1)纵向科研课题

国家自然科学基金课题，基于脂质代谢组学探究抗精神分裂症药物诱导新生糖尿病和胰岛素抵抗的缘由和作用研究（50.00万，2016.1-2019.12，NO.81573509）

‚湖北省自然科学基金课题。长期服用抗抑郁药诱发新生糖尿病和胰岛素抵抗的原因探究和机制研究（3.0万）。2015CFB446,2015,1~2016.1。

ƒ十三五重大新药创制课题,2014ZX09101009,原创国家1.1类新药盐酸去甲乌药碱的试生产技术研究,2014/01~2016/12，218.58万，在研、主持。

④十二五重大新药创制课题,2011ZX09101-002-06,原创国家1.1类新药盐酸去甲乌药碱注射液的临床研究,2011/01~2013/12，300.0万、已结题、主持。

⑤十二五重大新药创制课题,2011ZX09302-002-01,创新生物药临床研究技术平台建设,2010/01~2013/12,1800万,药代动力学技术平台建设负责人,已结题、参与。

⑥国家自然科学基金面上项目，30271552，聚合物修饰的蓖麻毒素A链在肿瘤细胞内靶向释放，2003/01~2005/12,18.0万元，已结题、主持。

⑦武汉市科委资助课题，适配分子介导的蓖麻毒素A链在肿瘤细胞内靶向释，2010/01~2011/12，8.0万、已结题、主持。

⑧湖北省科委科研课题《肿瘤血管栓塞剂—白芨微球的研制与开发》（2002~2004）、《肿瘤热敏靶向脂质体的研制与开发》（2003~2005）、国家中医药管理局资助课题《榄香烯靶向纳米微乳冻干粉针的研制》（2005~2007）、湖北省自然科学基金《靶向肝星状细胞己酮可可碱纳米脂质体的研制和肝纤维化治疗》（2005ABA170）、华中科技大学医工交叉合作项目《高纯度蓖麻毒素A链的制备和靶向药物制剂的研制》（2004）和《蓖麻毒素A链肿瘤细胞靶向前药的研究》（2007，华中科技大学校内资助项目）、十一五重大新药创制“肿瘤靶向聚合物修饰的蓖麻毒素A链前药的研制”（2010~2011）等

2）新药临床安全性和药代评价

·生物制品1类新药“注射用鼠抗人T淋巴细胞CD25抗原单克隆抗体WuTac在健康志愿者和肾移植患者的耐受性和药代动力学研究”（武汉生物制品研究所）；

·生物制品1类类新药“注射用重组人甲状旁腺激素在健康志愿者的耐受性和药代动力学研究”（北京双鹭制药有限公司）；

·全球首创化学1.1类新药“巴替非班注射液在健康志愿者的耐受性和药代动力学研究”（百奥泰生物科技（广州）有限公司）；

·3.1类新药“盐酸美普他酚片、注射液在中国健康志愿者的药代动力学研究”（浙江仙琚制药有限公司）

3）新药动物药代评价

·马来酸氟伏沙明缓释片在比格犬中的药代动力学试验研究（珠海丽珠）；

·注射用三花冻干粉针比格犬药代动力学试验研究（珠海丽珠）

·埃索美拉唑肠溶胶囊beagle犬药代动力学研究（河南天方药业）

2．中国食品药品监督管理局新药审评中心：2003.2~2003.11

国家新药审评中心审评三部，特聘外聘专家，从事进口药的技术审评。

3．访问研究员：

· 2000、1-2000、8：在加拿大BC肿瘤研究中心高级治疗部（Dr.Lawrence），参与肿瘤热敏靶向脂质体的研究（国家留学基金委资助）

· 2000、9-2001、6：在加拿大多伦多大学药学院药物化学实验室（Dr.Kotra）从事肝炎丙肝病毒蛋白酶抑制剂的设计与合成（国家留学基金委资助）。

Mingzhen Xu, Yang Ni, Shihong Li, Juan Du, Huqun Li, Ying Zhou, Weiyong Li, Hui Chen. Development and validation of a rapid LC–MS/MS method forsimultaneous determination of netupitant and palonosetron inhuman plasma and its application to a pharmacokinetic study. Journal of Chromatography B. 2016; 1027: 187–193. IF：2.687

2. Mingzhen Xu#, Yang Ni#, Ying Zhou, Xiaomeng He, Huqun Li, Hui Chen*, Weiyong Li*. Pharmacokinetics and Tolerability of Rufinamide Following Single and Multiple Oral Doses and Effect of Food on Pharmacokinetics in Healthy Chinese Subjects. Eur J Drug Metab Pharmacokinet. 2016; 41(5): 541-548. IF：1.68

3 Huqun Li, Maosheng Fang, Mingzhen Xu, Shihong Li, Juan Du, Weiyong Li*, Hui Chen. Chronic Olanzapine Treatment Induces Disorders of Plasma Fatty Acid Profile in Balb/c Mice: A Potential Mechanism for Olanzapine-Induced Insulin Resistance.PLOS ONE, DOI:10.1371/journal.pone.0167930 Dec 14,2016.

