教育背景
工作经历
1993年毕业留校后一直从事药代动力学研究和教学工作20余年,期间在国家药品审评中心外聘工作近一年
项目课题经历
主持并承担多项国家自然科学基金、国家重大新药创制专项。近几年科研经费累积超过500万元。
论文、成果、著作等
Fan G, Cao Y, Yang J(Correspondence Author). In vitro inhibition and induction of human cytochrome P450 enzymes by SIPI5357, a potential antidepressant. Biopharm Drug Dispos. 2015 Mar 16. doi: 10.1002/bdd.1947
2) Jing Z, Kuang L, Liu N, Yang J(Correspondence Author). LC-MS/MS for the simultaneous determination of polar endogenous ADMA and CML in plasma and urine from diabetics. Bioanalysis. 2015 May;7(10):1261-71. doi: 10.4155/bio.15.58.
3) Xu R, Liu X, Yang J(Correspondence Author). A semi-physiologically based pharmacokinetic pharmacodynamic model for glycyrrhizin-induced pseudoaldosteronism and prediction of the dose limit causing hypokalemia in a virtual elderly population. PLoS One. 2014 Dec 2;9(12): e114049. doi: 10.1371/journal.pone.0114049. eCollection 2014
4) Biao Yu, Pengcheng Ma, Linwen Yuan, Dingding Chen, and Jin Yang∗(Correspondence Author) Evaluation of change in the skin concentration of tazarotene and betamethasone dipropionate based on drug–drug interaction for transdermal drug delivery in miniature pig. Xenobiotica. 2014 Nov 20:1-5.
5) Xu R, Wang Q, Zhang J, Zang M, Liu X, Yang J(Correspondence Author). Changes in pharmacokinetic profiles of acetaminophen and its glucuronide after pretreatment with combinations of N-acetylcysteine and either glycyrrhizin, silibinin or spironolactone in rat. Xenobiotica. 2014 Jun;44(6):541-6.
6) Min Zang, Xiaoqiang Liu, Lin Chen, Qingqing Xiao, Linwen Yuan, Jin Yang∗(Correspondence Author) Determination of BmKCT-13, a chlorotoxin-like peptide, in rat plasma by LC–MS/MS: Application to a preclinical pharmacokinetic study Journal of Chromatography B, 947–948 (2014) 125– 131
7) Liqing Kuang, Zhiqiang Jing, Jing Wang, Liyuan Ma, Xiaoqiang Liu, Jin Yang (Correspondence Author) Quantitative determination of ε-N-Carboxymethyl-L-lysine in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry. Journal of Pharmaceutical and Biomedical Analysis(IF=2.97) Journal of Pharmaceutical and Biomedical Analysis 90 (2014) 1–6
8) Shuming LI, Xiangyang WANG, Wei LI, Yang CHU. Jiahua GUO, Xiaohui MA, Jin YANG (Correspondence Author) Characterization of Metabolites in Rat after Administration of Danshensu by Liquid Chromatography-tandem Mass Spectrometry Lat. Am. J. Pharm. 2013:32 (4): 582-6
9) Yuan Lu • Jinbo Yang • Haiyan Zhang • Jin Yang. (Correspondence Author) Prediction of Warfarin Maintenance Dose in Han Chinese Patients Using a Mechanistic Model Based on Genetic and Non-Genetic Factors. Clinical Pharmacokinetics(IF=5.40). (2013) 52:567–581
10) R. Xu, Q. Xiao, Y. Cao, J.Yang(Correspondence Author) Comparison of the Exposure of Glycyrrhizin and its Metabolites and the Pseudoaldosteronism after Intravenous Administration of Alpha- and Beta-glycyrrhizin in Rat. Drug Res (Stuttg). 2013 Jul 17
11) Xu R, Zhang X, Yang J(Correspondence Author), Liu X, Davey AK, Wang J. Effects of glycyrrhizin on biliary transport and hepatic levels of glutathione in rats. Biopharm Drug Dispos(IF=2.07). 2012 Apr 17. doi: 10.1002/bdd.1789.
12) Min Zhang, Jin Yang(Correspondence Author), Lei Tao, Lingjun Li, Pengcheng Ma, and John Paul Fawcett, Acarbose Bioequivalence: Exploration of New Pharmacodynamic Parameters AAPS J(IF=5.09). 2012 Jun;14(2):345-51.
