cn/releasepaper/content/201401-1247.

32.张孟科, 詹冠群, 雷亮, 薛永波, 罗增伟,万谦, 姚广民*, 张勇慧,“照山白枝叶化学成分研究”,中国科技论文在线, 2014,http://www.paper.edu.cn/releasepaper/content/201401-1244.；中国科技论文在线精品论文, 2015, 8 (17): 1861-1865.;Highlights of Sciencepaper Online, 2015, 8(17):1861-1865.

31. Yang, K.; Li, S.; Wang, Y.; Zhang, W.; Xu, Z.; Zhou, X.;Zhu, R.*; Luo, J.*;Wan, Q.*“Enantio-selective recognition of inherently chiral calyx[4]arene crown-6 carboxylic acid cone conformer towards chiral aminoalcohols”RSCAdvances,2014,4, 6517. (IF: 3.289)

30.Li, S.; Yang, K.; Liu, H., Xia, Y.; Zhu, R.*; Luo, J.*;Wan, Q.*“Inherently chiral biscalixarene conecone conformers consisting of calix[4]arene and calix[5]arene subunits”Tetrahedron Lett.2013,54, 5901. (IF: 2.347)

29.Zhang, M.; Zhu, Y.; Zhan, G.; Shu, P.; Sa, R.; Lei, L.; Xiang, M.; Xue, Y.; Luo, Z.;Wan, Q.; Yao, G.;*Zhang, Y.*“Micranthanone A, a New Diterpene with an Unprecedented Carbon Skeleton from Rhododendron micranthum”Org. Lett.2013, 3094. (IF: 6.732)

28.Shi, J.; Li, S.; Xia, X.; Wang, X.;*Luo, J.;*Wan, Q.“An inherently chiral calix[4]crown carboxylic acid in the 1,2-alternate conformation”J. Incl . Phenom. Macrocycl. Chem.2013, 327.(IF: 1.426)

27.Schenkel, L.; Huang, X.; Cheng, A.; Deak, H.; Doherty, E.; Emkey, R.; Gu, Y.; Gunaydin, H.; Kim, J.; Lee, J.; Loberg, R.; Olivieri, P. Pistillo, J.; Tang, J.;Wan, Q.; Wang, H.; Wang, S.; Wells, M.; Wu, B.; Yu, V.; Liu, L.; Geuns-Meyer, S.*“Discovery of Potent and Highly Selective Thienopyridine Janus Kinase 2 Inhibitors”J. Med. Chem.2011,54, 8440. (IF: 5.447)

26. Yuan, Y.; Chen, J.;Wan, Q.;Wilson, R. M.; Danishefsky, S. J.*“Toward Fully Synthetic, Homogeneous Glycoproteins: Advances in Chemical Ligation ”Biopolymers2010,94, 373. (IF: 2.248)

25. Chen, J.; Wang, P.; Zhu, J.;Wan, Q.;Danishefsky, S. J.*“A Program for Ligation at Threonine Sites: Application to the Controlled Total Synthesis of Glycopeptides”Tetrahedron2010,66, 2277. (IF: 2.645)

• Highlighted as Cover

24. Nagorny, P.; Kim, W. H.;Wan, Q.; Lee, D.; Danishefsky, S. J.*“On the Emerging Role of Chemistry in the Fashioning of Biologics: Synthesis of a Bidomainal Fucosyl GM1-Based Vaccine, for the Treatment of Small Cell Lung Cancer”J. Org. Chem.2009,74, 5157. (IF: 4.785)

• Highlighted as Featured Article

23. Zhu, J.;Wan, Q.;Lee, D.; Yang, G.;Spassova, M. K.;Ouerfelli, O.; Ragupathi, G.; Damani, P.; Livingston, P. O.; Danishefsky, S. J.*“From Synthesis to Biologics: Preclinical Data on a Chemistry Derived Anticancer Vaccine”J. Am. Chem. Soc.2009,131, 9298. (IF: 13.038)

