教育背景
2000.9 –2003.12,北京大学药学院化学生物学系,博士,王夔教授,杨晓达教授
1997.9 –2000.7,华中科技大学化学系,硕士,徐辉碧教授,刘长林教授
1992.9 –1996.7,四川轻化工学院化学工程系,学士,王曙教授
工作经历
2018.1至今,北京大学药学院分子与细胞药理学系,副教授,博士生导师
2008.12 - 2017.12,北京大学药学院化学生物学系,副教授,硕士生导师
2004.12 –2008.12,美国Rutgers, The State University of New Jersey,博士后
2003.12 -2004.12,成都新康药业有限公司,总经理助理
1996.7 –1997.7,四川广康化纤股份有限公司,助理工程师
项目课题经历
论文、成果、著作等
Cao M, Wang H, Guo L, Yang S, Liu C, Khor TO, Yu S*, Kong AN. Dibenzoylmethane Protects Against CCl4-Induced Acute Liver Injury by Activating Nrf2 via JNK, AMPK, and Calcium Signaling. AAPS J. 2017;19(6):1703-1714
Cheng W, Liu Z, Yu Y, van Ofwegen L, Proksch P, Yu S*, Lin W*, An unusual spinaceamine-bearing pregnane from a soft coral Scleronephthya sp. inhibits the migration of tumor cells, Bioorg Med Chem Lett, 2017;27(12):2736-2741
Ji L, Yang S, Li S, Liu S, Tang S, Liu Z, Meng X*, Yu S*, A novel triazolonaphthalimide induces apoptosis and inhibits tumor growth by targeting DNA and DNA-associated processes, Oncotarget, 2017;8(23):37394-37408
Ji S, Tang S, Li K, Li Z, Liang W, Qiao X, Wang Q, Yu S*, Ye M*, Licoricidin inhibits the growth of SW480 human colorectal adenocarcinoma cells in vitro and in vivo by inducing cycle arrest, apoptosis and autophagy, Toxicol Appl Pharmacol, 2017;326:25-33
Li K, Ji S, Song W, Kuang Y, Lin Y, Tang S, Cui Z, Qiao X, Yu S, Ye M*, Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra, J Nat Prod, 2017;80(2):334-346
Que L, He L, Yu C, Yin W, Ma L, Cao B*, Yu S*, Activation of Nrf2-ARE signaling mitigates cyclophosphamide-induced myelosuppression, Toxicol Lett, 2016; 262:17-26
Zhao, Y., Liu, D., Proksch, P., Yu, S.*, Lin, W.*, Isocoumarin Derivatives from the Sponge-Associated Fungus Peyronellaea glomerata with Antioxidant Activities, Chem Biodivers, 2016 Jul 23. doi: 10.1002/cbdv.201600012
Yang, J., Yang, S., Zhou, S., Lu, D., Ji, L., Li, Z., Yu, S.*, Meng, X.*, Synthesis, anti-cancer evaluation of benzenesulfonamide derivatives as potent tubulin-targeting agents, Eur J Med Chem. 2016 Oct 21;122:488-496
Wu ZH, Wang YR, Liu D, Proksch P, Yu SW*, Lin WH*. Antioxidative phenolic compounds from a marine-derived fungus Aspergillus versicolor. Tetrahedron. 2016; 72(1):50-57.
Ji S, Li Z, Song W, Wang Y, Liang W, Li K, Tang S, Wang Q, Qiao X, Zhou D, Yu S*, Ye M*. Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine. J Nat Prod. 2016;79(2):281-292.
Yu S*, Yang CS, Li J, You W, Chen JG, Cao Y, Dong Z, Qiao YL, Cancer Prevention Research in China, Cancer Prev Res (Phila), 2015, 8(8):662-74 (Cover story)
Guo Y, Yu S*, Zhang C, Tony Kong AN, Epigenetic regulation of Keap1-Nrf2 signaling, Free Radic Biol Med, doi:10.1016/j.freeradbiomed.2015.06.013
Ji S, Li R, Wang Q, Miao WJ, Li ZW, Si LL, Qiao X, Yu SW, Zhou DM, Ye M, Anti-H1N1 virus, cytotoxic and Nrf2 activation activities of chemical constituents from Scutellaria baicalensis. J Ethnopharmacol. 2015 Nov 11. pii: S0378-8741(15)30221-X.
Zhang C, Zhong B, Yang S, Pan L, Yu S, Li Z, Li S, Su B, Meng X, Synthesis and biological evaluation of thiabendazole derivatives as anti-angiogenesis and vascular disrupting agents, Bioorg Med Chem, 2015, 23(13):3774-80
Yang SM, Ji LY, Que LL, Wang K, Yu SW*, Metformin activates Nrf2 signaling and induces the expression of antioxidant genes in skeletal muscle and C2C12 myoblasts, J Chin Pharma Sci, 2014, 23(12):837-43
Jian Bai, Dong Liu, Siwang Yu, Peter Proksch, Wenhan Lin, Amicoumacins from the marine-derived bacterium Bacillus sp. with the inhibition of NO production, Tetrahedron Letters, 2014, 55(45):6286–6291
Yang J, Zhou S, Ji L, Zhang C, Yu S, Li Z, Meng X, Synthesis and structure-activity relationship of 4-azaheterocycle benzenesulfonamide derivatives as new microtubule-targeting agents, Bioorg Med Chem Lett, 2014, 24(21):5055-5058
Lou Q, Ji L, Zhong W, Li S, Yu S*, Li Z, Meng X*, Synthesis and cytotoxicity evaluation of naphthalimide derived N-mustards, Molecules, 2014, 19(7):8803-19
Lin XH, Cao MN, He WN, Yu SW*, Guo DA, Ye M*, Biotransformation of 20(R)-panaxadiol by the fungus Rhizopus chinensis, Phytochemistry, 2014, 105:129-34
Ma WW, Tang SN, Cao MN, Ge ZM, Li RT, Yu SW*, IC5, a dithiocarbamate derivative, inhibits colon cancer cell proliferation in vitro and colitis-associated colorectal carcinogenesis in vivo, J Chin Pharma Sci, 2014, 23(9): 610-6
Huang W, Tang S, Qiao X, Ma W, Ji S, Wang K, Ye M*, Yu S*,Isoangustone A induces apoptosis in SW480 human colorectal adenocarcinoma cells by disrupt- ing mitochondrial functions, Fitoterapia, 2014, doi: 10.1016/j.fitote.2014.01.016.
