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刘熙秋

领域:生物产业 学校:华中科技大学职称:副教授

研究方向: 天然多糖的生物材料应用 药物筛选体外模型的构建...

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教育背景

2007年中国科学技术大学生命科学本科,2012年中国科学技术大学生物材料博士

工作经历

2012.10-2013.03法国格勒诺布尔国立理工学院博士后,2013.04-2016.12法国国家科学院研究员。

项目课题经历

1. 国家自然科学基金青年基金:构建基质硬度与生长因子可控动态模型研究肝癌发展中的细胞行为和分子机制,2019.01-2021.12,负责人。

2. 华中科技大学自主创新研究基金项目面上项目:体外构建可控微环境模型研究肝癌发展中的细胞行为和药物响应性机制,2018.01-2020.12,负责人。

3. 湖北省自然科学青年基金:体外模拟肝癌发生发展的力学环境对细胞行为和药物响应性的影响和机理研究,2018.01-2019.12,负责人。

4. 华中科技大学引进人才基金:细胞微环境的体外构建与界面生物功能调控,2016.12-2019.12,负责人。

5. 法国癌症研究协会青年研究员基金:Délivrance de chimiokines par la surface d'un biomatériau par un film à base de biopolymères: impact sur l'adhesion et la migration de myoblastes et cellules cancéreuses(生物膜输送生长因子对纤维细胞分化和癌细胞迁移行为的影响),2013.04-2016.03,负责人。

论文、成果、著作等

1. Tang R.Z., Gu S.S., Chen X.T., He L.J., Wang K.P. and LIU X.Q.* Immobilized Transforming Growth Factor-Beta 1 in a Stiffness-Tunable Artificial Extracellular Matrix Enhances Mechanotransduction in the Epithelial Mesenchymal Transition of Hepatocellular Carcinoma. ACS Applied Materials & Interfaces, 2019, 11, 14660-14671(IF=8.456)

2. LIU X.Q.* and Tang R.Z.; Localized delivery of chemokine for in vitro manipulation of hepatocellular carcinoma cell behaviors during the epithelial–mesenchymal transition. Journal of Biomaterials Applications, 2018, 32, 945–956(IF=2.442)

3. LIU X.Q.* and Tang R.Z.; Biological responses to nanomaterials: understanding nano-bio effects on cell behaviors. Drug Delivery, 2017, 24, 1-15(发表当年IF= 6.402)

4. LIU X.Q.*, Fourel L., Dalonneau F., Sadir R., Lortat-Jacob H., Weidenhaupt M., Albiges-Rizo C., and Picart C.*; Biomaterial-enabled delivery of SDF-1α at the ventral side of breast cancer cells reveals a crosstalk between cell receptors to promote the invasive phenotype. Biomaterials, 2017, 127, 61-74(IF= 10.273)

5. LIU X.Q.*, Picart C.*; Layer-by-layer assemblies for cancer research and treatments, Advanced Materials, 2016, 28, 1295–1301(IF= 25.809)

6. Dalonneau F., LIU X.Q.(共第一作者), Sadir R., Almodovar J., Mertani HC., Albiges-Rizo C., Bruckert F., Weidenhaupt M., Lortat-Jacob H., and Picart C.*; The effect of delivering the chemokine SDF-1α in a matrix-bound manner on myogenesis. Biomaterials, 2014, 35, 4525–4535(IF=10.273)

7. LIU X.Q., Sun C.Y., Yang X.Z., and Wang J.*; Polymeric-micelle-based nanomedicine for siRNA delivery. Particle & Particle Systems Characterization, 2013, 30, 211-228(IF= 4.194)

8. LIU X.Q., Xiong M.H., Shu X.T., Tang RZ., and Wang J.*; Therapeutic delivery of siRNA silencing HIF-1 Alpha with micellar nanoparticles inhibits hypoxic tumor growth. Molecular Pharmaceutics, 2012, 9, 2863-2874 (IF= 4.396)

9. LIU X.Q., Song W.J., Sun T.M., Zhang P.Z., Wang J.*; Targeted delivery of antisense inhibitor of miRNA for antiangiogenesis therapy using cRGD-functionalized nanoparticles. Molecular Pharmaceutics, 2011, 8, 250-259(IF= 4.396)

10. LIU X.Q., Du, J.Z., Zhang C.P., Zhao F., Yang X.Z., and Wang J.*; Brush-shaped polycation with poly(ethylenimine)-b-poly(ethylene glycol) side chains as highly efficient gene delivery vector. International Journal of Pharmaceutics, 2010, 392, 118-126(IF= 4.213)

11. Wang Y.C., LIU X.Q. (共第一作者), Sun T.M., Xiong M.H., and Wang J.*; Functionalized micelles from block copolymer of polyphosphoester and poly(e-caprolactone) for receptor-mediated drug delivery. Journal of Controlled Release, 2008, 128, 32-40(IF= 7.901)

专利、著作版权等

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