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王晶

领域:生物产业 学校:北京大学职称:研究员

化学生物学在药物新靶标发现中的重要应用...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

2004.09-2009.07 理学博士,中国科学院上海有机化学研究所,导师:马大为研究员

2000.09-2004.07 理学学士,苏州大学,导师:沈琪教授和马大为研究员

工作经历

2016.3-至今 研究员,博士生导师,北京大学药学院化学生物学系 2009.08-2014.09 博士后,美国芝加哥大学化学系,霍华德休斯医学研究所(HHMI),导师:Chuan He教授

项目课题经历

论文、成果、著作等

1)He, G.; Wang, J; Ma, D.W. Highly Convergent Route to Cyclopeptide Alkaloids. Total Synthesis of Ziziphine N.Org. Lett. 2007, 9, 1367-1369.

2) Wang, J; Schaeffler, L.; He, G.; Ma, D.W. Total synthesis and stereo-chemistry assignment of 15-membered peptide alkaloids abyssenine B and mucronine E. Tetrahedron Lett. 2007, 48, 6717–6721.

3) Wang, J; Yu, F.; Zhang, X.J.; Ma, D.W. Enantioselective Assembly of 3,4,5,6-Tetrasubstituted Dihydropyrones via OrganocatalyticReaction between Aldehydes and α-Keto-α,β-unsaturated Esters. Org. Lett.2008, 10, 2561-2564.

4) Wang, J; Ma, A.Q.; Ma, D.W. Organocatalytic Michael Addition of Aldehydes to g-Keto-a, b-unsaturated Esters. An Efficient Entry to Versatile Chiral Building Blocks.Org. Lett. 2008, 10, 5425-5428.

5) Song, C.X.; Szulwach, K.E.; Fu, Y.; Dia, Q.; Yi, C.; Li, X.; Li, Y.; Chen, C.H.; Zhang, W.; Jian, X.; Wang, J.; Zhang, L.; Looney, T.J.; Zhang, B.; Godley, L.A.; Hicks, L.M.; Lahn, B.T.; Jin, P.; He, C. Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat. Biotechnol.2011,29, 68-72.

6) Wang, J.; Karpus, J.; Zhao, B. S.; Luo, Z.; Chen, P. R.; He, C. A selective fluorescent probe for carbon monoxide imaging in living cells. Angew. Chem. Int. Ed. 2012, 51, 9652-9656.

Hot paperand Hightlights by Angew. Chem. Int. Ed. 2013, 52, 1628 -1630.

7) Wang, J.; Luo, C.; Shan, C.L.; Lu, J.Y.; Elf, S.; Zhou, Y.; Wen, Y.; Xie, Y.X.; Vinkenborg, J.L.; Fan, J.; Kang, H.B.; Lin, R.T.; Han, D.L.; Karpus, J.; Chen, S.J.; Ouyang, S.S.; Luan, C.H.; Zhang, N.X.; Merkx, M.; Liu, H.; Chen, J.; Jiang, H.L.; He, C. Inhibition of human copper trafficking by small molecule significantly attenuates cancer cell proliferation. Nat. Chem. 2015, 7, 968-979.

Highlightsby Chemical & Engineering News“Agent Could Fight Cancer By Inhibiting Copper Transport In Diseased Cells”, Nov. 9,2015

专利、著作版权等

U.S. Provisional Patent Application No. WO 2014/116859: "Methods and Compositions for Inhibiting Human Copper Trafficking Proteins Atox1 and CCS".
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