Que LL, Wang XZ, Qian PZ, Cao BS, Wang K, Yu SW*, Upregulation of Nrf2 regulated gene expression by tBHQ alleviates cyclophosphamideinduced hematotoxicity in mice, J Chin Pharma Sci, 2014, 23(1): 39-45
Qiao X, Ji S, Yu SW, Lin XH, Jin HW, Duan YK, Zhang LR, Guo DA, Ye M*, Identification of Key Licorice Constituents Which Interact with Cytochrome P450: Evaluation by LC/MS/MS Cocktail Assay and Metabolic Profiling, AAPS J, 2014, 16(1):101-13
Wu TY, Khor TO, Su ZY, Saw CL, Shu L, Cheung KL, Huang Y, Yu S, Kong AN, Epigenetic Modifications of Nrf2 by 3,3'-diindolylmethane In Vitro in TRAMP C1 Cell Line and In Vivo TRAMP Prostate Tumors, AAPS J, 2013, 15(3): 864-74
余四旺*,杨中枢,癌症化学预防在中国,化学进展,2013, 25(9): 1411-4
Kim JH,Yu S, Chen JD, Kong AN*, The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains, Oncogene, 2013;32(4): 514-27
Gao Z, Zhang C, Yu S*, Yang X*, Wang K, Vanadyl bisacetylacetonate protects β cells from palmitate-induced cell death through the unfolded protein response pathway, J Biol Inorg Chem. 2011;16(5):789-98
Que LL, Wang HX, Cao BS, Yang XD, Wang K, Yu SW*, The regulation and functions of transcription factor Nrf2 in cancer chemoprevention and chemoresistance, J Chin Pharm Sci 2011 20 (1): 5-19
Yu S, Khor TO, Cheung K-L, Li W, Wu T-Y, Huang Y, Foster BA, Kan YW, Kong AN*, Nrf2 Expression Is Regulated by Epigenetic Mechanisms in Prostate Cancer of TRAMP Mice. PLoS One. 2010 Jan 5;5(1):e8579
Khor TO*, Yu S*, Barve A, Hao X, Hong JL, Lin W, Foster B, Huang MT, Newmark HL, Kong AN., Dietary Feeding of Dibenzoylmethane (DBM) Inhibits Prostate Cancer in Transgenic Adenocarcinoma of the Mouse Prostate Model, Cancer Res, 2009, 69:7096-102
Yu S, Shen G, Khor TO, Kim JH, Kong AN., Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism, Mol Cancer Ther, 2008, 7:2609-20
Yu, S., Kong, A.N., Targeting carcinogen metabolism by dietary cancer preventive compounds, Curr Cancer Drug Targets, 2007, 7:416-424
Li, W.*, Yu, S.* & Kong, A.N., Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain, J Biol Chem, 2006, 281:27251-27263
Yu, S., Hu, J., Yang, X., Wang, K. & Qian, Z.M., La(3+)-induced extracellular signal-regulated kinase (ERK) signaling via a metal-sensing mechanism linking proliferation and apoptosis in NIH 3T3 cells, Biochemistry, 2006, 45:11217-11225
Yu, S., Yuan, L., Yang, X., Wang, K., Ke, Y. & Qian, Z.M., La3+-promoted proliferation is interconnected with apoptosis in NIH 3T3 cells, J Cell Biochem, 2005, 94:508-519
专著:
余四旺,杨中枢,癌症化学预防研究前沿,《2014科学发展报告》,中国科学院编,科学出版社,2014.3,ISBN978-7-03-039834-5
余四旺,微量元素化学生物学,《中国学科发展战略化学生物学》,张礼和等,科学出版社,2014
余四旺,杨中枢,癌症化学预防专辑,《化学进展》编辑部,16万字,2013
Wang K, Yu S and Zhang T, Arsenic in Traditional Chinese Medicine, p113 – 133, in Biological Chemistry of Arsenic, Antimony and Bismuth, edited by Dr. Hongzhe Sun, 2011 John Wiley & Sons, Inc., ISBN: 978-0-470-71390-7
Yu S, Cheung KL, Li W and Kong ANT, Plant Phenolic Compounds - modulation of cytoprotective enzymes and Nrf2/ARE signaling, p402-426, in Plant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology, edited by Dr. Cesar G Fraga,2009 John Wiley & Sons, Inc., ISBN: 978-0-470-28721-7
专利、著作版权等
余四旺,叶敏等,一种异戊烯基黄酮类化合物的药物新用途,ZL201210348167.8,中国专利,授权
叶敏,余四旺等,刺甘草査尔酮的新用途,CN105232501A,中国专利
叶敏,余四旺等,甘草中一类异戊烯基异黄酮类化合物的医药新用途,201510918824.1,中国专利
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