4.Shihong Li, Mingzhen Xu, Huqun Li, Juan Du, Weiyong Li*. Pharmacokinetic Properties of Oral Lafutidine Tablets and the Effect of Food on its Pharmacokinetics in Healthy Chinese Subjects[J]. Advance in Therapy.DOI 10.1007/s12325-016-0383-9

5.Xu S#, Tao Z#, Hai B, Liang H, Shi Y, Wang T, Song W, Chen Y, OuYang J, Chen J, Kong F, Dong Y, Jiang SW, Li W, Wang P, Yuan Z, Wan X, Wang C, Li W, Zhang X, Chen K*. miR-424(322) reverses chemoresistance via T cell immune response activation by blocking the PD-L1 immune checkpoint. Nat Commun. 2016, 7: 11406. (IF=11.47)

6. Mingzhen Xu, Ying Zhou,Yang Ni,Xiao-Meng He, Huqun Li,Haseeb Sattar, Hui

Chen, Weiyong Li*. Tolerability and Pharmacokinetic Comparison of Oral, Intramuscular, and Intavenous Administration of Levosulpiride After Single and Multiple Dosing in Healthy Chinese Volunteers. Clinical Therapeutics, 2015, 37(11):2458-2467

7.Xiao-Meng He, Ying Zhou, Ming-Zhen Xu, Yang Li, Hu-Qun Li, Wei-Yong Li*,Effects of long-term smoking on the activity and mRNA expression of CYP isozymes in rats.J Thorac Dis 2015;7(10):1725-1731.

8.Lixiu Yu, Ying Zhou, Xiaomeng He, Huqun Li, Hui Chen,Weiyong Li.Simultaneous determination of macitentan and its active metabolitein human plasma by liquid chromatography-tandem massspectrometry. Journal of Chromatography B, 1002 (2015) 358–363.

9 Mingzhen Xu, Yang Ni, Ying Zhou, Huqun Li,Hui Chen, Weiyong Li*. Pharmacokinetics and Tolerability of Rufinamide Following Single and Multiple Oral Doses and Effect of Food on Pharmacokinetics in Healthy Chinese Subjects.Eur J Drug Metab Pharmacokinet,DOI 10.1007/s13318-015-0291-4

10.Ying Zhou; Xiaomeng He; Huqun Li; Yang Ni; Mingzhen Xu; Haseeb Sattar; Hui Chen*; and Weiyong Li*,.Pharmacokinetics and Tolerability of Minodronic Acid Tablets in Healthy Chinese Subjects and Food and Age Effects on the Pharmacokinetics. Clinical Therapeutics，2015 Apr 1;37(4):869-76. (IF=2.586)

11. Ni Y, Zhou Y, Xu M, He X, Li H, Haseeb S, Chen H*, Li W*.Simultaneous determination of phentermine and topiramate in human plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application in pharmacokinetic study. J Pharm Biomed Anal. 2015 Jan 24;107C:444-449. doi: 10.1016/j.jpba.2015.01.035 (IF=2.829)

12.Ying ZHOU , Xiao-meng HE , Hu-qun LI , Yang NI , Ming-zhen XU , Hui CHEN *, Wei-yong LI *,Pharmacokinetics and Tissue Distribution of Clevidipine and Its Metabolite in Dogs and Rats*.J Huazhong Univ Sci Technol［Med Sci］34(6):856-860,2014.(IF=0.779)

13.Ying Zhou, Huqun Li, Xiaomeng He, Mengmeng Jia, Yang Ni, Mingzhen Xu, Hui Chen*,Weiyong Li*。Simultaneous determination of clevidipine and its primary metabolitein dog plasma by liquid chromatography–tandem mass spectrometry:Application to pharmacokinetic study。Journal of Pharmaceutical and Biomedical Analysis 100 (2014) 294–299.(IF=2.829)

14.Wang T,liu Z,Guo S,Wu L, Li M,Yang J,Chen H,Li W,Wang L,Hu Z,Zhuang Q,Xu S,Wang L,liu J,YeZ,JiJY，WangC, Chen K. The tumor suppressive role of CAMK2N1 in castration-resistant prostate cancer. Journal Oncotarget，2014 Jun 15;5(11):3611-21.(IF=6.627)

15. Mengmeng Jia, Ying Zhou, Xiao-meng He, Hui Chen∗,Weiyong Li* et al. Development of a liquid chromatography-tandem mass spectrometry method for determination of butoconazole nitrate in human plasma and its application to a pharmacokinetic study. Journal of Huazhong University of Science and Technology [Medical Sciences] .34(3):431-436, 2014.(IF=0.779)

