1982年北京医学院药学系（现北京大学药学院）毕业

1982-1987在本校药学系任教

国家自然科学基金面上项目：针对脑缺血损伤多环节损伤的融合蛋白分子设计、制备及活性研究

1. Yuanjun Zhu#, Yuanqing Gao#, Danping Zheng#, Mengyang Shui, Kuai Yu, Xiaoyan liu, Yuan Lin, Li Su, Wenxing Yang, Yinye Wang*. Design and evaluation of EphrinA1 mutants with cerebral protective effect. Scientific Reports, 2017; 7: 1881.
2. Yuanjun Zhu#, Mengyang Shui#, Xiaoyan Liu, Wenhui Hu*, Yinye Wang*.Increased autophagic degradation contributes to the neuroprotection of hydrogen sulfide against cerebral ischemia/reperfusion injury. Metabolic Brain Disease, 2017, doi: 10.1007/s11011-017-0014-4.
3. Yuanjun Zhu#, Tongliang Zhou#, Lingfei Yang, Lan Yuan, Lei Liang*, Ping Xu*.Revelation of the dynamic progression of hypoxia-reoxygenation injury by visualization of the lysosomal hydrogen peroxide. Biochemical & Biophysical Research Communication, 2017, 486 (4):904-908.
4. Yuanjun Zhu#, Yuan Lin#, Xiaoyan Liu, Wenhui Hu*, Yinye Wang*. Identification of AcAP5 as a novel factor Xa inhibitor with both direct and allosteric inhibition. Biochemical and Biophysical Research Communications, 2017, 483(1):495-501.
5. Yuanjun Zhu#, Ruyi Li#, Yuan Lin, Mengyang Shui, Xiaoyan Liu, Huan Chen, Yinye Wang*. Engineering Factor Xa Inhibitor with Multiple Platelet-Binding Sites Facilitates its Platelet Targeting. Scientific Reports. 2016; 6: 29895.
6. Mengyang Shui, Xiaoyan Liu, Yuanjun Zhu*, Yinye Wang*. Exogenous hydrogen sulfide attenuates cerebral ischemia-reperfusion injury by inhibiting autophagy in mice. Canadian Journal of Physiology and Pharmacology, 2016, 94(11): 1187-1192,
7. Yuanjun Zhu, Yuan Lin, Aihua Liu, Mengyang Shui, Ruyi Li, Xiaoyan Liu, Wenhui Hu, Yinye Wang*. Structure-guided creation of AcAP5-derived and platelet targeted factor Xa inhibitors. Biochemical Pharmacology. 2015, 95(4):253-62.
8. Hongfei Li, Xiaoyan Liu, Yuanjun Zhu, Ye Liu, Yinye Wang*. Magnolol derivative 002C-3 protects brain against ischemia–reperfusion injury via inhibiting apoptosis and autophagy, Neuroscience Letters, 2015, 588:178-183
9. Kun Hu, Xiaoyan Liu, Yuanjun Zhu, Jingliang Zhang, Ye Liu , Yinye Wang*.Antithrombotic effect of W007B, a newly synthesized compound, in vitro and in vivo.J. Chin. Pharm. Sci. 2014, 23 (11), 760–764
10. Yuanjun Zhu, Qixin Bu, Xiaoyan Liu, Wenhui Hu, and Yinye Wang*. Neuroprotective Effect of TAT-14-3-3ε Fusion Protein against Cerebral Ischemia/Reperfusion Injury in Rats. PLoS One. 2014; 9(3): e93334.
11. Qixin Bu, Xiaoyan Liu, Yuanjun Zhu, Ye Liu, Yinye Wang*, w007B protects brain against ischemia-reperfusion injury in rats through inhibiting inflammation, apoptosis and autophagy. Brain Res. 2014,1558:100-8.
12. Yuanjun Zhu, Aihua Liu, Xiaoyan Liu and Yinye Wang*. Engineering Novel Anticoagulant Proteins by Motif Grafting. Protein Pept Lett. 2014, 21(2):159-63.
13. Yanan Zhu, Yuanjun Zhu, Qixin Bu, Xiaoyan Liu, Yinye Wang*. rAcAP5: high-yield strain screening, expression, purification and thrombolytic effect evaluation in rat embolic middle cerebral artery occlusion model. J. Chin. Pharm. Sci. 2014, 23 (1), 22-27.
14. Peng Zhang, Xiaoyan Liu , Yuanjun Zhu , Shizhong Chen, Demin Zhou, Yinye Wang*, Honokiol inhibits the inflammatory reaction during cerebral ischemia reperfusion by suppressing NF-kB activation and cytokine production of glial cells, Neuroscience Letters, 2013,534, 123–127
