教育背景
1998—2002年毕业于北京大学药学院,获学士学位;
2004—2008年毕业于英国University College London,获神经药理学博士学位
工作经历
2008—2013年,英国University College London,博士后,神经药理学专业;
2013年至今,北京大学药学院 特聘研究员 主要从事离子通道药物筛选与确证、神经精神系统疾病新靶标发现、抗癫痫药物药理学的科研和教学工作。
项目课题经历
论文、成果、著作等
1. Jin XQ, Chen Q, Song Y, Zheng J, Xiao K, Shao S, Fu ZB, Yi M, Yang Y, and Huang Z* (2019) Dopamine D2 Receptors Regulate the Action Potential Threshold by Modulating T-type Calcium Channels in Stellate Cells of the Entorhinal Cortex, Journal of Physiology, 597(13):3363-3387.
2. Liu YQ, Li MH, Fan MH, Song Y, Yu HJ, Zhi XJ, Xiao K, Lai SR, Zhang JL, Jin XQ, Shang YF, Liang J*, and Huang Z* (2018) CDYL-mediated histone crotonylation regulates stress-induced depressive behaviors, Biological Psychiatry, 85(8):635-649.
3. Zhang J, Chen X, K?rb? M, Zhao Y, An L, Wang R, Wang K, Huang Z* (2018) Anticonvulsant effect of dipropofol by enhancing native GABA currents in cortical neurons in mice. J Neurophysiology, 120 (3):1404-1414
4. Xiao K, Sun Z, Jin X, Ma W, Song Y, Lai S, Chen Q, Fan M, Zhang J, Yue W, Huang Z* (2018) ERG3 potassium channel-mediated suppression of neuronal intrinsic excitability and prevention of seizure generation in mice. Journal of Physiology, 596(19):4729-4752.
5. Li W, Liu J, Fan M, Li Z, Chen Y, Zhang G, Huang Z, Zhang L*. (2018) Scale-Up Synthesis and Identification of GLYX-13, a NMDAR Glycine-Site Partial Agonist for the Treatment of Major Depressive Disorder. Molecules. 24;23(5)
6. Liu YQ, Lai SR, Ma WN, Ke W, Zhang C, Liu SM, Zhang Y, Pei F, Li SY, Yi M, Shu YS, Shang YF, Liang J*, andHuang Z* (2017) CDYL suppresses epileptogenesis through repression of axonal Nav1.6 sodium channel expression. Nature Communications, 8(1):355.
7. Li X, Liu D, Ma Y, Du X, Jing J, Wang L, Xie B, Sun D, Sun S, Jin X, Zhang X, Zhao T, Guan J, Yi Z, Lai W, Zheng P, Huang Z, Chang Y, Chai Z, Xu J, Deng H.(2017)Direct Reprogramming of Fibroblasts via a Chemically Induced XEN-like State. Cell Stem cell. S1934-5909(17) 30185-6.
8. Huang Z, Li G, Aguado C, Lujan R, Shah MM. (2016) HCN1 channels reduce the rate of exocytosis from a subset of cortical synaptic terminals. Scientific Reports 7:40257.
9. Martinello K, Huang Z, Lujan R, Tran B, Watanabe M, Cooper EC, Brown DA, Shah MM. (2015) Cholinergic afferent stimulation induces axonal function plasticity in adult hippocampal granule cells, Neuron, 85: 346-363
10. Zhou J, Tang Y, Zheng Q, Li M, Yuan T, Chen L, Huang Z, Wang K. (2015) Different KChIPs compete for heteromultimeric assembly with pore-forming Kv4 subunits. Biophysical Journal, 108(11):2658-69.
11. Sun ZM and Huang Z* (2015) Progress in Research of Hyperpolarization-activated Cation Non-selective Channels and Antiepileptic Drugs Targeting the Channels. Progress in Pharmaceutical Science, 39(2): 98-104. (Invited review)
12. Huang Z* and Gibb A.J.* (2014) Mg2+ block properties of NMDA receptors in neonatal rat substantia nigra pars compacta dopaminergic neurones. Journal of Physiology, 592(10): 2059-78.
13. Shah MM*, Huang Z, Martinello K. (2013) HCN and K(V)7 (M-) channels as targets for epilepsy treatment. Neuropharmacology, 69:75-81. (Invited review)
14. Huang Z, Lujan R, Martinez-Hernandez J, Lewis AS, Chetkovich DM, Shah MM. (2012) TRIP8b-Independent Trafficking and Plasticity of Adult Cortical Presynaptic HCN1 Channels. Journal of Neuroscience, 32(42):14835-48.
15. Huang Z, Lujan R, Kadurin I, Uebele VN, Renger JJ, Dolphin AC, Shah MM. (2011) Presynaptic HCN1 channels regulate Ca(V)3.2 activity and neurotransmission at select cortical synapses, Nature Neuroscience, 14(4):478-86
16. Huang Z, Walker MC, Shah MM. (2009) Loss of dendritic HCN1 subunits enhances cortical excitability and epileptogenesis, Journal of Neuroscience, 29(35):10979-88.
专利、著作版权等
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