1994.9-1998.6同济医科大学 药学学士

1998.9-2001.6浙江大学 药剂学硕士

2003.9-2006.6华中科技大学药理学博士

2009.11-华中科技大学同济医学院药学院药学系，副教授 2011.10-2012.10 University of Toronto, Leslie Dan Faculty of Pharmacy国家公派访问学者（博士后） 2003.9-2009.10华中科技大学同济医学院药学院药学系，讲师 2001.9-2003.8华中科技大学同济医学院药学院药学系，助教

1）新型肾上腺素受体和受体双重阻断药物-TJ0711的研发，国家科技部重大专项（2009ZX09103-146，2012ZX09102101-016），第二

2）VP16纳米粒对肝药酶功能的影响及作用机制研究,华中科技大学自主创新前沿探索项目，主持

3）药用辅料促进肠道pept1转运作用及其机理研究，国家自然科学基金（30903025），主持

4）具有P-gp药泵/CYP3A药酶双重抑制作用的促口服吸收载药系统的构建与机制研究，国家自然科学基金（30873171）

5）IBL胶囊剂的研发（3.1类）.企业课题，主持

6）VIN滴眼剂的研究.武汉新药创制平台项目.主持

7）米力农注射剂安全性评价.企业课题，主持

[1]Gang Zhao,Jiangeng Huang,Kewen Xue,Luqin Si*,Gao Li. Enhanced intestinal absorption of etoposide by self-microemulsifying drug delivery systems: roles of P-glycoprotein and cytochrome P450 3A inhibition.Eur J Pharm Sci,.2013; 20; 50(3-4):429-39.

[2] Jiangeng Huang, Lei Hu, Li Xu, Minghui Sun, Zhaoze Fan, Jun Qiu, Gao Li,Luqin Si *. In vitro enantioselective metabolism of TJ0711 hydrochloride by human liver microsomes using a novel chiral liquid chromatography-tandem mass spectrometry method.J Chromatogr B Analyt Technol Biomed Life Sci.2012; 891-892:98-101.

[3] Minghui Sun, Xuezhen Zhai, Kewen Xue, Lei Hu, Xiangliang Yang, Gao Li,Luqin Si *. Intestinal absorption and intestinal lymphatic transport of sirolimus from self-microemulsifying drug delivery systems assessed using the single-pass intestinal perfusion (SPIP) technique and a chylomicron flow blocking approach: linear correlation with oral bioavailabilities in rats. Eur J Pharm Sci, 2011; 14;43(3):132-40.

[4] Jiangeng Huang,Luqin Si, Zhaoze Fan, Lei Hu, Jun Qiu, Gao Li*. In vitro metabolic stability and metabolite profiling of TJ0711 hydrochloride, a newly developed vasodilatory β-blocker, using a liquid chromatography-tandem mass spectrometry method.J Chromatogr B Analyt Technol Biomed Life Sci,2011;879(30):3386-92.

[5] AK Rabba,Luqin Si, Kewen Xue, Ming Li, Gao Li*.In Situintestinal perfusion of irinotecan: application to P-gp mediated drug interaction and introduction of an improved HPLC assay.J Pharm Pharm Sci,2011;14(2):138-47.

[6] Minghui Sun,Luqin Si, Xuezhen Zhai, Zhaoze Fan, Yiming Ma, Rui Zhang, Xiangliang Yang*. The influence of co-solvents on the stability and bioavailability of rapamycin formulated in self-microemulsifying drug delivery systems.Drug Dev Ind Pharm,2011;37(8):986-94. [6] Guan Yanbin, Huang Jiangeng, Zuo Lan, Xu Jiaqiang,Si Luqin, Qiu Jun, Li Gao. Effect of pluronic P123 and F127 block copolymer on P-glycoprotein transport and CYP3A metabolism.Arch Pharm Res,2011;34(10): 1719-28.

[7] Ming Li,Luqin Si, Hongping Pan, AK Rabba, Fang Yan, Jun Qiu, Gao Li. Excipients enhance intestinal absorption of ganciclovir by P-gp inhibition: assessedin vitroby everted gut sac andin situby improved intestinal perfusion.Int J Pharm, 2011;403(1-2): 37-45.

[8]Yanbin Guan,Jiangeng Huang,Lan Zuo, Jiaqiang Xu,Luqin Si, Jun Qiu, Gao Li*. Effect of pluronic P123 and F127 block copolymer on P-glycoprotein transport and CYP3A metabolism.Arch Pharm Res.2011,34(10):1719-1728.

[9] Zhaoze Fan,Luqin Si *, Li Xu, Yiming Ma, Le Hu i, Jun Qiu, Gao Li*. Determination of TJ0711 hydrochloride in rat plasma by high performance liquid chromatography with fluorescence detection and its application to pharmacokinetics.J Chromatogr B Analyt Technol Biomed Life Sci,2010;878(22): 2035-2038.

[10] Zichao Rao,Luqin Si, Yanbin Guan, Hongping Pan, Jun Qiu, Gao Li*. Inhibitive effect of cremophor RH40 or tween 80-based self-microemulsiflying drug delivery system on cytochrome P450 3A enzymes in murine hepatocytes.J Huazhong Univ Sci Technolog Med Sci,

[11] Sun Shuping,Si Luqin, Fan Zhaoze, Qiu Jun, Li Gao. Stereoselective HPLC assay of TJ0711 enantiomers by precolumn derivatization with GITC using UV detection and its application in pharmacokinetics in rats.J Huazhong Univ Sci Technol [Med Sci], 2009;29(4): 427-430.

[12]Luqin Si, Ying Zhao, Sha Li, Xuezhen Zhai, Gao Li*. Calcium pectinate gel bead intended for oral protein delivery: preparation improvement and formulation development.Chem Pharm Bull,2009;57(7): 663-667.

[13] Xiuhua Ren, Xinliang Mao, Lei Cao, Kewen Xue,Luqin Si *, Jun Qiu, D Aaron. Schimmer and Gao Li. Nonionic surfactants are strong inhibitors of cytochrome P450 3A biotransformation activity in vitro and in vivo.Eur J Pharm Sci ,2009;36(4-5): 401-411.

[14]LuqinSi,Ying Zhao,Jiangeng Huang, Sha Li, Xuezhen Zhai, Gao Li. Calcium pectinate gel bead intended for oral protein delivery: preparation improvement and formulation development.Chem Pharm Bull.2009; 57(7):663-667.

[15] Luqin Si, Gao Li, Sanlan Wu,Jiangeng Huang, Dapeng Wu, Quan Gan. Disposition and tissue distribution of ML12 in rats.J Huazhong Univ Sci Technolog Med Sci.2008; 28(2):125-127.

[16]Jiangeng Huang,Luqin Si, Lingli Jiang, Zhaoze Fan, Jun Qiu, Gao Li*. Effect of pluronic F68 block copolymer on P-glycoprotein transport and CYP3A4 metabolism.Int J Pharm；2008; 356(1-2):351-353.

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