2001年-2006年就读于兰州大学药物化学与神经药理学方向，师从王锐院士，获博士学位（硕博连读）。

2006年-2010年，在中国科学院神经科学研究所从事博士后研究。2015年-2016年，在美国德克萨斯州贝勒医学院从事高级访问学者研究。2011年3月-2018年3月，担任上海交通大学医学院PI,“膜生物物理与化学生物学”研究组组长、研究员、博士生导师。2018年4月份加入中国药科大学，直聘教授。

目前已主持科技部国家重大科学研究计划子课题，科技部新药创制重大研究专项子方向，国家自然科学基金委“优青”、面上基金等国家级项目10余项。

1.Wang, J. #, Wang, Y. #, Cui, W.W. #, Huang, Y. #, Yang, Y., Liu, Y., Zhao, W.S., Cheng, X.Y.,Sun, W.S., Cao, P., Zhu, M.X., Wang, R.*, Hattori, M.*, Yu, Y.*(2018). Druggable negative allosteric site of P2X3 receptors. PNAS. 115(19) 4939-4944.

2.Gabriele Stephan; Lumei Huang; Yong Tang; Sandra Vilotti; Elsa Fabbretti; Yu, Y.; Wolfgang Nörenberg; Heike Franke; Flóra Göröncsér; Beáta Sperlágh; Anke Dopychai; Ralf Hausmann; Günther Schmalzing; Patrizia Rubini; Peter Illes. (2018).The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel. Nat. Commun. 9(1).

3.Yang, X.N., Niu, Y.Y., Liu,Y. Yang,Y. Wang,J., Cheng, X.Y., Liang, H., Wang, H.S., Hu,Y.M., Lu. X.Y., Zhu, M.X., Xu, T.L., Tian, Y., Yu, Y* (2017).The nonproton ligand of acid-sensing ion channel activates mollusk-specific FaNaC channels via a mechanism independent of native FMRFamide peptide.J Biol Chem. 292(52):21662-21675.

4.Wang, J., Sun, L.F., Cui, W.W., Zhao, W.S., Ma, X.F., Li, B., Liu, Y., Yang, Y., Hu, Y.M., Huang, L.D., Cheng, X.Y., Li, L., Lu, X.Y., Tian, Y.*, Yu, Y* (2017). Intersubunit physical couplings fostered by the left flipper domain facilitate channel opening of P2X4 receptors. J Biol. Chem., 292(18):7619-7635.

5.Kasuya, G., Yamaura, T., Ma, X.B., Nakamura, R., Takemoto, M., Nagumo, H., Tanaka, E., Dohmae, N., Nakane, T., Yu, Y., Ishitani, R., Matsuzaki, O., Hattori, M., Nureki1, O. (2017). Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel. Nat Commun,(1):876.

6.Zhao, W.S. #, Sun, M.Y.#, Sun, L.F., Liu. Y., Yang. Y., Huang, L.D., Fan, Y.Z., Cheng. X.Y., Cao, P., H, Y.M., Li, L.Y., Tian, Y., Wang, R.*,Yu, Y.* (2016). A Highly Conserved Salt-bridge Stabilizes the Kinked Conformation of β2,3-sheet Essential for Channel Function of P2X4 Receptors. J Biol Chem.291 (15): 7990-8003

7.Niu, Y.Y. #,Yang, Y. #, Liu, Y., Huang, L.D., Yang, X.N., Fan Y.Z., Cheng, X.Y., Cao, P., Hu Y.M., Li, L.Y., Lu, X.Y., Tian, Y.*, Yu, Y.* (2016). Exploration of the Peptide-recognition of an Amiloride-sensitive FMRFamide Peptide-gated Sodium Channel. J Biol Chem.291 (14): 7571-82

8.Wang, J., Yu, Y.* (2016). Insights into channel gating of P2X receptors from structures, dynamics and small molecules. Acta Pharmacol Sin. (Invited review). 37(1):44-55.

9.Zhao, W.S., Wang, J., Ma, X.J., Yang, Y., Liu, Y., Huang, L.D., Fan, Y.Z., Cheng, X.Y., Chen, H.Z., Wang, R.*, Yu, Y.* (2014). Relative motions between left flipper and dorsal fin domains favour P2X4 receptor activation.Nat Commun, 5:4189.

10.Yu, Y. #, Li, W.G. # (#equal contribution), Chen, Z., Jiang, H.L., Xu, T.L. (2011). Atomic level characterization of the nonproton ligand-sensing domain of ASIC3 channel. J Biol Chem, 286: 24996-5006.

11.Yu, Y#., Chen, Z.#, Li, W.G. (#equal contribution), Cao, H., Feng, E.G., Yu, F., Liu, H., Jiang H.L.*, & Xu, T.L.* (2010). A nonproton ligand sensor in the acid-sensing ion channel. Neuron,68(1), 61-72.