13) Feng-Juan Zhao, Hong Tang, Qing-Hua Zhang, Jin Yang, (Correspondence Author), Andrew K., Daveyc, Ji-ping Wang. Salting-out homogeneous liquid–liquid extraction approach applied in sample pre-processing for the quantitative determination of entecavir in human plasma by LC–MS Journal of Chromatography B(IF=2.89), 881–882 (2012) 119– 125
14) Guo-fu LI, Kun WANG, Rui CHEN, Hao-ru ZHAO, Jin YANG, Qing-shan ZHENG, Simulation of the pharmacokinetics of bisoprolol in healthy adults and patients with impaired renal function using whole-body physiologically based pharmacokinetic modeling. Acta Pharmacologica Sinica (2012) 33: 1359–1371
15) Chen Yanxiao Xu Ruijuan Yang Jin(Correspondence Author) Organic anion and cation transporters are possibly involved in renal excretion of entecavir in rats Life Sciences 89 (2011) (IF=2.56)1–6
16) Xiong Yu ; Yang yuqing ; Yang jin, Dr.; chai hong yan; Li ying; Yang Jing , Dr. Tectoridin, an isoflavone glycoside from the flower of Pueraria lobata, prevents acute ethanolinduced liver steatosis in mice, Toxicology. 2010 Sep 30;276(1):64-72.
17) Qing-Hua Zhang, Jin Yang(Correspondence Author) Food effect on the pharmacokinetics of entecavir from dispersible tablets following oral administration in healthy Chinese volunteers Arzneimittelforschung 2010;60(10):640–644
18) L. Chen, J. Yang(Correspondence Author), A. K. Davey, Y.-X. Chen, J.-P. Wang, and X.-Q. Liu Efects of diammonium glycyrrhizinate on the pharmacokinetics of aconitine in rats and the potential mechanism Xenobiotica(IF=1.918), 2009; 39(12): 955–963
19) Jin Yang, Ying He Pharmacokinetic Properties of S-adenosylmethionine after Oral and intravenous administration of its Tosylate disulfate salt: a Multiple-dose, Open-Label, Parallel-Group study in Healthy Chinese volunteers Clinical Therapeutics Volume 31, Number 2, 2009 (IF=3.261):311-320
20) Jin Yang, Liang Zhou, JipingWang, GuangjiWang, Andrew K Davey The Disposition of Diammonium Glycyrrhizinate and Glycyrrhetinic Acid in the Isolated Perfused Rat Intestine and Liver Planta Medica 2008; 74: 1351–1356
21) 袁淋文 杨劲(通讯作者) Beagel犬药动学研究在缓释制剂评价体系中的作用比较. 中国新药杂志 2015年第24卷第 10期:1134-1140
22) 赵明,杨劲(通讯作者),魏敏吉 置信区间法用于线性药代动力学特征评价. 中国临床药理学杂志2015 年 2 月:238-240
23) 赵明,谢松梅,杨劲(通讯作者),魏敏吉. 关于生物等效性试验中血药峰浓度等效界值的思考 中国临床药理学杂志 2014 年 10 月:970-973
24) 陈晓媛 杨 劲 关于甲磺酸伊马替尼口服制剂生物等效性试验设计的几点考虑 中国临床药理学杂志 2014 年 9 月:840-843
25) 肖青青 赵凤娟 杨劲(通讯作者) 王友群 药物分布容积的预测方法 中国药科大学学报2013年第03
26) 何清 杨劲(通讯作者);数字胃肠道模型的建立及在硝苯地平缓释片人体吸收预测中的应用 中国药科大学学报 2012(01):85-91.
27) 陈春,林志强,杨劲(通讯作者) 模型设计在制剂研发及生产过程质量控制中的应用《药学进展》2011年第35卷第7期 289-296
28) 尹雪芬 林志强 杨劲(通讯作者) 基于转运蛋白的代谢性数字肝生理模型预测普伐他汀、匹伐他汀与环孢素的药代动力学相互作用 药学学报 Acta Pharmaceutica Sinica 2011, 46 (9): 1108−1116
29) 黎国富, 杨 劲(通讯作者), 华小懿, 陈蕊, 赵浩如 Ussing chamber模型研究甘草酸二铵经大鼠肠黏膜的转运特征 中国中药杂志 2010; 35(17); p 2261-2266
30) 黎国富 杨 劲(通讯作者) 张雪莹 赵浩如 基于胃肠道生理模型的口服药物吸收预测 中国临床药理学与治疗学 2010 Jun ; 15 (6):656 – 662
31) 张雪莹,杨劲(通讯作者) 谷胱甘肽的肝脏转运及其在胆汁淤积中的作用 药学学报2009, 44 (4): 1-6
32) 汪音 杨劲(通讯作者) 傅继华 刘晓东 王广基 基于体外模型数据模拟和预测人体内群体药代参数 中国临床药理学与治疗学 2008年13卷5期:545-551
33) 苏笠 杨劲(通讯作者) 化合物脂水分配系数计算软件及比较研究 中国药科大学学报 2008,39(2):178~182
34) 周亮 杨劲(通讯作者),张雪莹,柳晓泉,王广基 磷脂对甘草酸二铵小肠吸收的影响 药学学报 2008年vol.43 No.1 71~75
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