1978毕业于同济医科大学药学专业

留校任教以来一直从事“生物药剂学与药物动力学”、“药剂学”和“临床药学”的教学及科研工作。1986.9-1987.7在广州外国语学院学习德语，获DAAD语言合格证书。1988.6-1989.10在德国Tubingen大学人体药理研究所学习（访问学者），1998.10-1990.6在德国Stuttgart市Dr. Margarete Fischer-Bosch临床药理研究所学习（访问学者），1997.1-1998.1在德国Heidelberg大学药剂与生物药剂研究所学习（高级访问学者）。

1．国家科技部重大专项：新型肾上腺素受体和受体双重阻断药物-TJ0711的研发2012.1-2015.12，滚动课题编号：2012ZX09102101-016

2．国家科技部重大专项：新型肾上腺素受体和受体双重阻断药物-TJ0711的研发2009.1-2013.12课题编号：2009ZX09103-146

3．国家自然科学基金： 具有P-gp药泵/CYP3A药酶双重抑制作用的促口服吸收载药系统的构建与机制研究2009.1~2011.12

课题编号：30873171

4．国家自然科学基金： 抑制小肠P-gp药泵和/或CYP3A4药酶作用的药用辅

料与药物生物利用度关系研究2006.1~2008.12

课题编号：30572265

5.国家自然科学基金： 小肠P-gp药泵作用与药物生物利用度关系的研究

2001.1~2003.12 课题编号：30070899

6.国家自然科学基金： 药物两对映体间的相互作用研究 95.1~97.12,

课题编号：39470822

7.教育部骨干教师基金： P-gp介导的MDR逆转剂与药物生物利用度的关系研究2000.1~2002.12

8.科技部“863”项目： 纳米生物磁靶向药囊治疗肝胆胰恶性肿瘤的研究

(副组长)2003.1~2005.12编号：2002AA214061

9.湖北省自然科学基金： 药物制剂生物有效度理论研究, 93.1~95.12

10.湖北省自然科学基金： 地高辛小肠外吸渗作用与血药浓度关系

19 99.1~2000.12

11.湖北省科委攻关课题：新型抗高血压药物MELE的药效学和药动学研究

2003.8-2005.8

12.湖北省科委攻关课题：双氯芬酸钾速释、缓释双层片的研制

2001.8-2003.8

1]Gang Zhao,Jiangeng Huang, Kewen Xue, Luqin Si*, Gao Li. Enhanced intestinal absorption of etoposide by self-microemulsifying drug delivery systems: roles of P-glycoprotein and cytochrome P450 3A inhibition.Eur J Pharm Sci,.2013; 20; 50(3-4):429-39.

[2]Jiangeng Huang, Juanjuan Liu, Cong Zhang, Jiaojiao Wei, Li Mei, Shan Yu, Gao Li*, Li Xu*. Determination of sulfonamides in food samples by membrane-protected micro-solid phase extraction coupled with high performance liquid chromatography.J Chromatogr A.2012;1219:66-74.

[3] Jiangeng Huang, Lei Hu, Li Xu, Minghui Sun, Zhaoze Fan, Jun Qiu, Gao Li,Luqin Si*. In vitro enantioselective metabolism of TJ0711 hydrochloride by human liver microsomes using a novel chiral liquid chromatography-tandem mass spectrometry method.J Chromatogr B Analyt Technol Biomed Life Sci.2012; 891-892:98-101.

[4] Minghui Sun, Xuezhen Zhai, Kewen Xue, Lei Hu, Xiangliang Yang, Gao Li, Luqin Si*. Intestinal absorption and intestinal lymphatic transport of sirolimus from self-microemulsifying drug delivery systems assessed using the single-pass intestinal perfusion (SPIP) technique and a chylomicron flow blocking approach: linear correlation with oral bioavailabilities in rats. Eur J Pharm Sci, 2011; 14;43(3):132-40.

[5] Jiangeng Huang, Luqin Si, Zhaoze Fan, Lei Hu, Jun Qiu, Gao Li*. In vitro metabolic stability and metabolite profiling of TJ0711 hydrochloride, a newly developed vasodilatory β-blocker, using a liquid chromatography-tandem mass spectrometry method.J Chromatogr B Analyt Technol Biomed Life Sci,2011;879(30):3386-92.

[6] AK Rabba, Luqin Si, Kewen Xue, Ming Li, Gao Li*.In Situintestinal perfusion of irinotecan: application to P-gp mediated drug interaction and introduction of an improved HPLC assay.J Pharm Pharm Sci,2011;14(2):138-47.