22. Kan, C.; Trupek, J.; Wu, B.;Wan, Q.;Chen, G.; Tan, Z.; Yuan, Y.; Danishefsky, S. J.*“Toward Homogeneous Erythropoietin: Chemical Synthesis of the Ala1-Gly28 Glycopeptide Domain by “Alanine” Ligation”J. Am. Chem. Soc.2009,131, 5438. (IF: 13.038)

21. Yuan, Y.; Chen, J.;Wan, Q.;Tang, Z.; Chen, G.; Kan, C.; Danishefsky, S. J.*“Toward Homogeneous Erythropoietin: Fine Tuning of the C-Terminal Acyl Donor in the Chemical Synthesis of the Cys29–Gly77 Glycopeptide Domain”J. Am. Chem. Soc.2009,131, 5432. (IF: 13.038)

20. Zhu, J.;Wan, Q.;Ragupathi, G.; George, C. M.; Livingston, P. O.; Danishefsky, S. J.*“ Biologic Through Chemical: Total Synthesis of a Proposed Dual-Acting Vaccine Targeting Ovarian Cancer Orchestration of Oligosaccharide and Polypeptide Domains”J. Am. Chem. Soc.2009,131, 4151. (IF: 13.038)

• Highlighted inACS Chemical Biology2009, 4, 238 (spotlight).

19. Zhu, J.;Wan, Q.;Yang, G.; Ouerfelli, O.; Danishefsky, S. J.*“Synthesis of Human Cancer Associated Globo-H (MBR1) Glycosylamino Acid: Some Mechanistic and Conformational Reinvestigations”Heterocycles, 2009,79, 441. (IF: 1.107)

18. Zhu, J.;Wan, Q.;Danishefsky, S. J.*“Synthesis of Biotinylated Tumor-Associated Carbohydrate Antigens for Immunological Studies”Tetrahedron Lett.2009,50, 712. (IF: 2.347)

17. Chen, J.;Wan, Q.;Yuan, Y.; Zhu, J.; Danishefsky, S. J.*“Native Chemical Ligation at Valine: A Contribution to Peptide and Glycopeptide Synthesis”Angew. Chem.2008,120, 8649;Angew. Chem. Int. Ed.2008,47, 8521. (IF: 11.709)

16.Wan, Q.;Chen, J.; Yuan, Y.; Danishefsky, S. J.*“Oxo-ester Mediated Native Chemical Ligation: Concept and Applications”J. Am. Chem. Soc.2008,130,15814. (IF: 13.038)

• Highlighted inFaculty of 1000 Biology2009 (article ID 1147955)

15.Wan, Q.;Lubineau, A.; Guillot, R.;Scherrmann, M. -C.*“Synthesis of C-disaccharidesviaa Hetero-Diels-Alder Reaction and Further Stereocontrolled Transformations”Carbohydrate Res.2008,343, 1754-1765. (IF: 1.817).

14.Wan, Q.;Danishefsky, S. J.*“Free Radical Based, Specific Desulfurization of Cysteine: A Powerful Advance in the Synthesis of Polypeptides and Glycopolypeptides”Angew. Chem.2007,119, 9408;Angew. Chem. Int. Ed.2007,46, 9248. (IF: 11.709)

• Highlighted as a Very Important Paper (VIP)

• Highlighted inAngew. Chem. Int. Ed.2008, 47, 1553.

• Abstracted byCheminform2008, 13-185.

13. Chen, G.;Wan, Q.;Tan, Z.; Kan, C.; Hua, Z.;Ranganathan, K.;Danishefsky, S. J.*“ Development of Efficient Methods for Accomplishing Cysteine-Free Peptide and Glycopeptide Coupling”Angew. Chem.2007,119, 7527;Angew. Chem. Int. Ed.2007,46, 7383. (IF: 11.709)

• Highlighted as a Hot Paper

• Abstracted byCheminform2007, 51-199

12. Wu, B.; Tan, T.; Chen, G.; Chen, J.; Hua, Z.;Wan, Q.;Ranganathan, K.;Danishefsky, S. J.*“Mature Homogeneous Erythropoietin Building Blocks by Chemical Synthesis: The EPO 22-37 Glycopeptide Domain Presenting the FullyN-Linked Dodecasaccharide”Tetrahedron Lett.2006,47,8009. (IF: 2.347)

