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张之昊

领域:生物产业 学校:中国药科大学职称:副研究员

慢性肾脏病机制及生物标志物的代谢组学研究 与肾脏病相关天然产物活性物质基础研究...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

2010年毕业于中国药科大学药物化学系,同年加入澳门科技大学林瑞超教授课题组进行中药化学和代谢组学研究,并于2013年获颁博士学位。

工作经历

项目课题经历

国家自然科学基金青年科学基金项目,81703691,主持;

中国药科大学高层次人才引进科研基金。

国家新药科技重大专项课题, 2017ZX09309027,治疗K-ras突变结直肠癌的天然环肽类创新药物TNH-1551-01注射剂新品种研发,在研,参与,2017/1-2020/12。

论文、成果、著作等

1Huachao Chen, Fei Li, Yongrong Yao, Zhe Wang, Zhihao Zhang*, Ninghua Tan*. Redox Dual-Responsive and O2‑Evolving Theranostic Nanosystem for Highly Selective Chemotherapy against Hypoxic Tumor, Theranostics, 2019, 9 (1), 90-103. IF = 8.537

2Zhi-Hao Zhang, Hua Chen, Nosratola D. Vaziri, Jia-Rong Mao, LiZhang, Xu Bai, Ying-Yong Zhao*. Metabolomic signatures of chronic kidneydisease of diverse etiologies in the rats and humans. Journal of Proteome Research 2016, 15:3802-3812. IF = 4.268

3Zhi-Hao Zhang, Zulfiqar Ali, Shabana I. Khan, Ikhlas A. Khan*. Cytotoxic monacolins from red yeast rice, a Chinese medicine and food. Food Chemistry2016, 202: 262-268. IF = 4.529

4Zhi-Hao Zhang#, Xiaoyan Wang#*, Jingcheng Wang, Zhiying Jia, YuminLiu, Xie Xie, Chongchong Wang, Wei Jia*. Metabonomics approach to assessingthe metabolism variation and endoexogenous metabolic interaction ofginsenosides in cold stress rats. Journal of Proteome Research 2016, 15: 1842-1852. IF = 4.268

5Zhi-Hao Zhang, Feng Wei, Nosratola D. Vaziri, Xian-Long Cheng, XuBai, Rui-Chao Lin, Ying-Yong Zhao*. Metabolomics insights into chronic kidneydisease and modulatory effect of rhubarb against tubulointerstitial fibrosis. Scientific reports 2015, 5: 14472. IF = 5.228

6Zhihao Zhang, Ming-Hua Li, Dan Liu, Hua Chen, Dan-Qian Chen, Ning-Hua Tan, Shuang-Cheng Ma*, Ying-Yong Zhao*. Rhubarb protect against tubulointerstitial fibrosis by inhibiting TGF-β/Smad pathway and improving abnormal metabolome in chronic kidney disease, Frontiers in Pharmacology 2018, doi: 10.3389/fphar.2018.01029. IF = 3.831

7Zhi-Hao Zhang, Nosratola D. Vaziri, Feng Wei, Xian-Long Cheng, Xu Bai, Ying-Yong Zhao*. An integrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinale in chronic renal failure.Scientific reports2016 , 6: 22151. IF = 5.228

8Zhi-Hao Zhang, Jun-Qiu Hea, Wei-Wei Qin, et al. Biomarkers of Obstructive Nephropathy Using a Metabolomics Approach in Rat, Chemico-Biological Interactions, 2018, 296, 229-239. doi: 10.1016/j.cbi.2018.10.004.IF = 3.296

9Zhi-Hao Zhang, Ying-Yong Zhao, Xian-long Cheng, Zhong Dai, Chao Zhou,Xu Bai, Rui-Chao Lin*.General toxicity of Pinellia ternata (Thunb.) Berit.in rat: a metabonomic method for profiling of serum metabolic changes. Journalof Ethnopharmacology 2013, 149: 303-310. IF = 2.939

10Zhi-Hao Zhang, Ying-Yong Zhao, Xian-Long Cheng, Rui-Chao Lin*, Zhong Dai, Chao Zhou. Metabonomic study of biochemical changes in the rat urine induced by Pinellia ternata (Thunb.) Berit. Journal of Pharmaceutical and Biomedical Analysis 2013, 85: 186-193. IF = 3.255

11Zhi-Hao Zhang#, Jia-Rong Mao#, Hua Chen#, Wei Su, Yuan Zhang, Li Zhang, Dan-Qian Chen, Ying-Yong Zhao*, Nosratola D.Vaziri*. Removal of uremic retention products by hemodialysis is coupled with indiscriminate loss of vital metabolites. Clinical Biochemistry 2017, 50: 1078-1086. IF = 2.434

12Zhi-Hao Zhang, Wen-jie Li, Rui-chao Lin*, Zhong Dai*, Xiao-feng Li. Isolation and structure elucidation of alkaloids from Pinellia ternate. Heterocycles 2013, 87: 637-643. IF = 1.107

13Wen-Jie Li#, Zhi-Hao Zhang#, Xian-Long Cheng, Jing Liu, Yi He, Chao Zhou, Ying Guo, Rui-Chao Lin*, Gang-Li Wang. Two new compounds isolated from Liriope muscari. Molecules 2012, 17: 8773-81. IF = 2.861

14Hua Chen, Gang Cao, Dan-Qian Chen, Ming Wang, Nosratola D. Vaziri, Zhi-Hao Zhang, Jia-Rong Mao, Xu Bai, Ying-Yong Zhao*. Metabolomics insights into activated redox signaling and lipid metabolism dysfunction in chronic kidney disease progression. Redox Biology 2016, 10: 168-178.IF = 7.126

15Jin-feng Wang, Zi-yao Jia, Zhi-Hao Zhang, Yu-tong Wang, Xi Liu, Ling-hua Wang and Rui-chao Lin*. Analysis of chemical constituents of melastoma dodecandrum Lour. by UPLC-ESI-Q-Exactive Focus-MS/MS. Molecules 2017, 22:476.IF = 3.098

16Jessica M. Carpentera, Catherine A. Criddle, Helaina K. Craig, Zulfiqar Ali, Zhi-Hao Zhang, Ikhlas A. Khan, Kenneth J. Sufk*. Comparative effects of Mitragyna speciosa extract, mitragynine, and opioid agonists on thermal nociception in rats. Fitoterapia 2016, 109: 87-90.IF =2.642

17Ming Wang, Dan-Qian Chen, Lin Chen, Hui Zhao, Dan Liu, Zhi-Hao Zhang, Nosratola D. Vaziri, et al. Novel RAS inhibitors poricoic acid ZG and poricoic acid ZH attenuate renal fibrosis via Wnt/#-catenin pathway and targeted phosphorylation smad3 signaling. Journal of Agricultural and Food Chemistry, 2018, Jan 31. DOI:10.1021/acs.jafc.8b00099. IF = 3.412

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