1989年毕业于中国药科大学生药学专业获理学博士学位，导师为徐国均院士

1988年在日本昭和大学药学部任客座研究员，1995年在美国伊利诺大学芝加哥分校药学院从事博士后研究工作，1996年至1997年在美国依阿华大学药学院任访问教授。

先后承担国家863重大新药创制项目、国家自然科学基金重大专项、国家科技支撑计划等研究项目30多项

1．Identification and Determination of the Major Triterpenes in RhizomaAlismatis by HPLC-Evaporative Light Scattering Detection and HPLC/Electrospray Ionization-MSn [J] Journal of AOAC International. 2013, 96(2): 260-264.

2．Effect of Kai Xin San on Learning and Memory in a Rat Model of Paradoxical Sleep Deprivation [J]. Journal of medicinal food. 2013, 16(4): 280-287.

3．A facile drug delivery system preparation through the interaction between drug and iron ion of transferring [J]. Journal of Nanoparticle Research. 2013, 15(9): 1-12.

4．Diosgenin down-regulates NF-κB p65/p50 and p38MAPK pathways and attenuates acute lung injury induced by lipopolysaccharide in mice. [J] International Immunopharmacology, 2013, 15: 240-245.

5．Screening and identifying the myocardial-injury protective ingredients from Sheng-Mai-San. Pharmaceutical Biology, 2013, 51(10): 1219-1227.

6．Ruscogenin reduces cerebral ischemic injury via NF-κB-mediated inflammatory pathway in the mouse model of experimental stroke. European Journal of Pharmacology, 2013, 714: 303-311.

7．Ruscogenin inhibits lipopolysaccharide-induced acute lung injury in mice: Involvement of tissue factor, inducible NO synthase and nuclear factor (NF)-κB. Int Immunopharmacol. 2012, 12(1): 88-92.

8．Regio- and enantio- selective glycosylation of tetrahydroprotoberberines by Gliocladium deliquescens NRRL1086 resulting in unique alkaloidal glycosides. Appl Microbiol Biot, 2012, 93: 2357–2364.

9．Antioxidant anthocyanins screening through spectrum–effect relationships and DPPH-HPLC-DAD analysis on nine cultivars of introduced rabbiteye blueberry in China. Food Chem, 2012, 132: 759–765.

10．Efficient synthesis of Guanfu base G via highly regioselective lipase-catalyzed acylation in non-aqueous phase. Bioorg Med Chem Lett.2012, 22(9): 3100-3103.

11．Ginsenoside Rg1 protects against hydrogen peroxide-induced cell death in PC12 cells via inhibiting NF-kB activation. Neurochem Int, 2011, 58(1): 119-125.

12．Safety evaluation of steroidal saponin DT-13 isolated from the tuber of Liriope muscari (Decne.) Baily. Food Chem Toxicol, 2011, 49(9): 2243-2251.

13．New approaches to the structural modification of olean-type pentacylic triterpenes via microbial oxidation and glycosylation. Tetrahedron, 2011, 67(23): 4206-4211.

14．On-line high-performance liquid chromatography–diode array detection–electrospray ionization–mass spectrometry–chemiluminescence assay of radical scavengers in Epimedium. J Chromatogr A, 2011, 121(9): 1227-1235.

15．Two new benzofuran derivatives with anti-inflammatory activity from Liriope spicata var. prolifera. Fitoterapia, 2011, 82(2): 190–192.

16． Identification of multiple constituents in the traditional Chinese medicine formula Sheng-Mai San and rat plasma after oral administration by HPLC–DAD–MS/MS. J Pharmaceut Biomed,2011,54 (5): 1110–1127.

17．Ruscogenin Mainly Inhibits Nuclear Factor-κB but Not Akt and Mitogen-Activated Protein Kinase Signaling Pathways in Human Umbilical Vein Endothelial Cells. J Pharmacol Sci, 2010,113(4): 409 – 413.

18．A new sol–gel silica nanovehicle preparation for photodynamic therapy in vitro. Int J Pharmaceut, 2010, 386(12): 131–137.

19．Effects of Storage Condition Factors on Fungal Invasion of Radix Ophiopogonis. J Agric Food Chem, 2010, 58(9): 5432-5437.

20．Homoisoflavonoids from the Fibrous Roots of Polygonatum odoratum with Glucose Uptake-Stimulatory Activity in 3T3-L1 Adipocytes. J Nat Prod, 2010, 73(4): 548–552.

21．One unique steroidal sapogenin obtained through the microbial transformation of ruscogenin by Phytophthora cactorum ATCC 32134 and its potential inhibitory effect on tissue factor (TF) procoagulant activity. Bioorg Med Chem Lett, 2010, 20(14): 4015-4017.

22．Quality and antioxidant activity detection of Crataegus leaves using on-line high-performance liquid chromatography with diode array detector coupled to chemiluminescence detection. Food Chem, 2010, 120(3): 929-933.

23．Microbial conversion of ruscogenin by Gliocladium deliquescens NRRL1086: glycosylation at C-1. Appl Microbiol Biot, 2010, 86(2): 491-497.

24．Isolation and Anti-Inflammatory Activity Evaluation of Triterpenoids and a Monoterpenoid Glycoside from Harpagophytum procumbens. Planta Med, 2010, 76(16): 1892–1896.

25．Biotransformation of Bioactive Natural Products for Pharmaceutical Lead Compounds. Curr Org Chem, 2010, 14(14): 1400-1406.

26．Quality control of flavonoids in Ginkgo biloba leaves by high-performance liquid chromatography with diode array detection and on-line radical scavenging activity detection. J Chrom. A, 2009,1216: 2204–2210

27．The antioxidant-activity-integrated fingerprint: An advantageous tool for the evaluation of quality of herbal medicines. J Chromatogr A. 2008, 1208(1-2):76-82

28．Evaluation of the analgesic and anti-inflammatory activities of Liu-Shen-Wan and its individual fractions in mice. J Ethnopharmacol., 2007,117:108-114

29．Determination of glycyrrhizin in Chinese prescriptions and biological samples by enzyme-linked immunosorbent assay. Analytica Chimica Acta 2006; 564（2）：173-178

30．Novel biotransformation of pentacyclic triterpenoid acids by Nocardia sp. NRRL 5646. Tetrahedron Letter,2005,46,2337-2340

请发明专利30多项，其中授权10多项，