1986年在山东大学化学系获得理学学士学位。1989年在山东大学化学系获得理学硕士学位

2000年至今，任北京大学药学院药剂学系副教授

主持或参加的基金项目包括国家自然科学基金、973重大研究计划、国家重大新药创制专项新剂型与新释药系统技术平台等

发表论文80余篇1.Xiaoyou Qu, Yang Zou, Yuanhang Zhou, Yan Liu*, et al. Self-assembled nanoparticles from vitamin E succinate-based amphiphilic polymers for effective intestinal delivery of paclitaxel and their transcellular transport mechanisms and intracellular trafficking routes. Drug Delivery , 2018, 25(1):210-225.


2. Dishi Wang, Yanxia Zhou, Xinru Li, Yan Liu*, et al. Mechanisms of pH-sensitivity and cellular internalization of PEOz-b-PLA micelles with varied hydrophilic/hydrophobic ratios and intracellular trafficking routes and fate of the copolymer. ACS Applied Materials and Interfaces, 2017,9:6916-6930.

3. Ziqi Wang, Xinru Li, Dishi Wang, Yan Liu*, et al. Concurrently suppressing multidrug resistance and metastasis of breast cancer by co-delivery of paclitaxel and honokiol with polymeric micelles. Acta Biomaterialia , 2017, 62:144-156.

4. Xiaoyou Qu, Yang Zou, Yuanhang Zhou, Yan Liu*, et al. Preparation and characterization of pH-responsive polymeric micelles based on poly(2-ethyl-2-oxazoline)-vitamin E succinate for paclitaxel delivery. Journal of Chinese Pharmaceutical Sciences . 2017, 26(8): 582-588.

5. Yajie Gao, Yanfang Li, Yushu Li, Yan Liu*, et al. PSMA-mediated endosome escape-accelerating polymeric micelles for targeted therapy ofprostate cancerand the real time tracing of their intracellular trafficking. Nanoscale , 2015, 7(2):597-612.

6. Jinwen Li, Yanxia Zhou, Chengwei Li, Yan Liu*, et al. Poly(2-ethyl-2-oxazoline)-doxorubicin conjugate-based dual endosomal pH-sensitive micelles with enhanced antitumor efficacy. Bioconjugate Chemistry , 2015, 26(1):110-119.

7. Yong Zhao, Yanxia Zhou, Dishi Wang, Yan Liu*, et al. pH-responsive polymeric micelles based on poly(2-ethyl-2-oxazoline)-poly(D,L-lactide) for tumor-targeting and controlled delivery of doxorubicin and P-gp inhibitor. Acta Biomaterialia , 2015,17:182-192.

8. Yajie Gao, Chao Zhang, Yanxia Zhou, Yan Liu*, et al. Endosomal pH-responsive polymer-based dual-ligand-modified micellar nanoparticles for tumor targeted delivery and facilitated intracellular releaseof paclitaxel. Pharmaceutical Research , 2015, 32(8):2649-2662.

9. Lei Zhao, Yanxia Zhou, Yajie Gao, Yan Liu*, et al.Bovine serum albumin nanoparticles for delivery of tacrolimus to reduce its kidney uptake and functional nephrotoxicity. International Journal of Pharmaceutics , 2015, 483:180-187.

10. Yajie Gao, Yanxia Zhou, Lei Zhao, Yan Liu*, et al. Enhanced antitumor efficacy by cyclic RGDyK-conjugated and paclitaxel-loaded pH-responsive polymeric micelles. Acta Biomaterialia , 2015, 23:127-135.

11. Wenjing Li, Xinru Li, Yajie Gao, Yan Liu*, et al. The Inhibition Mechanism of P-glycoprotein Mediated Efflux by mPEG-PLA and Influence of PLA Chain Length on P-glycoprotein Inhibition Activity. Molecular Pharmaceutics, 2014,11:71-80.

12. Chao Fan, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Enhancedtopical delivery of tetrandrine by ethosomes for treatment of arthritis. Journal of Biomedicine and Biotechnology , 2013, Article ID 161943.

13. Na Li, Xinru Li, Yanxia Zhou, Yan Liu*, et al. The use of polyion complex micelles to enhance the oral delivery of salmon calcitonin and transport mechanism across the intestinal epithelial barrier. Biomaterials , 2012, 33(34):8881-8892.

14. Guiling Li, Yating Fan, Xinru Li, Yan Liu*, et al. In vitro and in vivo evaluation of a simple microemulsion formulation for propofol. International Journal of Pharmaceutics , 2012, 425:53–61.

