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周国春

领域:生物产业 学校:南京工业大学职称:教授

药物化学,化学生物学...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

1997,9 - 2000,7博士中国科学院上海药物研究所

1986,9 - 1989,6硕士兰州大学化学系

1982,9 -1986,7本科南京大学 化学系

工作经历

2010,3-现在,教授、课题负责人、博士生导师南京工业大学药学院

项目课题经历

论文、成果、著作等

Yuran Peng, Jingjing Li, Yicheng Sun, Judy Yuet-Wa Chan, Dekuan Sheng, Kun Wang, Ping Wei, Pingkai Ouyang, Decai Wang,* Simon Ming Yuen Lee,* Guo-Chun Zhou*(周国春) “SAR studies of 3,14,19-derivatives of andrographolide on anti-proliferative activity to cancer cells and toxicity to zebrafish: an in vitro and in vivo study” RSC Adv., 2015, 5, 22510 - 22526 (*共同通讯作者)

2. Z Liu, W-K Law, D Wang, X Nie, D Sheng, S Song, K Guo, P Wei, P Ouyang, C-W Wong*, Guo-Chun Zhou (周国春)* “Synthesis and discovery of andrographolide derivatives as non-steroidal farnesoid X receptor (FXR) antagonists” RSC Adv., 2014, 4, 13533–13545 (*共同通讯作者)

3. Guo-Chun Zhou (周国春)*, Fang Liu, Junting Wan, Jing Wang*, Decai Wang, Ping Wei, Pingkai Ouyang “Design, synthesis and evaluation of a cellular stable and detectable biotinylated fumagillin probe and investigation of cell permeability of fumagillin and its analogs to endothelial and cancer cells” Eur J Med Chem 2013, 70, 631-639. (共同通讯作者)

4. Guo-Chun Zhou (周国春)*, Zhibing Weng, Xiaoxia Shao, Fang Liu, Xin Nie, Jinsong Liu, Decai Wang, Chunguang Wang, Kai Guo* “Discovery and SAR studies of methionine–proline anilides as dengue virus NS2B-NS3 protease inhibitors”, Bioorg Med Chem Lett 2013, 23, 6549–6554. (共同通讯作者)

5. Jing Wang, Shaopeng Chen, Hao Cheng, Fangyi Yang, Junting Wan, Jian Bo, Yingxue Liu,Junyun Yang,Jinsong Liu, andGuo-Chun Zhou“Identification, Structural Properties and Chelating Capacity of Miltipolone as a Broad-spectrum Growth Inhibitor to Cancer Cells”,Eur. J. Med. Chem.2011,46, 1117-1121.(通讯作者)

6. Qijun Liu, Hong Li, Shaopeng Chen,Guo-Chun Zhou“Synthesis of (3S,4R)-bengamide E”,Chin. Chem. Lett., 2011, 22, 505–507..(通讯作者)

7. Huimin Cheng, Lianwen Zhang, Yingxue Liu, Shaopeng Chen, Hao Cheng,Xin Lu, Zhuxia Zheng,Guo-Chun Zhou“Design, Synthesis and Discovery of 5-Hydroxyaurone Derivatives as Growth Inhibitors against HUVEC and Some Cancer Cell Lines”, Eur. J. Med. Chem.,2010,45, 5950-5957.(通讯作者)

8. Hong Li, Yingxue Liu, Qijun Liu, Wenhui Hu,Guo-Chun Zhou“Asymmetric Synthesis of 2-Amino-5-Hydroxy-Caprolactam Derivatives Mediated byE-Selective Olefination and Asymmetric Oxidation of Enol Ether”,Synthesis,2010,23, 4068-4074.(通讯作者)

9. Fangyi Yang, Jie Wang, Hao Cheng, Junting Wan, Zhiyu Xiao,Guo-Chun Zhou“Amplificationin vitroof Unknown RNAs and RNA Mixtures Based on Unique Restriction Enzyme Cleavage”,Acta Biochim Biophys Sin,2010,42, 873-882.(通讯作者)