[7] Guan Yanbin, Huang Jiangeng, Zuo Lan, Xu Jiaqiang, Si Luqin, Qiu Jun, Li Gao*. Effect of pluronic P123 and F127 block copolymer on P-glycoprotein transport and CYP3Ametabolism.Arch Pharm Res,2011;34(10): 1719-28.

[8] Ming Li, Luqin Si, Hongping Pan, AK Rabba, Fang Yan, Jun Qiu, Gao Li*.Excipients enhance intestinal absorption of ganciclovir by P-gp inhibition: assessed in vitro by everted gut sac and in situ by improved intestinal perfusion.Int J Pharm, 2011;403(1-2): 37-45.

[9] Zhaoze Fan, Luqin Si*, Li Xu, Yiming Ma, Le Hu i, Jun Qiu, Gao Li*.Determination of TJ0711 hydrochloride in rat plasma by high performance liquid chromatography with fluorescence detection and its application to pharmacokinetics.J Chromatogr B Analyt Technol Biomed Life Sci, 2010;878(22): 2035-2038.

[10] Zichao Rao, Luqin Si, Yanbin Guan, Hongping Pan, Jun Qiu, Gao Li*. Inhibitive effect of cremophor RH40 or tween 80-based self-microemulsiflying drug delivery system on cytochrome P4503Aenzymes in murine hepatocytes. 2009；J Huazhong Univ Sci Technolog Med Sci,

[11] Sun Shuping,Si Luqin, Fan Zhaoze, Qiu Jun, Li Gao*. Stereoselective HPLC assay of TJ0711 enantiomers by precolumn derivatization with GITC using UV detection and its application in pharmacokinetics in rats.J Huazhong Univ Sci Technol Med Sci, 2009; 9(4): 427-430.

[12] Luqin Si, Ying Zhao, Sha Li, Xuezhen Zhai, Gao Li*. Calcium pectinate gel bead intended for oral protein delivery: preparation improvement and formulation development.Chem Pharm Bull,2009; 7(7): 663-667.

[13] Xiuhua Ren, Xinliang Mao, Lei Cao, Kewen Xue, Luqin Si*, Jun Qiu, D Aaron. Schimmer and Gao Li. Nonionic surfactants are strong inhibitors of cytochrome P4503Abiotransformation activity in vitro and in vivo.Eur J Pharm Sci,2009; 6(4-5): 401-411.

[14]Pan HP,Li G*.Protecting mechanism of puerarin on the brain neurocyte of rat in acute local ischemia brain injury and local cerebral ischemia-reperfusion injury.Yakugaku Zasshi. 2008; 128(11):1689-1698.

[15] Luqin Si, Gao Li*, Sanlan Wu,Jiangeng Huang, Dapeng Wu, Quan Gan. Disposition and tissue distribution of ML12 in rats.J Huazhong Univ Sci Technolog Med Sci.2008; 28(2):125-127.

[16]Jiangeng Huang, Luqin Si, Lingli Jiang, Zhaoze Fan, Jun Qiu, Gao Li*. Effect of pluronic F68 block copolymer on P-glycoprotein transport and CYP3A4 metabolism.Int J Pharm.2008; 356(1-2):351-353.

[17]. Self-microemulsifying drug delivery system (SMEDDS) of vinpocetine: formulation development and in vivo assessment. Biol Pharm Bull. 2008, 31(1):118-125.

[18]. Pharmaceutical Excipients Inhibit Cytochrome P450 Activity in Cell Free Systems and After Systemic Administration.Eur. J. Pharm. Biopharm.2008;70(1):279-288.

[19]. Interaction of arginine oligomer with medel membrane.Biochem Biophys Res Commun. 2007, 359(4):1024-1029. (SCI)

[20]Wu xianggen,Gao yongliang,Ligao.Optimization of the preparation of nalmefene-loaded sustained-release microspheres using central composite design.Chem Pharm Bull, 2006，54(7):977-981.

[21]Gao Li, Pei-Li Gong, Jun Qiu, et. al. Stereoselective steady state disposition and action of propafenone in Chinese subjects. Br. J. Clin. Pharmacol. 1998: 46: 441~445

[22]Disposition of ibuprofen in patients with liver cirrhosis. Clin. Pharmacokinet. 1993; 25: 154~163

[23]Is cyclosporin A an inhibitor of drug metabilism? Br. J. Clin. Pharmacol.[16]1990;30:71~77

[24]Inhibitory effect of omeprazole on the metabolism of midazolam in vitro. Drug Research 1990;40：1105~1107

[25]The ibuprofen-cimetidine interaction-stereochemical consideration. Drug Investigation. 1989;1:11~17

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