15. Guiling Li, Chao Fan, Xinru Li, Yan Liu*, et al. Preparation and in vitro evaluation of tacrolimus loaded ethosomes. The Scientific World Journal , 2012, Article ID 874053.

16. Guiling Li, Yating Fan, Chao Fan, Yan Liu*, et al. Tacrolimus-loaded ethosomes: Physicochemical characterization and in vivo evaluation. European Journal of Pharmaceutics and Biopharmaceutics , 2012, 82:49-57.

17. Xingwei Chen, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Chitosan-based thermosensitive hydrogel as a promising ocular drug delivery system: preparation, characterization and in vivo evaluation. Journal of Biomaterials Applications , 2012, 27(4): 391-402.

18. Xiaoning Wang, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Synthesis, characterization and biocompatibility of poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)-poly(2-ethyl-2-oxazoline) hydrogels. Acta Biomaterialia , 2011, 7: 4149-4159.

19. Xinru Li, Yuanting Yue, Yanxia Zhou, Yan Liu*, et al. An oil-free microemulsion for intravenous delivery of diallyl trisulfide: Formulation and evaluation. International Journal of Pharmaceutics , 2011, 407:158-166.

20. Xinru Li, Yanhui Zhang, Yating Fan, Yan Liu*, et al. Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol. Nanoscale Research Letters , 2011, 6:275.

21. Yating Fan, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Improved intestinal delivery of salmon calcitonin by water-in-oil microemulsions. International Journal of Pharmaceutics, 2011, 416:323-330.

22. Yanhui Zhang, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Cyclosporine A-loaded poly(ethylene glycol)-b-poly(D,L-lactic acid) micelles: preparation, in vitro and in vivo characterization and transport mechanism across the intestinal barrier. Molecular Pharmaceutics , 2010, 7(4):1169-1182.

23. Wang Fei, Li Xinru, Zhou Yanxia, Yan Liu*, et al. Novel nanoscaled polyion complex micelles for targeted delivery of recombinant hirudin to platelets based on cationic copolymer. Molecular Pharmaceutics , 2010, 7(3):718-726.

24. Xinru Li, Pingzhu Li, Yan Liu*, et al. Novel mixed polymeric micelles for enhancing delivery of anticancer drug and overcoming multidrug resistance in tumor cell lines simultaneously. Pharmaceutical Research , 2010, 27(8):1498-1511.

25. Xinru Li, Xiaoyan Li, Yanxia Zhou, Yan Liu*, et al. Development of patch and spray formulations for enhancing topical delivery of sinomenine hydrochloride. Journal of Pharmaceutical Sciences, 2010, 99(4):1790-1799.

26. Yanhui Zhang, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Preparation and evaluation of poly(ethylene glycol)–poly(Lactide) micelles as nanocarriers for oral Deliveryof cyclosporine A. Nanoscale Resrarch Letters , 2010, 5:917-925.

27. Xinru Li, Quan Yuan, Yanqing Huang, Yan Liu*, et al.Development of silymarin self-microemulsifying drug delivery system with enhanced oral bioavailability. AAPS PharmSciTech , 2010, 11(2):672-678.

28. Ming Chen, Xin-Ru Li, Yan-Xia Zhou,Yan Liu*, et al. Improved absorption of salmon calcitonin by ultraflexible liposomes through intranasal delivery. Peptides , 2009,30:1288-1295.

29. Kewei Yang, Xinru Li, Zhuoli Yang, Yan Liu*, et al. Novel polyion complex micelles for liver-targeted delivery of diammonium glycyrrhizinate: in vitro and in vivo characterization. Journal of Biomedical Materials Research Part A, 2009, 87(4):140-148.

30. Xinru Li, Yanqing Huang, Xingwei Chen, Yanxia Zhou, Yan Liu*, et al. Self-assembly and characterization of Pluronic P105 micelles for liver-targeted delivery of silybin. Journal of Drug Targeting , 2009, 17(10):739-750.

31. Xinru Li, Zhuoli Yang, Kewei Yang, Yan Liu*, et al. Self-assembled polymeric micellar nanoparticles as nanocarriers for poorly soluble anticancer drug ethaselen. Nanoscale Resrarch Letters , 2009, 4:1502-1511.

32. Zhuoli Yang, Xinru Li, Kewei Yang, Yan Liu*. Amphotericin B-loaded poly(ethylene glycol)-poly(lactide) micelles: preparation, freeze-drying and in vitro release. Journal of Biomedical Materials Research Part A, 2008, 85(2):539-546.

获得国家发明专利9项