• Abstracted byCheminform2007, 02-181

11. Chen, J.; Chen, G.; Wu, B.;Wan, Q.;Tan, Z.; Hua, Z.; Danishefsky, S. J.*“Mature Homogeneous Erythropoietin Building Blocks by Chemical Synthesis: The EPO 114-166 Glycopeptide Domain Presenting ItsO-Linked Glycophorin”Tetrahedron Lett.2006,47, 8013. (IF: 2.347)

• Abstracted byCheminform2007, 02-182

10.Wan, Q.;Chen, J.; Chen, G.; Danishefsky, S. J.*“A Valuable Advance in the Synthesis of Carbohydrate Based Anticancer Vaccines Through Extended Cycloaddition Chemistry:”J. Org. Chem.2006,71, 8244. (IF: 4.785)

• Abstracted byCheminform2007, 01-187

9. Wu, B.; Hua, Z.; Warren, D. J.;Ranganathan, K.;Wan, Q.;Chen, G.; Tang, Z.; Chen, J.; Endo, A.;Danishefsky, S. J.*“Synthesis of the BiantennaryN-Glycan of Erythropoietin”Tetrahedron Lett.2006,47, 5577. (IF: 2.347)

8. Chen, J.; Warren, D. J.; Wu, B.; Chen, G.;Wan, Q.;Danishefsky, S. J.*“ Synthesis of Cyclic Peptides and Glycopeptides by Native Chemical Ligation Usingin situDerived Thioester”Tetrahedron Lett.2006,47, 1969. (IF: 2.347)

7. Chen, G.; Warren, D. J.; Chen, J.; Wu, B.;Wan, Q.;Danishefsky, S. J.*“New Chemical Ligation Method for Peptide Synthesis: Concept, Model Study, and Mechanistic Investigation”J. Am. Chem. Soc.2006, 7460. (IF: 13.038)

• Highlighted inChem. Eng. News, 2006, 84 (June, 5).

6. Ragupathi, G.; Koide, F.; Livingston, P. O.; Cho, Y. S.; Atsushi, E.;Wan, Q.;Spassova, M. K.; Keding, S. J.; Allen, J.; Ouerfelli, O.; Wilson, R. M.; Danishefsky, S. J.*“Preparation and Evaluation of Unimolecular Pentavalent and Hexavalent Antigenic Constructs Targeting Prostate and Breast Cancer: A Synthetic Route to Anticancer Vaccines Candidates”J. Am. Chem. Soc.2006, 2715. (IF: 13.038)

•科学通报 2008, 53, 17, 2126. 动态报道

5.Wan, Q.;Cho, Y. S.; Lambert, T. H.; Danishefsky, S. J.*“Olefin Cross-Metathesis: A Powerful Tool for Constructing Vaccines Composed of Multimeric Antigens.”J. Carbohydr.Chem.2005,24, 425. (IF: 0.738)

4. Cho, Y. S.;Wan, Q.;Danishefsky, S. J.*“Organic Synthesis in Pursuit of Immunology: Large Scale Synthesis of Peracetylated GM2Glycosylamino Acid for Preparation of a Multiantigenic Prostate Cancer Vaccine”Bioorg. Med. Chem.2005,13, 5259. (IF: 2.932)

3.Wan, Q.*“Di-n-butyltin oxide (DBTO)”Synlett.2004, 1847. (IF: 2.323)

2.Wan, Q.;Lubineau, A.*; Scherrmann, M. -C.*“Synthesis ofC-3 branched allyl and pentadienyl glucosaminesviaradical coupling of sugar-thionocarbonates.”J. Carbohydr.Chem.2004,23, 83. (IF: 0.738)

• Abstracted byCheminform2004, 41-190

1. Yu, X.Y.; Lu, B. X.;Wan, Q.;Wang, Y. G.*“Synthesis and biological activity of Schiff base on carboxylate of triazole.”J. Central China Normal. University. (Natural Sciences).1999,225.