教育背景
1997.7毕业于沈阳药科大学日语药学专业,获理学学士学位;同年于沈阳药科大学生药学专业,硕博连读 2002.6毕业于沈阳药科大学生药学专业,获药学博士学位。
工作经历
2002.7进入中国药科大学中药学院,药学博士后。2004.4博士后出站留校到中药学院任教至今。2012年至今任中药资源系党支部书记。2012.2-2013.2日本九州大学农学部公派留学1年
项目课题经历
主持自然科学基金项目“罗汉果基于AMPK-TLR4信号标本兼治肺纤维化的物质基础和作用机制研究”、中药材墨旱莲双靶调控肺纤维化的物质基础及其作用机制研究、中国蓼族植物化学成分、遗传基因与其系统位置的相关性研究”、国家药典委项目及10余项企业合作项目。作为主要完成人参加10余项“重大新药创制”科技重大专项“十一五”计划及多项国家、省部级项目。
论文、成果、著作等
1.Yang Hu, Jie Ren, Lei Wang, Xin Zhao, Mian Zhang, Kuniyoshi Shimizu,Chaofeng Zhang*,Protective effects of total alkaloids from Dendrobium crepidatum, against LPS-induced acute lung injury in mice and its chemical components,Phytochemistry. 149 (2018) 12-23
2.KaiZhou, RuiCheng, BeiLiu, LeiWang, HaifengXie, ChaofengZhang*.Eupatilin ameliorates dextran sulphate sodium -induced colitis in mice partly through promoting AMPK activation. Phytomedicne, July2018, 46(15) 46-56
3.Xixiao Wang, Jie Ren, Shixing Zhu, Guoqing Ren, Lei Wang, Xiaoyan Chen, Zhixia Qiu*, Chaofeng Zhang*. Pharmacokinetics and tissue distribution of eupatilin and its metabolite in rats by an HPLC-MS/MS method Journal of Pharmaceutical and Biomedical Analysis, 2018-06-22 , DOI: 10.1016/j.jpba.2018.06.037
4.Fengyan Cao, Yunfang Zhang, Weiguang Li, Kuniyoshi Shimizu, Haifeng Xie, Chaofeng Zhang*. Mogroside IVE attenuates experimental liver fibrosis in mice and inhibits HSC activation through downregulating TLR4-mediated pathways, International Immunopharmacology 55 (2018) 183–192
5.Yongbin Tong, Weitong Xu, Yan Wu, Liting Ou, Mian Zhang∗, Xianghong Xu,Chaofeng Zhang∗. Metabolic profiles of neotuberostemonine and tuberostemonine inrats by high performance liquid chromatography -quadrupoletime of flight mass spectrometry Journal of Pharmaceutical and Biomedical Analysis 141 (2017) 210–221
6.Lijun Tao, Fengyan Cao,Gonghao Xu, Haifeng Xie, Mian Zhang,Chaofeng Zhang*. Mogroside IIIE Attenuates LPS-Induced Acute Lung Injury in Mice Partly Through Regulation of the TLR4/MAPK/NF-κB Axis via AMPK Activation Phytotherapy Research. 31(2017): 109–1106
7.Lijun Tao, Juan Cao, WenchengWei, Haifeng Xie, Mian Zhanga, Chaofeng Zhang*. Protective role of rhapontin in experimental pulmonary fibrosis in vitro and in vivo. International Immunopharmacology 47 (2017) 38–46
8.Lijun Tao, Jinyu Yang, Fengyan Cao, Haifeng Xie, Mian Zhang, Yanqing Gong*, Chaofeng Zhang*. Mogroside IIIE, a novel anti-Fibrotic compound, reduces pulmonary fibrosis through Toll-Like Receptor 4 Pathways. Journal of Pharmacology Exp Ther, 361 (2017): 268–279
9.Wencheng Wei, Meiling Ding, Kai Zhou, Haifeng Xie, Mian Zhang,Chaofeng Zhang*. Protective effects of wedelolactone on dextran sodium sulfate induced murine colitis partly through inhibiting the NLRP3 inflammasome activation via AMPK signaling Biomedicine & Pharmacotherapy 94 (2017) 27–36
10.Yang Hu, Lijun Tao,Hui Tan, Mian Zhang, Kuniyoshi Shimizu, Fei Zhang, Chaofeng Zhang*. An Active Drimane-Type Lactone from Polygonum jucundum Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Mice Through TLR4-MAPKs Signaling Pathway.Inflammation, 4 (2017): 1204- 1212
专利、著作版权等
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