教育背景
工作经历
华中科技大学同济医学院附属协和医院药剂科副主任,西院药剂科主任,美国佛罗里达大学访问学者。
项目课题经历
2017-2020基于糖皮质激素代谢组学研究客观化诠释柴胡疏肝散“疏肝解郁”的作用机制。国家自然科学基金项目,No 81673715,负责人
2015-2018 利用PBPK模型整合生理、代谢酶与转运体等多种因素系统研究辣椒素-药物相互作用。国家自然科学基金项目,No 81473287,负责人
2015-2017 基于糖皮质激素代谢组学的金丝桃素抗抑郁作用机制的研究。国家自然科学基金项目,No81403012,第二研究者
2014-2015 抑郁症患者糖皮质激素代谢组学研究。湖北省自然科学基金项目,No 2013CFC042,负责人
2012-2013 辣椒素对辛伐他汀降脂疗效的影响及机制研究。华中科技大学创新研究基金(专项),No 01-18-530034,负责人
2007-2009 荧光偏振免疫法测定环孢素A全血浓度专用试剂盒和地高辛血清浓度专用试剂盒的研制。 武汉市重点科技攻关计划项目,No 200760423152 ,负责人
2007-2009 治疗药物监测试剂盒的研制与评价。湖北省科技攻关项目,No 2007AA301B23-4,负责人
2007-2008 Steigerwald Arzneimittelwerk GmbH,Darmstadt,Germany. Effects of St John Wort in modulating the immune and inflammatory response in depressant rats induced by chronic restraint
2007-2008 University of Florida Evaluation of potential central nervous system activities of a Mangosteen fruit extract (Garcinia mangosteen)
论文、成果、著作等
Wang N, Zhu C, Zhang X, et al. Food–drug interactions involving multiple mechanisms: A case study with effect of Capsaicin on the pharmacokinetics of Irinotecan and its main metabolites in rat[J]. Journal of Functional Foods, 2018, 40:292-298.
Qin Y, Wang N, Zhang X, et al. IDO and TDO as a potential therapeutic target in different types of depression[J]. Metabolic Brain Disease, 2018:1-14.
Darbalaei S, Zhang X, Wang N, et al. Effects of aprepitant on the pharmacokinetics of imatinib and its main metabolite in rats.[J]. Die Pharmazie, 2018, 73(6):329.
秦琰杰, 汪难喜, 张新林,等. 药物代谢酶和转运体介导的辣椒素-药物相互作用研究进展[J]. 中国药学杂志, 2018, 53(1):1-5.
汪难喜, 张新林, 翟学佳,等. 超滤法测定辣椒素对辛伐他汀血浆蛋白结合率的影响[J]. 中国药学杂志, 2017, 52(22):2018-2022.
Development of LC-MS/MS Method for Simultaneous Determination of Irinotecan and Its Main Metabolites in Rat Plasma, and Its Application in Pharmacokinetic Studies[J]. Chromatographia,2017,80(1):77-85.
Capsaicin induces metabolism of simvasatin in rat: involvement of upregulating expression of Ugt1a1 [J]. Die Pharmazie.2016,71(5):269-273.
LC-MS/MS based studies on the anti-depressant effect of hypericin in the chronic unpredictable mild stress rat model .Journal of Ethnopharmacology 169(2015), 363-369
A simple LC-MS/MS method for quantitative analysis of underivatized neurotransmitters in rats urine: assay development, validation and application in the CUMS rat model. Biomedical Chromatography 2015
A simple LC-MS/MS method for the determination of cortisol, cortisone and tetrahydro-metabolites in human urine: assay development, validation and application in depression patients. Journal of Pharmaceutical and Biomedical Analysis 107(2015), 450-455
Capsaicin pretreatment increased the bioavailability of cyclosporin in rats: Involvement of P-glycoprotein and CYP 3A inhibition. Food Chem Toxicol. 62, pp 323-328, 2013.