& Commented in “Small molecule ion channel match making: a natural fit for new ASIC ligands”, Bagriantsev, S.N. and Minor, D.L. Jr. Neuron, 68:1-3.

12.Yang, H.#, Yu, Y.# (#equal contribution), Li, W.G., Yu, F., Cao, H., Xu, T.L.*, Jiang, H.L.* (2009). Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism. PLOS Biology, 7:e1000151.

13.Yang, H.#, Yu, Y.# (#equal contribution), Li, W.G., Xu, T.L.*, & Jiang, H.L.* (2009). Conformational sampling on acid-sensing ion channel 1 (ASIC1): implication for a symmetric conformation. Cell Research, 19: 1035-1037.

14.Yu, Y., Shao, X., Cui, Y., Liu, H.M., Wang, C.L., Fan, Y.Z., Liu, J., Dong, S.L., Cui, Y. X., Wang, R.* (2007). Structure–activity study on the spatial arrangement of the third aromatic ring of endomorphins 1 and 2 using an atypical constrained C terminus. ChemMedChem, 2: 309-317.

15.Yu, Y., Cui, Y., Wang, X., Lai, L.H., Wang, C.L., Fan, Y.Z., Liu, J., Wang, R.* (2007). In vitro characterization of the effects of endomorphin 1 and 2, endogenous ligands for mu-opioid receptors, on mouse colonic motility.Biochem Pharmacol, 73:1384-93.

16.Yu, Y., Shao, X., Wang, C.L., Liu, H.M., Cui, Y., Fan, Y.Z., Liu, J., Dong, S.L., Wang, R.* (2007). In vitro and in vivo characterization of opioid activities of endomorphins analogs with novel constrained C-terminus: evidence for the important role of proper spatial disposition of the third aromatic ring. Peptides, 28: 859-870.

17.Yu, Y., Wang, C.L., Cui, Y., Fan, Y.Z., Liu, J., Shao, X., Liu, H.M., Wang, R.* (2006). C-terminal amide to alcohol conversion changes the cardiovascular effects of endomorphins in anesthetized rats. Peptides, 27: 136-143.

18.Yu, Y., Cui, Y., Wang, X., Fan, Y.Z., Liu, J., Yan, X., Wang, R.* (2006). Endomorphin1 and endomorphin2, endogenous potent inhibitors of electrical field stimulation (EFS)-induced cholinergic contractions of rat isolated bronchus. Peptides, 27: 1846-1851.

19.Yu, Y., Wang, X., Cui, Y., Fan, Y.Z., Liu, J., Wang, R.* (2006). Abnormal modulation of cholinergic neurotransmission by endomorphin 1 and endomorphin 2 in isolated bronchus of type 1 diabetic rats. Peptides, 27:2770-7.

20.Li, W.G.#, Yu, Y.# (#equal contribution), Zhang, Z.D., Cao, H., Xu, T.L.* (2010). ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domain. Mol Pain, 6:88.

21.Hu, R., Duan, B., Wang, D., Yu, Y., Li, W., Luo, H., Lu, P., Lin, J., Zhu, G., Wan, Q., Feng, H*.(2011). Role of Acid-sensing ion channel 1a in the secondary damage of traumatic spinal cord injury. Ann Surg, 254(2): 353-62.

22.Li, W.G.#, Yu, Y.# (#equal contribution), Huang, C., Cao, H, Xu, T.L.* (2011). Nonproton ligand sensing domain is required for paradoxical stimulation of acid-sensing ion channel 3 (ASIC3) channels by amiloride. J Biol Chem, 286:42635-46.

23.Yang,Y.#, Yu, Y.# (#equal contribution), Cheng, J., Liu, Y,. Liu, D.S., Wang, J., Zhu, M.X., Wang,R., Xu, T.L.* (2012). Highly conserved salt-bridge stabilizes a rigid signal patch at the extracellular loop critical for surface expression of acid-sensing ion channel. J Biol Chem, 287:14443-55.

24.Duan, B., Wang, Y.Z., Yang, T., Chu, X.P., Yu, Y., Xu, T.L.*(2011). Extracellular Spermine Exacerbates Ischemic Neuronal Injury through Sensitization of ASIC1a Channels to Extracellular Acidosis. J Neurosci, 31: 2011-12.

25.Wang, X., Li, W.G., Yu, Y., Xiao, X., Cheng, J., Zeng, W.Z., Peng, Z., Zhu, X.M., Xu, T.L.* (2013). Serotonin facilitates peripheral pain sensitivity in a manner that depends on the nonproton ligandsensing domain of ASIC3 channel. J Neurosci, 33:4265-79.