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梁磊

领域:生物产业 学校:北京大学职称:副教授

1. 基于靶点的药物设计、合成与构效关系研究 2. 分子探针的设计及生物学应用...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

2000.9-2004.7 四川大学化学学院(理学学士)

2004.9-2009.7 四川大学-美国伊利诺依大学UIUC(联合培养博士)

工作经历

2009.7-2011.6 北京大学化学与分子工程学院(博士后) 2011.7-2014.7 北京大学药学院讲师 2014.8-至今 北京大学药学院副教授,硕士生导师

项目课题经历

论文、成果、著作等

1. Tongliang Zhou, Lingfei Yang, Lei Liang,* Hui Liu, Yuanjun Zhu,* Mengyang Shui, Lan Yuan,* Fengrong Xu, Yan Niu, Chao Wang, and Ping Xu,* Rational Design of a Near-infrared Fluorescent Probe Based on Pyridazinone Scaffold. Eur. J. Org. Chem ., 2017, 3274-3281.

2. Yuanjun Zhu, Tongliang Zhou, Lingfei Yang, Lan Yuan, Lei Liang,* Ping Xu,* Revelation of the dynamic progression of hypoxia-reoxygenation injury by visualization of the lysosomal hydrogen peroxide. Biochem & Biophy Res. Comm., 2017 , 486, 904-908.

3. Hongyue Li, Tongliang Zhou, Hui Liu, Fengrong Xu, Yan Niu, Chao Wang, Lei Liang,* Ping Xu,* Discovery of a cobalt complex with high MEK1 binding affinity. Bioorg. Med. Chem. Lett., 2017, 27 , 2221-2224.

4. Tongliang Zhou, Yuanbo Cai, Lei Liang,* Lingfei Yang, Fengrong Xu, Yan Niu, Chao Wang, Junlong Zhang,* Ping Xu,* Discovery of a potent and highly specific beta(2) proteasome inhibitor from a library of copper complexes. Bioorg. Med. Chem. Lett., 2016, 26 , 5780-5784.

5. Lingfei Yang, Yuanjun Zhu, Mengyang Shui, Tongliang Zhou, Yuanbo Cai, Wei Wang, Fengrong Xu, Yan Niu, Chao Wang, Jun-Long Zhang, Ping Xu,* Lan Yuan,* and Lei Liang,* Rational design of fluorescent phthalazinone derivatives for one- and two-photon imaging. Chem. Eur. J., 2016, 22 , 12363-12370.

6. Lingfei Yang, Wei Wang, Qi Sun, Fengrong Xu, Yan Niu, Chao Wang, Lei Liang,* Ping Xu,* Development of novel proteasome inhibitors based on phthalazinone scaffold. Bioorg. Med. Chem. Lett. 2016, 26 , 2801-2805.

7. Wei Wang, Lei Liang,* Fengrong Xu, Wenjie Huang, Yan Niu, Qi Sun, Ping Xu,* Ruthenium-Catalyzed Switchable N–H/C–H Alkenylation of 6-Phenyl(dihydro)pyridazinones with Alkynes. Eur. J. Org. Chem . 2014, 6863–6867.

8. Lei Liang, Wei Wang, Jun Wu, Fengrong Xu, Yan Niu, Bo Xu*, Ping Xu*, Rational Design, Green Synthesis, and Initial Evaluation of a Series of Full-Color Tunable Fluorescent Dyes Enabled by the Copper-Catalyzed N-Arylation of 6-Phenyl Pyridazinones and Their Application in Cell Imaging. Chem. Eur. J. 2013, 19 , 13774-13782.

9. Lei Liang, Wei Wang, Fengrong Xu, Yan Niu, Qi Sun, Ping Xu*, Relay Catalysis by a Multifunctional Cu Catalyst in a Tandem Dehydro-/Dehalogenation Sequence along with N-Arylation. Org. Lett , 2013, 15 , 2770-2773.

10. Lei Liang, Guanyu Yang, Fengrong Xu, Yan Niu, Qi Sun, Ping Xu*, A Copper-Catalyzed Aerobic Cascade Dehydrogenative Dehalogenative Reaction. Adv. Syn&Cat , 2013, 355 , 1284-1290.

11. Lei Liang, Guanyu Yang, Fengrong Xu, Yan Niu, Qi Sun, Ping Xu*, Copper-Catalyzed Aerobic Dehydrogenation of C–C to C="C" Bonds in the Synthesis of Pyridazinones. Eur. J. Org. Chem . 2013, 6130–6136.

12. Lei Liang, H. Lv, Y. Yu, P. Wang, J.-L. Zhang *, Iron(III) tetrakis(pentafluorophenyl)porpholactone catalyzes nitrogen atom transfer to C="C" and C-H bonds with organic azides. Dalton Trans., 2012, 41 , 1457-1460.

13. Lei Liang, G. Rao, H.-L. Sun, J.-L. Zhang *, Aerobic Oxidation of Primary Alcohols Catalyzed by Copper Salts and Catalytically Active m-Hydroxyl-Bridged Trinuclear Copper Intermediate. Adv. Synth. Catal., 2010, 352 , 2371-2377.

专利、著作版权等

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