中国药科大学药理学博士

药动药效研究与评价中心主任

承担国家自然科学基金面上项目5项（主持3项，联合单位负责人2项）；“十三五”国家重大新药创制专项1项；国家973预研项目1项；国际合作项目2项（美国纽约州立大学、美国FDA-马里兰大学）；江苏省人才基金1项（抗骨质疏松一类新药的临床前研究）；江苏省临床医学专项1项（骨质疏松生物标记物研究）；参与国家973、省部科研项目8项

[1] Diketopyrrolopyrrole–Triphenylamine Organic Nanoparticles as Multifunctional Reagents for Photoacoustic Imaging-Guided Photodynamic/Photothermal Synergistic Tumor Therapy [J]. ACS Nano, 2017, 11 (1): 1054–1063

[2] Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy [J]. Nano Research, 2017, 10 (3): 794-801

[3] Aza-Bodipy Photosensitizer for Photoacoustic and Photothermal Imaging Guided Dual Modal Cancer Phototherapy [J]. Journal of Materials Chemistry B, 2017, 5(8):1566-1573.

[4]SynthesisandpreclinicalpharmacokineticstudyofDHA-10,anovelpotentialantifungalpogostoneanalogue [J].JournalofPharmacyandPharmacology, 2017, 69 (9): 1084-1090

[5]Metabonomic analysis of fatty acids in seminal plasma between healthy and asthenozoospermic men based on gas chromatography mass spectrometry [J]. Andrologia, 2017, 49 (9): e12744.

[6] Tumor-targeting, enzyme-activated nanoparticles for simultaneous cancer diagnosis and photodynamic therapy [J]. Journal of Materials Chemistry B, 2016, 4(1): 113-120.

[7] Bromo-substituted diketopyrrolopyrrole derivative with specific targeting and high efficiency for photodynamic therapy [J]. ACS applied materials & interfaces, 2016, 8(17): 10737-10742.

[8] Association between the metabolome and bone mineral density in pre-and post-menopausal Chinese women using GC-MS [J]. Molecular BioSystems, 2016, 12(7): 2265-2275

[9]A Thienyl‐Substituted Diketopyrrolopyrrole Derivative with Efficient Reactive Oxygen Species Generation for Photodynamic Therapy [J]. ChemPlusChem, 2016, 81(6): 515-520.

[10] Diketopyrrolopyrrole Derivatives Grafting Hyaluronic Acid for Targeted Photodynamic Therapy [J]. ChemistrySelect, 2016, 1(12): 3071-3074.

[11] Wnt/β-catenin signaling plays an important role in the protective effects of FDP-Sr against oxidative stress induced apoptosis in MC3T3-E1 cell [J]. Bioorganic & Medicinal Chemistry Letters, 2016, 26(19): 4720-4723.

[12]Triptolide disrupts fatty acids and peroxisome proliferator-activated receptor (PPAR) levels in male mice testes followed by testicular injury: a GC–MS based metabolomics study [J]. Toxicology, 2015, 336: 84-95.

[13] Strontium fructose 1, 6‐diphosphate alleviate cyclophosphamide‐induced oligozoospermia by improving antioxidant and inhibiting testicular apoptosis via FAS/FASL pathway [J]. Andrologia, 2015, 47(9): 995-1003.

[14]PharmacokineticsandtissuedistributionofAucubin,AjugolandCatalpolinratsusingavalidatedsimultaneousLC-ESI-MS/MSassay.[J].JournalofChromatographyB,2015,1002:245-253.

[15] A pre-clinical pharmacokinetic study in rats of three naturally occurring iridoid glycosides, Picroside-I, II and III, using a validated simultaneous HPLC–MS/MS assay[J]. Journal of Chromatography B, 2015, 993: 47-59.

[16] Quantitative analysis of tenuifolin concentrations in rat plasma and tissue using LC-MS/MS: Application to pharmacokinetic and tissue distribution study [J]. Journal of pharmaceutical and biomedical analysis, 2014, 88: 191-200.

[17] Simultaneous determination of osthole, bergapten and isopimpinellin in rat plasma and tissues by liquid chromatography–tandem mass spectrometry [J]. Journal of Chromatography B, 2014, 970: 77-85.

[18] Metabolomic analysis of simvastatin and fenofibrate intervention in high-lipid diet-induced hyperlipidemia rats [J]. Acta Pharmacologica Sinica, 2014, 35(10): 1265-1273.

[19] Comparative pharmacokinetics with single substances and Semen Cuscutae extract after oral administration and intravenous administration Semen Cuscutae extract and single hyperoside and astragalin to rats [J]. Analytical Methods, 2014, 6(18): 7250-7259.

[20] Metabolomic profiles delineate signature metabolic shifts during estrogen deficiency-induced bone loss in rat by GC-TOF/MS [J]. PLoS One, 2013, 8(2): e54965.

[21] Simultaneous determination of Eleutheroside B and Eleutheroside E in rat plasma by high performance liquid chromatography–electrospray ionization mass spectrometry and its application in a pharmacokinetic study [J]. Journal of Chromatography B, 2013, 917: 84-92.

[22]Rapid analysis of tadalafil in human blood plasma and seminal plasma by liquid chromatography/tandem mass spectrometry [J]. Journal of pharmaceutical and biomedical analysis, 2013, 77: 149-157.

[23] Simultaneous Determination of Oridonin, Ponicidin and Rosmarinic Acid from Herba Isodi Rubescentis Extract by LC–MS-MS in Rat Plasma [J]. Journal of chromatographic science, 2013, 51(10): 910-918.

[24] Development and validation of a sensitive liquid chromatography/tandem mass spectrometry method for the determination of raddeanin A in rat plasma and its application to a pharmacokinetic study [J]. Journal of Chromatography B, 2013, 912: 16-23.

[25] Changes in expression and distribution of attractin in the testes of rats at different developmental stages [J]. International journal of molecular medicine, 2013, 32(3): 599-606.

[26] Metabonomic profiling in studying anti-osteoporosis effects of strontium fructose 1, 6-diphosphate on estrogen deficiency-induced osteoporosis in rats by GC/TOF-MS [J]. European journal of pharmacology, 2013, 718(1): 524-532.

申请专利8项