16. Ying Zhou, Jie Li, Xiaomeng He, Mengmeng Jia, Mingzhou Liu, Huqun Li, Zhengjiang Xiong, Yue Fan, Weiyong Li*. Development and validation of a liquid chromatography-tandem mass spectrometry method for simultaneous determination of amlodipine, atorvastatin and its metabolites ortho-hydroxy atorvastatin and para-hydroxy atorvastatin in human plasma and its application in a bioequivalence study, J Pharm Biomed Anal. 2013; 83:101-7. (IF=2.947)

17. Mengmeng Jia, Jie Li, Xiaomeng He, Mingzhou Liu, Ying Zhou, Yue Fan, Weiyong Li*. Simultaneous determination of iloperidone and its two active metabolites in human plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2013; 928:52-7. (IF=2.694)

18. Xiao-meng HE, Ying Zhou, Mengmeng Jia, Jie Li, Weiyong LI*. Pharmacokinetic and Pharmacodynamic Properties of Batifiban Coadministered with Antithrombin Agents in Chinese healthyVolunteers. Journal of Huazhong University of Science and Technology (Medical sciences). 2013; 33 (5):786-790. (IF=0.779)

19. Liqiong Song, Wei Xia, Zhao Zhou, Yi Li, Jie Wei, Zhengzheng Wei, Bing Xu, Jie Shen, Weiyong Li, Shunqing Xu*. Low-level phenolic estrogen pollutants impair islet morphology and β-cell function in isolated rat islets. J Endocrinol, 2012; 215(2):303-11. (IF=3.548)

20.Zhenxing Mao, Wei Xia, Jun Wang, Tian Chen, Qianqian Zeng, Bing Xu, Weiyong Li, Xi Chen, Shunqing Xu*. Perfluorooctane sulfonate induces apoptosis in lung cancer A549 cells through reactive oxygen species-mediated mitochondrion-dependent pathway. J Appl Toxicol, 2012; 13. (IF=2.478)

21. Tong Q, Li H, Li W, Chen H, Shu X, Lu X, Wang G. In vitro and in vivoanti-tumor effects of gemcitabine loaded with a new drug delivery system. J Nanosci Nanotechnol. 2011; 11(4):3651-8. (IF=1.987).

22. Qian Li, Jian Qiao, Li W.Y*. Safety, tolerability and pharmacokinetic study of recombinant human parathyroid hormone in Chinese healthy volunteers. Journal of Huazhong University of Science and Technology (Medicine Sciences). 2009; 29(4): 431-34. (IF=0.779)

23．Hui Chen, Jian Qiao, Weiyong Li*. Safety, Pharmacokinetic and Pharmacodynamic Study of Batifiban Injection Following Single- and Multiple-Dose Administration to Healthy Chinese Subjects. Journal of Huazhong University of Science and Technology (Medical sciences). 2009; 29 (1):12-18. (IF=0.779)

24．Jian Qiao, Zhirong Tan, Weiyong Li*. Liquid chromatography/positive ion electrospray tandem mass spectrometry method for the quantification of hydrochloride meptazinol in human plasma: Application to a pharmacokinetic study. Journal of Chromatography B. 2009; 877(30): 3787-3791.（IF=2.851）

25. Tan, ZR; Ou-Yang, DS; Zhou, G; Chen, Y; Li, WY*; Fan, L; Zhou, HH. Validated LC-MS-MS Method for Quantitative Determination of Batifiban in Human Plasma and Its Application to a Pharmacokinetic Study. Chromatographia. 2009; 70 (3): 415-421.(IF=1.37)

26. Weiyong Li*, Jungang Deng, Jian Qiao. HPLC Determination of 4-hydroxy-anethole trithione in plasma via enzymatic hydrolysis and its application to bioequivalence study. Journal of Pharmaceutical and Biomedical Analysis. 2008; 47(3):612-617. (IF=2.73).

27. Qian J, Vossoughi D, Li W.Y. Combined transarterial chemoembolization and arterial administrayion of Bletilla striata in the treatment of liver tumor in rats. World Journal of Gastroenterology. 2003; 9(12): 2676-2680.(IF=2.433)

28. Annedi, S.C, Li W.Y, Samson, S, Kotral L.P. Design and synthesis of novel fluoropeptidomimetics as potential mimics of the transition state during peptide hydrolysis. J.org.chem. 2003; 68(3):1043-9. (IF=3.79).

：①用于肿瘤动脉血管栓塞的白芨胶微球，专利号：03128062－5

②羟胺衍生物在神经退行性病变中的应用，专利申请号：201210194795.5