15. Zhenyu Hu, Xiling Bian, Xiaoyan Liu, Yuanjun Zhu, Xiaoyi Zhang, Shizhong Chen, Kewei Wang, Yinye Wang. Honokiol protects brain against ischemia-reperfusion injury in rats through disrupting PSD95-nNOS interaction. Brain Res. 2013; 1491:204-12.
16. Aihua Liu, Yuanjun Zhu, Xiaoyan Liu, Yinye Wang*.Expression, purification and evaluation of N-terminal domain of AcAP5 with Factor Xa inhibitory activity. J. Chin. Pharm. Sci. 2013, 22 (3), 205–208
17. Xiumei Liu, Xiaoyan Liu, Yinye Wang*. Methoxyl methyl ether isoamylene quercetin, a quercetin derivative, protects rat aorta endothelial cells against oxidation and apoptosis. J. Chin. Pharm. Sci. 2013, 22 (4), 289–292
18. 刘晓岩, 张超逸，王银叶*，车庆明, 6,7-二乙酰黄芩素对四氯化碳和D-氨基半乳糖所致的急性肝损伤的保护作用. 中国新药杂志，2012，21(13)：1517-19.
19. 杨爽，刘晓岩，胡振宇，陈世忠，王银叶* ，和厚朴酚通过抑制脑MPTP开放和调节PARP-1活性保护全脑缺血的作用研究，中国药理学通报，28（2）218-221, 2012
20. Shuang Ding, Xiaoyan Liu, Yuanjun Zhu, Yinye Wang*. Thrombolytic effect of rAcAP5 and its mechanism. JCPS2012, 21(1):70-75.
21. 王银叶，丁双，刘晓岩，朱元军. 犬钩虫抗凝肽及其突变体在制备溶血栓药物中的应用途.201110106956.6（专利）
22. Xiumei Liu, Xiaoyan Liu, Yinye Wang*, Shizhong Chen*. Cyclovirobuxine D inhibits blood coagulation and venous thrombosis. J Chin Pharmaceut Sci, 2010; 19(2):120-124
23. 胡涛，刘晓岩，郭宏宝，王银叶.三种中药活性部位对H2O2致PC12细胞损伤保护作用的比较研究.中国临床药理学与治疗学2010，1：53-58
24. Zhiyu Tang, Ming Zhao, Changling Li, Yinye Wang*, Shiqi Peng*, Polyaspartoyl·L-arginine inhibits platelet aggregation through stimulation of NO. Eur J Pharmacol 2008; 588: 41-46
25. Jian Yang, Zhiyu Tang, Yinye Wang*, Shiqi Peng*. Polyaspartoyl L-arginine protects endothelial cells against injury. Eur J Pharmacol 2008; 599: 96-101
26. Zhiyu Tang, Jian Yang, Xiaoyan Liu, Yinye Wang*, Shiqi Peng*. Polyaspartoyl·L-arginine enhances prostacyclin synthesis in rat aorticendothelial cells Eur J Pharmacol 2008; 601: 124-128
27. 李洁璇，张晓雪，王银叶. 新型多肽bg115-2体外对凝血因子X的抑制作用.中国新药杂志2008，17（8）656-660
28. Die Hu, Xiaoyan Liu, Yinye Wang*, Shizhong Chen*. Cyclovirobuxine D ameliorates acute myocardial ischemia by KATP channel opening, nitric oxide release and anti-thrombosis. Eur J Pharmacol 2007;569: 103-109
29. Xiaoxue Zhang, Shizhong Chen, Yinye Wang*. Honokiol up-regulates prostacyclin synthease protein expression and inhibits endothelial cell apoptosis Eur J Pharmacol 2007, 554: 1-7
30. 武源，郭宏宝，王铁军，王银叶. 几种中药组分对家兔体外血小板聚集作用的比较. 中国临床药理学与治疗学2007；12（9）：1047-1051
31. Wu XL, Wang YY, Cheng J, Zhao YY. Calcium channel blocking activity of calycosin, a major active component of Astragali Radix, on rat aorta. Acta Pharmacol Sin.2006; 27 (8): 1007-1012
32. Hu He，Tang Zhiyu，ChenShizhon，Wang Yinye*，Honokiol ameliorates focal cerebral ischemia and enhance tissue reactive oxygen species scavenging capacity after cerebral ischemial-reperfusion. Chin J Pharmacol Toxic 2006; 20: 455-460
33. Liu Xiaoyan,，Li Fengyun, Chi Zhihong, Wang Yinye*. Protective effect of oral fructose-1,6-diphosphate on liver injury in animal model. J Chin Pharmaceut Sci 2006; 15(3): 188-193
34. 胡蝶, 郭宏宝, 郭绪林, 王银叶. 单用和复方中硝酸异山梨酯的药动学比较研究. 中国药学杂志2006；12（4）：24
35. Hu H, Zhang XX, Wang YY*, Chen SZ. Honokiol inhibits arterial thrombosis through endothelial cell protection and stimulation of prostacyclin. Acta Pharmacologica Sinica 2005; 26(9)1063-1068.
36. 王银叶，张晓雪，刘晓岩，李洁璇. 重组犬钩虫抗凝肽突变体及其载体、核苷酸序列、其制备和用途. ZL200610065641.0（专利）

36. 王银叶，张晓雪，刘晓岩，李洁璇. 重组犬钩虫抗凝肽突变体及其载体、核苷酸序列、其制备和用途. ZL200610065641.0（专利