1．应用化学和生物信息学技术设计具有Nrf2-Keap1 "蛋白-蛋白"相互调控作用的类天然产物研究 国家自然科学基金重点项目
2．Hsp90与辅助伴侣分子Cdc37相互作用过程的调控、调控剂的设计及生物机制研究 国家自然科学基金项目
3．抗肿瘤及糖尿病新药开发企业创新综合平台建设 “重大新药创制”科技重大专项
4．基于类肽结构的MLL1备份候选化合物发现研究及靶点再确认 “重大新药创制”科技重大专项

1. The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update. Lu MC, Ji JA, Jiang ZY, You QD. Med Res Rev. 2016 36（5）：924-963.
2. Palladium(II)-Catalyzed C-H Bond Activation/C-C Coupling/Intramolecular Tsuji-Trost Reaction Cascade: Facile Access to 2H-Pyranonaphthoquinones. Bian, Jinlei; Qian, Xue; Wang, Nan; Mu, Tong; Li, Xiang; Sun, Haopeng; Zhang, Lianshan; You, Qidong; Zhang, Xiaojin. Org Lett. 2015, 17 (14):3410–3413.
3. Discovery and Development of Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction Inhibitors: Achievements, Challenges and Future Directions. Jiang, Zhengyu; Lu, Mengchen; You, Qi-Dong. J. Med. Chem., 2016, 59（24）：10837–10858
4. Novel Tetrahydropyrido[4,3-d]pyrimidines as Potent Inhibitors of Chaperone Heat Shock Protein 90. Fen Jiang, Hui-Jie Wang, Yu-Hui Jin, Qiong Zhang, Zhi-Hui Wang, Jian-Min Jia, Fang Liu, Lei Wang, Qi-Chao Bao, Dong-Dong Li, Qi-Dong You, and Xiao-Li Xu. J. Med. Chem., 2016, 59 (23):10498–10519
5. Design, Synthesis, and Initial Evaluation of Affinity-based Small-Molecule Probes for Fluorescent Visualization and Specific Detection of Keap1. Mengchen Lu, Hai-shan Zhou, Qi-Dong You, and Zhengyu Jiang. J. Med. Chem., 2016, 59 (15):7305–7310
6. Structure-Activity and Structure-Property Relationship and Exploratory in vivo Evaluation of the Nanomolar Keap1-Nrf2 Protein-Protein Interaction Inhibitor. Zhengyu Jiang, Lili Xu, Mengchen Lu, Zhiyun Chen, Zhenwei Yuan, Xiaoli Xu, Xiaoke Guo, Xiaojin Zhang, Haopeng Sun, Qi-Dong You. J. Med. Chem., 2015, 58 (16):6410–6421
7. Discovery and Modification of in vivo active Nrf2 Activators with 1, 2, 4-oxadiazole Core: Hits Identification and Structure-Activity Relationship Study. Xu, Lili; Zhu, Junfeng; Xu, Xiaoli; Zhu, Jie; Li, Li; Xi, Meiyang; Jiang, Zhengyu; Zhang, Mingye; Liu, Fang; Lu, Mengchen; Bao, Qichao; Zhang, Chao; Wei, Jinlian; Zhang, Xiaojin; You, Qi-Dong; Sun, Haopeng. J Med Chem. 2015, 58 (14), pp 5419–5436
8. Discovery of potent Keap1-Nrf2 Protein-Protein Interaction Inhibitor Based on Molecular Binding Determinants Analysis. Jiang Z, Lu M, Xu L, Yang T, Xi M, Xu X, Guo X, Zhang X, You Q*, Sun H*. J Med Chem. 2014, 57:2736-2745
9. 3-Aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as Potent Nrf2/ARE Inducers in Human Cancer Cells and AOM-DSS Treated Mice. Mei-yang Xi, Jian-min Jia, Hao-peng Sun*, Zhong-ying Sun, Jie-wei Jiang, Ya-jing Wang, Min-ye Zhang, Jun-feng Zhu, Li-li Xu, Zheng-yu Jiang, Xin Xue, Ming Ye, Xi Yang, Yuan Gao, Lei Tao, Xiao-ke Guo, Xiao-li Xu, Qing-long Guo, Xiao-jin Zhang, Rong Hu*, and Qi-dong You*. J Med Chem. 2013, 56(20),7925–7938
10. Garcinia Xanthones as Orally Active Antitumor Agents. Zhang X, Li X, Sun H, Wang X, Zhao L, Gao Y, Liu X, Zhang S, Wang Y, Yang Y, Su Z, Guo Q, You Q*.J Med Chem. 2013, 56(1), 276-292

申请美、英、德、中等国家发明专利50余项，其中授权专利28项