Comparative Bioavailability and Tolerability of a Single 2-mg Dose of 2 Repaglinide Tablet Formulations in Fasting, Healthy Chinese Male Volunteers: An Open-Label, Randomized-Sequence, 2-Period Crossover Study. Curr Ther Res. 75, pp 48-52, 2013.
Comparative Bioavailability and Tolerability of Single and Multiple Doses of 2 Diclofenac Sodium Sustained-Release Tablet Formulations in Fasting, Healthy Chinese Male Volunteers. Curr Ther Res. 75, pp 53-58, 2013.
Development and validation of a simple LC method for the determination of phenacetin, coumarin, tolbutamide, chlorzoxazone, testosterone and their metabolites as markers of cytochromes 1A2, 2A6, 2C11, 2E1 and 3A2 in rat microsomal medium. Pharmazie 68: 19–26 (2013)
Food - drug interactions: Effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats. Food Chem Toxicol. 2013 Mar; 53:168-73
Pharmacokinetic and pharmacodynamic interactions of ethanol and propofol in rabbits. Chromatographia.2010.72.981-985
Mechanism of St. John's wort extract (STW3-VI) during chronic restraint stress is mediated by the interrelationship of the immune, oxidative defense, and neuroendocrine system. Neuropharmacology. 2010 Mar-Apr;58(4-5):767-73.
Food–drug interactions: efect of capsaicin on the pharmacokinetics of galantamine in rats. Xenobiotica, 1366-5928,2012.5
Lc-ms/ms法测定肝微粒体孵育体系中伊立替康活性代谢物及其次级代谢产物浓度. 中国药师[J],2017,20(2):238-241.
Hplc-ms/ms法测定大鼠血浆中长春花碱的浓度及药动学研究. 中国药师,2016,19(2):218-221.
Hplc法同时测定白花蛇舌草中7种活性成分的含量[J]. 中国药师,2016,19(1):70-72.
头孢地尼在健康人体中生理药动学模型的建立与应用[J].中国药房,2016,27(35):4920-4923.
液相色谱-串联质谱联用法测定人血浆中头孢地尼的浓度及生物等效性研究[J].中国医院用药评价与分析, 2016,16(8):1014-1017.
cocktail探针药物法评价辣椒素对大鼠CYP1A2, 2C11和3A作用的研究,中国药学杂志,2013, 48(5): 42-46.
高效液相-质谱串联法测定大鼠血浆中辛伐他汀和辛伐他汀酸的浓度。中国医院药学杂志,2013,33(2): 121-125
高效液相色谱柱后修饰荧光检测法测定大鼠血浆中氢溴酸加兰他敏的浓度。中国医院药学杂志,2012,32(24): 1968-1971
抗抑郁药作用靶标下丘脑-垂体-肾上腺轴的研究进展。医药导报,2013,32 (1): 56-59
LC-MS/MS测定人血浆中辛伐他汀及其活性代谢物的含量。药物分析杂志,2012;32(9):1617-1622
辛伐他汀片及其活性代谢产物在中国健康人体的药动学和生物等效性评价。中国医院药学杂志,2012,32(19): 1530-1533
复方川脊片中3中活性成分的含量测定. 医药导报,2012;31(3):355-357
正交设计法优化大鼠肝细胞色素P450的孵育体系. 中国医院药学, 2012;32(4):283-285
健脑合剂的质量控制方法研究. 医药导报, 2012; 31:84-86
复方川脊片溶出度的测定. 中国药师, 2012; 15:227-229
RP-HPLC法同时测定健脑合剂中大黄素和齐墩果酸的含量. 中国药师, 2012;15:61-63
RP-HPLC法同时测定四物合剂中4种活性成分的含量。中国医院药学杂志。2011,31(4)
头孢克洛分散片健康人体药动学与生物等效性评价[J]。医药导报,2010,29(5):597-600.
专利、著作版权等
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