10. Xin Liu, Yingyong Ou, Shaopeng Chen,Xin Lu, Hao Cheng, Xian Jia, Decai Wang,Guo-Chun Zhou“Synthesis and inhibitory evaluation of cyclohexen-2-yl and cyclohexyl-substituted phenols and quinones to endothelial cell and cancer cells”,Eur. J. Med. Chem.,2010,45, 2147-2153.(通讯作者)

11. Wenjuan Zhang, Jing Xu, Fang Liu, Chunfang Li, Yanling Jie, Shaopeng Chen, Zhiyuan Li, Jinsong Liu, Ling Chen,Guo-ChunZhou“Heterodimers of Histidine and Amantadine as Inhibitors for Wild Type and Mutant M2 Channels of Influenza A”,Chin J Chem,2010,28 (8), 1417-1423.(通讯作者)

12. Yuan Chen, Shaopeng Chen, Xin Lu, Hao Cheng, Yingyong Ou, Huimin Cheng,Guo-Chun Zhou“Synthesis, Discovery and Preliminary SAR Study of Benzofuran Derivatives as Angiogenesis Inhibitors”,Bioorg. Med. Chem. Lett.2009,19, 1851-1854.(通讯作者)

13. Zhang, L.; Yan, K.; Zhang, Y.; etal andGuochun Zhou“High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections”,Proc. Natl. Acad. Sci. USA2007,104,4606–4611.

14. Guo-Chun Zhou, Sapan L. Parikh, Peter C. Tyler, Gary B. Evans, Richard H. Furneaux, Olga V. Zubkova, Paul A. Benjes and Vern L. Schramm “Inhibitors of ADP-Ribosylating Bacterial Toxins Based on Oxacarbenium Ion Character at their Transition States ”,J Am Chem Soc.2004,126 (18), 5690-5698.

15. Guochun Zhou, Chiawei Tsai, Jun O. Liu “Fumagalone, a reversible inhibitor of type 2 methionine aminopeptidase and angiogenesis”,J Med Chem.2003,46 (16), 3452-3454.

专利、著作版权等

周国春杨方义 成浩 万军庭 “用于RNA体外扩增的试剂及方法” 申请号:200810219765.9,已授权。

2. 周国春陈凌 李志远 陈绪林 徐静 李志远 刘劲松 “具有抑制和阻断M2离子通道活性的新化合物及其应用” 申请号:200910137821.9,已授权。

3. 周国春欧英勇 刘昕 陈少鹏 陆鑫 “具有抗肿瘤活性的新化合物及其应用” 申请号:200910041814.9,已授权。

4. 周国春杨俊芸 刘英学 陈少鹏 刘劲松 “ZXC-4A5或其药学上可接受的盐在制药中的新应用” 申请号:200910194170.9,已授权。

5. 周国春 黄志伟 刘竺云 盛德宽 聂鑫 王德才“14-芳基醚穿心莲内酯衍生物及其制备方法和应用” 申请号:201310146923.3,公开号:CN 103224492A

6. 周国春 翁智兵 王春光 邵晓霞 聂鑫 “二肽类似物的用途”申请号:201310354848.X,公开号:CN103585616A

7. 周国春 徐娟娟 苏进财 “5-羟基-2’-硝基橙酮或5-羟基-4’-硝基橙酮衍生物及其应用”申请号:201410222693.9

8. 周国春 翁智兵 王德才 “一种以巴卡丁III为原料制备卡巴他赛的方法”申请号:201410280836.1

9. 周国春 彭宇然 李銘源 李晶晶 孙亦诚 盛德宽 聂鑫 王德才“穿心莲內酯衍生物及其制备方法和应用”申请号:201410329264.1

10. 周国春 徐斌 王德才 “8-氯-1-甲基-2,3,4,5-四氢-1H-3-苯并氮杂卓的制备方法” 申请号:201410380481.3

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